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The map label for this gene is adiC [H]

Identifier: 226947780

GI number: 226947780

Start: 682964

End: 684337

Strand: Direct

Name: adiC [H]

Synonym: CLM_0629

Alternate gene names: 226947780

Gene position: 682964-684337 (Clockwise)

Preceding gene: 226947779

Following gene: 226947781

Centisome position: 16.44

GC content: 32.02

Gene sequence:

>1374_bases
ATGGAGAATGAAGGGCATAGTCACAAGAAAATAGGTTTATTTGGAGCTACCTGTGTAGTTGCAGGAAATATGATTGGGTC
TGGCGTATTTATGCTACCAGCTAGTTTGGCAGCAGTATCTAGTCCAGGAACTACTTTAATAGCTTGGTTAGTTACAGGTA
TAGGAGCTATATTTATGGCTTTATCCTGCGCTAGATTAGGAAGTAGAATTCCCAAGACAGGGGGACCTTATGAATTTGGT
AAATTAGCTTTTGGAGATTTTATAGGATTTTTAAATGCTTGGCTTTACTGGAGCGCTACATGGATATCCAATGCAGCAAT
TATAATAGCTATAGGAAGCTATGCATCTTATTTGATACCAGCTTTAAATAATGGATTTAATGCACTCTTATTTAACAGCG
CTATATTATGGATATTTACTTTTTTAAATATTAAGGGCGCTAAGGAAGCCGCAAGTTTTGAAACAGTTATTACAGTATTT
AAATTTTTAGTATTTATATTTTTCATAATATTTGCAGCTATTCACTTTAATGTTGCAAATATTACTCCAATTATGCCAAA
AGAAAAAGGAATGAATACTTTACCTTTAGCAGCAGCTACCACATTATGGGCCTTTACAGGTTTTGAATCTTCCACAGTAG
GTGCTGGAACAATTAAAGATCCAGAAAAAAATATAAGTAGAAGTACTATATTAGGTTTGGTTATAACGATTCTTTTTTAT
GTTGCAATAAGCTTTTTCGCTATGGGGGCTATACCCAAAGATGTTTTAGCTAATAGTCCTTCACCAATGACAGATATATT
GGCTCAATTCTTTGGTAGTGGAGTAGTAAAAGTATTTAATTTAGCTATAGTTATAACTATATTGGGAACTATAGCAGGAT
GGATTATGATTGCAGGCCAGATGAGCTATGCAGTAGCTAAGGATGGGTTATTTCCAGCAGTATTTGCAAAATTACATCAT
AAGTATAAAACTCCATATAAAGGATTAATAATAAATGCTATATTAACTAATATATTATTAATATTAAATTCATCAAAGGG
AATGGTATCTGCCTATAATTTTATGATACTTTTAGCCACCTTATCATATTTACCTGTTTATGCTACGACTTCTGCATCAG
ATATAGTATTGCTATTTAAATGTAGGGGACAATTAACTGTAGGTAAATTTATAAAGATAGCTATAATACCATTAATAGGG
TTCACCTATGCTTGTTGGGCAATATACGGTTCAGGAGCTGAAACAGTACTATATGGATTTATGTTAATGTTAGCAGGAGT
CCCATTCTATATATATATGAAGTTAAAAAATAAAAAAGATATTTCTAAAGCTACTATAGATATAGATAATATTGTTGAAT
GTTTTAATGAGTAA

Upstream 100 bases:

>100_bases
TTAATTAAATTAAAAGGATTGACAAAATTATAACTCAATATAAAATATAAAGTAACAAAGCTTCTTATTATGAAGTTGGA
GGTTGGGGGGAACTTGAAGA

Downstream 100 bases:

>100_bases
GGTGTAAATGGTTAATAATATTAATAAAAATTTTAAAGACTATTTTATATTAAAGTACATTTATTAAAATAGATGTTAAA
TCAAATATTTTATATATTTA

Product: amino acid permease family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MENEGHSHKKIGLFGATCVVAGNMIGSGVFMLPASLAAVSSPGTTLIAWLVTGIGAIFMALSCARLGSRIPKTGGPYEFG
KLAFGDFIGFLNAWLYWSATWISNAAIIIAIGSYASYLIPALNNGFNALLFNSAILWIFTFLNIKGAKEAASFETVITVF
KFLVFIFFIIFAAIHFNVANITPIMPKEKGMNTLPLAAATTLWAFTGFESSTVGAGTIKDPEKNISRSTILGLVITILFY
VAISFFAMGAIPKDVLANSPSPMTDILAQFFGSGVVKVFNLAIVITILGTIAGWIMIAGQMSYAVAKDGLFPAVFAKLHH
KYKTPYKGLIINAILTNILLILNSSKGMVSAYNFMILLATLSYLPVYATTSASDIVLLFKCRGQLTVGKFIKIAIIPLIG
FTYACWAIYGSGAETVLYGFMLMLAGVPFYIYMKLKNKKDISKATIDIDNIVECFNE

Sequences:

>Translated_457_residues
MENEGHSHKKIGLFGATCVVAGNMIGSGVFMLPASLAAVSSPGTTLIAWLVTGIGAIFMALSCARLGSRIPKTGGPYEFG
KLAFGDFIGFLNAWLYWSATWISNAAIIIAIGSYASYLIPALNNGFNALLFNSAILWIFTFLNIKGAKEAASFETVITVF
KFLVFIFFIIFAAIHFNVANITPIMPKEKGMNTLPLAAATTLWAFTGFESSTVGAGTIKDPEKNISRSTILGLVITILFY
VAISFFAMGAIPKDVLANSPSPMTDILAQFFGSGVVKVFNLAIVITILGTIAGWIMIAGQMSYAVAKDGLFPAVFAKLHH
KYKTPYKGLIINAILTNILLILNSSKGMVSAYNFMILLATLSYLPVYATTSASDIVLLFKCRGQLTVGKFIKIAIIPLIG
FTYACWAIYGSGAETVLYGFMLMLAGVPFYIYMKLKNKKDISKATIDIDNIVECFNE
>Mature_457_residues
MENEGHSHKKIGLFGATCVVAGNMIGSGVFMLPASLAAVSSPGTTLIAWLVTGIGAIFMALSCARLGSRIPKTGGPYEFG
KLAFGDFIGFLNAWLYWSATWISNAAIIIAIGSYASYLIPALNNGFNALLFNSAILWIFTFLNIKGAKEAASFETVITVF
KFLVFIFFIIFAAIHFNVANITPIMPKEKGMNTLPLAAATTLWAFTGFESSTVGAGTIKDPEKNISRSTILGLVITILFY
VAISFFAMGAIPKDVLANSPSPMTDILAQFFGSGVVKVFNLAIVITILGTIAGWIMIAGQMSYAVAKDGLFPAVFAKLHH
KYKTPYKGLIINAILTNILLILNSSKGMVSAYNFMILLATLSYLPVYATTSASDIVLLFKCRGQLTVGKFIKIAIIPLIG
FTYACWAIYGSGAETVLYGFMLMLAGVPFYIYMKLKNKKDISKATIDIDNIVECFNE

Specific function: Major component of the acid-resistance (AR) system allowing enteric pathogens to survive the acidic environment in the stomach. Exchanges extracellular arginine for its intracellular decarboxylation product agmatine (Agm) thereby expelling intracellular p

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI33286428, Length=458, Percent_Identity=27.0742358078603, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI186910308, Length=363, Percent_Identity=25.6198347107438, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI186910306, Length=363, Percent_Identity=25.6198347107438, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI186910304, Length=363, Percent_Identity=25.6198347107438, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI115648063, Length=362, Percent_Identity=25.6906077348066, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI115648022, Length=362, Percent_Identity=25.6906077348066, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI187423910, Length=472, Percent_Identity=23.728813559322, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI7657591, Length=472, Percent_Identity=23.728813559322, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI71979932, Length=368, Percent_Identity=23.6413043478261, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI258614003, Length=393, Percent_Identity=22.64631043257, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI258614005, Length=393, Percent_Identity=22.64631043257, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI7657683, Length=423, Percent_Identity=23.1678486997636, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI258645169, Length=391, Percent_Identity=21.4833759590793, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI71999149, Length=361, Percent_Identity=24.0997229916898, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI9790235, Length=367, Percent_Identity=23.433242506812, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI2367353, Length=460, Percent_Identity=32.1739130434783, Blast_Score=211, Evalue=8e-56,
Organism=Escherichia coli, GI1787890, Length=459, Percent_Identity=27.0152505446623, Blast_Score=154, Evalue=2e-38,
Organism=Escherichia coli, GI1790575, Length=354, Percent_Identity=32.4858757062147, Blast_Score=148, Evalue=7e-37,
Organism=Escherichia coli, GI1786908, Length=442, Percent_Identity=26.4705882352941, Blast_Score=141, Evalue=7e-35,
Organism=Escherichia coli, GI87082250, Length=337, Percent_Identity=28.1899109792285, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1788480, Length=320, Percent_Identity=24.375, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1786302, Length=356, Percent_Identity=21.0674157303371, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1790653, Length=401, Percent_Identity=21.4463840399002, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI87081708, Length=448, Percent_Identity=21.6517857142857, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1786694, Length=250, Percent_Identity=24, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1790584, Length=288, Percent_Identity=27.0833333333333, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI1786789, Length=352, Percent_Identity=20.4545454545455, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI71982612, Length=357, Percent_Identity=26.6106442577031, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71982608, Length=357, Percent_Identity=26.6106442577031, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17540018, Length=467, Percent_Identity=23.5546038543897, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71982623, Length=260, Percent_Identity=29.2307692307692, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI32566699, Length=449, Percent_Identity=23.6080178173719, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71995382, Length=350, Percent_Identity=21.7142857142857, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71995388, Length=351, Percent_Identity=22.5071225071225, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71990446, Length=499, Percent_Identity=21.0420841683367, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17568033, Length=485, Percent_Identity=23.0927835051546, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17533459, Length=386, Percent_Identity=23.0569948186528, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71993915, Length=354, Percent_Identity=21.4689265536723, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17532491, Length=456, Percent_Identity=22.1491228070175, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17531343, Length=409, Percent_Identity=21.5158924205379, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI45550968, Length=455, Percent_Identity=24.3956043956044, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI19921172, Length=455, Percent_Identity=24.3956043956044, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24641995, Length=368, Percent_Identity=24.7282608695652, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24641993, Length=368, Percent_Identity=24.7282608695652, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI221512776, Length=365, Percent_Identity=24.6575342465753, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24666159, Length=366, Percent_Identity=24.5901639344262, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21357367, Length=466, Percent_Identity=25.7510729613734, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI221331183, Length=465, Percent_Identity=24.0860215053763, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17647653, Length=465, Percent_Identity=24.0860215053763, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24664379, Length=465, Percent_Identity=24.0860215053763, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24651635, Length=453, Percent_Identity=21.4128035320088, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24651633, Length=453, Percent_Identity=21.4128035320088, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24667468, Length=388, Percent_Identity=23.1958762886598, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24668806, Length=398, Percent_Identity=23.3668341708543, Blast_Score=79, Evalue=9e-15,
Organism=Drosophila melanogaster, GI21356285, Length=398, Percent_Identity=23.3668341708543, Blast_Score=79, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24668802, Length=398, Percent_Identity=23.3668341708543, Blast_Score=79, Evalue=9e-15,
Organism=Drosophila melanogaster, GI281366235, Length=393, Percent_Identity=22.3918575063613, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI116007820, Length=393, Percent_Identity=22.3918575063613, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 49318; Mature: 49318

Theoretical pI: Translated: 9.60; Mature: 9.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENEGHSHKKIGLFGATCVVAGNMIGSGVFMLPASLAAVSSPGTTLIAWLVTGIGAIFMA
CCCCCCCCCEEEEEHHHHHHHCCHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
LSCARLGSRIPKTGGPYEFGKLAFGDFIGFLNAWLYWSATWISNAAIIIAIGSYASYLIP
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHH
ALNNGFNALLFNSAILWIFTFLNIKGAKEAASFETVITVFKFLVFIFFIIFAAIHFNVAN
HHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHC
ITPIMPKEKGMNTLPLAAATTLWAFTGFESSTVGAGTIKDPEKNISRSTILGLVITILFY
CCCCCCCCCCCCCCCHHHHHHHHHEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
VAISFFAMGAIPKDVLANSPSPMTDILAQFFGSGVVKVFNLAIVITILGTIAGWIMIAGQ
HHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
MSYAVAKDGLFPAVFAKLHHKYKTPYKGLIINAILTNILLILNSSKGMVSAYNFMILLAT
HHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LSYLPVYATTSASDIVLLFKCRGQLTVGKFIKIAIIPLIGFTYACWAIYGSGAETVLYGF
HHHCCEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
MLMLAGVPFYIYMKLKNKKDISKATIDIDNIVECFNE
HHHHCCCCEEEEEEECCCCCCHHHHCCHHHHHHHHCC
>Mature Secondary Structure
MENEGHSHKKIGLFGATCVVAGNMIGSGVFMLPASLAAVSSPGTTLIAWLVTGIGAIFMA
CCCCCCCCCEEEEEHHHHHHHCCHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
LSCARLGSRIPKTGGPYEFGKLAFGDFIGFLNAWLYWSATWISNAAIIIAIGSYASYLIP
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHH
ALNNGFNALLFNSAILWIFTFLNIKGAKEAASFETVITVFKFLVFIFFIIFAAIHFNVAN
HHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHC
ITPIMPKEKGMNTLPLAAATTLWAFTGFESSTVGAGTIKDPEKNISRSTILGLVITILFY
CCCCCCCCCCCCCCCHHHHHHHHHEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
VAISFFAMGAIPKDVLANSPSPMTDILAQFFGSGVVKVFNLAIVITILGTIAGWIMIAGQ
HHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
MSYAVAKDGLFPAVFAKLHHKYKTPYKGLIINAILTNILLILNSSKGMVSAYNFMILLAT
HHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LSYLPVYATTSASDIVLLFKCRGQLTVGKFIKIAIIPLIGFTYACWAIYGSGAETVLYGF
HHHCCEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
MLMLAGVPFYIYMKLKNKKDISKATIDIDNIVECFNE
HHHHCCCCEEEEEEECCCCCCHHHHCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]