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The map label for this gene is ycbM [H]

Identifier: 226949655

GI number: 226949655

Start: 2625428

End: 2626339

Strand: Reverse

Name: ycbM [H]

Synonym: CLM_2592

Alternate gene names: 226949655

Gene position: 2626339-2625428 (Counterclockwise)

Preceding gene: 226949656

Following gene: 226949654

Centisome position: 63.2

GC content: 26.97

Gene sequence:

>912_bases
ATGAGTTGGATATTAATAATTATTATAATAATACTATCTATACTATTATTAAATGATAAAATAAAAACTAAAAGAATTAC
GGCAAAATTAAAAGAGATTCTTAAAGAAAATTCAAGAGAAAGAATAAAATTTTATAATTTAAGTACAAATAAGAAGGAAC
TTGTTAGAGAAATTAATATTTTTCTTGATAAATACCAGAGTATTTCTATTGATAATAAAAATTATAAAGAACATCACCAA
AAGATGATTTCAAATATTTCTCATGATATAAGAACTCCACTTACTGCTCTTATGGGATATGTTGACCTTCTTTCGGATAA
TTCTATTACAAAAGGGAAGAAGGAAGAATATATTAGTATTATTAGAGAAAGAGGCACTGCTTTAAAGGATCTTATGGAAG
AGTTTTTTCAAATGGCAAAGCTCGAATGTAATGATGTAGAGATAACTATTGAAAAATTTAATATATCCGAAGTAGTAAGA
AAAAATATAATTACTTTTATGAATGAAATAAATGAAAGAACTATAACCCCTGAGATAAACATAGGCGATGAAGAAATTTT
TGCTTTAGGGGATAAAAATTATATGAGTAGGATCATAACCAACCTTATTTCAAATAGTTTAAAATATGGATATGAAGGAA
AAGTTATTGGTATTGATCTAAAGGAAGACAATAAATGGGTAATTCTTAGTATATGGGACAAAGGAAAGGGTATCGATAAA
AATGAGCTTCCTTATATTTTTGATAGATTATATACAGGGGAAAAGTCTAGAAATAGAAGTTTTCAAGGCAGCGGTCTTGG
GCTTAGTATAGTAAAGAATATGGCTCAGCATATGAATGGAAGTATAATTGCTCAAAGCATACCCTATGAGAAAACTATAT
TTACAGTAAAGATTCCTAAGGCTAATAGTTAA

Upstream 100 bases:

>100_bases
ATATGAGAAGGCTTAGAAGTAAAATCGAGGATGATCCTAATAACCCTAAACTTATAGAAACTGTTTGGGGAATAGGATAC
AAATTAACAGGTGATAGACA

Downstream 100 bases:

>100_bases
AATTGACTAAACATGCTAAAAATATTAGGTGAAATTACTAAACTATTGTATAGCTTTTTATACAATTCTTAATAAATATC
TAAAAAGTATTTAATTTAAT

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MSWILIIIIIILSILLLNDKIKTKRITAKLKEILKENSRERIKFYNLSTNKKELVREINIFLDKYQSISIDNKNYKEHHQ
KMISNISHDIRTPLTALMGYVDLLSDNSITKGKKEEYISIIRERGTALKDLMEEFFQMAKLECNDVEITIEKFNISEVVR
KNIITFMNEINERTITPEINIGDEEIFALGDKNYMSRIITNLISNSLKYGYEGKVIGIDLKEDNKWVILSIWDKGKGIDK
NELPYIFDRLYTGEKSRNRSFQGSGLGLSIVKNMAQHMNGSIIAQSIPYEKTIFTVKIPKANS

Sequences:

>Translated_303_residues
MSWILIIIIIILSILLLNDKIKTKRITAKLKEILKENSRERIKFYNLSTNKKELVREINIFLDKYQSISIDNKNYKEHHQ
KMISNISHDIRTPLTALMGYVDLLSDNSITKGKKEEYISIIRERGTALKDLMEEFFQMAKLECNDVEITIEKFNISEVVR
KNIITFMNEINERTITPEINIGDEEIFALGDKNYMSRIITNLISNSLKYGYEGKVIGIDLKEDNKWVILSIWDKGKGIDK
NELPYIFDRLYTGEKSRNRSFQGSGLGLSIVKNMAQHMNGSIIAQSIPYEKTIFTVKIPKANS
>Mature_302_residues
SWILIIIIIILSILLLNDKIKTKRITAKLKEILKENSRERIKFYNLSTNKKELVREINIFLDKYQSISIDNKNYKEHHQK
MISNISHDIRTPLTALMGYVDLLSDNSITKGKKEEYISIIRERGTALKDLMEEFFQMAKLECNDVEITIEKFNISEVVRK
NIITFMNEINERTITPEINIGDEEIFALGDKNYMSRIITNLISNSLKYGYEGKVIGIDLKEDNKWVILSIWDKGKGIDKN
ELPYIFDRLYTGEKSRNRSFQGSGLGLSIVKNMAQHMNGSIIAQSIPYEKTIFTVKIPKANS

Specific function: Member of the two-component regulatory system ycbM/ycbL. Probably activates ycbL by phosphorylation [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788713, Length=224, Percent_Identity=29.4642857142857, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1788393, Length=227, Percent_Identity=29.5154185022026, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI1786600, Length=253, Percent_Identity=25.6916996047431, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI87081816, Length=269, Percent_Identity=25.2788104089219, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI145693157, Length=218, Percent_Identity=26.605504587156, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1786783, Length=296, Percent_Identity=22.972972972973, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1786912, Length=225, Percent_Identity=27.1111111111111, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1790861, Length=224, Percent_Identity=22.7678571428571, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790436, Length=218, Percent_Identity=20.6422018348624, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI48994928, Length=221, Percent_Identity=24.8868778280543, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI87082128, Length=227, Percent_Identity=21.5859030837004, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1788279, Length=302, Percent_Identity=24.5033112582781, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1790346, Length=223, Percent_Identity=25.5605381165919, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1789149, Length=223, Percent_Identity=23.3183856502242, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1787894, Length=203, Percent_Identity=25.615763546798, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790551, Length=293, Percent_Identity=22.5255972696246, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1789403, Length=282, Percent_Identity=21.6312056737589, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 35093; Mature: 34962

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSWILIIIIIILSILLLNDKIKTKRITAKLKEILKENSRERIKFYNLSTNKKELVREINI
CHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHH
FLDKYQSISIDNKNYKEHHQKMISNISHDIRTPLTALMGYVDLLSDNSITKGKKEEYISI
HHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
IRERGTALKDLMEEFFQMAKLECNDVEITIEKFNISEVVRKNIITFMNEINERTITPEIN
HHHCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCC
IGDEEIFALGDKNYMSRIITNLISNSLKYGYEGKVIGIDLKEDNKWVILSIWDKGKGIDK
CCCHHEEEECCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEEEECCCCCCCC
NELPYIFDRLYTGEKSRNRSFQGSGLGLSIVKNMAQHMNGSIIAQSIPYEKTIFTVKIPK
CCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCEEEEEEECCC
ANS
CCC
>Mature Secondary Structure 
SWILIIIIIILSILLLNDKIKTKRITAKLKEILKENSRERIKFYNLSTNKKELVREINI
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHH
FLDKYQSISIDNKNYKEHHQKMISNISHDIRTPLTALMGYVDLLSDNSITKGKKEEYISI
HHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
IRERGTALKDLMEEFFQMAKLECNDVEITIEKFNISEVVRKNIITFMNEINERTITPEIN
HHHCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCC
IGDEEIFALGDKNYMSRIITNLISNSLKYGYEGKVIGIDLKEDNKWVILSIWDKGKGIDK
CCCHHEEEECCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEEEECCCCCCCC
NELPYIFDRLYTGEKSRNRSFQGSGLGLSIVKNMAQHMNGSIIAQSIPYEKTIFTVKIPK
CCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCEEEEEEECCC
ANS
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7704254; 9384377 [H]