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The map label for this gene is wecC [H]

Identifier: 226950125

GI number: 226950125

Start: 3076925

End: 3078235

Strand: Reverse

Name: wecC [H]

Synonym: CLM_3079

Alternate gene names: 226950125

Gene position: 3078235-3076925 (Counterclockwise)

Preceding gene: 226950126

Following gene: 226950124

Centisome position: 74.08

GC content: 27.0

Gene sequence:

>1311_bases
ATGAAAACTGAAAAATATAAAGTGTGTATTGTAGGACAAGGATTTGTAGGTTTGCCTTTGGCATTAAGTTTTTCATTAAA
TGGTATCAAAACTATGGGTGTGGATATAGATGAAAAATTAGTAACAGAAATAAATAAAGGAAATACTCCCCTTAAAGAAG
AATACAATGGACAAACTATACAAACTATATTAAAAACTCAATTAAATACAGGAAATTATAATATATTAAATAATATAAAA
AAAGCGGTAGAAGAGTGTAGTGTTATAGTTCTTACAGTAGGAATACCAATTTATAAAAATAATCCTATAATGGATGGAAT
AATAAATGCTATTAAAGAAATAGGTGAAAATTTAAAAAAAGATGATTTAGTTTTAATAAGAAGTACAGTGATACCTGGAA
CAACAGAAGAAATACTTTTACCTATTTTAGAAGAAGAATCTAAATTAAAAGCAGGAGAAGATTTTTATTTAGCTTATGCT
TCAGAAAGAATTGCTGAAGGACAAGCTTTTTATGAATTTGAAAATATGCCTACAGTTGTAGCAGGGATAAATGAAGAAAG
TTTTAAAAGAGCAGAAGAGGTTTTAAAAATAGTTTGCAAAGCAGATATAATAAAAGCTTCTAGTATAAAAGTCGTTGAAA
CCTCTAAAGTTTTTGAAAATGTTCAAAGAGATGTTAATATTGCCATGGCTCAAGAATTTGCAAGGTTTAGTGAAAAAGTT
GATATAGATATTTTTGAGGTTATTGAAGTTGCAAATTCTCATAAGAGAGTAAATTTATTAACACCAGGACCAGGAGTTGG
GGGTTACTGCATTCCCAATGCCTATTACTATTTAAAACCTAAAGCTGAAGAATTAAATCTATCTTTAGACATTTTAAAAC
TATGTAGGGAAAAGAACAAGGGAATTCCTTATTATATTGTTTCAAAAGTTGAAGAATTATTAAGCTCTTTAGGAAAAAAT
ATTTCCAATTGTAAAATAGGGGTATTAGGTATAGCAATGAAGGATTATTCCAATGATGATAGGCTTAGTCCAGTGTTAGA
TATTATAAATTTATTTATAGAAAAGAAAGCCTTAACATATTGTTATGATCCTGCTGTTGATAGTGAATACGAATTTAAAA
AAGATAACATAGATGAAGTTATACAAAATGCAGATGTTTTAATAATAGCTACAAAACAAAAAGAAATTAATTACAAAAAT
TTTGCCTATTATAAAAATTTAATGAGAGAAAGAGCTATTTATATAGATTTGAAAAATGCTATAAACAAGAAAGAAGCAGA
TGAGCATGGATTTATTTATTGGAGAATATAA

Upstream 100 bases:

>100_bases
GTTATAAAAAATTTTAGTAATGATAAAGTTCTAGAGATATATAAAGAGATTTTTAATTATTAAGCTATTATATATAAAAA
TAAAGATATTGGGTGATAAA

Downstream 100 bases:

>100_bases
GGAGCGGAATTTGCTTTGAAATAGACTATACATATTGATGTATGAAAGGAATGCTTTTATGGAAAATTTAAAGTTTGCTA
CTTTAAGATTGTACCGAACA

Product: GDP-mannose 6-dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: UDP-ManNAc 6-dehydrogenase [H]

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MKTEKYKVCIVGQGFVGLPLALSFSLNGIKTMGVDIDEKLVTEINKGNTPLKEEYNGQTIQTILKTQLNTGNYNILNNIK
KAVEECSVIVLTVGIPIYKNNPIMDGIINAIKEIGENLKKDDLVLIRSTVIPGTTEEILLPILEEESKLKAGEDFYLAYA
SERIAEGQAFYEFENMPTVVAGINEESFKRAEEVLKIVCKADIIKASSIKVVETSKVFENVQRDVNIAMAQEFARFSEKV
DIDIFEVIEVANSHKRVNLLTPGPGVGGYCIPNAYYYLKPKAEELNLSLDILKLCREKNKGIPYYIVSKVEELLSSLGKN
ISNCKIGVLGIAMKDYSNDDRLSPVLDIINLFIEKKALTYCYDPAVDSEYEFKKDNIDEVIQNADVLIIATKQKEINYKN
FAYYKNLMRERAIYIDLKNAINKKEADEHGFIYWRI

Sequences:

