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The map label for this gene is adk

Identifier: 226950912

GI number: 226950912

Start: 3964291

End: 3964941

Strand: Reverse

Name: adk

Synonym: CLM_3927

Alternate gene names: 226950912

Gene position: 3964941-3964291 (Counterclockwise)

Preceding gene: 226950913

Following gene: 226950911

Centisome position: 95.42

GC content: 30.72

Gene sequence:

>651_bases
ATGCGTATAATTTTGTTAGGTCCTCCAGGAGCAGGTAAAGGAACTCAAGCAAAATTAATAAGTGAAGAATTTTCTATTCC
TCATATATCAACAGGTGATATATTTAGGGCAAACATAAAGGAGAAAACTCCTTTAGGAATAGAAGCAAAAAGATATATAG
ATAATGGTCAATTAGTACCAGATGAGGTAACTATAGGAATAGTTAAAGATAGATTAACAAAAGATGATTGTGATAATGGT
TTCCTTTTAGATGGTTTTCCAAGAACAGTTGCTCAAGCAGAAGCTTTAGATGAATTTCTAAAGGGTATAAATAAGGAGCT
AGATGTAGCACTATTAATTAAAGTGCCTGAAGAATTTATCTTGGAAAGAATGACTGGTAGAAGAGTTTGCACATCTTGTG
GTGCAAGTTATCACATAAGATTTAATCCTCCTAAAATAGAAGGAAAATGTGATATATGTGATAATGAATTAATTCAAAGA
AAAGATGATACAGAAGCAACAGTAAAAGAAAGATTAGAAGTTTACAGCAAACAAACTTATCCGCTTATAAATTATTATAA
AGACAATGGTATAATCTCAGAGGTTAATGGGACTGAATCAATTAATGAGGTATTTGGAAATATTTCAAATATCTTAGGGA
GAGATAAATAA

Upstream 100 bases:

>100_bases
TTGGATTTGCATTGGATACTATAAGACAAATAGAATCTCAATTAGTTATGCGTCACTATCAAGGTTTCTTAAAATAAAAA
TGTTTTGGAGATGATTATGG

Downstream 100 bases:

>100_bases
TGATAATAATAAAAACCGATTCTGAAATAGAATATATGGTAAAAGCAGGAAAAGTTGTTGCTGAGGCCTTAGACACTTTA
GAAAAACATGTGAAGCCAGG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MRIILLGPPGAGKGTQAKLISEEFSIPHISTGDIFRANIKEKTPLGIEAKRYIDNGQLVPDEVTIGIVKDRLTKDDCDNG
FLLDGFPRTVAQAEALDEFLKGINKELDVALLIKVPEEFILERMTGRRVCTSCGASYHIRFNPPKIEGKCDICDNELIQR
KDDTEATVKERLEVYSKQTYPLINYYKDNGIISEVNGTESINEVFGNISNILGRDK

Sequences:

>Translated_216_residues
MRIILLGPPGAGKGTQAKLISEEFSIPHISTGDIFRANIKEKTPLGIEAKRYIDNGQLVPDEVTIGIVKDRLTKDDCDNG
FLLDGFPRTVAQAEALDEFLKGINKELDVALLIKVPEEFILERMTGRRVCTSCGASYHIRFNPPKIEGKCDICDNELIQR
KDDTEATVKERLEVYSKQTYPLINYYKDNGIISEVNGTESINEVFGNISNILGRDK
>Mature_216_residues
MRIILLGPPGAGKGTQAKLISEEFSIPHISTGDIFRANIKEKTPLGIEAKRYIDNGQLVPDEVTIGIVKDRLTKDDCDNG
FLLDGFPRTVAQAEALDEFLKGINKELDVALLIKVPEEFILERMTGRRVCTSCGASYHIRFNPPKIEGKCDICDNELIQR
KDDTEATVKERLEVYSKQTYPLINYYKDNGIISEVNGTESINEVFGNISNILGRDK

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=208, Percent_Identity=44.2307692307692, Blast_Score=191, Evalue=3e-49,
Organism=Homo sapiens, GI4502013, Length=208, Percent_Identity=44.2307692307692, Blast_Score=191, Evalue=4e-49,
Organism=Homo sapiens, GI19923437, Length=212, Percent_Identity=39.1509433962264, Blast_Score=163, Evalue=9e-41,
Organism=Homo sapiens, GI310110345, Length=213, Percent_Identity=35.6807511737089, Blast_Score=149, Evalue=1e-36,
Organism=Homo sapiens, GI53832003, Length=213, Percent_Identity=35.6807511737089, Blast_Score=149, Evalue=1e-36,
Organism=Homo sapiens, GI8051579, Length=213, Percent_Identity=35.6807511737089, Blast_Score=149, Evalue=1e-36,
Organism=Homo sapiens, GI53832001, Length=213, Percent_Identity=35.6807511737089, Blast_Score=149, Evalue=1e-36,
Organism=Homo sapiens, GI4502011, Length=211, Percent_Identity=31.2796208530806, Blast_Score=107, Evalue=5e-24,
Organism=Homo sapiens, GI22749187, Length=213, Percent_Identity=27.2300469483568, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI7706497, Length=218, Percent_Identity=26.605504587156, Blast_Score=91, Evalue=6e-19,
Organism=Homo sapiens, GI28144899, Length=210, Percent_Identity=28.5714285714286, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI28144897, Length=210, Percent_Identity=28.5714285714286, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1786680, Length=218, Percent_Identity=51.3761467889908, Blast_Score=221, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI17552384, Length=214, Percent_Identity=38.785046728972, Blast_Score=180, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI17537943, Length=217, Percent_Identity=30.8755760368664, Blast_Score=119, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17533833, Length=211, Percent_Identity=30.3317535545024, Blast_Score=107, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17567503, Length=208, Percent_Identity=27.8846153846154, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17550688, Length=212, Percent_Identity=29.2452830188679, Blast_Score=101, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI25147457, Length=216, Percent_Identity=23.1481481481481, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6320432, Length=216, Percent_Identity=44.9074074074074, Blast_Score=206, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6321018, Length=205, Percent_Identity=42.9268292682927, Blast_Score=157, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6322828, Length=213, Percent_Identity=27.2300469483568, Blast_Score=87, Evalue=3e-18,
Organism=Drosophila melanogaster, GI22026816, Length=213, Percent_Identity=43.6619718309859, Blast_Score=191, Evalue=4e-49,
Organism=Drosophila melanogaster, GI17737899, Length=200, Percent_Identity=38, Blast_Score=150, Evalue=8e-37,
Organism=Drosophila melanogaster, GI24645822, Length=200, Percent_Identity=38, Blast_Score=150, Evalue=8e-37,
Organism=Drosophila melanogaster, GI221459597, Length=211, Percent_Identity=28.9099526066351, Blast_Score=91, Evalue=7e-19,
Organism=Drosophila melanogaster, GI21356893, Length=211, Percent_Identity=28.9099526066351, Blast_Score=91, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24663208, Length=204, Percent_Identity=25, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17647141, Length=204, Percent_Identity=25, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_CLOB1 (A7FZ52)

Other databases:

- EMBL:   CP000726
- RefSeq:   YP_001385775.1
- ProteinModelPortal:   A7FZ52
- SMR:   A7FZ52
- STRING:   A7FZ52
- GeneID:   5395550
- GenomeReviews:   CP000726_GR
- KEGG:   cba:CLB_3516
- eggNOG:   COG0563
- HOGENOM:   HBG630208
- OMA:   CGEGYHD
- ProtClustDB:   PRK00279
- BioCyc:   CBOT441770:CLB_3516-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid

EC number: =2.7.4.3

Molecular weight: Translated: 24134; Mature: 24134

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIILLGPPGAGKGTQAKLISEEFSIPHISTGDIFRANIKEKTPLGIEAKRYIDNGQLVP
CEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCHHEECCCCCCCC
DEVTIGIVKDRLTKDDCDNGFLLDGFPRTVAQAEALDEFLKGINKELDVALLIKVPEEFI
CCEEEEHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHH
LERMTGRRVCTSCGASYHIRFNPPKIEGKCDICDNELIQRKDDTEATVKERLEVYSKQTY
HHHHCCHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHCCCC
PLINYYKDNGIISEVNGTESINEVFGNISNILGRDK
CEEEEECCCCEEEECCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRIILLGPPGAGKGTQAKLISEEFSIPHISTGDIFRANIKEKTPLGIEAKRYIDNGQLVP
CEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCHHEECCCCCCCC
DEVTIGIVKDRLTKDDCDNGFLLDGFPRTVAQAEALDEFLKGINKELDVALLIKVPEEFI
CCEEEEHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHH
LERMTGRRVCTSCGASYHIRFNPPKIEGKCDICDNELIQRKDDTEATVKERLEVYSKQTY
HHHHCCHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHCCCC
PLINYYKDNGIISEVNGTESINEVFGNISNILGRDK
CEEEEECCCCEEEECCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA