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The map label for this gene is ykoH [H]

Identifier: 226949682

GI number: 226949682

Start: 2649269

End: 2650519

Strand: Reverse

Name: ykoH [H]

Synonym: CLM_2622

Alternate gene names: 226949682

Gene position: 2650519-2649269 (Counterclockwise)

Preceding gene: 226949683

Following gene: 226949680

Centisome position: 63.79

GC content: 28.46

Gene sequence:

>1251_bases
ATGAGTAGAAAAAATAAAACAAAAAATGTTATATCTATTGCAATAAAATTAAACTCTGTTTTTGTAAGAAGTTTATTTTT
AAAGTTTCTTATCCTTGATATATGCATAATTGCTGGATTTATTGGAGTTTGGTGTATTGAAAATGAAATAAATTTTTATG
GTGAGATCGTAAGAAATGCTCAAAGGTCATTTGAATTTTATCCTATAGAAACAGCAAATTATAAAGTTATTTGGGATAAT
GGAAAAGTTATGATAAAAGAGGCTAGCACTTTTTTAAACATTTTTATAAAAGTAATTAGTGCTATTGGAATTATAGAAGG
AATAATGCTATTAATGCAAATGATATTTGGTACTGCAAAAAATAGAAGGATTTTAAAACCACTTAATGAAATAGCAGAAG
CTGCAAGTAGGCTTAGTGATATAGCTTTTGATGAGCAAAAATTTCAAAGTCTTGAGGATGCTATATCTAAAATAAGTCCT
GCTACATCTGATGAAAGAATTCATATTAAAGATAGTGAACTTCAGGGTTTAGAGGAAGCAATTAATAACCTATTAGATAG
AATGAGAGATTCTTATAGGCAACAAGCAAGATTTGTTTCAGATGCATCCCATGAACTTAGAACTCCTATATCTGTAATTC
AAGGGTATGCTAATATGTTAGATCGTTGGGGAAAAGATGATGAAGAAGTATTAGAGGAATCTATTGCGGCTATAAAAAGT
GAATCAGAAAATATGAAAAACTTAATAGAACAGTTATTATTTTTAGCCAGAGGTATTAATGGTAAAACTCAACTTAAGGT
TATGGAGTTTTCACTTAATGATATGATGAAAGAGGTTTTAGAAGAATCTAAAATGATAGATAAAGATCATATATATAGAT
ATATAGATTCAGAAAATATAAATGTTTATGGTGATATATCATTACTTAAACAAACAGCTAGAATATTAATAGAAAATGCA
GCAAAGTATACAGATAAAGGTGAAGATATAATACTAAGAACAGGGAAAAATAATAAAAATGAGCCGTATTTTTCTATTCA
AGATAATGGAATAGGCATGGATGAGAATGATGTATTACACATGTTTGAACGTTTTTTCAGAGCTGATACTGCAAGAGTTA
GAAAAAATGGTGGTACAGGGCTAGGCCTTTCCATTGCTAAATGGATTATTGATAGTCATAAAGGATATTTTAGCGTTTTA
AGTAGGAAAGAAATAGGTACAAGAATAACTGTTTTTTTACCTAAAAGATAG

Upstream 100 bases:

>100_bases
GTTATAGATGTTTATATAAGGTTCTTAAGAACAAAAATAGATGATGCTTTTAAGGTTAAAATAATAACTACAGTTCGTGG
TGTAGGATACGTAATTAAAG

Downstream 100 bases:

>100_bases
TAAAAGCTTTCTATGATTTATTATTTTATCATGGAAAGCTTCTTAGATGTCGAATTTATAGATTATTAATATATTAGTTA
TTATTATGAAGATTTTGTTT

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MSRKNKTKNVISIAIKLNSVFVRSLFLKFLILDICIIAGFIGVWCIENEINFYGEIVRNAQRSFEFYPIETANYKVIWDN
GKVMIKEASTFLNIFIKVISAIGIIEGIMLLMQMIFGTAKNRRILKPLNEIAEAASRLSDIAFDEQKFQSLEDAISKISP
ATSDERIHIKDSELQGLEEAINNLLDRMRDSYRQQARFVSDASHELRTPISVIQGYANMLDRWGKDDEEVLEESIAAIKS
ESENMKNLIEQLLFLARGINGKTQLKVMEFSLNDMMKEVLEESKMIDKDHIYRYIDSENINVYGDISLLKQTARILIENA
AKYTDKGEDIILRTGKNNKNEPYFSIQDNGIGMDENDVLHMFERFFRADTARVRKNGGTGLGLSIAKWIIDSHKGYFSVL
SRKEIGTRITVFLPKR

Sequences:

>Translated_416_residues
MSRKNKTKNVISIAIKLNSVFVRSLFLKFLILDICIIAGFIGVWCIENEINFYGEIVRNAQRSFEFYPIETANYKVIWDN
GKVMIKEASTFLNIFIKVISAIGIIEGIMLLMQMIFGTAKNRRILKPLNEIAEAASRLSDIAFDEQKFQSLEDAISKISP
ATSDERIHIKDSELQGLEEAINNLLDRMRDSYRQQARFVSDASHELRTPISVIQGYANMLDRWGKDDEEVLEESIAAIKS
ESENMKNLIEQLLFLARGINGKTQLKVMEFSLNDMMKEVLEESKMIDKDHIYRYIDSENINVYGDISLLKQTARILIENA
AKYTDKGEDIILRTGKNNKNEPYFSIQDNGIGMDENDVLHMFERFFRADTARVRKNGGTGLGLSIAKWIIDSHKGYFSVL
SRKEIGTRITVFLPKR
>Mature_415_residues
SRKNKTKNVISIAIKLNSVFVRSLFLKFLILDICIIAGFIGVWCIENEINFYGEIVRNAQRSFEFYPIETANYKVIWDNG
KVMIKEASTFLNIFIKVISAIGIIEGIMLLMQMIFGTAKNRRILKPLNEIAEAASRLSDIAFDEQKFQSLEDAISKISPA
TSDERIHIKDSELQGLEEAINNLLDRMRDSYRQQARFVSDASHELRTPISVIQGYANMLDRWGKDDEEVLEESIAAIKSE
SENMKNLIEQLLFLARGINGKTQLKVMEFSLNDMMKEVLEESKMIDKDHIYRYIDSENINVYGDISLLKQTARILIENAA
KYTDKGEDIILRTGKNNKNEPYFSIQDNGIGMDENDVLHMFERFFRADTARVRKNGGTGLGLSIAKWIIDSHKGYFSVLS
RKEIGTRITVFLPKR

Specific function: Probable member of the two-component regulatory system ykoH/ykoG. Potentially phosphorylates ykoG [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=220, Percent_Identity=30, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI1786783, Length=244, Percent_Identity=28.6885245901639, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1790551, Length=322, Percent_Identity=27.3291925465839, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1788393, Length=296, Percent_Identity=24.6621621621622, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1790346, Length=235, Percent_Identity=28.936170212766, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1789149, Length=265, Percent_Identity=28.6792452830189, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788549, Length=266, Percent_Identity=25.9398496240602, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI145693157, Length=244, Percent_Identity=27.0491803278689, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1788279, Length=246, Percent_Identity=28.4552845528455, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1789808, Length=246, Percent_Identity=26.8292682926829, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1787894, Length=273, Percent_Identity=26.007326007326, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1788713, Length=229, Percent_Identity=27.5109170305677, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1789403, Length=230, Percent_Identity=26.9565217391304, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786912, Length=228, Percent_Identity=26.3157894736842, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87081816, Length=365, Percent_Identity=23.8356164383562, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1790861, Length=226, Percent_Identity=24.7787610619469, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI87082128, Length=295, Percent_Identity=24.7457627118644, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI48994928, Length=233, Percent_Identity=22.7467811158798, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 47670; Mature: 47538

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRKNKTKNVISIAIKLNSVFVRSLFLKFLILDICIIAGFIGVWCIENEINFYGEIVRNA
CCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
QRSFEFYPIETANYKVIWDNGKVMIKEASTFLNIFIKVISAIGIIEGIMLLMQMIFGTAK
HHCCEEEEECCCCEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
NRRILKPLNEIAEAASRLSDIAFDEQKFQSLEDAISKISPATSDERIHIKDSELQGLEEA
CCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCEEEEECHHHHHHHHH
INNLLDRMRDSYRQQARFVSDASHELRTPISVIQGYANMLDRWGKDDEEVLEESIAAIKS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHC
ESENMKNLIEQLLFLARGINGKTQLKVMEFSLNDMMKEVLEESKMIDKDHIYRYIDSENI
CHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCC
NVYGDISLLKQTARILIENAAKYTDKGEDIILRTGKNNKNEPYFSIQDNGIGMDENDVLH
EEEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEECCCCCCCCHHHHH
MFERFFRADTARVRKNGGTGLGLSIAKWIIDSHKGYFSVLSRKEIGTRITVFLPKR
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEEECCC
>Mature Secondary Structure 
SRKNKTKNVISIAIKLNSVFVRSLFLKFLILDICIIAGFIGVWCIENEINFYGEIVRNA
CCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
QRSFEFYPIETANYKVIWDNGKVMIKEASTFLNIFIKVISAIGIIEGIMLLMQMIFGTAK
HHCCEEEEECCCCEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
NRRILKPLNEIAEAASRLSDIAFDEQKFQSLEDAISKISPATSDERIHIKDSELQGLEEA
CCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCEEEEECHHHHHHHHH
INNLLDRMRDSYRQQARFVSDASHELRTPISVIQGYANMLDRWGKDDEEVLEESIAAIKS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHC
ESENMKNLIEQLLFLARGINGKTQLKVMEFSLNDMMKEVLEESKMIDKDHIYRYIDSENI
CHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCC
NVYGDISLLKQTARILIENAAKYTDKGEDIILRTGKNNKNEPYFSIQDNGIGMDENDVLH
EEEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEECCCCCCCCHHHHH
MFERFFRADTARVRKNGGTGLGLSIAKWIIDSHKGYFSVLSRKEIGTRITVFLPKR
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]