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The map label for this gene is clpC [H]

Identifier: 226950963

GI number: 226950963

Start: 4006187

End: 4008622

Strand: Reverse

Name: clpC [H]

Synonym: CLM_3980

Alternate gene names: 226950963

Gene position: 4008622-4006187 (Counterclockwise)

Preceding gene: 226950964

Following gene: 226950962

Centisome position: 96.47

GC content: 30.99

Gene sequence:

>2436_bases
ATGATGTTTGGAAGATTTACGGAAAGAGCTCAGAAAGTACTTATGAATGCTCAGGAAGAAGCAGAAAAATTTAAACATGG
ATATGTAGGTACAGAACATATTCTTTTAGGAATTTTAATAGAAGATGGAGTAGCCAAAGAATTATTAAATAATTTTAGTA
TAACAGAAGATAAGGTTAGACAGTTAATAGAAAGATATGAAGGAAAAGGGGAAATGGATCTTTATAAAAATGAGATTCCA
CTTACACCAAGAACAAAAAGGTTACTTGAAATGAGTTTATTAGAAGCTAGAAATTTAAATCATAATTATATAACTCCAGA
ACATATATTATTGGGATTAATAAGAGAAGCTGAAGGGGTAGCCTTTACCATTCTTTCTAATTTAGGATTAGATGCTGAAA
GATTAAGAAAAGAGTTAGTAAAGAATTTATCTGGGCAAGAAACTCCTAAAGATGAAGGCAGTAAAAAAAGTTCTAAAAGC
TCTACCCCTACATTAGACCAATTTGGAAGAGATTTAACTGAAATGGCAGAAGAGGGGAAGGTTGACCCTGTTATTGGAAG
AGATAAAGAAACCCAAAGAGTTTTAGAAATATTATGTAGAAGAACTAAGAACAATCCTTGCTTAATAGGTGAACCAGGAG
TTGGGAAAACAGCAATAGCCGAAGGCTTAGCTCAAAATATAATTGATGGAAATATACCAGAAATATTAAAAAACAAAAGA
GTAGTTACATTAGACTTAACATCTATGATAGCAGGGGCCAAGTATAGGGGTGAATTTGAGGATAGATTAAAGAAAATAAT
GGAGGAAGTAAGAAGTTCTAAGGATACAATATTGTTTATAGATGAAATTCATACAATAGTTGGAGCTGGGGCAGCAGAAG
GGGCTATAGATGCAGCAAACATATTAAAACCAGCATTAGCGAGAGGAGAAATTCAATGTATAGGTGCAACTACACTAGAT
GAATATAGAAAGTATATAGAAAAAGATTCTGCTTTAGAGAGAAGATTCCAGCCTATAAACGTAGGAGAACCTACAAAAGA
AGAAACAATAGAAATTTTAAAGGGATTAAGAGATAAGTATGAAGCACATCATAGAGTTAAATTTACAGATGATGCTATAT
ATGCAGCAGTTAATTTATCTGATAGATATATAAGAGATAGATTTTTGCCAGATAAAGCGATAGATCTGATGGATGAAGCT
GGTTCCAAGGTTAGAATACAAAATTTAATTGCACCACCAGATCTGAAGAATATAGAAGAACAACTAGATAAAGTTGTTAA
AGAAAAAGAAGATGCAATAAGAGTGCAGGATTTTGAAAAAGCTGCTAATTTAAGAGATAAAGAAAAAGAATTAAAAGAAA
AGTTAGAAGGGTTGAAAAAGGATTGGAATGCAGAAAAAGAAGGTTCTAATTTAATTGTATCAGAACAACAAATAGCAGCA
GTAGTTTCAAATTGGACTAATATACCAGTTAATAAGCTTACTGAAAAGGAATCTGAAAGACTCTTAAAATTAGAAAATAT
TCTTCATAATAGGGTAATCGGCCAAGAAGAAGCTATTAAATCAGTATCAAGATCTGTAAGAAGAGCAAGAGTAGGCTTGA
AAGATCCAAAGAGACCAATAGGTTCATTTATATTTTTGGGACCAACAGGTGTAGGGAAAACTGAATTGACTAAAGCCTTA
GCAGAAGCTATGTTTGGAAATGAAAATAATATGATTAGGGTTGACATGTCAGAATATATGGAAAAACATTCAGTATCTAG
ATTAATAGGATCACCTCCAGGATATGTAGGGCACGATGAAGGTGGTCAATTAACAGACAAGGTAAGGACAAATCCATATT
CAGTTGTTTTATTTGATGAAATAGAAAAAGCTCATCCAGAAGTGTTTAATATATTACTTCAAATATTAGAAGATGGAAGG
CTTACAGATGGAAAAGGAAAAACAGTAGATTTCAGAAATACTATAATCATAATGACATCTAATGTGGGAGCATCAACTAT
AAGTAGGCAAAAGACATTAGGTTTTAATACCTCCATAGAAGAAGAAAGAGAAACAGAATATGAAAAAATGAAGGATAACA
TTATGAATGAATTAAAACATTCATTTAGACCAGAATTCTTAAATAGAATAGATGATATAATAGTTTTCCATCAATTAAGA
GAAGAGCATATTAGAGAAATAGTTAAACTTATGCTAAAAACTGTATCAAATAGAGTTAAAGATCAAGGAATAAAATTAGA
GTTTACAGAAGAAGCAGAAAAAATATTGGCAAAAGAAGGATACGATACTAATTATGGAGCGAGACCTTTAAGAAGAGCTA
TAACTAAAATTGTAGAAGATAAATTGTCAGAAGAAATATTAAAGGGAAATATTAAAAAAGGTGATTCAGTTAAAGTTAAT
ACAATTGAAGATAAATTAAATTTTTATAAGATGTAA