>Translated_436_residues
MKTEKYKVCIVGQGFVGLPLALSFSLNGIKTMGVDIDEKLVTEINKGNTPLKEEYNGQTIQTILKTQLNTGNYNILNNIK
KAVEECSVIVLTVGIPIYKNNPIMDGIINAIKEIGENLKKDDLVLIRSTVIPGTTEEILLPILEEESKLKAGEDFYLAYA
SERIAEGQAFYEFENMPTVVAGINEESFKRAEEVLKIVCKADIIKASSIKVVETSKVFENVQRDVNIAMAQEFARFSEKV
DIDIFEVIEVANSHKRVNLLTPGPGVGGYCIPNAYYYLKPKAEELNLSLDILKLCREKNKGIPYYIVSKVEELLSSLGKN
ISNCKIGVLGIAMKDYSNDDRLSPVLDIINLFIEKKALTYCYDPAVDSEYEFKKDNIDEVIQNADVLIIATKQKEINYKN
FAYYKNLMRERAIYIDLKNAINKKEADEHGFIYWRI
>Mature_436_residues
MKTEKYKVCIVGQGFVGLPLALSFSLNGIKTMGVDIDEKLVTEINKGNTPLKEEYNGQTIQTILKTQLNTGNYNILNNIK
KAVEECSVIVLTVGIPIYKNNPIMDGIINAIKEIGENLKKDDLVLIRSTVIPGTTEEILLPILEEESKLKAGEDFYLAYA
SERIAEGQAFYEFENMPTVVAGINEESFKRAEEVLKIVCKADIIKASSIKVVETSKVFENVQRDVNIAMAQEFARFSEKV
DIDIFEVIEVANSHKRVNLLTPGPGVGGYCIPNAYYYLKPKAEELNLSLDILKLCREKNKGIPYYIVSKVEELLSSLGKN
ISNCKIGVLGIAMKDYSNDDRLSPVLDIINLFIEKKALTYCYDPAVDSEYEFKKDNIDEVIQNADVLIIATKQKEINYKN
FAYYKNLMRERAIYIDLKNAINKKEADEHGFIYWRI

Specific function: Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA) [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI48994968, Length=414, Percent_Identity=28.2608695652174, Blast_Score=160, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 49239; Mature: 49239

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTEKYKVCIVGQGFVGLPLALSFSLNGIKTMGVDIDEKLVTEINKGNTPLKEEYNGQTI
CCCCCEEEEEEECCCCCCCEEEEEECCCEEEECCCCHHHHHHHHCCCCCCCHHCCCCHHH
QTILKTQLNTGNYNILNNIKKAVEECSVIVLTVGIPIYKNNPIMDGIINAIKEIGENLKK
HHHHHHHCCCCCHHHHHHHHHHHHHCEEEEEEECCEEECCCCHHHHHHHHHHHHHHCCCC
DDLVLIRSTVIPGTTEEILLPILEEESKLKAGEDFYLAYASERIAEGQAFYEFENMPTVV
CCEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHCCCCEEEECCCCEEE
AGINEESFKRAEEVLKIVCKADIIKASSIKVVETSKVFENVQRDVNIAMAQEFARFSEKV
ECCCHHHHHHHHHHHHHHHHHHHEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCC
DIDIFEVIEVANSHKRVNLLTPGPGVGGYCIPNAYYYLKPKAEELNLSLDILKLCREKNK
CCHHHHHHHHHCCCCEEEEECCCCCCCCEECCCCEEEECCCHHHHCCHHHHHHHHHHHCC
GIPYYIVSKVEELLSSLGKNISNCKIGVLGIAMKDYSNDDRLSPVLDIINLFIEKKALTY
CCCCHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHEE
CYDPAVDSEYEFKKDNIDEVIQNADVLIIATKQKEINYKNFAYYKNLMRERAIYIDLKNA
EECCCCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHEEEEEEHHH
INKKEADEHGFIYWRI
CCCCCCCCCCEEEEEC
>Mature Secondary Structure
MKTEKYKVCIVGQGFVGLPLALSFSLNGIKTMGVDIDEKLVTEINKGNTPLKEEYNGQTI
CCCCCEEEEEEECCCCCCCEEEEEECCCEEEECCCCHHHHHHHHCCCCCCCHHCCCCHHH
QTILKTQLNTGNYNILNNIKKAVEECSVIVLTVGIPIYKNNPIMDGIINAIKEIGENLKK
HHHHHHHCCCCCHHHHHHHHHHHHHCEEEEEEECCEEECCCCHHHHHHHHHHHHHHCCCC
DDLVLIRSTVIPGTTEEILLPILEEESKLKAGEDFYLAYASERIAEGQAFYEFENMPTVV
CCEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHCCCCEEEECCCCEEE
AGINEESFKRAEEVLKIVCKADIIKASSIKVVETSKVFENVQRDVNIAMAQEFARFSEKV
ECCCHHHHHHHHHHHHHHHHHHHEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCC
DIDIFEVIEVANSHKRVNLLTPGPGVGGYCIPNAYYYLKPKAEELNLSLDILKLCREKNK
CCHHHHHHHHHCCCCEEEEECCCCCCCCEECCCCEEEECCCHHHHCCHHHHHHHHHHHCC
GIPYYIVSKVEELLSSLGKNISNCKIGVLGIAMKDYSNDDRLSPVLDIINLFIEKKALTY
CCCCHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHEE
CYDPAVDSEYEFKKDNIDEVIQNADVLIIATKQKEINYKNFAYYKNLMRERAIYIDLKNA
EECCCCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHEEEEEEHHH
INKKEADEHGFIYWRI
CCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA