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The map label for this gene is patB [H]

Identifier: 226948678

GI number: 226948678

Start: 1636878

End: 1638056

Strand: Direct

Name: patB [H]

Synonym: CLM_1576

Alternate gene names: 226948678

Gene position: 1636878-1638056 (Clockwise)

Preceding gene: 226948677

Following gene: 226948679

Centisome position: 39.39

GC content: 30.45

Gene sequence:

>1179_bases
ATGAAGTATAATTTTGACAAAGTAGTAAATAGGGATAATACAAATTGTAGTAAATGGAATTTTAATAAAGAAACCTTTGG
GTATGAAGATATTATATCTATGTGGATAGCTGATATGGATTTTGAAACAGTTCCAGAGGTAAAAGAAGAAATAATAAATA
GGGCTCATCATGGTATTTACGGATATACTGCTACGACAGAATCCTATTATAAAGAAGTTGTAAATTGGATGAAAAAACGT
CATGGATGGAATATAAAAAAAGAATGGATAACTAATACTCCTGGAATAGTTATGGCTGTAAATACTATAGTTAGAACTTT
TACTCATTCAGGGGACAAGGTGCTACTCCAAAGACCTATATATTATCCATTTTTTAAGGCTATAAACAATAATGGATGTC
ATATAGTAAACAATCCATTAAAGTTTGATGGAAAAAGATATGAAATGGATTTTGAGGACTTAGATAACAAACTTTCAGAC
CCTAGAGTAAAGATAATGATATTATGTAGTCCCCATAATCCTACAGGAAGAGTCTGGACTAAAGAAGAGCTAGTAAAGGT
AGGTAATCTTTGTTTAAAACATAATGTATTAGTAATCTCAGATGAAATACATTCAGACTTAATATATAAACCTAATAAAC
ATATTCCTTTTGCAGCTATATGTAAAGAATTTGCAGATATAAGTATAACTTGTACAGCACCAAGTAAAACCTTTAATTTA
GCAGGACTTCAAGGTTCAAATATAATAATATCTAATGAAAGATTGATGAATGAATTCAAAATAGCTATGGAAAATATAGG
ATTGTCAAGATTGAATATTTTTGCATCTATAGCATGTGAAGCGGCCTATAAATATGGAGAACAATGGGTAGAAGAATTAA
TAGATTATTTACAAGAGAATAAAGAATTTGCAAAGAAATTTATTGAAGAAAAAGTGCCTATGTTAAAGGTAATAGAGCCA
GAGGGAACATATCTCTTATGGATAGATTGCAGAGAATTAAAAATGTCAAAGGAGGAACTCGAGGAATTTATGCTAAAAGA
AGCAGGAGTAGCTTTTGATGAAGGCTATATATTTGGAGAAGAAGCTATAGGTTTTGAAAGAATGAATATAGCTTGCCCTA
GAGAGGTACTAAAGGAGGCTCTAGAGAGAATTGAAAAAGCTATAAACGATAAAATGTAG

Upstream 100 bases:

>100_bases
GGATATTTATAATAAAATAATTAATTTAATATAAAGTAAGAAATTCTTTATGTTATTAAAAATGTAAATATTTAAAATAA
TTTTATATGGAGTGATAATT

Downstream 100 bases:

>100_bases
GATATATAAGGAAAAACATTTATTAGTAAGTAATGAATTTGGATAAATAAGGAAATGAATATAAGATATTTAGAGGTTAA
ATTAATATAAAGTTAATAAT

Product: class I/II aminotransferase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MKYNFDKVVNRDNTNCSKWNFNKETFGYEDIISMWIADMDFETVPEVKEEIINRAHHGIYGYTATTESYYKEVVNWMKKR
HGWNIKKEWITNTPGIVMAVNTIVRTFTHSGDKVLLQRPIYYPFFKAINNNGCHIVNNPLKFDGKRYEMDFEDLDNKLSD
PRVKIMILCSPHNPTGRVWTKEELVKVGNLCLKHNVLVISDEIHSDLIYKPNKHIPFAAICKEFADISITCTAPSKTFNL
AGLQGSNIIISNERLMNEFKIAMENIGLSRLNIFASIACEAAYKYGEQWVEELIDYLQENKEFAKKFIEEKVPMLKVIEP
EGTYLLWIDCRELKMSKEELEEFMLKEAGVAFDEGYIFGEEAIGFERMNIACPREVLKEALERIEKAINDKM

Sequences:

>Translated_392_residues
MKYNFDKVVNRDNTNCSKWNFNKETFGYEDIISMWIADMDFETVPEVKEEIINRAHHGIYGYTATTESYYKEVVNWMKKR
HGWNIKKEWITNTPGIVMAVNTIVRTFTHSGDKVLLQRPIYYPFFKAINNNGCHIVNNPLKFDGKRYEMDFEDLDNKLSD
PRVKIMILCSPHNPTGRVWTKEELVKVGNLCLKHNVLVISDEIHSDLIYKPNKHIPFAAICKEFADISITCTAPSKTFNL
AGLQGSNIIISNERLMNEFKIAMENIGLSRLNIFASIACEAAYKYGEQWVEELIDYLQENKEFAKKFIEEKVPMLKVIEP
EGTYLLWIDCRELKMSKEELEEFMLKEAGVAFDEGYIFGEEAIGFERMNIACPREVLKEALERIEKAINDKM
>Mature_392_residues
MKYNFDKVVNRDNTNCSKWNFNKETFGYEDIISMWIADMDFETVPEVKEEIINRAHHGIYGYTATTESYYKEVVNWMKKR
HGWNIKKEWITNTPGIVMAVNTIVRTFTHSGDKVLLQRPIYYPFFKAINNNGCHIVNNPLKFDGKRYEMDFEDLDNKLSD
PRVKIMILCSPHNPTGRVWTKEELVKVGNLCLKHNVLVISDEIHSDLIYKPNKHIPFAAICKEFADISITCTAPSKTFNL
AGLQGSNIIISNERLMNEFKIAMENIGLSRLNIFASIACEAAYKYGEQWVEELIDYLQENKEFAKKFIEEKVPMLKVIEP
EGTYLLWIDCRELKMSKEELEEFMLKEAGVAFDEGYIFGEEAIGFERMNIACPREVLKEALERIEKAINDKM

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI56713256, Length=161, Percent_Identity=31.6770186335404, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI56713254, Length=161, Percent_Identity=31.6770186335404, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI95147551, Length=263, Percent_Identity=22.0532319391635, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI169881279, Length=263, Percent_Identity=22.0532319391635, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1787909, Length=388, Percent_Identity=33.2474226804124, Blast_Score=252, Evalue=3e-68,
Organism=Escherichia coli, GI1788627, Length=301, Percent_Identity=23.9202657807309, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786816, Length=353, Percent_Identity=20.3966005665722, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788722, Length=375, Percent_Identity=23.2, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17567663, Length=300, Percent_Identity=24, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71994476, Length=155, Percent_Identity=26.4516129032258, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71994472, Length=155, Percent_Identity=26.4516129032258, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17567369, Length=177, Percent_Identity=23.728813559322, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6322401, Length=292, Percent_Identity=26.027397260274, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI28573069, Length=278, Percent_Identity=25.5395683453237, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24646114, Length=278, Percent_Identity=25.5395683453237, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI28573067, Length=278, Percent_Identity=25.5395683453237, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI28573065, Length=278, Percent_Identity=25.5395683453237, Blast_Score=76, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 45585; Mature: 45585

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYNFDKVVNRDNTNCSKWNFNKETFGYEDIISMWIADMDFETVPEVKEEIINRAHHGIY
CCCCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCEE
GYTATTESYYKEVVNWMKKRHGWNIKKEWITNTPGIVMAVNTIVRTFTHSGDKVLLQRPI
EEECCCHHHHHHHHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEECCC
YYPFFKAINNNGCHIVNNPLKFDGKRYEMDFEDLDNKLSDPRVKIMILCSPHNPTGRVWT
HHHHHHHHCCCCCEEECCCCCCCCCEEECCHHHHHHCCCCCCEEEEEEECCCCCCCCEEC
KEELVKVGNLCLKHNVLVISDEIHSDLIYKPNKHIPFAAICKEFADISITCTAPSKTFNL
HHHHHHHHHHHHHCCEEEEECCCCCCCEECCCCCCCHHHHHHHHCCEEEEEECCCCEEEE
AGLQGSNIIISNERLMNEFKIAMENIGLSRLNIFASIACEAAYKYGEQWVEELIDYLQEN
ECCCCCEEEEECHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KEFAKKFIEEKVPMLKVIEPEGTYLLWIDCRELKMSKEELEEFMLKEAGVAFDEGYIFGE
HHHHHHHHHHCCCEEEEECCCCCEEEEEEHHHHHCCHHHHHHHHHHHCCCEECCCEEECC
EAIGFERMNIACPREVLKEALERIEKAINDKM
HHCCEECCCCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKYNFDKVVNRDNTNCSKWNFNKETFGYEDIISMWIADMDFETVPEVKEEIINRAHHGIY
CCCCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCEE
GYTATTESYYKEVVNWMKKRHGWNIKKEWITNTPGIVMAVNTIVRTFTHSGDKVLLQRPI
EEECCCHHHHHHHHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEECCC
YYPFFKAINNNGCHIVNNPLKFDGKRYEMDFEDLDNKLSDPRVKIMILCSPHNPTGRVWT
HHHHHHHHCCCCCEEECCCCCCCCCEEECCHHHHHHCCCCCCEEEEEEECCCCCCCCEEC
KEELVKVGNLCLKHNVLVISDEIHSDLIYKPNKHIPFAAICKEFADISITCTAPSKTFNL
HHHHHHHHHHHHHCCEEEEECCCCCCCEECCCCCCCHHHHHHHHCCEEEEEECCCCEEEE
AGLQGSNIIISNERLMNEFKIAMENIGLSRLNIFASIACEAAYKYGEQWVEELIDYLQEN
ECCCCCEEEEECHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KEFAKKFIEEKVPMLKVIEPEGTYLLWIDCRELKMSKEELEEFMLKEAGVAFDEGYIFGE
HHHHHHHHHHCCCEEEEECCCCCEEEEEEHHHHHCCHHHHHHHHHHHCCCEECCCEEECC
EAIGFERMNIACPREVLKEALERIEKAINDKM
HHCCEECCCCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]