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The map label for this gene is ldh [H]

Identifier: 226948852

GI number: 226948852

Start: 1792710

End: 1793666

Strand: Reverse

Name: ldh [H]

Synonym: CLM_1754

Alternate gene names: 226948852

Gene position: 1793666-1792710 (Counterclockwise)

Preceding gene: 226948854

Following gene: 226948843

Centisome position: 43.17

GC content: 29.68

Gene sequence:

>957_bases
ATGATAAAAAAAAGAAATACTACTAAAATATCAGTTATAGGAGCAGGTTCAGTAGGTGCAACCACTGCTTATGCATTAAT
GCTATCAGGTGTTGCAACAGAAATAGTATTAGTAGATGTTAATAAATCAAAAACTGAGGGAGAGGCTATGGATTTATCCC
ATGGAGCAGATTTCGTAAAGCCTGTAAATATACTAAGTGGAGATTATAAAGATACTGAAGGTTCAGATATTGTTGTAATT
ACAGCTGGTGCAGCACAAAAAGTAGGTGAAACAAGACTTCAACTTATAAATAAAAATATTAATATATTTAAATCAATAAT
TCCGGAAGTAGTAAAATATAATAAAGATGCTATTTTATTAGTAGTTTCAAATCCTGTAGATGTATTAAGTTATGTAACCT
ATAAACTATCAGGTTTTCCTAAAGAAAGAGTTATAGGTTCCGGTACAGTTTTAGACACATCAAGACTTAAACACGAGATA
GGGAAAAGATATAAAATCGACCCAAGAAACGTAAATACTTATATAATGGGAGAACACGGTGATTCAGAAATCGCTACTTG
GAGTGTAACTAATATTCAAAACATTAAAATTGATGAATATGCTAATAAAGAAAATCTTGAGTATAATGATAACTTTAGAA
AAGAAGTCTATGAAAATGTTAAAAATGCGGCTTACGAAGTTATAAATAGAAAAGGTGCTACTTTCTATGCTATAGCTTTA
GCGGTAACACGTATTGTAAAAGCTATATTAGGGGATGAAAAAACTATATTACCAGTTTCTACTTTAGTAGAAAATTACTA
TGGAATTAAAGATGTTTACCTAGGAATGCCATGTATTGTAGGTGGATCAGGTATTGAAAAAGCATTAAGTATAGATTTAA
ATAAAACAGAAGCATCTAAATTAGTTAAATCTGCTGAAACTTTAAAAAATACTTTAAATAATGCATCTTGTCTATAG

Upstream 100 bases:

>100_bases
CATGTGATCATTGGTAATACCACTAAACCAAAATACCAAAATACCAATAATCTACTGAATTAATTTATATTAAGTTAAAG
TTTTTAGGGGGTAATTTAAA

Downstream 100 bases:

>100_bases
TTTTTATATAAGATAAACATTACTATCAAAATTACCCTATAGATAGACTTTAATATGTGCCCTTTCCAATAACAGATTTT
TATTTTTTAATCTGTCTACC

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: L-LDH [H]

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MIKKRNTTKISVIGAGSVGATTAYALMLSGVATEIVLVDVNKSKTEGEAMDLSHGADFVKPVNILSGDYKDTEGSDIVVI
TAGAAQKVGETRLQLINKNINIFKSIIPEVVKYNKDAILLVVSNPVDVLSYVTYKLSGFPKERVIGSGTVLDTSRLKHEI
GKRYKIDPRNVNTYIMGEHGDSEIATWSVTNIQNIKIDEYANKENLEYNDNFRKEVYENVKNAAYEVINRKGATFYAIAL
AVTRIVKAILGDEKTILPVSTLVENYYGIKDVYLGMPCIVGGSGIEKALSIDLNKTEASKLVKSAETLKNTLNNASCL

Sequences:

>Translated_318_residues
MIKKRNTTKISVIGAGSVGATTAYALMLSGVATEIVLVDVNKSKTEGEAMDLSHGADFVKPVNILSGDYKDTEGSDIVVI
TAGAAQKVGETRLQLINKNINIFKSIIPEVVKYNKDAILLVVSNPVDVLSYVTYKLSGFPKERVIGSGTVLDTSRLKHEI
GKRYKIDPRNVNTYIMGEHGDSEIATWSVTNIQNIKIDEYANKENLEYNDNFRKEVYENVKNAAYEVINRKGATFYAIAL
AVTRIVKAILGDEKTILPVSTLVENYYGIKDVYLGMPCIVGGSGIEKALSIDLNKTEASKLVKSAETLKNTLNNASCL
>Mature_318_residues
MIKKRNTTKISVIGAGSVGATTAYALMLSGVATEIVLVDVNKSKTEGEAMDLSHGADFVKPVNILSGDYKDTEGSDIVVI
TAGAAQKVGETRLQLINKNINIFKSIIPEVVKYNKDAILLVVSNPVDVLSYVTYKLSGFPKERVIGSGTVLDTSRLKHEI
GKRYKIDPRNVNTYIMGEHGDSEIATWSVTNIQNIKIDEYANKENLEYNDNFRKEVYENVKNAAYEVINRKGATFYAIAL
AVTRIVKAILGDEKTILPVSTLVENYYGIKDVYLGMPCIVGGSGIEKALSIDLNKTEASKLVKSAETLKNTLNNASCL

Specific function: Catalyzes The Reversible Oxidation Of Malate To Oxaloacetate. [C]

COG id: COG0039

COG function: function code C; Malate/lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH/MDH superfamily. LDH family [H]

