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The map label for this gene is mepA [H]

Identifier: 226950193

GI number: 226950193

Start: 3154683

End: 3156104

Strand: Reverse

Name: mepA [H]

Synonym: CLM_3147

Alternate gene names: 226950193

Gene position: 3156104-3154683 (Counterclockwise)

Preceding gene: 226950194

Following gene: 226950192

Centisome position: 75.95

GC content: 29.89

Gene sequence:

>1422_bases
ATGGGAATTGACTACAGGTTATTTTCAAAAGAAAAGGTAGAAAAAGCTTTATTAAAATTTGCAGTTCCAGCTATGATTTC
TTTATTAGTTATGGAATTATATAATATGGTAGATACATTTTTCGTAGGTTTAGCTATAGGGCCGAAAGCCATAGGAGCAT
TAACCATAGCTTTTCCAGTACAAAGACTTATGTCTTCACTGGGGATGATGATAGCAGTGGGTGCATCTACTGCAGTAGCC
AGAAGTTTAGGTAAAAAAGATTATGATAACCTAAAATCGGTAATATTAAACGCTATAAATGTTACTATAGTTATAATGCT
AGTTTTAACTTTTATAATTTCAATCTTTAAAAAAGATATGATCACAGGCCTATTAGGTGCTAGTCAATCTATTTATCCTT
ATGCCGAAGAATACATTTCTATAGTAATACTTGGTGGACTATTTCAAGCCTTAACTTTAGTTATTTGTTATATAATGACA
TCCTTAGGTTATACAAATATAACATTAAAAGCTACTTCGGTAGGAGCTATATTAAATGTTATAATTGACTATTTCTTAGT
TATGCATTTAAACTTTGGAGTAGCAGGAGCAGCTATAGCAACTGTGTTTTCACAAACAGTGGCATTAGTATATGCGATAT
ATAAATTTAATAAGGTTAGAAAGAAGATAGGATTAAATTTAAAATTAAATTTTGAACTTAAATTAGATATATTAAAGCCA
ATCTTAGCAGTAGGATTTTCAACCTTTATTATAGAAATATCTGATGCAGTGGTGGCAGTAATATTAAACAATATACTTTC
TATTTATGGAGGAGATAAGGCGTTGGTTATAGTAGGGGTAACTACTAAAATATCAATGTTCTTATTCATAACAGTTATAG
GTATAAGTTCGGCAATGCAACCTATAGCAGCATTTAACTATGGTGCAAAAGATTTAGTTCGTGTAAAAGAAGTAGTTGTA
AAGACTATAGTAGCTGTAACAGGAGCAACTTTAATATTATGGGCAGTAATGTTTATATTTGCAAATCCTATAATAGGATT
ATTTTTAAAGGATACAAGTCTTTTAGGTGAAACCGTAAAAGCTTTTAGAATAATAATATCTCTATTCCCGACTATAGGGA
TATATTATGTATCCATATATTATTACCAATCTATGGGAAAGGCAAAAACTTCACTTATACTATCTGTATATAGGCAAATG
ATAATATTTATACCATTATTATTTATATTAGTTGGTAAATTTAATATCATGGGAGCTTGGATAGCTTATCCAATTTCAGA
TTTAATATCAGCTATTACAGGAGTAATATATGTAAGAGTAGCGTTAAAAGAAAAAGATAAGGCTATAGAAGCCCAAGAAT
ATGAAAAAGAGAGAAAAGATAAAGCATTCAAAGGAAGATCCGTAGAAGTAGGTGGCCTTTAA

Upstream 100 bases:

>100_bases
TTTATATAACATTATAATTTTAAAAAGAAGGAGTGGATAACAAAATGAGTGCAAAAATGTTACCTAAAAATACAAAATCC
ATTAGAACGGGGTGCTTAAT

Downstream 100 bases:

>100_bases
AGTATATAACAGTAAAGATGATGAAACAGCTTAGGCAAAATATATGGTAATAATAATAGTAAATAATTTAATAATTAATT
AAATTAAAAAGTATTTTTAT

Product: MATE efflux family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 473; Mature: 472

Protein sequence:

>473_residues
MGIDYRLFSKEKVEKALLKFAVPAMISLLVMELYNMVDTFFVGLAIGPKAIGALTIAFPVQRLMSSLGMMIAVGASTAVA
RSLGKKDYDNLKSVILNAINVTIVIMLVLTFIISIFKKDMITGLLGASQSIYPYAEEYISIVILGGLFQALTLVICYIMT
SLGYTNITLKATSVGAILNVIIDYFLVMHLNFGVAGAAIATVFSQTVALVYAIYKFNKVRKKIGLNLKLNFELKLDILKP
ILAVGFSTFIIEISDAVVAVILNNILSIYGGDKALVIVGVTTKISMFLFITVIGISSAMQPIAAFNYGAKDLVRVKEVVV
KTIVAVTGATLILWAVMFIFANPIIGLFLKDTSLLGETVKAFRIIISLFPTIGIYYVSIYYYQSMGKAKTSLILSVYRQM
IIFIPLLFILVGKFNIMGAWIAYPISDLISAITGVIYVRVALKEKDKAIEAQEYEKERKDKAFKGRSVEVGGL

Sequences:

>Translated_473_residues
MGIDYRLFSKEKVEKALLKFAVPAMISLLVMELYNMVDTFFVGLAIGPKAIGALTIAFPVQRLMSSLGMMIAVGASTAVA
RSLGKKDYDNLKSVILNAINVTIVIMLVLTFIISIFKKDMITGLLGASQSIYPYAEEYISIVILGGLFQALTLVICYIMT
SLGYTNITLKATSVGAILNVIIDYFLVMHLNFGVAGAAIATVFSQTVALVYAIYKFNKVRKKIGLNLKLNFELKLDILKP
ILAVGFSTFIIEISDAVVAVILNNILSIYGGDKALVIVGVTTKISMFLFITVIGISSAMQPIAAFNYGAKDLVRVKEVVV
KTIVAVTGATLILWAVMFIFANPIIGLFLKDTSLLGETVKAFRIIISLFPTIGIYYVSIYYYQSMGKAKTSLILSVYRQM
IIFIPLLFILVGKFNIMGAWIAYPISDLISAITGVIYVRVALKEKDKAIEAQEYEKERKDKAFKGRSVEVGGL
>Mature_472_residues
GIDYRLFSKEKVEKALLKFAVPAMISLLVMELYNMVDTFFVGLAIGPKAIGALTIAFPVQRLMSSLGMMIAVGASTAVAR
SLGKKDYDNLKSVILNAINVTIVIMLVLTFIISIFKKDMITGLLGASQSIYPYAEEYISIVILGGLFQALTLVICYIMTS
LGYTNITLKATSVGAILNVIIDYFLVMHLNFGVAGAAIATVFSQTVALVYAIYKFNKVRKKIGLNLKLNFELKLDILKPI
LAVGFSTFIIEISDAVVAVILNNILSIYGGDKALVIVGVTTKISMFLFITVIGISSAMQPIAAFNYGAKDLVRVKEVVVK
TIVAVTGATLILWAVMFIFANPIIGLFLKDTSLLGETVKAFRIIISLFPTIGIYYVSIYYYQSMGKAKTSLILSVYRQMI
IFIPLLFILVGKFNIMGAWIAYPISDLISAITGVIYVRVALKEKDKAIEAQEYEKERKDKAFKGRSVEVGGL

Specific function: Multidrug resistance efflux protein [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 51804; Mature: 51673

Theoretical pI: Translated: 9.98; Mature: 9.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIDYRLFSKEKVEKALLKFAVPAMISLLVMELYNMVDTFFVGLAIGPKAIGALTIAFPV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
QRLMSSLGMMIAVGASTAVARSLGKKDYDNLKSVILNAINVTIVIMLVLTFIISIFKKDM
HHHHHHCCHHEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ITGLLGASQSIYPYAEEYISIVILGGLFQALTLVICYIMTSLGYTNITLKATSVGAILNV
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHH
IIDYFLVMHLNFGVAGAAIATVFSQTVALVYAIYKFNKVRKKIGLNLKLNFELKLDILKP
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEHHHHHHH
ILAVGFSTFIIEISDAVVAVILNNILSIYGGDKALVIVGVTTKISMFLFITVIGISSAMQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHH
PIAAFNYGAKDLVRVKEVVVKTIVAVTGATLILWAVMFIFANPIIGLFLKDTSLLGETVK
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFRIIISLFPTIGIYYVSIYYYQSMGKAKTSLILSVYRQMIIFIPLLFILVGKFNIMGAW
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAYPISDLISAITGVIYVRVALKEKDKAIEAQEYEKERKDKAFKGRSVEVGGL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEECCCC
>Mature Secondary Structure 
GIDYRLFSKEKVEKALLKFAVPAMISLLVMELYNMVDTFFVGLAIGPKAIGALTIAFPV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
QRLMSSLGMMIAVGASTAVARSLGKKDYDNLKSVILNAINVTIVIMLVLTFIISIFKKDM
HHHHHHCCHHEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ITGLLGASQSIYPYAEEYISIVILGGLFQALTLVICYIMTSLGYTNITLKATSVGAILNV
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHH
IIDYFLVMHLNFGVAGAAIATVFSQTVALVYAIYKFNKVRKKIGLNLKLNFELKLDILKP
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEHHHHHHH
ILAVGFSTFIIEISDAVVAVILNNILSIYGGDKALVIVGVTTKISMFLFITVIGISSAMQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHH
PIAAFNYGAKDLVRVKEVVVKTIVAVTGATLILWAVMFIFANPIIGLFLKDTSLLGETVK
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFRIIISLFPTIGIYYVSIYYYQSMGKAKTSLILSVYRQMIIFIPLLFILVGKFNIMGAW
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAYPISDLISAITGVIYVRVALKEKDKAIEAQEYEKERKDKAFKGRSVEVGGL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA