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The map label for this gene is mutS [H]

Identifier: 226949284

GI number: 226949284

Start: 2268218

End: 2269783

Strand: Direct

Name: mutS [H]

Synonym: CLM_2203

Alternate gene names: 226949284

Gene position: 2268218-2269783 (Clockwise)

Preceding gene: 226949281

Following gene: 226949285

Centisome position: 54.59

GC content: 28.22

Gene sequence:

>1566_bases
TTGAATAAAAAGGTAGCTTTAAATTGGGCAAAAACACAATATGAAGAAGGTGATGAAAAGGATAGAAAGTTTAATAATAT
AAGAAAGTTCTTTGATATGAAAGAAAAACAGGATTATACCATTGATGATGAAACCTGGTCTGATATGGATATGGATAGAG
TCTATGGAAAATTAGATAGAAATTCTAGTACTTTAGGAGAGTCTGTTTTATATCATATGCTTAGAAATCCCTTAAAGGAT
GAGGAAAAATTAAAGGATAGGAATAAGTTAATTCAATCATTTAAAGAGGATGTAAAATTAAGAGAACAGCTTTTGATTAC
ATACTACCAATTAGGTAGAGATAGAAAAAATACCTTTTTAGAGATGATAGAAAGTGAACTAGTAGTAAATAAAATGAAAT
ATTATTTATACACAATATTAGGAAAAATATTTCCTTTAATAGCTGTTTTGCTTACCGTATTTGTAAATGAAAGCTATGCT
AAATATATAGCTGGCTCTGCAATTTTAAATATGATTGTTAATCATATGGAAAGAAATACAATAAAATCTAGAGGAATAAT
ATATTTAAGGGAAATTATAAAAACAGCTAAAAAAATAGCTAGTATAAAAAACAATGGACTTAGTCATTATGTGGATAATA
TAAACCATAATCTTAAACAGGTTAAAGATGTGGATAGAAGTACTTTTTTAATAGGCTTTGTAAATATGTGGCAAGGCTTT
TTCGAAGTTATATCCGTGCTATTTTTAGTAGAAGAATGTGCCTATTATAAAGTATCTGGAGCTTTAAAAGGAAAAAAAGA
ATACATAATGAATATATTTTATATTCTAGGTGAATTAGAAGCATTATTATCTATATCTGGATATCAAAAGAACTTAAAGG
AGTACTATGTAAATCCAATTTTTACAAAGGAAGTCTCCTTAGATATTAAAGAGGGAATTCATCCCCTTTTAGATAAATCC
GTAGCAAATTCTATTTCTATTAAAGATAAGGGTATAGTACTTACAGGTACAAATATGTCTGGTAAATCAACCTTTTTAAG
GATGCTAGGTATAAACATACTATTATCACAAACCTTTTATTTTGCATTAGCTAAAGAATATAAGGCTTCTTTTTTCAATA
TAGTATCTTCTATTAGTCCTAATGATGACCTATCAAAGGGAAAAAGTTACTATATGGCTGAAGCAGAAGGAATACTTAGA
ATAGTTAAAGCGCTAGAAAAAGATTTACCTGTATTCTGCCCTATAGATGAGATATTTAGAGGAACAAATCCTATTGAGAG
AATAGCTATGTCAGCAGAAATACTTTCTTATCTTCAAAATGGAAGAACAGTCTCTATTGTAGCTACTCACGATAGAGAAT
TAGTAGATATTTTAAAGGATAGTTACGAGTTTTATTATTTCAGCGAATCTGTTGATAGTAAAAATGGATTAAACTTTGAT
TATAAGCTAAAGGTTGGAGTTTCTAATACAAGAAATGCCATAAGACTTTTAGAATATATTGGCTATCCAAAGGAAGTAAC
TAAAAAAGCCTATAAGCGAGCTGAAACTATTAAAGGATTTATCTAA

Upstream 100 bases:

>100_bases
ATAAAATGTAAAAAACTGATATTAAGTCGTAAAATACATGTTAAAATATTATTATATAGAATTTTTATATTTCATATTCA
AAATTGAAAGGAGAACGAAA

Downstream 100 bases:

>100_bases
CTTATCATAGTATACTATATTTTAATACAGTATTAAAAATAGTATTTTTAGTATATAAGTTAAAAATTTAAAACTATGTA
ATGATTACTCTTAAATTAAT

Product: MutS domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 521; Mature: 521

Protein sequence:

>521_residues
MNKKVALNWAKTQYEEGDEKDRKFNNIRKFFDMKEKQDYTIDDETWSDMDMDRVYGKLDRNSSTLGESVLYHMLRNPLKD
EEKLKDRNKLIQSFKEDVKLREQLLITYYQLGRDRKNTFLEMIESELVVNKMKYYLYTILGKIFPLIAVLLTVFVNESYA
KYIAGSAILNMIVNHMERNTIKSRGIIYLREIIKTAKKIASIKNNGLSHYVDNINHNLKQVKDVDRSTFLIGFVNMWQGF
FEVISVLFLVEECAYYKVSGALKGKKEYIMNIFYILGELEALLSISGYQKNLKEYYVNPIFTKEVSLDIKEGIHPLLDKS
VANSISIKDKGIVLTGTNMSGKSTFLRMLGINILLSQTFYFALAKEYKASFFNIVSSISPNDDLSKGKSYYMAEAEGILR
IVKALEKDLPVFCPIDEIFRGTNPIERIAMSAEILSYLQNGRTVSIVATHDRELVDILKDSYEFYYFSESVDSKNGLNFD
YKLKVGVSNTRNAIRLLEYIGYPKEVTKKAYKRAETIKGFI

Sequences:

>Translated_521_residues
MNKKVALNWAKTQYEEGDEKDRKFNNIRKFFDMKEKQDYTIDDETWSDMDMDRVYGKLDRNSSTLGESVLYHMLRNPLKD
EEKLKDRNKLIQSFKEDVKLREQLLITYYQLGRDRKNTFLEMIESELVVNKMKYYLYTILGKIFPLIAVLLTVFVNESYA
KYIAGSAILNMIVNHMERNTIKSRGIIYLREIIKTAKKIASIKNNGLSHYVDNINHNLKQVKDVDRSTFLIGFVNMWQGF
FEVISVLFLVEECAYYKVSGALKGKKEYIMNIFYILGELEALLSISGYQKNLKEYYVNPIFTKEVSLDIKEGIHPLLDKS
VANSISIKDKGIVLTGTNMSGKSTFLRMLGINILLSQTFYFALAKEYKASFFNIVSSISPNDDLSKGKSYYMAEAEGILR
IVKALEKDLPVFCPIDEIFRGTNPIERIAMSAEILSYLQNGRTVSIVATHDRELVDILKDSYEFYYFSESVDSKNGLNFD
YKLKVGVSNTRNAIRLLEYIGYPKEVTKKAYKRAETIKGFI
>Mature_521_residues
MNKKVALNWAKTQYEEGDEKDRKFNNIRKFFDMKEKQDYTIDDETWSDMDMDRVYGKLDRNSSTLGESVLYHMLRNPLKD
EEKLKDRNKLIQSFKEDVKLREQLLITYYQLGRDRKNTFLEMIESELVVNKMKYYLYTILGKIFPLIAVLLTVFVNESYA
KYIAGSAILNMIVNHMERNTIKSRGIIYLREIIKTAKKIASIKNNGLSHYVDNINHNLKQVKDVDRSTFLIGFVNMWQGF
FEVISVLFLVEECAYYKVSGALKGKKEYIMNIFYILGELEALLSISGYQKNLKEYYVNPIFTKEVSLDIKEGIHPLLDKS
VANSISIKDKGIVLTGTNMSGKSTFLRMLGINILLSQTFYFALAKEYKASFFNIVSSISPNDDLSKGKSYYMAEAEGILR
IVKALEKDLPVFCPIDEIFRGTNPIERIAMSAEILSYLQNGRTVSIVATHDRELVDILKDSYEFYYFSESVDSKNGLNFD
YKLKVGVSNTRNAIRLLEYIGYPKEVTKKAYKRAETIKGFI

Specific function: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. Binds double-stranded DNA [H]

COG id: COG0249

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutS family [H]

Homologues:

Organism=Homo sapiens, GI36949366, Length=230, Percent_Identity=31.304347826087, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI284813531, Length=255, Percent_Identity=22.3529411764706, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI4557761, Length=271, Percent_Identity=24.3542435424354, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1789089, Length=250, Percent_Identity=25.2, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17508445, Length=254, Percent_Identity=25.5905511811024, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17534743, Length=219, Percent_Identity=26.4840182648402, Blast_Score=65, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6321912, Length=266, Percent_Identity=29.6992481203008, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6319935, Length=259, Percent_Identity=25.4826254826255, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324482, Length=221, Percent_Identity=23.9819004524887, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24584320, Length=252, Percent_Identity=25, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24664545, Length=229, Percent_Identity=23.1441048034935, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005748
- InterPro:   IPR007695
- InterPro:   IPR000432
- InterPro:   IPR007861
- InterPro:   IPR007860
- InterPro:   IPR007696
- InterPro:   IPR016151 [H]

Pfam domain/function: PF01624 MutS_I; PF05188 MutS_II; PF05192 MutS_III; PF05190 MutS_IV; PF00488 MutS_V [H]

EC number: NA

Molecular weight: Translated: 60292; Mature: 60292

Theoretical pI: Translated: 9.33; Mature: 9.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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EEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure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EEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8604304; 9722634 [H]