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The map label for this gene is tcyA [H]

Identifier: 226948690

GI number: 226948690

Start: 1649828

End: 1650634

Strand: Direct

Name: tcyA [H]

Synonym: CLM_1588

Alternate gene names: 226948690

Gene position: 1649828-1650634 (Clockwise)

Preceding gene: 226948688

Following gene: 226948691

Centisome position: 39.7

GC content: 29.0

Gene sequence:

>807_bases
ATGTCTAAGAAAAAAATATTAAGTGTTTTATTTATAGTGGTATGTATCATATCTTTTACATTAATTGGATGTGGTCAGAA
AAATTCTTCTAATGGAAAAGACAGTTCCTATTCAAAAATTAAAGATAAAGGGCAATTAGTAGTAGGGTTATGTGCTCAAT
ATCCACCCTTTGAGTCAAGAAATGATAAAACAGGTGAAATAGAAGGCTTTGATGTAGATTTAGCGAAGGAACTAGGAAAA
GAAATGGATTTAAAGGTTGAAATAAAAGATGCAGAATGGGAAGCACTTTTAGGTGGTGTCAATAAAGGGGATTATGATGT
TTTAATAACTTGTATGTCTAAAAAAGAAGCGGCGGAAGCTAATATAAACACTTCTGATACATATTACAAATTGGATGATA
TAATAGTGGTAAATAAGAATAATAATTTTATACATAATAAAGGTGATTTAAAGGGAAAAGTAGTTGGAGTTCAAACATCT
ACAAGCAGTGAACAAGTAGTTGATAAATTAGATGGAATAAAGGAGATTAAAAGATATAATAGAAATCCTGAAGCATTCAT
AGATTTAAAAAATAATAGGATTGATGCTGTAGTTGTAGGATATGCTTATGCGGCTACCACCATGAAAGATAAAAAGGATG
ATAATTTAAAAATAATAAATTCTCCTGTAGGTTCATCGGACATAGTTATGGTTACTAAAAAGGGTTCAGATGACTTAACA
AAAGAGTTAAATAAAGCGCTAAAAAAAGTAAAAGAAGATGGTAAATATGAAGAGATTAAAAATAAGTGGTTAAGTTTAAA
GAAATAA

Upstream 100 bases:

>100_bases
TTATATTAAACTTATTATGATAAATACATAAGCTTAGTATAATTTTATTTTATATATAATATTAACTATATAATTATTAA
TTATTCTGGGGGGGAAAATT

Downstream 100 bases:

>100_bases
TATGGAACTTAATTTTGATATTATTTTTAGAAATTTACCATTCTTATTAAAGGCTACGTTAGTAACTATAAAAATAACTT
TACTTTCTTTTATTGTGGCT

Product: polar amino acid uptake ABC transporter amino acid-binding protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 268; Mature: 267

Protein sequence:

>268_residues
MSKKKILSVLFIVVCIISFTLIGCGQKNSSNGKDSSYSKIKDKGQLVVGLCAQYPPFESRNDKTGEIEGFDVDLAKELGK
EMDLKVEIKDAEWEALLGGVNKGDYDVLITCMSKKEAAEANINTSDTYYKLDDIIVVNKNNNFIHNKGDLKGKVVGVQTS
TSSEQVVDKLDGIKEIKRYNRNPEAFIDLKNNRIDAVVVGYAYAATTMKDKKDDNLKIINSPVGSSDIVMVTKKGSDDLT
KELNKALKKVKEDGKYEEIKNKWLSLKK

Sequences:

>Translated_268_residues
MSKKKILSVLFIVVCIISFTLIGCGQKNSSNGKDSSYSKIKDKGQLVVGLCAQYPPFESRNDKTGEIEGFDVDLAKELGK
EMDLKVEIKDAEWEALLGGVNKGDYDVLITCMSKKEAAEANINTSDTYYKLDDIIVVNKNNNFIHNKGDLKGKVVGVQTS
TSSEQVVDKLDGIKEIKRYNRNPEAFIDLKNNRIDAVVVGYAYAATTMKDKKDDNLKIINSPVGSSDIVMVTKKGSDDLT
KELNKALKKVKEDGKYEEIKNKWLSLKK
>Mature_267_residues
SKKKILSVLFIVVCIISFTLIGCGQKNSSNGKDSSYSKIKDKGQLVVGLCAQYPPFESRNDKTGEIEGFDVDLAKELGKE
MDLKVEIKDAEWEALLGGVNKGDYDVLITCMSKKEAAEANINTSDTYYKLDDIIVVNKNNNFIHNKGDLKGKVVGVQTST
SSEQVVDKLDGIKEIKRYNRNPEAFIDLKNNRIDAVVVGYAYAATTMKDKKDDNLKIINSPVGSSDIVMVTKKGSDDLTK
ELNKALKKVKEDGKYEEIKNKWLSLKK

Specific function: Part of the ABC transporter complex tcyABC involved in L-cystine import [H]

COG id: COG0834

COG function: function code ET; ABC-type amino acid transport/signal transduction systems, periplasmic component/domain

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 3 family [H]

Homologues:

Organism=Escherichia coli, GI1788228, Length=255, Percent_Identity=27.843137254902, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI1787031, Length=220, Percent_Identity=28.6363636363636, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1787085, Length=222, Percent_Identity=28.3783783783784, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1787088, Length=219, Percent_Identity=31.9634703196347, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1788648, Length=237, Percent_Identity=29.535864978903, Blast_Score=87, Evalue=9e-19,
Organism=Escherichia coli, GI1788649, Length=249, Percent_Identity=25.7028112449799, Blast_Score=76, Evalue=3e-15,

Paralogues:

None

Copy number: 1920 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1060 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 80 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001638
- InterPro:   IPR018313 [H]

Pfam domain/function: PF00497 SBP_bac_3 [H]

EC number: NA

Molecular weight: Translated: 29789; Mature: 29658

Theoretical pI: Translated: 8.78; Mature: 8.78

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS01039 SBP_BACTERIAL_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKKILSVLFIVVCIISFTLIGCGQKNSSNGKDSSYSKIKDKGQLVVGLCAQYPPFESR
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCEEEEEECCCCCCCCC
NDKTGEIEGFDVDLAKELGKEMDLKVEIKDAEWEALLGGVNKGDYDVLITCMSKKEAAEA
CCCCCCCCCCCCHHHHHCCCCCCEEEEEECCCHHHHHCCCCCCCEEEEEEEECCCCHHHC
NINTSDTYYKLDDIIVVNKNNNFIHNKGDLKGKVVGVQTSTSSEQVVDKLDGIKEIKRYN
CCCCCCCEEEEEEEEEEECCCCEEECCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHC
RNPEAFIDLKNNRIDAVVVGYAYAATTMKDKKDDNLKIINSPVGSSDIVMVTKKGSDDLT
CCCCEEEEECCCCEEEEEEEEHHHHHHCCCCCCCCEEEEECCCCCCCEEEEEECCCHHHH
KELNKALKKVKEDGKYEEIKNKWLSLKK
HHHHHHHHHHHHCCCHHHHHHHHHCCCC
>Mature Secondary Structure 
SKKKILSVLFIVVCIISFTLIGCGQKNSSNGKDSSYSKIKDKGQLVVGLCAQYPPFESR
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCEEEEEECCCCCCCCC
NDKTGEIEGFDVDLAKELGKEMDLKVEIKDAEWEALLGGVNKGDYDVLITCMSKKEAAEA
CCCCCCCCCCCCHHHHHCCCCCCEEEEEECCCHHHHHCCCCCCCEEEEEEEECCCCHHHC
NINTSDTYYKLDDIIVVNKNNNFIHNKGDLKGKVVGVQTSTSSEQVVDKLDGIKEIKRYN
CCCCCCCEEEEEEEEEEECCCCEEECCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHC
RNPEAFIDLKNNRIDAVVVGYAYAATTMKDKKDDNLKIINSPVGSSDIVMVTKKGSDDLT
CCCCEEEEECCCCEEEEEEEEHHHHHHCCCCCCCCEEEEECCCCCCCEEEEEECCCHHHH
KELNKALKKVKEDGKYEEIKNKWLSLKK
HHHHHHHHHHHHCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7551042; 8969502; 9384377 [H]