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The map label for this gene is serS [H]

Identifier: 226947753

GI number: 226947753

Start: 650877

End: 652154

Strand: Direct

Name: serS [H]

Synonym: CLM_0602

Alternate gene names: 226947753

Gene position: 650877-652154 (Clockwise)

Preceding gene: 226947752

Following gene: 226947754

Centisome position: 15.66

GC content: 34.35

Gene sequence:

>1278_bases
ATGTTAGATTTAAAATTTGTAAGAGAAAATCCAGAAGTCGTTAAGGAAAACATAAGGAAAAAATTTCAGCATAATAAGCT
GGAATTAGTAGATAAAGTAATCGCTCTAGATGCTGAACTCAGAGATATAAAGCCAGAAGCAGATAATTTAAGAGCTAAGA
GAAATAAGATTTCAAAACAAATCGGTGGATTAATGGCTCAGGGAAAAAAAGGAGAAGCAGAAGAACTAAAGAAACAGGTT
ACAGCAGCATCAGATCATTTAGCTGAGTTAGAAAAAGGAGAAAGCGAACTGGAAGAAAAAATAAAAAAAATTATGATTAC
TATTCCAAATATTATTGATCCAAGTGTTCCTATTGGTAAAGATGATAGCGAGAATGTGGAAATTCAACGATATGGGGAAC
CAGTTGTGCCAGATTTTGAGGTTCCTTATCATACTGAAATTATGGAGAAGTTTAATGGAATTGATTTGGATAGTGCTAGA
AAAGTTGCCGGTAATGGTTTTTATTATTTGATGGGAGATATTGCTAGACTACATTCTGCAGTGATTTCTTATGCCAGAGA
CTTTATGATTAACCGTGGTTTTACATATTGTATTCCACCTTTTATGATTCGTAGTGAAGTTGTGACTGGTGTTATGAGCT
TTGCAGAAATGGATGCTATGATGTATAAAATAGAAGGTGAAGATTTATATTTGATTGGAACCAGTGAACATTCTATGATT
GGTAAATTTATTGATACAATATCACCAGAAACTTCTTTGCCACAAACATTAACTAGTTACTCACCTTGCTTTAGAAAGGA
AAAAGGAGCTCATGGTATTGAAGAAAGAGGAGTATATAGAATTCATCAATTTGAAAAGCAAGAAATGATTGTTGTATGTA
AACCGGAAGATAGTGTAATGTGGTATGATAAGCTATGGCAAAATACAGTAGATTTTTTTCGCTCTTTGGATATTCCCGTA
AGAACTTTGGAATGCTGTTCTGGTGACTTGGCAGATTTAAAAGTAAAATCAGTTGATGTAGAAGCTTGGTCCCCTAGACA
GAAAAAATACTTCGAGGTAGGAAGTTGTTCTAATTTAGGTGATGCACAAGCACGCCGTCTTAAAATTCGTGTAGCTGGTG
AGAATGGTAAATACTTTGCGCATACATTAAACAATACCGTAGTTGCACCTCCAAGAATGCTAATTGCTTTTTTAGAGAAC
AACTTGAATGCAGATGGCTCTGTCAATATTCCAGTTCCATTACAGCCATATATGGGTGGAATGACTATCATTAAATAA

Upstream 100 bases:

>100_bases
CGCGGATACTTCCGTCCCATATTTATATATGAGATGGGAGTTTTTTATTTTATGATTTCAAAATTATAATATTATTTATA
TTTATGTAGGAGGAAAAACT

Downstream 100 bases:

>100_bases
TTAATATTTGTTTTTTAGAATATATGTTCCCAAATTAAACTTAATGAACGCTTCAGGAATAATATGGAATATGAGAAAGT
TATAACTTAACAGCTTTTAA

Product: serine--tRNA ligase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MLDLKFVRENPEVVKENIRKKFQHNKLELVDKVIALDAELRDIKPEADNLRAKRNKISKQIGGLMAQGKKGEAEELKKQV
TAASDHLAELEKGESELEEKIKKIMITIPNIIDPSVPIGKDDSENVEIQRYGEPVVPDFEVPYHTEIMEKFNGIDLDSAR
KVAGNGFYYLMGDIARLHSAVISYARDFMINRGFTYCIPPFMIRSEVVTGVMSFAEMDAMMYKIEGEDLYLIGTSEHSMI
GKFIDTISPETSLPQTLTSYSPCFRKEKGAHGIEERGVYRIHQFEKQEMIVVCKPEDSVMWYDKLWQNTVDFFRSLDIPV
RTLECCSGDLADLKVKSVDVEAWSPRQKKYFEVGSCSNLGDAQARRLKIRVAGENGKYFAHTLNNTVVAPPRMLIAFLEN
NLNADGSVNIPVPLQPYMGGMTIIK

Sequences:

>Translated_425_residues
MLDLKFVRENPEVVKENIRKKFQHNKLELVDKVIALDAELRDIKPEADNLRAKRNKISKQIGGLMAQGKKGEAEELKKQV
TAASDHLAELEKGESELEEKIKKIMITIPNIIDPSVPIGKDDSENVEIQRYGEPVVPDFEVPYHTEIMEKFNGIDLDSAR
KVAGNGFYYLMGDIARLHSAVISYARDFMINRGFTYCIPPFMIRSEVVTGVMSFAEMDAMMYKIEGEDLYLIGTSEHSMI
GKFIDTISPETSLPQTLTSYSPCFRKEKGAHGIEERGVYRIHQFEKQEMIVVCKPEDSVMWYDKLWQNTVDFFRSLDIPV
RTLECCSGDLADLKVKSVDVEAWSPRQKKYFEVGSCSNLGDAQARRLKIRVAGENGKYFAHTLNNTVVAPPRMLIAFLEN
NLNADGSVNIPVPLQPYMGGMTIIK
>Mature_425_residues
MLDLKFVRENPEVVKENIRKKFQHNKLELVDKVIALDAELRDIKPEADNLRAKRNKISKQIGGLMAQGKKGEAEELKKQV
TAASDHLAELEKGESELEEKIKKIMITIPNIIDPSVPIGKDDSENVEIQRYGEPVVPDFEVPYHTEIMEKFNGIDLDSAR
KVAGNGFYYLMGDIARLHSAVISYARDFMINRGFTYCIPPFMIRSEVVTGVMSFAEMDAMMYKIEGEDLYLIGTSEHSMI
GKFIDTISPETSLPQTLTSYSPCFRKEKGAHGIEERGVYRIHQFEKQEMIVVCKPEDSVMWYDKLWQNTVDFFRSLDIPV
RTLECCSGDLADLKVKSVDVEAWSPRQKKYFEVGSCSNLGDAQARRLKIRVAGENGKYFAHTLNNTVVAPPRMLIAFLEN
NLNADGSVNIPVPLQPYMGGMTIIK

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=465, Percent_Identity=31.1827956989247, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI8923421, Length=400, Percent_Identity=32, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI225579074, Length=404, Percent_Identity=31.9306930693069, Blast_Score=187, Evalue=2e-47,
Organism=Escherichia coli, GI1787120, Length=435, Percent_Identity=32.8735632183908, Blast_Score=252, Evalue=4e-68,
Organism=Caenorhabditis elegans, GI17539260, Length=468, Percent_Identity=31.6239316239316, Blast_Score=212, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI17542084, Length=316, Percent_Identity=31.9620253164557, Blast_Score=135, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6320226, Length=445, Percent_Identity=33.2584269662921, Blast_Score=218, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6321799, Length=392, Percent_Identity=32.3979591836735, Blast_Score=192, Evalue=6e-50,
Organism=Drosophila melanogaster, GI24581334, Length=467, Percent_Identity=31.9057815845824, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI17737985, Length=344, Percent_Identity=31.9767441860465, Blast_Score=161, Evalue=6e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 48143; Mature: 48143

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDLKFVRENPEVVKENIRKKFQHNKLELVDKVIALDAELRDIKPEADNLRAKRNKISKQ
CCCCEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHH
IGGLMAQGKKGEAEELKKQVTAASDHLAELEKGESELEEKIKKIMITIPNIIDPSVPIGK
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCC
DDSENVEIQRYGEPVVPDFEVPYHTEIMEKFNGIDLDSARKVAGNGFYYLMGDIARLHSA
CCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHCCCEEEEHHHHHHHHHH
VISYARDFMINRGFTYCIPPFMIRSEVVTGVMSFAEMDAMMYKIEGEDLYLIGTSEHSMI
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCEEEEEECCCHHHH
GKFIDTISPETSLPQTLTSYSPCFRKEKGAHGIEERGVYRIHQFEKQEMIVVCKPEDSVM
HHHHHHCCCCCCCCHHHHHCCHHHHHCCCCCCCHHCCCHHHHHCCCCCEEEEECCCCCEE
WYDKLWQNTVDFFRSLDIPVRTLECCSGDLADLKVKSVDVEAWSPRQKKYFEVGSCSNLG
HHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHEEEEEEECCCCCCCHHHEEECCCCCCCC
DAQARRLKIRVAGENGKYFAHTLNNTVVAPPRMLIAFLENNLNADGSVNIPVPLQPYMGG
CCCEEEEEEEEECCCCCEEEEECCCCEECCHHHHHHHHHCCCCCCCEEECCCCCCCCCCC
MTIIK
EEEEC
>Mature Secondary Structure
MLDLKFVRENPEVVKENIRKKFQHNKLELVDKVIALDAELRDIKPEADNLRAKRNKISKQ
CCCCEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHH
IGGLMAQGKKGEAEELKKQVTAASDHLAELEKGESELEEKIKKIMITIPNIIDPSVPIGK
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCC
DDSENVEIQRYGEPVVPDFEVPYHTEIMEKFNGIDLDSARKVAGNGFYYLMGDIARLHSA
CCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHCCCEEEEHHHHHHHHHH
VISYARDFMINRGFTYCIPPFMIRSEVVTGVMSFAEMDAMMYKIEGEDLYLIGTSEHSMI
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCEEEEEECCCHHHH
GKFIDTISPETSLPQTLTSYSPCFRKEKGAHGIEERGVYRIHQFEKQEMIVVCKPEDSVM
HHHHHHCCCCCCCCHHHHHCCHHHHHCCCCCCCHHCCCHHHHHCCCCCEEEEECCCCCEE
WYDKLWQNTVDFFRSLDIPVRTLECCSGDLADLKVKSVDVEAWSPRQKKYFEVGSCSNLG
HHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHEEEEEEECCCCCCCHHHEEECCCCCCCC
DAQARRLKIRVAGENGKYFAHTLNNTVVAPPRMLIAFLENNLNADGSVNIPVPLQPYMGG
CCCEEEEEEEEECCCCCEEEEECCCCEECCHHHHHHHHHCCCCCCCEEECCCCCCCCCCC
MTIIK
EEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA