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The map label for this gene is moeA [C]

Identifier: 226949239

GI number: 226949239

Start: 2213702

End: 2215606

Strand: Reverse

Name: moeA [C]

Synonym: CLM_2158

Alternate gene names: 226949239

Gene position: 2215606-2213702 (Counterclockwise)

Preceding gene: 226949240

Following gene: 226949238

Centisome position: 53.32

GC content: 31.02

Gene sequence:

>1905_bases
ATGGGGCAAAATATTTATCTTTCAAATTATGAAATTGAAGAGGCATTAAAATTTTATTTTAGTAAGATAAGCATAGAAAG
ACAAAATGAATTTATAGATACAGAATATTCAAGCAATAGAATAACCGCATCACCTATATATTCTAAAATATCTTCTCCTT
TCTACAATTCTTCTGCTATGGATGGTATTGCGGTTAATAGTGAAAAAACCTTAGGAGCAAATGAAAAGAATCATATAGCT
TTAGAAGAAGAAAAGGATTATATAGTAGTAGATACAGGAGATCCTATACCTAGAGAGTATAATGCTGTAATAATGGTGGA
GGATTTAATCAAAGTAGATGATAAAAGGGTGAAAATATATAAAAGTATAGCACCTTATGAAAACATAAGACCTTTAGGAG
AGGATATAGTGGAGAAATCTCTTATAGTTCCATCCTATCATAAAATAAGACCTGTGGATATTTCAGCAATGATTGCAGGG
GGAGTAAATGAAGTAGAAGTTTATAAAAAACCTCTAGTAGGCATAATCCCTACTGGCACAGAACTTGTAGAACCAGGTAA
CAATTTAAAAGTAGGAGATATAATAGACTTTAATTCAAGAACCTTTGCAGCACAGGTCTTTGAGTATGGTGGTATTGCTA
AAAGATATGAAATAGTTAAAGATAATTATGAAAAAATTAAAGATACTATAAAAAAAGCAGTAAAAGAATGTGATATAGTT
CTTGTAAACGCTGGTTCCTCTGCAGGAAGAGAGGATTACACAGCTAAAATTATAGAAGATTTAGGTAAGGTATATATACA
TGGAGTAGCCATAAAGCCAGGAAAACCGGTTATTTTAGGAAAGATAGATAATAAACCTGTTATAGGAATACCTGGATATC
CTGTGTCAGCCTATGTTATTATGGAGAACTTTGTAAGACCTATGGTGAAAAAATTTGCAGGAGAAAAACCCTATAAATAT
AAAAAAATTAAAGCTACATTATCTAAAAGGGTTATGTCTTCATTAAAATATGTTGAATTTATTAGGATAAAATTAGGTAA
AGTAGGAGAAAAAATAGTAGCTACACCTTTAAATAGGGGAGCTGGCGCCACCATGTCTCTTGTTAGAGCAGATGGAATAC
TTGAAGTTCCACAAAATGTGGAAGGTATCGAAAAAGGAACGGAAGTAGATGTAAAACTTCTAAAGGATGAAGAGGAAATA
AATAATACTATAGTTTGTATAGGAAGTCATGATCCTATAATAGATGTTATAGCAGATTTAATTCATGTAAAACAGGGTGG
ATATTATTTATCCTCTGCTCATGTAGGTAGTATGGGAGGAATAATGGCACTTAAAAATGGTGAAACCCATATAGCTCCTA
TACATCTTTTAGATATGGAAAGTGGAGAATATAACGTAAGCTACATTAAAAAATATATTGGGAATAGACCAATGGCTCTT
ATAAAATGCGTAAAAAGAATTCAAGGAATTATGGTTCCTAAAGGAAATCCTAATAATATTACTTCTATTAGGGATATAAG
AGATAAAAAATTGAAATTTGTAAATAGACAAAGGGGTGCAGGTACAAGACTTCTTCTTGATTATAATCTTAAAAAATTAA
ATATAAACCCTAGAGAAATACAAGGGTATGAAAGGGAAGAGTATACTCATTTACAGGTAGCTGCAGCTATTTCAAATGGA
GATGCCCATTGTGGGCTTGGGGTATATTCTGCGGCAAATATGATGGGACTAGATTTTATATCTGTTTGTAATGAAGAATA
TGATATAGTAATTTTTGAAGAATTTTTAAGTATGCCCTCAATAAAAGAATTTATAAGTATTATAAAAAGTGATAAGTTTA
AAGAGAGATTGGATGAATTAGGTGGTTATGACTATAGTGAAGCAGGTAATATTGTTTTTATATAA

