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The map label for this gene is malX [H]

Identifier: 226947512

GI number: 226947512

Start: 331369

End: 332952

Strand: Direct

Name: malX [H]

Synonym: CLM_0346

Alternate gene names: 226947512

Gene position: 331369-332952 (Clockwise)

Preceding gene: 226947511

Following gene: 226947513

Centisome position: 7.97

GC content: 30.49

Gene sequence:

>1584_bases
ATGATGAAAGAAAAGATATTAAATCAATTACAAAACTTTTCTAAAGGAATGTTTGTTCCTGTATTGATATTACCAATAGC
CGGTATAATAATTGCAATAGGGAACATTTTAACAAATGCAAAACTAGCAGAATACCTTCCATTTTTAAAGAATGGAATGG
TATTTGGATTAGGAAAAATGTTATCTGGTTCATTAGTTTCAATTTTAACTAATTTAGGAATTATATTCTGTGTTGGTCTT
GCAGTAGGACTTTCTAAGAAAAAGAAAGCAGAAGCAGGATTTACATCACTTTTAGTATTTTTAGTATTTATAAATGCAAT
GAACATTTTTTTAGAATTAAATAATAGATTAGCACCACAAGATGCCTTAAGAGGATCTGGCCAAACTATGGTTTTAGGTG
TTCAAGTTCTTGATATGGGAGTTTTCTTAGGAATTATTTTAGGTATTGTCGTTGCTTATATACATAATAGGTTTTGTGAA
AAAGAATTTGATGGAGCTTTTCAAATTTATGGTGGTTCAAGATTAGTATTTATAATATTAATACCTATTACTGTTTTTTT
AGCAATAATATTGAGTTATGTTTGGCCTTCAGTACAATATTTAATTTCAAGTCTTGGTAACTTTATAACAGGAGCGGGAA
ATTTTGGTATATTTACTTATGGTACTTTAGAGAGATTACTTATTCCTACTGGATTGCATCACTTAGTTTATACTCCATTT
CTATATAGTCCTTTAGGTGGAGTGGCTGAAATAGGAGGAAAAGTATTTGAAGGAGCAAGAAATATATACTTTGCAGAAAT
GGCTGATCCTAATATAGCAAAATTATCAGCATCAGTAATTTGGGATGCTAGAGGATTGTCAAAAATGTTTGGTTTAATTG
GTGCATGTTTGGCTATGTACCATACAGCATTGCCAGAGAATAAGTCTAAGATAAAGGCAATTTTAATTCCAGCTGCGGTT
ACATCAATATTAGCAGGAGTAACAGAGCCAATAGAATTTTCATTTATGTTCGTAGCACCAATATTATTTGTTATACATGC
CGTTTTAAGTGGATTGGGAATGGTGGTATTAAATATTCTTGGAGTTACAGCTATAGGTCCAAATGGGTTAATAGACTTCT
TATTATACAACATACCTCTTGGAGTTGCCAAAACAGGATGGCCAATGTTTATTTTGATCGGTTTAGGACAATTCGTTGTA
TATTATGTTATATTCAGATTTTTAATAGTTAAGTTTAAACTTAAGACTCCAGGAAGAGAAGAAGATGGAAATACAAAGCT
ATATAGTAAAAAAGATTATAAAGAAAAGTCTAAAGCAAATACAAAGTCAGGTGATTCAAGTATTGCGCCAATTGTAGTAG
AAGGTTTAGGTGGCAAGGATAATATATTAAAAGTTGATAATTGTTACACTAGATTAAGATTAGTGGTAAAAGATTCTTCA
TTAGTTAATGAACAATTATTAAAAAATGAAACAGCAGCAAATGGAGTAATAATTAAAGGAGAAAACGTACAGGTTGTCTA
TGGTTTAAAGGTTACAAGTGTAAGAAAGAACGTAGACGAATATCTTGGAATAGAATCAAATTAG

Upstream 100 bases:

>100_bases
AACACGTTTTTTACATAAGAAAATCTATATACATATAGATATCTAATTATTATAATGTGAAATGTAAATGGTTTCTCAAA
AATAAATAATGGGGGTTACA

Downstream 100 bases:

>100_bases
AATAAACAGAGTTCTTGGCTTCAGAGGGAGTTCTTACTCCCACTAAAGCTTAGAAATCGTTATCCAGAGATGTAGCCGCT
CTTTACCCCTATTTTGAAGA

Product: PTS system glucose/maltose-specfic transporter subunit IIBC

Products: NA

Alternate protein names: Maltose and glucose permease IIC component; PTS system maltose- and glucose-specific EIIC component; Maltose- and glucose-specific phosphotransferase enzyme IIB component; PTS system maltose- and glucose-specific EIIB component [H]

Number of amino acids: Translated: 527; Mature: 527

Protein sequence:

>527_residues
MMKEKILNQLQNFSKGMFVPVLILPIAGIIIAIGNILTNAKLAEYLPFLKNGMVFGLGKMLSGSLVSILTNLGIIFCVGL
AVGLSKKKKAEAGFTSLLVFLVFINAMNIFLELNNRLAPQDALRGSGQTMVLGVQVLDMGVFLGIILGIVVAYIHNRFCE
KEFDGAFQIYGGSRLVFIILIPITVFLAIILSYVWPSVQYLISSLGNFITGAGNFGIFTYGTLERLLIPTGLHHLVYTPF
LYSPLGGVAEIGGKVFEGARNIYFAEMADPNIAKLSASVIWDARGLSKMFGLIGACLAMYHTALPENKSKIKAILIPAAV
TSILAGVTEPIEFSFMFVAPILFVIHAVLSGLGMVVLNILGVTAIGPNGLIDFLLYNIPLGVAKTGWPMFILIGLGQFVV
YYVIFRFLIVKFKLKTPGREEDGNTKLYSKKDYKEKSKANTKSGDSSIAPIVVEGLGGKDNILKVDNCYTRLRLVVKDSS
LVNEQLLKNETAANGVIIKGENVQVVYGLKVTSVRKNVDEYLGIESN

Sequences:

>Translated_527_residues
MMKEKILNQLQNFSKGMFVPVLILPIAGIIIAIGNILTNAKLAEYLPFLKNGMVFGLGKMLSGSLVSILTNLGIIFCVGL
AVGLSKKKKAEAGFTSLLVFLVFINAMNIFLELNNRLAPQDALRGSGQTMVLGVQVLDMGVFLGIILGIVVAYIHNRFCE
KEFDGAFQIYGGSRLVFIILIPITVFLAIILSYVWPSVQYLISSLGNFITGAGNFGIFTYGTLERLLIPTGLHHLVYTPF
LYSPLGGVAEIGGKVFEGARNIYFAEMADPNIAKLSASVIWDARGLSKMFGLIGACLAMYHTALPENKSKIKAILIPAAV
TSILAGVTEPIEFSFMFVAPILFVIHAVLSGLGMVVLNILGVTAIGPNGLIDFLLYNIPLGVAKTGWPMFILIGLGQFVV
YYVIFRFLIVKFKLKTPGREEDGNTKLYSKKDYKEKSKANTKSGDSSIAPIVVEGLGGKDNILKVDNCYTRLRLVVKDSS
LVNEQLLKNETAANGVIIKGENVQVVYGLKVTSVRKNVDEYLGIESN
>Mature_527_residues
MMKEKILNQLQNFSKGMFVPVLILPIAGIIIAIGNILTNAKLAEYLPFLKNGMVFGLGKMLSGSLVSILTNLGIIFCVGL
AVGLSKKKKAEAGFTSLLVFLVFINAMNIFLELNNRLAPQDALRGSGQTMVLGVQVLDMGVFLGIILGIVVAYIHNRFCE
KEFDGAFQIYGGSRLVFIILIPITVFLAIILSYVWPSVQYLISSLGNFITGAGNFGIFTYGTLERLLIPTGLHHLVYTPF
LYSPLGGVAEIGGKVFEGARNIYFAEMADPNIAKLSASVIWDARGLSKMFGLIGACLAMYHTALPENKSKIKAILIPAAV
TSILAGVTEPIEFSFMFVAPILFVIHAVLSGLGMVVLNILGVTAIGPNGLIDFLLYNIPLGVAKTGWPMFILIGLGQFVV
YYVIFRFLIVKFKLKTPGREEDGNTKLYSKKDYKEKSKANTKSGDSSIAPIVVEGLGGKDNILKVDNCYTRLRLVVKDSS
LVNEQLLKNETAANGVIIKGENVQVVYGLKVTSVRKNVDEYLGIESN

Specific function: MalX encodes a phosphotransferase system enzyme II that can recognize glucose and maltose as substrates even though these sugars may not represent the natural substrates of the system [H]

COG id: COG1263

COG function: function code G; Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1787908, Length=523, Percent_Identity=37.8585086042065, Blast_Score=327, Evalue=2e-90,
Organism=Escherichia coli, GI1787343, Length=528, Percent_Identity=35.4166666666667, Blast_Score=278, Evalue=6e-76,
Organism=Escherichia coli, GI1786894, Length=517, Percent_Identity=32.495164410058, Blast_Score=217, Evalue=1e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018113
- InterPro:   IPR004719
- InterPro:   IPR001996
- InterPro:   IPR003352
- InterPro:   IPR013013
- InterPro:   IPR011535
- InterPro:   IPR011301 [H]

Pfam domain/function: PF00367 PTS_EIIB; PF02378 PTS_EIIC [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 57257; Mature: 57257

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS01035 PTS_EIIB_TYPE_1_CYS ; PS51098 PTS_EIIB_TYPE_1 ; PS51103 PTS_EIIC_TYPE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKEKILNQLQNFSKGMFVPVLILPIAGIIIAIGNILTNAKLAEYLPFLKNGMVFGLGKM
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEHHHH
LSGSLVSILTNLGIIFCVGLAVGLSKKKKAEAGFTSLLVFLVFINAMNIFLELNNRLAPQ
HCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
DALRGSGQTMVLGVQVLDMGVFLGIILGIVVAYIHNRFCEKEFDGAFQIYGGSRLVFIIL
HHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEHHHH
IPITVFLAIILSYVWPSVQYLISSLGNFITGAGNFGIFTYGTLERLLIPTGLHHLVYTPF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHCCHHHHHHHHH
LYSPLGGVAEIGGKVFEGARNIYFAEMADPNIAKLSASVIWDARGLSKMFGLIGACLAMY
HHCCCCCHHHHCHHHHHCCCCEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
HTALPENKSKIKAILIPAAVTSILAGVTEPIEFSFMFVAPILFVIHAVLSGLGMVVLNIL
HHHCCCCCCHHEEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVTAIGPNGLIDFLLYNIPLGVAKTGWPMFILIGLGQFVVYYVIFRFLIVKFKLKTPGRE
HHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCC
EDGNTKLYSKKDYKEKSKANTKSGDSSIAPIVVEGLGGKDNILKVDNCYTRLRLVVKDSS
CCCCCCCCCCHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCEEEHHHHHHHHEEEECCHH
LVNEQLLKNETAANGVIIKGENVQVVYGLKVTSVRKNVDEYLGIESN
HHHHHHHHCCCCCCCEEEECCCEEEEEEEEHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MMKEKILNQLQNFSKGMFVPVLILPIAGIIIAIGNILTNAKLAEYLPFLKNGMVFGLGKM
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEHHHH
LSGSLVSILTNLGIIFCVGLAVGLSKKKKAEAGFTSLLVFLVFINAMNIFLELNNRLAPQ
HCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
DALRGSGQTMVLGVQVLDMGVFLGIILGIVVAYIHNRFCEKEFDGAFQIYGGSRLVFIIL
HHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEHHHH
IPITVFLAIILSYVWPSVQYLISSLGNFITGAGNFGIFTYGTLERLLIPTGLHHLVYTPF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHCCHHHHHHHHH
LYSPLGGVAEIGGKVFEGARNIYFAEMADPNIAKLSASVIWDARGLSKMFGLIGACLAMY
HHCCCCCHHHHCHHHHHCCCCEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
HTALPENKSKIKAILIPAAVTSILAGVTEPIEFSFMFVAPILFVIHAVLSGLGMVVLNIL
HHHCCCCCCHHEEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVTAIGPNGLIDFLLYNIPLGVAKTGWPMFILIGLGQFVVYYVIFRFLIVKFKLKTPGRE
HHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCC
EDGNTKLYSKKDYKEKSKANTKSGDSSIAPIVVEGLGGKDNILKVDNCYTRLRLVVKDSS
CCCCCCCCCCHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCEEEHHHHHHHHEEEECCHH
LVNEQLLKNETAANGVIIKGENVQVVYGLKVTSVRKNVDEYLGIESN
HHHHHHHHCCCCCCCEEEECCCEEEEEEEEHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1856179; 9097039; 9278503; 2670898 [H]