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The map label for this gene is map [H]

Identifier: 226950911

GI number: 226950911

Start: 3963542

End: 3964291

Strand: Reverse

Name: map [H]

Synonym: CLM_3926

Alternate gene names: 226950911

Gene position: 3964291-3963542 (Counterclockwise)

Preceding gene: 226950912

Following gene: 226950910

Centisome position: 95.4

GC content: 34.27

Gene sequence:

>750_bases
ATGATAATAATAAAAACCGATTCTGAAATAGAATATATGGTAAAAGCAGGAAAAGTTGTTGCTGAGGCCTTAGACACTTT
AGAAAAACATGTGAAGCCAGGAATAAGCACTGGAGAGTTAGATAGAATCGCAGAAGAGATTATATTAGGCAAAAATGCCA
AACCATCTTTTAAGGGATACTATGGTTTCCCAGCTTCTATATGTGCATCTGTGAATAATGAAGTAGTTCATGGAATACCA
AATAAAGATAGAATTTTAAATGAAGGAGACATAATTAGTATAGATTGTGGAGCCATTTTAAATGGATATCAGGGCGATGC
AGCAAGAACATTTCCAGTAGGGAATGTTTCAGAAGAAGCTGCTAAGCTAATAGAGGTCACAAAAAATAGTTTTTTTAAAG
GTATAGAAAAAGCTAAAGTTGGCAATAGATTAACTGATATATCTGCAGCTATTCAAGAATATGTTGAAAGTTATGGACTT
TCTATTGTAAGGGACTATGTAGGTCATGGCATAGGAAAAAACATGCATGAAGATCCAGAAATCCCTAACTTTGGTAGACC
AGGAAGGGGACCTAAATTATCAAAAGGAATGTGTTTAGCTATTGAGCCTATGGTTAATATAGGGGACTTCAATGTAAAAG
TTGAACCAAATAAATGGACTGTAGTTACTGTAGATGGTAGTTTATCTGCTCATTATGAAAATACTGTGGCTATACTAGAT
GATGGACCCAAAATAACCACTTTGATTTAA

Upstream 100 bases:

>100_bases
ATTATTATAAAGACAATGGTATAATCTCAGAGGTTAATGGGACTGAATCAATTAATGAGGTATTTGGAAATATTTCAAAT
ATCTTAGGGAGAGATAAATA

Downstream 100 bases:

>100_bases
TAGAGGTGAATATATTGGCTAAAGAGTGCCAGATTGGTAGATTGGTTTTATCGAAAGCAGGTAGAGATAAAGATAATAGT
TTCATTATAATAGATATACT

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 249; Mature: 249

Protein sequence:

>249_residues
MIIIKTDSEIEYMVKAGKVVAEALDTLEKHVKPGISTGELDRIAEEIILGKNAKPSFKGYYGFPASICASVNNEVVHGIP
NKDRILNEGDIISIDCGAILNGYQGDAARTFPVGNVSEEAAKLIEVTKNSFFKGIEKAKVGNRLTDISAAIQEYVESYGL
SIVRDYVGHGIGKNMHEDPEIPNFGRPGRGPKLSKGMCLAIEPMVNIGDFNVKVEPNKWTVVTVDGSLSAHYENTVAILD
DGPKITTLI

Sequences:

>Translated_249_residues
MIIIKTDSEIEYMVKAGKVVAEALDTLEKHVKPGISTGELDRIAEEIILGKNAKPSFKGYYGFPASICASVNNEVVHGIP
NKDRILNEGDIISIDCGAILNGYQGDAARTFPVGNVSEEAAKLIEVTKNSFFKGIEKAKVGNRLTDISAAIQEYVESYGL
SIVRDYVGHGIGKNMHEDPEIPNFGRPGRGPKLSKGMCLAIEPMVNIGDFNVKVEPNKWTVVTVDGSLSAHYENTVAILD
DGPKITTLI
>Mature_249_residues
MIIIKTDSEIEYMVKAGKVVAEALDTLEKHVKPGISTGELDRIAEEIILGKNAKPSFKGYYGFPASICASVNNEVVHGIP
NKDRILNEGDIISIDCGAILNGYQGDAARTFPVGNVSEEAAKLIEVTKNSFFKGIEKAKVGNRLTDISAAIQEYVESYGL
SIVRDYVGHGIGKNMHEDPEIPNFGRPGRGPKLSKGMCLAIEPMVNIGDFNVKVEPNKWTVVTVDGSLSAHYENTVAILD
DGPKITTLI

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=247, Percent_Identity=36.4372469635627, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI40385867, Length=246, Percent_Identity=37.3983739837398, Blast_Score=161, Evalue=5e-40,
Organism=Escherichia coli, GI1786364, Length=248, Percent_Identity=42.741935483871, Blast_Score=213, Evalue=8e-57,
Organism=Caenorhabditis elegans, GI71996291, Length=248, Percent_Identity=36.6935483870968, Blast_Score=168, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6323273, Length=248, Percent_Identity=37.0967741935484, Blast_Score=169, Evalue=5e-43,
Organism=Drosophila melanogaster, GI21355531, Length=246, Percent_Identity=40.650406504065, Blast_Score=192, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24583427, Length=246, Percent_Identity=38.6178861788618, Blast_Score=171, Evalue=6e-43,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 26933; Mature: 26933

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIIKTDSEIEYMVKAGKVVAEALDTLEKHVKPGISTGELDRIAEEIILGKNAKPSFKGY
CEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCC
YGFPASICASVNNEVVHGIPNKDRILNEGDIISIDCGAILNGYQGDAARTFPVGNVSEEA
CCCHHHHHHHCCCCEEECCCCCCCCCCCCCEEEEEHHHHHCCCCCCCCEECCCCCCHHHH
AKLIEVTKNSFFKGIEKAKVGNRLTDISAAIQEYVESYGLSIVRDYVGHGIGKNMHEDPE
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCC
IPNFGRPGRGPKLSKGMCLAIEPMVNIGDFNVKVEPNKWTVVTVDGSLSAHYENTVAILD
CCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEECCCCEEEEEECCCEEECCCCEEEEEE
DGPKITTLI
CCCEEEEEC
>Mature Secondary Structure
MIIIKTDSEIEYMVKAGKVVAEALDTLEKHVKPGISTGELDRIAEEIILGKNAKPSFKGY
CEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCC
YGFPASICASVNNEVVHGIPNKDRILNEGDIISIDCGAILNGYQGDAARTFPVGNVSEEA
CCCHHHHHHHCCCCEEECCCCCCCCCCCCCEEEEEHHHHHCCCCCCCCEECCCCCCHHHH
AKLIEVTKNSFFKGIEKAKVGNRLTDISAAIQEYVESYGLSIVRDYVGHGIGKNMHEDPE
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCC
IPNFGRPGRGPKLSKGMCLAIEPMVNIGDFNVKVEPNKWTVVTVDGSLSAHYENTVAILD
CCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEECCCCEEEEEECCCEEECCCCEEEEEE
DGPKITTLI
CCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]