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The map label for this gene is dnaA [H]

Identifier: 226947223

GI number: 226947223

Start: 157

End: 1494

Strand: Direct

Name: dnaA [H]

Synonym: CLM_0001

Alternate gene names: 226947223

Gene position: 157-1494 (Clockwise)

Preceding gene: NA

Following gene: 226947224

Centisome position: 0.0

GC content: 27.88

Gene sequence:

>1338_bases
ATGAGTACCCACCTTACAGAAACCTGGGAAAAAGCAATAAATATTATAAAAGGTGAACTTACGGAAGTAAGTTTTAATAC
ATGGATTAAAAGTATTAACCCTATTTCTCTTGAAAATAATTCATTGAAACTAGCTGTACCAAATGATTTTACAAAAGGAA
TTCTTGAAAGTAGGTACAAAGATCTTATAGTTAATGCTCTAAAATTACTTACCTCAAAAAAATATAATATAGATTTTATT
GTAACTACTGAAGAAAAAATAGAAAAAAATCATAATAACGAAAAATCTAATATAGTTGTAAATGATGAAATGTCTACTAT
GTTAAATCCTAAATATACTTTTGATTCGTTTGTAATAGGAAATAGTAATAGATTCGCTCATGCAGCATCTTTAGCAGTAG
CAGAATCACCTGCTAAAGCATATAATCCTTTATTTATATATGGTGGAGTTGGTCTTGGTAAAACTCACTTAATGCATGCT
ATCGGTCATTATATATTGCATAACAATCCTAAATCTCAAGTAGTTTATGTATCTTCTGAGAAATTTACAAATGAATTAAT
TAATTCTATAAAAGATGATAAAAATGTAGAATTTAGAAATAAATATAGAAATATAGATATTTTATTAGTTGATGATATTC
AATTTATTGCTGGAAAAGAAAGAACTCAAGAGGAATTTTTCCATACTTTTAATGCACTGTATGAAGCTAACAAACAAATA
ATTATATCAAGTGACCGTCCCCCAAAAGAAATACCTACTTTAGAAGATAGATTAAGATCTAGATTTGAATGGGGACTTAT
AGCTGATATTCAAGCACCTGATTTTGAAACCAGGATGGCCATTTTAAAGAAAAAAGCTGATGTAGAAAAATTAAATATTC
CTAATGAAGTAATGGTATATATAGCTACAAAAATTAAATCAAATATTCGTGAATTAGAAGGAGCTTTAATAAGAATAGTA
GCCTTTTCATCACTTACTAATAAAGAAATAAGTGTAGATTTAGCTTCTGAAGCACTGAAAGATATAATCTCAAGTAAACA
AACAAGGCAAGTCACTATAGATATTATTCAAGAAGTTGTAGCAAACTATTATAATCTAAAAATAGAAGATCTAAAATCAG
CTAGAAGAACAAGAAATATTGCTTTCCCGCGTCAAATAGCCATGTACCTTTCTAGAAAACTAACGGACATGTCATTACCT
AAAATTGGTGAAGAATTTGGCGGACGTGATCATACTACAGTTATTCATGCCTATGAAAAGATATCTAATAACTTAAAAAA
AGACGAAAGTCTTCAAAATGCAATAAAGGAATTAAATAAACGAATTAATCAAAAATAA

Upstream 100 bases:

>100_bases
CAATTGTCAAGTTAATATAAATAATGTATATAAAGTTGTTTATATTTTGTTTACTATATGTGAACATTCTAAGTTTCTAT
CAAGACTGGAGGATTAAATT

Downstream 100 bases:

>100_bases
AAATAATATACAAATGTTTATAATAATATCTTATTTATTTGTTGATAATGTACTAAATATAAATTAAACATATTTCCTGT
GGATAAGCACTTAATTTTAA

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 445; Mature: 444

Protein sequence:

>445_residues
MSTHLTETWEKAINIIKGELTEVSFNTWIKSINPISLENNSLKLAVPNDFTKGILESRYKDLIVNALKLLTSKKYNIDFI
VTTEEKIEKNHNNEKSNIVVNDEMSTMLNPKYTFDSFVIGNSNRFAHAASLAVAESPAKAYNPLFIYGGVGLGKTHLMHA
IGHYILHNNPKSQVVYVSSEKFTNELINSIKDDKNVEFRNKYRNIDILLVDDIQFIAGKERTQEEFFHTFNALYEANKQI
IISSDRPPKEIPTLEDRLRSRFEWGLIADIQAPDFETRMAILKKKADVEKLNIPNEVMVYIATKIKSNIRELEGALIRIV
AFSSLTNKEISVDLASEALKDIISSKQTRQVTIDIIQEVVANYYNLKIEDLKSARRTRNIAFPRQIAMYLSRKLTDMSLP
KIGEEFGGRDHTTVIHAYEKISNNLKKDESLQNAIKELNKRINQK

Sequences:

>Translated_445_residues
MSTHLTETWEKAINIIKGELTEVSFNTWIKSINPISLENNSLKLAVPNDFTKGILESRYKDLIVNALKLLTSKKYNIDFI
VTTEEKIEKNHNNEKSNIVVNDEMSTMLNPKYTFDSFVIGNSNRFAHAASLAVAESPAKAYNPLFIYGGVGLGKTHLMHA
IGHYILHNNPKSQVVYVSSEKFTNELINSIKDDKNVEFRNKYRNIDILLVDDIQFIAGKERTQEEFFHTFNALYEANKQI
IISSDRPPKEIPTLEDRLRSRFEWGLIADIQAPDFETRMAILKKKADVEKLNIPNEVMVYIATKIKSNIRELEGALIRIV
AFSSLTNKEISVDLASEALKDIISSKQTRQVTIDIIQEVVANYYNLKIEDLKSARRTRNIAFPRQIAMYLSRKLTDMSLP
KIGEEFGGRDHTTVIHAYEKISNNLKKDESLQNAIKELNKRINQK
>Mature_444_residues
STHLTETWEKAINIIKGELTEVSFNTWIKSINPISLENNSLKLAVPNDFTKGILESRYKDLIVNALKLLTSKKYNIDFIV
TTEEKIEKNHNNEKSNIVVNDEMSTMLNPKYTFDSFVIGNSNRFAHAASLAVAESPAKAYNPLFIYGGVGLGKTHLMHAI
GHYILHNNPKSQVVYVSSEKFTNELINSIKDDKNVEFRNKYRNIDILLVDDIQFIAGKERTQEEFFHTFNALYEANKQII
ISSDRPPKEIPTLEDRLRSRFEWGLIADIQAPDFETRMAILKKKADVEKLNIPNEVMVYIATKIKSNIRELEGALIRIVA
FSSLTNKEISVDLASEALKDIISSKQTRQVTIDIIQEVVANYYNLKIEDLKSARRTRNIAFPRQIAMYLSRKLTDMSLPK
IGEEFGGRDHTTVIHAYEKISNNLKKDESLQNAIKELNKRINQK

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family [H]

Homologues:

Organism=Escherichia coli, GI2367267, Length=465, Percent_Identity=43.010752688172, Blast_Score=387, Evalue=1e-109,
Organism=Escherichia coli, GI226510964, Length=232, Percent_Identity=23.7068965517241, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921 [H]

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C [H]

EC number: NA

Molecular weight: Translated: 50926; Mature: 50795

Theoretical pI: Translated: 9.30; Mature: 9.30

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTHLTETWEKAINIIKGELTEVSFNTWIKSINPISLENNSLKLAVPNDFTKGILESRYK
CCCCHHHHHHHHHHHHHHHHHHEEHHHHHHCCCCEEECCCEEEEECCCHHHHHHHHHHHH
DLIVNALKLLTSKKYNIDFIVTTEEKIEKNHNNEKSNIVVNDEMSTMLNPKYTFDSFVIG
HHHHHHHHHHHCCCCCEEEEEECHHHHHHCCCCCCCEEEECCCHHHHCCCCCCCCCEEEC
NSNRFAHAASLAVAESPAKAYNPLFIYGGVGLGKTHLMHAIGHYILHNNPKSQVVYVSSE
CCCCCHHHHHHHHHCCCHHHCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCEEEEECH
KFTNELINSIKDDKNVEFRNKYRNIDILLVDDIQFIAGKERTQEEFFHTFNALYEANKQI
HHHHHHHHHHCCCCCCHHHHHHCCEEEEEECCHHHHHCCCHHHHHHHHHHHHHHHCCCEE
IISSDRPPKEIPTLEDRLRSRFEWGLIADIQAPDFETRMAILKKKADVEKLNIPNEVMVY
EEECCCCCCCCCCHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHCCHHHCCCCCHHHHH
IATKIKSNIRELEGALIRIVAFSSLTNKEISVDLASEALKDIISSKQTRQVTIDIIQEVV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
ANYYNLKIEDLKSARRTRNIAFPRQIAMYLSRKLTDMSLPKIGEEFGGRDHTTVIHAYEK
HHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHHH
ISNNLKKDESLQNAIKELNKRINQK
HHHHCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
STHLTETWEKAINIIKGELTEVSFNTWIKSINPISLENNSLKLAVPNDFTKGILESRYK
CCCHHHHHHHHHHHHHHHHHHEEHHHHHHCCCCEEECCCEEEEECCCHHHHHHHHHHHH
DLIVNALKLLTSKKYNIDFIVTTEEKIEKNHNNEKSNIVVNDEMSTMLNPKYTFDSFVIG
HHHHHHHHHHHCCCCCEEEEEECHHHHHHCCCCCCCEEEECCCHHHHCCCCCCCCCEEEC
NSNRFAHAASLAVAESPAKAYNPLFIYGGVGLGKTHLMHAIGHYILHNNPKSQVVYVSSE
CCCCCHHHHHHHHHCCCHHHCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCEEEEECH
KFTNELINSIKDDKNVEFRNKYRNIDILLVDDIQFIAGKERTQEEFFHTFNALYEANKQI
HHHHHHHHHHCCCCCCHHHHHHCCEEEEEECCHHHHHCCCHHHHHHHHHHHHHHHCCCEE
IISSDRPPKEIPTLEDRLRSRFEWGLIADIQAPDFETRMAILKKKADVEKLNIPNEVMVY
EEECCCCCCCCCCHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHCCHHHCCCCCHHHHH
IATKIKSNIRELEGALIRIVAFSSLTNKEISVDLASEALKDIISSKQTRQVTIDIIQEVV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
ANYYNLKIEDLKSARRTRNIAFPRQIAMYLSRKLTDMSLPKIGEEFGGRDHTTVIHAYEK
HHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHHH
ISNNLKKDESLQNAIKELNKRINQK
HHHHCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA