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The map label for this gene is fabF [H]

Identifier: 226951052

GI number: 226951052

Start: 4110600

End: 4111838

Strand: Reverse

Name: fabF [H]

Synonym: CLM_4091

Alternate gene names: 226951052

Gene position: 4111838-4110600 (Counterclockwise)

Preceding gene: 226951053

Following gene: 226951051

Centisome position: 98.95

GC content: 34.22

Gene sequence:

>1239_bases
ATGAATAAAAGAGTAGTTATAACTGGTATGGGTGCTATTACACCTATTGGCAATAATCTTGAGGACTTTTGGAAAGGCAT
AAAAGAAGAAAAAATAGGAATAGGTAATATAAAATCTTTTGACATAGAAGATTATAAAGTTAAGTTAGCAGCAGAGGTTA
AAGATTTTGATCCAGAAGAATATATGGATAAAAAAGAAGCTAGAAGATTAGATAGGTTTTGCCAATTTGCTATAGCAGCA
GCACAGCAAGCTATTGATAATAGTAAATTAGATTTAGATAAAATAAATAAAGAAAAATTTGGAGTTATAGTAGGATCAGG
TATTGGCGGATTAGCAACTATAGAAAAGGAAGAACAAAAATTATTAGAAAAGGGACCTAATAGAGTAAGTCCATTATTTA
TACCAACAATAATAAGTAATATGGCAGCGGGAAATATAGCTATTAGATTTGGAGCTAAGGCTATATGTAGTACTGTAGTT
ACAGCCTGTGCTACAGGAACTAATTGCGTAGGGGAGGCTTTTAGAGCTATAAAGAATGGAGAAGCTGACATAATGCTAGC
AGGAGGTACAGAAGCAGCTATAACTCCTATAGCTATAGCAGGTTTTACAACTCTTACAGCTTTAAGTAAAAGTACAGATC
CTAATAGAGCGTCTATACCTTTTGATAAAGATAGAGACGGGTTTGTTATGGGTGAAGGTTCAGGATTATTAGTATTAGAA
TCACTAGATCATGCACTAGAGAGAGGTGCTAAAATTTATGCAGAAGTAGTTGGATACGGATCTACTTGTGATGCATATCA
TATGACATCTCCTGCTCCAGGAGGAGAAGGAGCGGCAAGGGCTATAGAGCTTGCTATAAAGGAAGCAGGTATAAATAAAG
AAGAAGTATCCTATATAAATGCCCATGGAACTAGTACTCCATATAATGATAAATTTGAAACAGAAGCAATTAAAAGAGTG
TTCGGAGATTATTCATCTAGTATACCTGTCAGTTCTACAAAATCTATGATAGGTCATTTATTGGGAGCAGCGGGAGCAGT
TGAAGCTATAATATGTGCAAAGTCTTTAGAAGAAGGATATATACCTGCAACAGTTGGATATAAGGTTAAAGATGAAGAAT
GTGATTTGGACTATGTGACTTCAGGCGGAAGAAATAAAATAATAAATTATGCTATGTCTAATTCTTTAGGTTTTGGAGGA
CATAATGCAGTAATATTATTAAAAAAATGGGGTGAGTAA

Upstream 100 bases:

>100_bases
ACTGTAGGATTTTTAGCTTCAGATAAAGCTGCATATATAACAGGTCAAGTTATACATGTAGATGGTGGAATGATTATATA
GGTAAAAAGGGGTGAATAAT

Downstream 100 bases:

>100_bases
TAAATGGATTTTAAAGGCATAGAAAATTTAATAAAAGCTATGAGTGAATCAAATTTATCTTCTATGGATATAGAGTATAA
TGGTATAGCTATAAAAATGA

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MNKRVVITGMGAITPIGNNLEDFWKGIKEEKIGIGNIKSFDIEDYKVKLAAEVKDFDPEEYMDKKEARRLDRFCQFAIAA
AQQAIDNSKLDLDKINKEKFGVIVGSGIGGLATIEKEEQKLLEKGPNRVSPLFIPTIISNMAAGNIAIRFGAKAICSTVV
TACATGTNCVGEAFRAIKNGEADIMLAGGTEAAITPIAIAGFTTLTALSKSTDPNRASIPFDKDRDGFVMGEGSGLLVLE
SLDHALERGAKIYAEVVGYGSTCDAYHMTSPAPGGEGAARAIELAIKEAGINKEEVSYINAHGTSTPYNDKFETEAIKRV
FGDYSSSIPVSSTKSMIGHLLGAAGAVEAIICAKSLEEGYIPATVGYKVKDEECDLDYVTSGGRNKIINYAMSNSLGFGG
HNAVILLKKWGE

Sequences:

>Translated_412_residues
MNKRVVITGMGAITPIGNNLEDFWKGIKEEKIGIGNIKSFDIEDYKVKLAAEVKDFDPEEYMDKKEARRLDRFCQFAIAA
AQQAIDNSKLDLDKINKEKFGVIVGSGIGGLATIEKEEQKLLEKGPNRVSPLFIPTIISNMAAGNIAIRFGAKAICSTVV
TACATGTNCVGEAFRAIKNGEADIMLAGGTEAAITPIAIAGFTTLTALSKSTDPNRASIPFDKDRDGFVMGEGSGLLVLE
SLDHALERGAKIYAEVVGYGSTCDAYHMTSPAPGGEGAARAIELAIKEAGINKEEVSYINAHGTSTPYNDKFETEAIKRV
FGDYSSSIPVSSTKSMIGHLLGAAGAVEAIICAKSLEEGYIPATVGYKVKDEECDLDYVTSGGRNKIINYAMSNSLGFGG
HNAVILLKKWGE
>Mature_412_residues
MNKRVVITGMGAITPIGNNLEDFWKGIKEEKIGIGNIKSFDIEDYKVKLAAEVKDFDPEEYMDKKEARRLDRFCQFAIAA
AQQAIDNSKLDLDKINKEKFGVIVGSGIGGLATIEKEEQKLLEKGPNRVSPLFIPTIISNMAAGNIAIRFGAKAICSTVV
TACATGTNCVGEAFRAIKNGEADIMLAGGTEAAITPIAIAGFTTLTALSKSTDPNRASIPFDKDRDGFVMGEGSGLLVLE
SLDHALERGAKIYAEVVGYGSTCDAYHMTSPAPGGEGAARAIELAIKEAGINKEEVSYINAHGTSTPYNDKFETEAIKRV
FGDYSSSIPVSSTKSMIGHLLGAAGAVEAIICAKSLEEGYIPATVGYKVKDEECDLDYVTSGGRNKIINYAMSNSLGFGG
HNAVILLKKWGE

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=419, Percent_Identity=40.5727923627685, Blast_Score=311, Evalue=6e-85,
Organism=Homo sapiens, GI223972627, Length=178, Percent_Identity=41.0112359550562, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI41872631, Length=428, Percent_Identity=25, Blast_Score=99, Evalue=6e-21,
Organism=Escherichia coli, GI1787337, Length=409, Percent_Identity=46.9437652811736, Blast_Score=357, Evalue=1e-100,
Organism=Escherichia coli, GI1788663, Length=412, Percent_Identity=35.6796116504854, Blast_Score=227, Evalue=9e-61,
Organism=Caenorhabditis elegans, GI71983541, Length=415, Percent_Identity=38.3132530120482, Blast_Score=272, Evalue=3e-73,
Organism=Caenorhabditis elegans, GI71983535, Length=258, Percent_Identity=44.1860465116279, Blast_Score=211, Evalue=8e-55,
Organism=Caenorhabditis elegans, GI212642053, Length=356, Percent_Identity=26.123595505618, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17550940, Length=415, Percent_Identity=24.3373493975904, Blast_Score=98, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6320904, Length=448, Percent_Identity=38.6160714285714, Blast_Score=290, Evalue=4e-79,
Organism=Drosophila melanogaster, GI24644341, Length=418, Percent_Identity=41.1483253588517, Blast_Score=320, Evalue=1e-87,
Organism=Drosophila melanogaster, GI221330659, Length=437, Percent_Identity=24.2562929061785, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI19920632, Length=437, Percent_Identity=24.2562929061785, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24581345, Length=426, Percent_Identity=23.943661971831, Blast_Score=104, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43929; Mature: 43929

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKRVVITGMGAITPIGNNLEDFWKGIKEEKIGIGNIKSFDIEDYKVKLAAEVKDFDPEE
CCCEEEEEECCCCCCCCCCHHHHHCCHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCHHH
YMDKKEARRLDRFCQFAIAAAQQAIDNSKLDLDKINKEKFGVIVGSGIGGLATIEKEEQK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCEEEEEECCCCCCEECCHHHHH
LLEKGPNRVSPLFIPTIISNMAAGNIAIRFGAKAICSTVVTACATGTNCVGEAFRAIKNG
HHHCCCCCCCCEEHHHHHHHHCCCCEEEEECHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
EADIMLAGGTEAAITPIAIAGFTTLTALSKSTDPNRASIPFDKDRDGFVMGEGSGLLVLE
CCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCEEEEH
SLDHALERGAKIYAEVVGYGSTCDAYHMTSPAPGGEGAARAIELAIKEAGINKEEVSYIN
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHEEEE
AHGTSTPYNDKFETEAIKRVFGDYSSSIPVSSTKSMIGHLLGAAGAVEAIICAKSLEEGY
CCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
IPATVGYKVKDEECDLDYVTSGGRNKIINYAMSNSLGFGGHNAVILLKKWGE
CCEEECEEECCCCCCCHHCCCCCCHHEEEEEHHCCCCCCCCCEEEEEEECCC
>Mature Secondary Structure
MNKRVVITGMGAITPIGNNLEDFWKGIKEEKIGIGNIKSFDIEDYKVKLAAEVKDFDPEE
CCCEEEEEECCCCCCCCCCHHHHHCCHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCHHH
YMDKKEARRLDRFCQFAIAAAQQAIDNSKLDLDKINKEKFGVIVGSGIGGLATIEKEEQK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCEEEEEECCCCCCEECCHHHHH
LLEKGPNRVSPLFIPTIISNMAAGNIAIRFGAKAICSTVVTACATGTNCVGEAFRAIKNG
HHHCCCCCCCCEEHHHHHHHHCCCCEEEEECHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
EADIMLAGGTEAAITPIAIAGFTTLTALSKSTDPNRASIPFDKDRDGFVMGEGSGLLVLE
CCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCEEEEH
SLDHALERGAKIYAEVVGYGSTCDAYHMTSPAPGGEGAARAIELAIKEAGINKEEVSYIN
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHEEEE
AHGTSTPYNDKFETEAIKRVFGDYSSSIPVSSTKSMIGHLLGAAGAVEAIICAKSLEEGY
CCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
IPATVGYKVKDEECDLDYVTSGGRNKIINYAMSNSLGFGGHNAVILLKKWGE
CCEEECEEECCCCCCCHHCCCCCCHHEEEEEHHCCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]