Upstream 100 bases:

>100_bases
GTTTTTCTAAGGCTTATGGTTTTATAAAGATAGATAAGAATCTTGAGGGAATAAAAAAGGATGAGAAAGTATTTGTATAT
AGATTTTAGGAGGTTTTAAT

Downstream 100 bases:

>100_bases
GAAATGATAGATATGTTTCATATACTAAAGAGTAAGCTTTATATAAAGGAGGGGTTTGATGTTAGATAAGCATGGAAGGA
AAATTAACTATTTAAGAGTA

Product: putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 634; Mature: 633

Protein sequence:

>634_residues
MGQNIYLSNYEIEEALKFYFSKISIERQNEFIDTEYSSNRITASPIYSKISSPFYNSSAMDGIAVNSEKTLGANEKNHIA
LEEEKDYIVVDTGDPIPREYNAVIMVEDLIKVDDKRVKIYKSIAPYENIRPLGEDIVEKSLIVPSYHKIRPVDISAMIAG
GVNEVEVYKKPLVGIIPTGTELVEPGNNLKVGDIIDFNSRTFAAQVFEYGGIAKRYEIVKDNYEKIKDTIKKAVKECDIV
LVNAGSSAGREDYTAKIIEDLGKVYIHGVAIKPGKPVILGKIDNKPVIGIPGYPVSAYVIMENFVRPMVKKFAGEKPYKY
KKIKATLSKRVMSSLKYVEFIRIKLGKVGEKIVATPLNRGAGATMSLVRADGILEVPQNVEGIEKGTEVDVKLLKDEEEI
NNTIVCIGSHDPIIDVIADLIHVKQGGYYLSSAHVGSMGGIMALKNGETHIAPIHLLDMESGEYNVSYIKKYIGNRPMAL
IKCVKRIQGIMVPKGNPNNITSIRDIRDKKLKFVNRQRGAGTRLLLDYNLKKLNINPREIQGYEREEYTHLQVAAAISNG
DAHCGLGVYSAANMMGLDFISVCNEEYDIVIFEEFLSMPSIKEFISIIKSDKFKERLDELGGYDYSEAGNIVFI

Sequences:

>Translated_634_residues
MGQNIYLSNYEIEEALKFYFSKISIERQNEFIDTEYSSNRITASPIYSKISSPFYNSSAMDGIAVNSEKTLGANEKNHIA
LEEEKDYIVVDTGDPIPREYNAVIMVEDLIKVDDKRVKIYKSIAPYENIRPLGEDIVEKSLIVPSYHKIRPVDISAMIAG
GVNEVEVYKKPLVGIIPTGTELVEPGNNLKVGDIIDFNSRTFAAQVFEYGGIAKRYEIVKDNYEKIKDTIKKAVKECDIV
LVNAGSSAGREDYTAKIIEDLGKVYIHGVAIKPGKPVILGKIDNKPVIGIPGYPVSAYVIMENFVRPMVKKFAGEKPYKY
KKIKATLSKRVMSSLKYVEFIRIKLGKVGEKIVATPLNRGAGATMSLVRADGILEVPQNVEGIEKGTEVDVKLLKDEEEI
NNTIVCIGSHDPIIDVIADLIHVKQGGYYLSSAHVGSMGGIMALKNGETHIAPIHLLDMESGEYNVSYIKKYIGNRPMAL
IKCVKRIQGIMVPKGNPNNITSIRDIRDKKLKFVNRQRGAGTRLLLDYNLKKLNINPREIQGYEREEYTHLQVAAAISNG
DAHCGLGVYSAANMMGLDFISVCNEEYDIVIFEEFLSMPSIKEFISIIKSDKFKERLDELGGYDYSEAGNIVFI
>Mature_633_residues
GQNIYLSNYEIEEALKFYFSKISIERQNEFIDTEYSSNRITASPIYSKISSPFYNSSAMDGIAVNSEKTLGANEKNHIAL
EEEKDYIVVDTGDPIPREYNAVIMVEDLIKVDDKRVKIYKSIAPYENIRPLGEDIVEKSLIVPSYHKIRPVDISAMIAGG
VNEVEVYKKPLVGIIPTGTELVEPGNNLKVGDIIDFNSRTFAAQVFEYGGIAKRYEIVKDNYEKIKDTIKKAVKECDIVL
VNAGSSAGREDYTAKIIEDLGKVYIHGVAIKPGKPVILGKIDNKPVIGIPGYPVSAYVIMENFVRPMVKKFAGEKPYKYK
KIKATLSKRVMSSLKYVEFIRIKLGKVGEKIVATPLNRGAGATMSLVRADGILEVPQNVEGIEKGTEVDVKLLKDEEEIN
NTIVCIGSHDPIIDVIADLIHVKQGGYYLSSAHVGSMGGIMALKNGETHIAPIHLLDMESGEYNVSYIKKYIGNRPMALI
KCVKRIQGIMVPKGNPNNITSIRDIRDKKLKFVNRQRGAGTRLLLDYNLKKLNINPREIQGYEREEYTHLQVAAAISNGD
AHCGLGVYSAANMMGLDFISVCNEEYDIVIFEEFLSMPSIKEFISIIKSDKFKERLDELGGYDYSEAGNIVFI

Specific function: Involved In The Biosynthesis Of A Demolybdo-Cofactor (Molybdopterin), Necessary For Molybdo-Enzymes. Seems To Be Involved In A Step Of Activation Of Molybdenum In The Form Of Thiomolybdenum. [C]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=395, Percent_Identity=29.620253164557, Blast_Score=136, Evalue=6e-32,
Organism=Homo sapiens, GI10880983, Length=395, Percent_Identity=29.620253164557, Blast_Score=136, Evalue=6e-32,
Organism=Escherichia coli, GI1787049, Length=340, Percent_Identity=28.5294117647059, Blast_Score=146, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI25147659, Length=356, Percent_Identity=26.9662921348315, Blast_Score=115, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI17562606, Length=382, Percent_Identity=24.869109947644, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17136978, Length=349, Percent_Identity=28.080229226361, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24638841, Length=349, Percent_Identity=28.080229226361, Blast_Score=129, Evalue=5e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 70715; Mature: 70583

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGQNIYLSNYEIEEALKFYFSKISIERQNEFIDTEYSSNRITASPIYSKISSPFYNSSAM
CCCCEEEECCCHHHHHHHHHHHHEEECCCCEECCCCCCCCEECCHHHHHHCCCCCCCCCC
DGIAVNSEKTLGANEKNHIALEEEKDYIVVDTGDPIPREYNAVIMVEDLIKVDDKRVKIY
CCEEECCCCCCCCCCCCCEEEECCCCEEEEECCCCCCCCCCEEEEEEHHHHCCCCCEEEE
KSIAPYENIRPLGEDIVEKSLIVPSYHKIRPVDISAMIAGGVNEVEVYKKPLVGIIPTGT
HHHCCHHHCCHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCHHHHHHCCCEEEECCCH
ELVEPGNNLKVGDIIDFNSRTFAAQVFEYGGIAKRYEIVKDNYEKIKDTIKKAVKECDIV
HHCCCCCCEEECEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEE
LVNAGSSAGREDYTAKIIEDLGKVYIHGVAIKPGKPVILGKIDNKPVIGIPGYPVSAYVI
EEECCCCCCCCHHHHHHHHHHHHEEEEEEEECCCCCEEEEECCCCCEEECCCCCCHHHHH
MENFVRPMVKKFAGEKPYKYKKIKATLSKRVMSSLKYVEFIRIKLGKVGEKIVATPLNRG
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCC
AGATMSLVRADGILEVPQNVEGIEKGTEVDVKLLKDEEEINNTIVCIGSHDPIIDVIADL
CCCEEEEEECCCCEECCCCCCHHCCCCCEEEEEECCHHHCCCEEEEEECCCCHHHHHHHH
IHVKQGGYYLSSAHVGSMGGIMALKNGETHIAPIHLLDMESGEYNVSYIKKYIGNRPMAL
HHHCCCCEEEECCCCCCCCCEEEEECCCCEEEEEEEEECCCCCCCHHHHHHHHCCCCHHH
IKCVKRIQGIMVPKGNPNNITSIRDIRDKKLKFVNRQRGAGTRLLLDYNLKKLNINPREI
HHHHHHHCCEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECEEEECCCHHHC
QGYEREEYTHLQVAAAISNGDAHCGLGVYSAANMMGLDFISVCNEEYDIVIFEEFLSMPS
CCCCCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHCHHHHHHCCCCCCEEEEHHHCCCCC
IKEFISIIKSDKFKERLDELGGYDYSEAGNIVFI
HHHHHHHHHCCHHHHHHHHHCCCCCCCCCCEEEC
>Mature Secondary Structure 
GQNIYLSNYEIEEALKFYFSKISIERQNEFIDTEYSSNRITASPIYSKISSPFYNSSAM
CCCEEEECCCHHHHHHHHHHHHEEECCCCEECCCCCCCCEECCHHHHHHCCCCCCCCCC
DGIAVNSEKTLGANEKNHIALEEEKDYIVVDTGDPIPREYNAVIMVEDLIKVDDKRVKIY
CCEEECCCCCCCCCCCCCEEEECCCCEEEEECCCCCCCCCCEEEEEEHHHHCCCCCEEEE
KSIAPYENIRPLGEDIVEKSLIVPSYHKIRPVDISAMIAGGVNEVEVYKKPLVGIIPTGT
HHHCCHHHCCHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCHHHHHHCCCEEEECCCH
ELVEPGNNLKVGDIIDFNSRTFAAQVFEYGGIAKRYEIVKDNYEKIKDTIKKAVKECDIV
HHCCCCCCEEECEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEE
LVNAGSSAGREDYTAKIIEDLGKVYIHGVAIKPGKPVILGKIDNKPVIGIPGYPVSAYVI
EEECCCCCCCCHHHHHHHHHHHHEEEEEEEECCCCCEEEEECCCCCEEECCCCCCHHHHH
MENFVRPMVKKFAGEKPYKYKKIKATLSKRVMSSLKYVEFIRIKLGKVGEKIVATPLNRG
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCC
AGATMSLVRADGILEVPQNVEGIEKGTEVDVKLLKDEEEINNTIVCIGSHDPIIDVIADL
CCCEEEEEECCCCEECCCCCCHHCCCCCEEEEEECCHHHCCCEEEEEECCCCHHHHHHHH
IHVKQGGYYLSSAHVGSMGGIMALKNGETHIAPIHLLDMESGEYNVSYIKKYIGNRPMAL
HHHCCCCEEEECCCCCCCCCEEEEECCCCEEEEEEEEECCCCCCCHHHHHHHHCCCCHHH
IKCVKRIQGIMVPKGNPNNITSIRDIRDKKLKFVNRQRGAGTRLLLDYNLKKLNINPREI
HHHHHHHCCEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECEEEECCCHHHC
QGYEREEYTHLQVAAAISNGDAHCGLGVYSAANMMGLDFISVCNEEYDIVIFEEFLSMPS
CCCCCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHCHHHHHHCCCCCCEEEEHHHCCCCC
IKEFISIIKSDKFKERLDELGGYDYSEAGNIVFI
HHHHHHHHHCCHHHHHHHHHCCCCCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]