Upstream 100 bases:

>100_bases
ATTTATGATAAAGAAATGACTGAAAAAGAAAGTAAGTATTATAGGGCTATGTTAGTTAAAGAAAGATTAAAAAAACAAAA
GTTTAAGGAGGGTGATTAAT

Downstream 100 bases:

>100_bases
ATTTTGAATTTAATTTTAAGCCAATAATTAAATTTATTTAATTATTGGTTTTTTTAAAATTATTTTACTAATTGATGTTA
TAATAATATTATTGTAATTA

Product: negative regulator of genetic competence MecB/ClpC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 811; Mature: 811

Protein sequence:

>811_residues
MMFGRFTERAQKVLMNAQEEAEKFKHGYVGTEHILLGILIEDGVAKELLNNFSITEDKVRQLIERYEGKGEMDLYKNEIP
LTPRTKRLLEMSLLEARNLNHNYITPEHILLGLIREAEGVAFTILSNLGLDAERLRKELVKNLSGQETPKDEGSKKSSKS
STPTLDQFGRDLTEMAEEGKVDPVIGRDKETQRVLEILCRRTKNNPCLIGEPGVGKTAIAEGLAQNIIDGNIPEILKNKR
VVTLDLTSMIAGAKYRGEFEDRLKKIMEEVRSSKDTILFIDEIHTIVGAGAAEGAIDAANILKPALARGEIQCIGATTLD
EYRKYIEKDSALERRFQPINVGEPTKEETIEILKGLRDKYEAHHRVKFTDDAIYAAVNLSDRYIRDRFLPDKAIDLMDEA
GSKVRIQNLIAPPDLKNIEEQLDKVVKEKEDAIRVQDFEKAANLRDKEKELKEKLEGLKKDWNAEKEGSNLIVSEQQIAA
VVSNWTNIPVNKLTEKESERLLKLENILHNRVIGQEEAIKSVSRSVRRARVGLKDPKRPIGSFIFLGPTGVGKTELTKAL
AEAMFGNENNMIRVDMSEYMEKHSVSRLIGSPPGYVGHDEGGQLTDKVRTNPYSVVLFDEIEKAHPEVFNILLQILEDGR
LTDGKGKTVDFRNTIIIMTSNVGASTISRQKTLGFNTSIEEERETEYEKMKDNIMNELKHSFRPEFLNRIDDIIVFHQLR
EEHIREIVKLMLKTVSNRVKDQGIKLEFTEEAEKILAKEGYDTNYGARPLRRAITKIVEDKLSEEILKGNIKKGDSVKVN
TIEDKLNFYKM

Sequences:

>Translated_811_residues
MMFGRFTERAQKVLMNAQEEAEKFKHGYVGTEHILLGILIEDGVAKELLNNFSITEDKVRQLIERYEGKGEMDLYKNEIP
LTPRTKRLLEMSLLEARNLNHNYITPEHILLGLIREAEGVAFTILSNLGLDAERLRKELVKNLSGQETPKDEGSKKSSKS
STPTLDQFGRDLTEMAEEGKVDPVIGRDKETQRVLEILCRRTKNNPCLIGEPGVGKTAIAEGLAQNIIDGNIPEILKNKR
VVTLDLTSMIAGAKYRGEFEDRLKKIMEEVRSSKDTILFIDEIHTIVGAGAAEGAIDAANILKPALARGEIQCIGATTLD
EYRKYIEKDSALERRFQPINVGEPTKEETIEILKGLRDKYEAHHRVKFTDDAIYAAVNLSDRYIRDRFLPDKAIDLMDEA
GSKVRIQNLIAPPDLKNIEEQLDKVVKEKEDAIRVQDFEKAANLRDKEKELKEKLEGLKKDWNAEKEGSNLIVSEQQIAA
VVSNWTNIPVNKLTEKESERLLKLENILHNRVIGQEEAIKSVSRSVRRARVGLKDPKRPIGSFIFLGPTGVGKTELTKAL
AEAMFGNENNMIRVDMSEYMEKHSVSRLIGSPPGYVGHDEGGQLTDKVRTNPYSVVLFDEIEKAHPEVFNILLQILEDGR
LTDGKGKTVDFRNTIIIMTSNVGASTISRQKTLGFNTSIEEERETEYEKMKDNIMNELKHSFRPEFLNRIDDIIVFHQLR
EEHIREIVKLMLKTVSNRVKDQGIKLEFTEEAEKILAKEGYDTNYGARPLRRAITKIVEDKLSEEILKGNIKKGDSVKVN
TIEDKLNFYKM
>Mature_811_residues
MMFGRFTERAQKVLMNAQEEAEKFKHGYVGTEHILLGILIEDGVAKELLNNFSITEDKVRQLIERYEGKGEMDLYKNEIP
LTPRTKRLLEMSLLEARNLNHNYITPEHILLGLIREAEGVAFTILSNLGLDAERLRKELVKNLSGQETPKDEGSKKSSKS
STPTLDQFGRDLTEMAEEGKVDPVIGRDKETQRVLEILCRRTKNNPCLIGEPGVGKTAIAEGLAQNIIDGNIPEILKNKR
VVTLDLTSMIAGAKYRGEFEDRLKKIMEEVRSSKDTILFIDEIHTIVGAGAAEGAIDAANILKPALARGEIQCIGATTLD
EYRKYIEKDSALERRFQPINVGEPTKEETIEILKGLRDKYEAHHRVKFTDDAIYAAVNLSDRYIRDRFLPDKAIDLMDEA
GSKVRIQNLIAPPDLKNIEEQLDKVVKEKEDAIRVQDFEKAANLRDKEKELKEKLEGLKKDWNAEKEGSNLIVSEQQIAA
VVSNWTNIPVNKLTEKESERLLKLENILHNRVIGQEEAIKSVSRSVRRARVGLKDPKRPIGSFIFLGPTGVGKTELTKAL
AEAMFGNENNMIRVDMSEYMEKHSVSRLIGSPPGYVGHDEGGQLTDKVRTNPYSVVLFDEIEKAHPEVFNILLQILEDGR
LTDGKGKTVDFRNTIIIMTSNVGASTISRQKTLGFNTSIEEERETEYEKMKDNIMNELKHSFRPEFLNRIDDIIVFHQLR
EEHIREIVKLMLKTVSNRVKDQGIKLEFTEEAEKILAKEGYDTNYGARPLRRAITKIVEDKLSEEILKGNIKKGDSVKVN
TIEDKLNFYKM

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=322, Percent_Identity=37.888198757764, Blast_Score=215, Evalue=2e-55,
Organism=Escherichia coli, GI1788943, Length=880, Percent_Identity=44.0909090909091, Blast_Score=713, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=802, Percent_Identity=38.2793017456359, Blast_Score=550, Evalue=1e-157,
Organism=Saccharomyces cerevisiae, GI6320464, Length=710, Percent_Identity=45.2112676056338, Blast_Score=584, Evalue=1e-167,
Organism=Saccharomyces cerevisiae, GI6323002, Length=889, Percent_Identity=37.2328458942632, Blast_Score=502, Evalue=1e-143,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150
- InterPro:   IPR001943 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 92018; Mature: 92018