Homologues:

Organism=Homo sapiens, GI5031857, Length=312, Percent_Identity=43.5897435897436, Blast_Score=273, Evalue=1e-73,
Organism=Homo sapiens, GI260099723, Length=312, Percent_Identity=43.5897435897436, Blast_Score=273, Evalue=2e-73,
Organism=Homo sapiens, GI291575128, Length=302, Percent_Identity=43.7086092715232, Blast_Score=265, Evalue=3e-71,
Organism=Homo sapiens, GI4557032, Length=302, Percent_Identity=43.7086092715232, Blast_Score=265, Evalue=3e-71,
Organism=Homo sapiens, GI47059044, Length=302, Percent_Identity=44.0397350993377, Blast_Score=265, Evalue=4e-71,
Organism=Homo sapiens, GI221136809, Length=302, Percent_Identity=44.0397350993377, Blast_Score=265, Evalue=4e-71,
Organism=Homo sapiens, GI15082234, Length=313, Percent_Identity=42.8115015974441, Blast_Score=263, Evalue=2e-70,
Organism=Homo sapiens, GI9257228, Length=307, Percent_Identity=42.3452768729642, Blast_Score=261, Evalue=4e-70,
Organism=Homo sapiens, GI4504973, Length=307, Percent_Identity=42.3452768729642, Blast_Score=261, Evalue=4e-70,
Organism=Homo sapiens, GI260099727, Length=223, Percent_Identity=43.9461883408072, Blast_Score=202, Evalue=3e-52,
Organism=Homo sapiens, GI260099725, Length=200, Percent_Identity=47, Blast_Score=201, Evalue=6e-52,
Organism=Homo sapiens, GI207028494, Length=311, Percent_Identity=31.5112540192926, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI103472011, Length=308, Percent_Identity=29.2207792207792, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI103472015, Length=186, Percent_Identity=32.258064516129, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI21735621, Length=300, Percent_Identity=27, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI1789632, Length=324, Percent_Identity=26.8518518518519, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17535107, Length=296, Percent_Identity=41.8918918918919, Blast_Score=249, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI17554310, Length=300, Percent_Identity=25.3333333333333, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322765, Length=304, Percent_Identity=26.9736842105263, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17136226, Length=304, Percent_Identity=40.1315789473684, Blast_Score=248, Evalue=4e-66,
Organism=Drosophila melanogaster, GI45550422, Length=322, Percent_Identity=33.5403726708075, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24647881, Length=318, Percent_Identity=25.7861635220126, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24663599, Length=324, Percent_Identity=25, Blast_Score=68, Evalue=8e-12,

Paralogues:

None

Copy number: 2640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 260 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2380 Molecules/Cell In: Stationary-Phase, Rich-Media (Based on E. coli). 260 Molecules/Cell In: Stationary Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001557
- InterPro:   IPR011304
- InterPro:   IPR018177
- InterPro:   IPR022383
- InterPro:   IPR001236
- InterPro:   IPR015955
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02866 Ldh_1_C; PF00056 Ldh_1_N [H]

EC number: =1.1.1.27 [H]

Molecular weight: Translated: 34735; Mature: 34735

Theoretical pI: Translated: 8.52; Mature: 8.52

Prosite motif: PS00064 L_LDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKKRNTTKISVIGAGSVGATTAYALMLSGVATEIVLVDVNKSKTEGEAMDLSHGADFVK
CCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCCEECCCCCCHHH
PVNILSGDYKDTEGSDIVVITAGAAQKVGETRLQLINKNINIFKSIIPEVVKYNKDAILL
HHHHHCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEE
VVSNPVDVLSYVTYKLSGFPKERVIGSGTVLDTSRLKHEIGKRYKIDPRNVNTYIMGEHG
EECCCHHHHHHHHHHHCCCCHHHCCCCCCEEEHHHHHHHHCCCEECCCCCCCEEEEECCC
DSEIATWSVTNIQNIKIDEYANKENLEYNDNFRKEVYENVKNAAYEVINRKGATFYAIAL
CCCEEEEEECCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
AVTRIVKAILGDEKTILPVSTLVENYYGIKDVYLGMPCIVGGSGIEKALSIDLNKTEASK
HHHHHHHHHHCCCCEEEHHHHHHHHHCCHHHHHCCCCEEECCCCCCHHEEECCCHHHHHH
LVKSAETLKNTLNNASCL
HHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MIKKRNTTKISVIGAGSVGATTAYALMLSGVATEIVLVDVNKSKTEGEAMDLSHGADFVK
CCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCCEECCCCCCHHH
PVNILSGDYKDTEGSDIVVITAGAAQKVGETRLQLINKNINIFKSIIPEVVKYNKDAILL
HHHHHCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEE
VVSNPVDVLSYVTYKLSGFPKERVIGSGTVLDTSRLKHEIGKRYKIDPRNVNTYIMGEHG
EECCCHHHHHHHHHHHCCCCHHHCCCCCCEEEHHHHHHHHCCCEECCCCCCCEEEEECCC
DSEIATWSVTNIQNIKIDEYANKENLEYNDNFRKEVYENVKNAAYEVINRKGATFYAIAL
CCCEEEEEECCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
AVTRIVKAILGDEKTILPVSTLVENYYGIKDVYLGMPCIVGGSGIEKALSIDLNKTEASK
HHHHHHHHHHCCCCEEEHHHHHHHHHCCHHHHHCCCCEEECCCCCCHHEEECCCHHHHHH
LVKSAETLKNTLNNASCL
HHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA