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The map label for this gene is phoR [H]

Identifier: 226948578

GI number: 226948578

Start: 1528150

End: 1529397

Strand: Direct

Name: phoR [H]

Synonym: CLM_1470

Alternate gene names: 226948578

Gene position: 1528150-1529397 (Clockwise)

Preceding gene: 226948577

Following gene: 226948579

Centisome position: 36.78

GC content: 25.56

Gene sequence:

>1248_bases
ATGAATGAAAATATATCCAAAGAACCTATTATTAGAAAAACCATATTTTTATTCATAGGTTTAACGATTGTTATGTTATT
TTTTCAAGGTTTCTATTTTTACAATATGATAAATAAAATTGAAAATGAAGAGATTAAAAACTACGAAAATATTATAGGTA
CTTTAGTTAAAATTGCACCAGAGAAGCAGTATGAAATAGGACAAGCACTTTTTGAAAATAAGCAAAAGGATACTTTAGAT
TTAGGAAGGAAACTTCTAAAACAATATGGATACAAGAAAAATATGTACTTATTAAATAATAAAATTTCTGGAAAAGTATA
TAAAAATTTTTTATATAAAATTTTTATAGTAAGTATAGTAATCATAATTTCATTTACAATGTTGGCTATATCGGGGTATA
GATCTATTTTAAAAAAATTAGAGGAAATCAGTTATGGTTTAAAAAGAGTAGTGGAGGGGGATTGTTCTATAAGGTTAGAA
GATAATAAGGAAGGGATAATATGTAAAGTAGCTCATGAATTTAATATTATGGTTACAAGAACAAAAATAACATTGGAAAA
TTTAGATAAGGAAAAAGAAAAGACAAAAGCTCTAGTAAATGATATATCACATCAATTAAAAACGCCATTAAGTTCTTTAG
AATTATTTAATACTTTGCTTATAGAAGAGGATTTAGAGGAAGATGAAAGAATAGAATTTTTGGAAAAAAGCAAATATGAA
ATAAATAATCTTCAATGGTTAGTTAAAGCACTTATAAAAGTATCTAGATTAGAAACAGGGATGATTGATATAAAACCGGA
GTCCAATGATATAAAAAACACTCTTTTGGAGGCCATTAATAGCATTTATGGTAAAGCTTTAGAGAAAAATTTAAATATTA
AAGCAGATAATTTATTTTCTTATAAAATTAATCATGATAAAAGATGGACAAAGGAGTCTTTAGTAAATATTTTAGAAAAT
GCCTTAAAGTATACGAAAGAGGCAGGATATATTAATATAAGCATGGAAAAAAGTGAAATGTATATAAAGATTAATATTAG
AGATAGTGGTATTGGTATAGATAAACAGGAGATTAACAAAATTTTCAATAGATTCTATAGGGGAAATGATGAAATAGTGC
AGAGTACAGAAGGATCTGGTATAGGACTTTACCTAGCCAAATGGATTATTGAACAAGAGGGAGGTACTATAAGAGTAAAA
TCTGTATTAGGTGTTGGTACTACTTTTTCAGTTATAATTTTTACATAA

Upstream 100 bases:

>100_bases
GAAGGATAAGAGAAAAAATAGAAGAAGTGCCATCAAAACCTGAATATATACAAACTATCAGAGGGATAGGTTATGTTTGG
AAAGAAGGATGTGTTAGGAA

Downstream 100 bases:

>100_bases
TGAAGTTATTCTTATATTTATATGGGGTTTGTTTGTAAAAATTTTTTATCCATCTGAATATTATTAAAAATATGATTTAA
ACATTACAATTCTGTAAGGA

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MNENISKEPIIRKTIFLFIGLTIVMLFFQGFYFYNMINKIENEEIKNYENIIGTLVKIAPEKQYEIGQALFENKQKDTLD
LGRKLLKQYGYKKNMYLLNNKISGKVYKNFLYKIFIVSIVIIISFTMLAISGYRSILKKLEEISYGLKRVVEGDCSIRLE
DNKEGIICKVAHEFNIMVTRTKITLENLDKEKEKTKALVNDISHQLKTPLSSLELFNTLLIEEDLEEDERIEFLEKSKYE
INNLQWLVKALIKVSRLETGMIDIKPESNDIKNTLLEAINSIYGKALEKNLNIKADNLFSYKINHDKRWTKESLVNILEN
ALKYTKEAGYINISMEKSEMYIKINIRDSGIGIDKQEINKIFNRFYRGNDEIVQSTEGSGIGLYLAKWIIEQEGGTIRVK
SVLGVGTTFSVIIFT

Sequences:

>Translated_415_residues
MNENISKEPIIRKTIFLFIGLTIVMLFFQGFYFYNMINKIENEEIKNYENIIGTLVKIAPEKQYEIGQALFENKQKDTLD
LGRKLLKQYGYKKNMYLLNNKISGKVYKNFLYKIFIVSIVIIISFTMLAISGYRSILKKLEEISYGLKRVVEGDCSIRLE
DNKEGIICKVAHEFNIMVTRTKITLENLDKEKEKTKALVNDISHQLKTPLSSLELFNTLLIEEDLEEDERIEFLEKSKYE
INNLQWLVKALIKVSRLETGMIDIKPESNDIKNTLLEAINSIYGKALEKNLNIKADNLFSYKINHDKRWTKESLVNILEN
ALKYTKEAGYINISMEKSEMYIKINIRDSGIGIDKQEINKIFNRFYRGNDEIVQSTEGSGIGLYLAKWIIEQEGGTIRVK
SVLGVGTTFSVIIFT
>Mature_415_residues
MNENISKEPIIRKTIFLFIGLTIVMLFFQGFYFYNMINKIENEEIKNYENIIGTLVKIAPEKQYEIGQALFENKQKDTLD
LGRKLLKQYGYKKNMYLLNNKISGKVYKNFLYKIFIVSIVIIISFTMLAISGYRSILKKLEEISYGLKRVVEGDCSIRLE
DNKEGIICKVAHEFNIMVTRTKITLENLDKEKEKTKALVNDISHQLKTPLSSLELFNTLLIEEDLEEDERIEFLEKSKYE
INNLQWLVKALIKVSRLETGMIDIKPESNDIKNTLLEAINSIYGKALEKNLNIKADNLFSYKINHDKRWTKESLVNILEN
ALKYTKEAGYINISMEKSEMYIKINIRDSGIGIDKQEINKIFNRFYRGNDEIVQSTEGSGIGLYLAKWIIEQEGGTIRVK
SVLGVGTTFSVIIFT

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788713, Length=298, Percent_Identity=28.5234899328859, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI1789149, Length=225, Percent_Identity=29.7777777777778, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788393, Length=264, Percent_Identity=25, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1786600, Length=249, Percent_Identity=24.0963855421687, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1790436, Length=238, Percent_Identity=27.3109243697479, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI48994928, Length=248, Percent_Identity=24.1935483870968, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1786912, Length=229, Percent_Identity=25.764192139738, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1788549, Length=292, Percent_Identity=26.027397260274, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790346, Length=245, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI145693157, Length=220, Percent_Identity=24.5454545454545, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1786783, Length=301, Percent_Identity=20.265780730897, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1788279, Length=286, Percent_Identity=24.8251748251748, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI1787894, Length=308, Percent_Identity=23.0519480519481, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1787374, Length=311, Percent_Identity=24.7588424437299, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48070; Mature: 48070

Theoretical pI: Translated: 8.94; Mature: 8.94

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNENISKEPIIRKTIFLFIGLTIVMLFFQGFYFYNMINKIENEEIKNYENIIGTLVKIAP
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCC
EKQYEIGQALFENKQKDTLDLGRKLLKQYGYKKNMYLLNNKISGKVYKNFLYKIFIVSIV
CHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHH
IIISFTMLAISGYRSILKKLEEISYGLKRVVEGDCSIRLEDNKEGIICKVAHEFNIMVTR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEECCEEEEEE
TKITLENLDKEKEKTKALVNDISHQLKTPLSSLELFNTLLIEEDLEEDERIEFLEKSKYE
EEEEHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCH
INNLQWLVKALIKVSRLETGMIDIKPESNDIKNTLLEAINSIYGKALEKNLNIKADNLFS
HHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCEEECCEEE
YKINHDKRWTKESLVNILENALKYTKEAGYINISMEKSEMYIKINIRDSGIGIDKQEINK
EEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCEEEEEEEEECCCCCCCHHHHHH
IFNRFYRGNDEIVQSTEGSGIGLYLAKWIIEQEGGTIRVKSVLGVGTTFSVIIFT
HHHHHHCCCHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEEEEC
>Mature Secondary Structure
MNENISKEPIIRKTIFLFIGLTIVMLFFQGFYFYNMINKIENEEIKNYENIIGTLVKIAP
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCC
EKQYEIGQALFENKQKDTLDLGRKLLKQYGYKKNMYLLNNKISGKVYKNFLYKIFIVSIV
CHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHH
IIISFTMLAISGYRSILKKLEEISYGLKRVVEGDCSIRLEDNKEGIICKVAHEFNIMVTR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEECCEEEEEE
TKITLENLDKEKEKTKALVNDISHQLKTPLSSLELFNTLLIEEDLEEDERIEFLEKSKYE
EEEEHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCH
INNLQWLVKALIKVSRLETGMIDIKPESNDIKNTLLEAINSIYGKALEKNLNIKADNLFS
HHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCEEECCEEE
YKINHDKRWTKESLVNILENALKYTKEAGYINISMEKSEMYIKINIRDSGIGIDKQEINK
EEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCEEEEEEEEECCCCCCCHHHHHH
IFNRFYRGNDEIVQSTEGSGIGLYLAKWIIEQEGGTIRVKSVLGVGTTFSVIIFT
HHHHHHCCCHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]