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS50151 UVR ; PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMFGRFTERAQKVLMNAQEEAEKFKHGYVGTEHILLGILIEDGVAKELLNNFSITEDKVR
CCCCHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHCCCCCHHHHH
QLIERYEGKGEMDLYKNEIPLTPRTKRLLEMSLLEARNLNHNYITPEHILLGLIREAEGV
HHHHHHCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCC
AFTILSNLGLDAERLRKELVKNLSGQETPKDEGSKKSSKSSTPTLDQFGRDLTEMAEEGK
EEEHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHCHHHHHHHHCCC
VDPVIGRDKETQRVLEILCRRTKNNPCLIGEPGVGKTAIAEGLAQNIIDGNIPEILKNKR
CCCCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHCCCCCHHHHHCCC
VVTLDLTSMIAGAKYRGEFEDRLKKIMEEVRSSKDTILFIDEIHTIVGAGAAEGAIDAAN
EEEEEHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHCCCCCCCCCHHHH
ILKPALARGEIQCIGATTLDEYRKYIEKDSALERRFQPINVGEPTKEETIEILKGLRDKY
HHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
EAHHRVKFTDDAIYAAVNLSDRYIRDRFLPDKAIDLMDEAGSKVRIQNLIAPPDLKNIEE
HHHCCEEECCCCEEEEECCHHHHHHHHCCCHHHHHHHHHCCCEEEEHHCCCCCCHHHHHH
QLDKVVKEKEDAIRVQDFEKAANLRDKEKELKEKLEGLKKDWNAEKEGSNLIVSEQQIAA
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEECHHHHHH
VVSNWTNIPVNKLTEKESERLLKLENILHNRVIGQEEAIKSVSRSVRRARVGLKDPKRPI
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCC
GSFIFLGPTGVGKTELTKALAEAMFGNENNMIRVDMSEYMEKHSVSRLIGSPPGYVGHDE
CCEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCCCC
GGQLTDKVRTNPYSVVLFDEIEKAHPEVFNILLQILEDGRLTDGKGKTVDFRNTIIIMTS
CCCCHHHHCCCCEEEEEEHHHHHHCHHHHHHHHHHHHCCCCCCCCCCEEEECCEEEEEEC
NVGASTISRQKTLGFNTSIEEERETEYEKMKDNIMNELKHSFRPEFLNRIDDIIVFHQLR
CCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
EEHIREIVKLMLKTVSNRVKDQGIKLEFTEEAEKILAKEGYDTNYGARPLRRAITKIVED
HHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
KLSEEILKGNIKKGDSVKVNTIEDKLNFYKM
HHHHHHHHCCCCCCCCEEEEEHHHHHHHHCC
>Mature Secondary Structure
MMFGRFTERAQKVLMNAQEEAEKFKHGYVGTEHILLGILIEDGVAKELLNNFSITEDKVR
CCCCHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHCCCCCHHHHH
QLIERYEGKGEMDLYKNEIPLTPRTKRLLEMSLLEARNLNHNYITPEHILLGLIREAEGV
HHHHHHCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCC
AFTILSNLGLDAERLRKELVKNLSGQETPKDEGSKKSSKSSTPTLDQFGRDLTEMAEEGK
EEEHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHCHHHHHHHHCCC
VDPVIGRDKETQRVLEILCRRTKNNPCLIGEPGVGKTAIAEGLAQNIIDGNIPEILKNKR
CCCCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHCCCCCHHHHHCCC
VVTLDLTSMIAGAKYRGEFEDRLKKIMEEVRSSKDTILFIDEIHTIVGAGAAEGAIDAAN
EEEEEHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHCCCCCCCCCHHHH
ILKPALARGEIQCIGATTLDEYRKYIEKDSALERRFQPINVGEPTKEETIEILKGLRDKY
HHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
EAHHRVKFTDDAIYAAVNLSDRYIRDRFLPDKAIDLMDEAGSKVRIQNLIAPPDLKNIEE
HHHCCEEECCCCEEEEECCHHHHHHHHCCCHHHHHHHHHCCCEEEEHHCCCCCCHHHHHH
QLDKVVKEKEDAIRVQDFEKAANLRDKEKELKEKLEGLKKDWNAEKEGSNLIVSEQQIAA
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEECHHHHHH
VVSNWTNIPVNKLTEKESERLLKLENILHNRVIGQEEAIKSVSRSVRRARVGLKDPKRPI
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCC
GSFIFLGPTGVGKTELTKALAEAMFGNENNMIRVDMSEYMEKHSVSRLIGSPPGYVGHDE
CCEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCCCC
GGQLTDKVRTNPYSVVLFDEIEKAHPEVFNILLQILEDGRLTDGKGKTVDFRNTIIIMTS
CCCCHHHHCCCCEEEEEEHHHHHHCHHHHHHHHHHHHCCCCCCCCCCEEEECCEEEEEEC
NVGASTISRQKTLGFNTSIEEERETEYEKMKDNIMNELKHSFRPEFLNRIDDIIVFHQLR
CCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
EEHIREIVKLMLKTVSNRVKDQGIKLEFTEEAEKILAKEGYDTNYGARPLRRAITKIVED
HHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
KLSEEILKGNIKKGDSVKVNTIEDKLNFYKM
HHHHHHHHCCCCCCCCEEEEEHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376 [H]