| Definition | Burkholderia pseudomallei 1106a chromosome I, complete genome. |
|---|---|
| Accession | NC_009076 |
| Length | 3,988,455 |
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The map label for this gene is lgrD [H]
Identifier: 226830774
GI number: 226830774
Start: 1903726
End: 1908951
Strand: Direct
Name: lgrD [H]
Synonym: BURPS1106A_1943
Alternate gene names: 226830774
Gene position: 1903726-1908951 (Clockwise)
Preceding gene: 126452413
Following gene: 226830777
Centisome position: 47.73
GC content: 75.7
Gene sequence:
>5226_bases ATGAGGAGCACGCATGAAGGAGCCCGCATGACCCCCCCCGATCTGCTGTCGCTCGCCGCGCGTTTCGCGCGGCTGCCCGA CACGCAGCGCAAGCAGTTCCTCGCGAAGCTCGGCGACGCGGGAATCGATTTCCGGATGCTGCCGATTCCGCCGCGCGAGG ACCGCGCGGCGAGCGTGCCGGCATCGTTCGCGCAGACGCGCCTCTGGCTGCACGCGCGCCTGCTCGGCGAATCGGCCGCG TACCACATCACCGAGCGGCTGCGCCTCGACGGCGGGCTCGACGCGAACGCGCTGCGGCTGTCGTGCGACGCGCTGATCGC GCGCCACGAGGCGCTGCGCACGACGTTCGCCGAGGGCGCGGCCGGCGTGCTGCAGACGGTGCACGCGCCGATGCGCTGCC CGTGGCGCTTCACCGATCTCGCGGACGCGAGCGCCGGGTCGCGCGAGCAGCGCGCGGCCGCCATCGCCGAGCGCGACGAG GCCGAGCCGTTCGATCTCGCGCACGGCCCGCTCGTGCGCGCGCACCTGATCCGGCTCGATGCGGCCACGCACTGGTTCGT GCTGACGACGCACCACATCGTGTCGGACGGTTGGTCGGCCGACGTGATGCTCGCGGAGCTGTCGTCGTTCTACCGGTCGT ACGCGACGGGCGACGCGGTGTCGCTCGCGCCGCTGCCGGTGCAGTACGCGGACTACGCGCTCTGGCAGCGCCGCTGGCTC GACGCGGGCGAGGGCGAGCGCCAGCTCGCGTACTGGCGCGCGACGCTCGACGCGAGCCGTGACGCGCTGCTGCTGCCGGG CGCCGCGACGCGGCCCGCGCAGCGCGGCGCGAGCGGCGCGCGCCATGCGTTCGACATATCCGCCGAACTCGCGCGGCGCA TGCGTGCGCTGGCGCAGGCGCGCCGGGCGACGCCGTTCGCCGTGCTGCTCGCCGCGCTCGCGACGCTGCTCGCGCGCGCG AGCGGCGAGACCGGGATCCGGATCGGCGTGCCGTCGGCGAATCGCGAGCGCGGCGAGACCGTCGGGCTGATCGGCTTTTT CGTCAATACGCTGACGCTCGCGGCGAGCACGCCCGCGACGCTCGCGTTCGACGCGCTCGTCGACGCGACGCAGCGCGGCC TGATCGACGCGCAGTCGCACCAGGACGTGCCGTTCGATCAGGTGGTCGACGCGCTCGGCGTCGCGCGCAGCGCGAGCCAC CATCCGCTTTTTCAGGTGATGGCCGCCTACGGCGCGCGGCGCGTGCTGCCGTCGTTCGCCGAGGTGTGCGCGACCGAGCT GCCCTCGGGCATGCCGTATGCGAAATTCGATCTCGCGCTCAGCTTCGACGAGCGCGACGACGGCGGGCTCGACGCGCGCT TCGTCTATGCGACCGATCTGTTCGACGCCGACGCGATCGAGCGCTTCGCCGCGCGCTACGTCGAGCTGCTCGCGCACGCG CTCGACACGCCCGGCGCGGCGATCGGCGATCTGCAATGGCTGCCCGAAGCGGAGCGCCGCCAGCTCGCCGCGTGGAACGG GCAGACGCACGACTTCACCGGGCGCGCGTCGCCGGCGCGCGCCGGCGCCGGCGCGGCGGTGCCCCGCGAACGCGCCGGCC AAGCCGGCGGCGAGCCGTTCGTCCCGGTCCATGACCGGATTGCGCAGCACGCGCGCCGCCGCCCCGACGCGCGCGGCGTC GCCGACATCGAGCGCGCGCTCACGCGCGGCGAGGTCGACGCGCGCGCGACGCGGCTCGCGAAGCGCCTCGTCGCGGCGGG CGTGGGCGCGGAGATGCGCGTGGGCGTCGCGCTGTCGCGCTCGGTCGATCTGCTCGTCGGGCTGATCGCCGCGCTCAAGT CGGGCGGCGCGTTCGTGCCGCTCGATCCGAGCCACCCGCGCGAGCGCCTCGCGCAGATGCTGGAGGACGCGCAGATCGCG CACGTGATCACCGAGCGCGGCAGCGTCGACGCGCTGCCGCTCGCGGGCGCGACGCGCGCGTGGCTTGTCGACGACGCGAT CGCCGACGCGGAGATCGACGGCGTCGCGCTGCCCGCCGTGTCGCCGCATCAGGCCGCGTACGTGATCTACACGTCGGGCT CGACCGGCAAGCCGAAGGGCGTCGTCGTCGATCACGGCGCGTTCGCGCGCCATTGCGAGGCGATCGCCGCGCGCTACGGC GCGACCGAGCGCGACGTGTTCATGCTGTTCCAGTCGGTCAATTTCGACGGCGCGCACGAAGGCTGGTTCTCGCAGTACAT GTCGGGCGCGGCCGTCGCGGTGACGGCCGACACGCTGTGGCCGCCCGCGCGCACCTGCGCGCTCGCCGCGCGCGAAGGCG TGACGATGACCTACGTGCCGCCCGGCTGCGCGACGCAGCTCGCCGAATGGGCGCTCGAGCACGGTGCGCCGCCGTCGCTG CGCTCGATCACGGTGGGCGGCGAGGCGACGTCGCGCGAGGCGTTCGCGCTGATGCGCCGCGCGTTTCCGAACGCGCGCGT CGTCAACGGCTATGGGCCGACCGAAACGGTGATCACGCCGATGCTGTGGATGTTCGCGCCGGGCGACGATCCCGCCAAGC TCGCGGACGCCGCGTATCTGCCGATCGGCACGCTCGTCGGCGCGCGCACCGCGCACGTGCTGGACGCGCGCCTGAATCCG CTGCCCGTCGGCGTGATCGGCGAGTTGTATCTGGGCGGCGAGGGCGTCGGGCTCGCACGCGGCTACCTGGGCCGCGCGGC GCTCACCGCCGAGCGCTTCGTGCCCGATCCGTACGGCGCGCCGGGCGCGCGGCTGTACCGCACGGGCGACCTCGTGCGCC GCCGCGCCGACGGCGTGTTCGACTTCATCGGCCGCATCGATCACCAGGTGAAGCTGCGCGGCTTGCGCATCGAGCTCGGC GAGATCGAGGCGCAACTCGCCGCGCACGACGACGTGCGCGAGGCGGTGGCGGTCGTGTTCGGCGAGGGCGCGCACGCGCG GCTCGCCGCGTTCGTCGAGCTCACGGGCGACGCGCGCGCGCGCGCGCGGCGCGCGGATGCGGCCGAGCTCGACGCGCATT TGCGCCGCACGCTGCCCGATTACATGGTGCCCGCGCACATCGTCGTGCTCGACGCGCTGCCGCGCAACGCGAACAGCAAG GTCGACCGCGCGGCGCTGCCCGAGCCCGCGCACGTCGCGCGCGCGTACGAGGCGCCCGACGGCGAGCTCGAGACGGCGCT CGCCGAGATCTGGCGCGAGGTGCTCGGCGTCGAGCGCGTCGGGCGCGCCGATCATTTCTTCGAGCTGGGCGGCCATTCGC TCGCGGCGGTGCGGGTGGCCACGCGCGTCGCCGAGCGGCTCGCGCGTGACGTGCCGGTGCGCGCGCTGTTCGAGGCGCCG ATTCTCGCGCCGTACGCGCAGCGCGTCGCCGCCGCCGCGCCAGCGCACGCGCCGCAACGCGCGGGCAGCGCATCGTACGC GCCCGATGCCGACGGCGTGCTGCCGCTGTCGGCCGCGCAGCGCGGCCTGTGGTTCCTGTGGCGCGCGCAGCCGGACAGCG CCGCGTACAACATTCCCGTCGCGCTGCGGCTGCGCGGCGCGCTCGACGTCGATGCGCTCGCCGATGCGCTCGCGCATGCG GCTGTCCGCCACCCGGCGCTGCGCACGCGGATCGTCGCGCGGGCGGACGGCGCGCCGGGGCAGCGGATTGCGCCGGCGCG GCGCATCGAGCTGCCGGTCGTCGACCTGCGCGCCGACGCGCGCATCGCGGACGACGACGCGCGGCTCGCCGCCGCGATCG CGCTGACTGACGCCGACGCGCTCGCGCCGTTCGATCTCGCCGCCGACGCGCCGCTCTGGCGCGCGCGCGTGATCCGGCTC GGCGCGCACGACCACGTGCTGTCGCTCGTCGTCCATCACATCGTGTCGGACGGGCAATCGATCGATCTGTGGCTCGACGC GGTGCGCGCGGCGTACGTCGCGCGGCGCGCGGACGAACCCGCGACGGCGGCGGCGCGCGCAGCGGCGGACAGGCGAACCG ACAGGCACGCGGGCTCGCGGGCGGCGTCGCTTGCGCCGGCACGCGCGAAGGAAGCGCCCGCGCAATCGGCGACGATTGCG CCGATACAAGCGCCCGCCGACGCGCCTCAGCCCGCGCCGGACGCACCGGTGCTGCCGGCCGCCGCGCCGCACGCGCGGCT CGCGTTCTGGCGCGAGGCACTCGCCGGCGCGCCGTCGCACGCGCTGCCGCCGCCGCGCGCGGGCCGCGCGTGCGCGCCGC GCTGGGACGCGGGCCGTCTCGCGTTCGAATTCGACGCCGCGCTCGTGCGCCGCGCGCGCGCGATGGCGCTCGACGCGCAT GCGACGCTGCCGATGCTGCTGCACGCGGCGCTGAACGCGGCGTTCTACCGCGCGACGGGCGCGACCGATCAGCCGGTCGG CGTGCTCGCGTCGACCCGCGAACTGACGGGCGACGCGGCCGAGCGCGCGCTCGGGCTCTTCATCAACGCGGTCGTCGTGC GCACGCGGCTGTCGGGCGCCGATACGCCGGCCACGCTCGTCGCCGCGGTGCGCGACGCGGCGCTCGCCGCGTATGCGCAC GCGGACGCGCCGTTCTGCGATGTCGTCGCCGCGCTGCGCGCGCCGCGCACGGTCAACGGCAATCCGCTGTTCCAGGTGAT GTTCAACTACCTGCGGCCGGCGGGCGCCGCCGCGCGCGACTGGGCGGGGCTCGCGGTCGACGCGTTCAACGATGTCCGGC ACCGCGTCGTGTTCGAGCTCGAGCTCGACATCGTCGAGCATCCGGACGGCCGCGTGACGGGCGCGTTCTCGTATGCGGCC GAGCGCGTCGACGGCGCGTTCGTCGCCGCGCTCGCCGCCGACTATCTCGACGTCGTGCGCGGCTTCGTCGACGCGCCCGC GCGCGCGCTCGGCGCGTGCGCCGCGCGTTTCCCGCTCGCCTCGCACGAGGCGTACGCGCCGCCGCCGCCCGCCGCGGCGG ACGCGCGCGCCGCCGCGCGCGTAGCGCGCGCGCTCGCCGAGCTGTGGCGCGCGTCGCTCGGCCATGCCGCGCCCGCGCCC GAGGCCAACCTGTTCGAAGCGGGCGCGACGTCGTTCGACGTCGTGCGCTTCGTCGACGCGGCGCGCTCGGCCGGCTTCGC GCTCGCGATCGCCGACGTGTTCGCCGCGCCGAGCCTCGCGGCGCTCGGCGAGCGCGCCGCGCACACCGCCGGCCAGCCCG CCACGCAGGCGCGCGATGCCGATTGA
Upstream 100 bases:
>100_bases CCGCGCGCGCGACGCCGGCCGCGAGCGCGACGCCGCGGGCGCGATCGACGCGCTGCTCGGCGAGCTCGAAGCCCAGTAAG GCACTCAATCAGGAACACGC
Downstream 100 bases:
>100_bases GCGCCGCCCGCCGCGGCCGCGCCTGGCGCGGGCCGAGCACGATGGCCGCATCGGGCGCATCGATGAACGGCGCGGTCCGC ATCACGTTTTCGTCCGGCCG
Product: putative siderophore non-ribosomal peptide synthetase MbaI
Products: pyrophosphate; AMP; enterobactin; pyrophosphate; L-Seryl-AMP [C]
Alternate protein names: ATP-dependent tryptophan adenylase; TrpA; Tryptophan activase; ATP-dependent D-leucine adenylase; D-LeuA; D-Leucine activase; Leucine racemase [ATP-hydrolyzing]; ATP-dependent tryptophan adenylase; TrpA; Tryptophan activase; ATP-dependent glycine adenylase; GlyA; Glycine activase; Linear gramicidin--PCP reductase [H]
Number of amino acids: Translated: 1741; Mature: 1741
Protein sequence:
>1741_residues MRSTHEGARMTPPDLLSLAARFARLPDTQRKQFLAKLGDAGIDFRMLPIPPREDRAASVPASFAQTRLWLHARLLGESAA YHITERLRLDGGLDANALRLSCDALIARHEALRTTFAEGAAGVLQTVHAPMRCPWRFTDLADASAGSREQRAAAIAERDE AEPFDLAHGPLVRAHLIRLDAATHWFVLTTHHIVSDGWSADVMLAELSSFYRSYATGDAVSLAPLPVQYADYALWQRRWL DAGEGERQLAYWRATLDASRDALLLPGAATRPAQRGASGARHAFDISAELARRMRALAQARRATPFAVLLAALATLLARA SGETGIRIGVPSANRERGETVGLIGFFVNTLTLAASTPATLAFDALVDATQRGLIDAQSHQDVPFDQVVDALGVARSASH HPLFQVMAAYGARRVLPSFAEVCATELPSGMPYAKFDLALSFDERDDGGLDARFVYATDLFDADAIERFAARYVELLAHA LDTPGAAIGDLQWLPEAERRQLAAWNGQTHDFTGRASPARAGAGAAVPRERAGQAGGEPFVPVHDRIAQHARRRPDARGV ADIERALTRGEVDARATRLAKRLVAAGVGAEMRVGVALSRSVDLLVGLIAALKSGGAFVPLDPSHPRERLAQMLEDAQIA HVITERGSVDALPLAGATRAWLVDDAIADAEIDGVALPAVSPHQAAYVIYTSGSTGKPKGVVVDHGAFARHCEAIAARYG ATERDVFMLFQSVNFDGAHEGWFSQYMSGAAVAVTADTLWPPARTCALAAREGVTMTYVPPGCATQLAEWALEHGAPPSL RSITVGGEATSREAFALMRRAFPNARVVNGYGPTETVITPMLWMFAPGDDPAKLADAAYLPIGTLVGARTAHVLDARLNP LPVGVIGELYLGGEGVGLARGYLGRAALTAERFVPDPYGAPGARLYRTGDLVRRRADGVFDFIGRIDHQVKLRGLRIELG EIEAQLAAHDDVREAVAVVFGEGAHARLAAFVELTGDARARARRADAAELDAHLRRTLPDYMVPAHIVVLDALPRNANSK VDRAALPEPAHVARAYEAPDGELETALAEIWREVLGVERVGRADHFFELGGHSLAAVRVATRVAERLARDVPVRALFEAP ILAPYAQRVAAAAPAHAPQRAGSASYAPDADGVLPLSAAQRGLWFLWRAQPDSAAYNIPVALRLRGALDVDALADALAHA AVRHPALRTRIVARADGAPGQRIAPARRIELPVVDLRADARIADDDARLAAAIALTDADALAPFDLAADAPLWRARVIRL GAHDHVLSLVVHHIVSDGQSIDLWLDAVRAAYVARRADEPATAAARAAADRRTDRHAGSRAASLAPARAKEAPAQSATIA PIQAPADAPQPAPDAPVLPAAAPHARLAFWREALAGAPSHALPPPRAGRACAPRWDAGRLAFEFDAALVRRARAMALDAH ATLPMLLHAALNAAFYRATGATDQPVGVLASTRELTGDAAERALGLFINAVVVRTRLSGADTPATLVAAVRDAALAAYAH ADAPFCDVVAALRAPRTVNGNPLFQVMFNYLRPAGAAARDWAGLAVDAFNDVRHRVVFELELDIVEHPDGRVTGAFSYAA ERVDGAFVAALAADYLDVVRGFVDAPARALGACAARFPLASHEAYAPPPPAAADARAAARVARALAELWRASLGHAAPAP EANLFEAGATSFDVVRFVDAARSAGFALAIADVFAAPSLAALGERAAHTAGQPATQARDAD
Sequences:
>Translated_1741_residues MRSTHEGARMTPPDLLSLAARFARLPDTQRKQFLAKLGDAGIDFRMLPIPPREDRAASVPASFAQTRLWLHARLLGESAA YHITERLRLDGGLDANALRLSCDALIARHEALRTTFAEGAAGVLQTVHAPMRCPWRFTDLADASAGSREQRAAAIAERDE AEPFDLAHGPLVRAHLIRLDAATHWFVLTTHHIVSDGWSADVMLAELSSFYRSYATGDAVSLAPLPVQYADYALWQRRWL DAGEGERQLAYWRATLDASRDALLLPGAATRPAQRGASGARHAFDISAELARRMRALAQARRATPFAVLLAALATLLARA SGETGIRIGVPSANRERGETVGLIGFFVNTLTLAASTPATLAFDALVDATQRGLIDAQSHQDVPFDQVVDALGVARSASH HPLFQVMAAYGARRVLPSFAEVCATELPSGMPYAKFDLALSFDERDDGGLDARFVYATDLFDADAIERFAARYVELLAHA LDTPGAAIGDLQWLPEAERRQLAAWNGQTHDFTGRASPARAGAGAAVPRERAGQAGGEPFVPVHDRIAQHARRRPDARGV ADIERALTRGEVDARATRLAKRLVAAGVGAEMRVGVALSRSVDLLVGLIAALKSGGAFVPLDPSHPRERLAQMLEDAQIA HVITERGSVDALPLAGATRAWLVDDAIADAEIDGVALPAVSPHQAAYVIYTSGSTGKPKGVVVDHGAFARHCEAIAARYG ATERDVFMLFQSVNFDGAHEGWFSQYMSGAAVAVTADTLWPPARTCALAAREGVTMTYVPPGCATQLAEWALEHGAPPSL RSITVGGEATSREAFALMRRAFPNARVVNGYGPTETVITPMLWMFAPGDDPAKLADAAYLPIGTLVGARTAHVLDARLNP LPVGVIGELYLGGEGVGLARGYLGRAALTAERFVPDPYGAPGARLYRTGDLVRRRADGVFDFIGRIDHQVKLRGLRIELG EIEAQLAAHDDVREAVAVVFGEGAHARLAAFVELTGDARARARRADAAELDAHLRRTLPDYMVPAHIVVLDALPRNANSK VDRAALPEPAHVARAYEAPDGELETALAEIWREVLGVERVGRADHFFELGGHSLAAVRVATRVAERLARDVPVRALFEAP ILAPYAQRVAAAAPAHAPQRAGSASYAPDADGVLPLSAAQRGLWFLWRAQPDSAAYNIPVALRLRGALDVDALADALAHA AVRHPALRTRIVARADGAPGQRIAPARRIELPVVDLRADARIADDDARLAAAIALTDADALAPFDLAADAPLWRARVIRL GAHDHVLSLVVHHIVSDGQSIDLWLDAVRAAYVARRADEPATAAARAAADRRTDRHAGSRAASLAPARAKEAPAQSATIA PIQAPADAPQPAPDAPVLPAAAPHARLAFWREALAGAPSHALPPPRAGRACAPRWDAGRLAFEFDAALVRRARAMALDAH ATLPMLLHAALNAAFYRATGATDQPVGVLASTRELTGDAAERALGLFINAVVVRTRLSGADTPATLVAAVRDAALAAYAH ADAPFCDVVAALRAPRTVNGNPLFQVMFNYLRPAGAAARDWAGLAVDAFNDVRHRVVFELELDIVEHPDGRVTGAFSYAA ERVDGAFVAALAADYLDVVRGFVDAPARALGACAARFPLASHEAYAPPPPAAADARAAARVARALAELWRASLGHAAPAP EANLFEAGATSFDVVRFVDAARSAGFALAIADVFAAPSLAALGERAAHTAGQPATQARDAD >Mature_1741_residues MRSTHEGARMTPPDLLSLAARFARLPDTQRKQFLAKLGDAGIDFRMLPIPPREDRAASVPASFAQTRLWLHARLLGESAA YHITERLRLDGGLDANALRLSCDALIARHEALRTTFAEGAAGVLQTVHAPMRCPWRFTDLADASAGSREQRAAAIAERDE AEPFDLAHGPLVRAHLIRLDAATHWFVLTTHHIVSDGWSADVMLAELSSFYRSYATGDAVSLAPLPVQYADYALWQRRWL DAGEGERQLAYWRATLDASRDALLLPGAATRPAQRGASGARHAFDISAELARRMRALAQARRATPFAVLLAALATLLARA SGETGIRIGVPSANRERGETVGLIGFFVNTLTLAASTPATLAFDALVDATQRGLIDAQSHQDVPFDQVVDALGVARSASH HPLFQVMAAYGARRVLPSFAEVCATELPSGMPYAKFDLALSFDERDDGGLDARFVYATDLFDADAIERFAARYVELLAHA LDTPGAAIGDLQWLPEAERRQLAAWNGQTHDFTGRASPARAGAGAAVPRERAGQAGGEPFVPVHDRIAQHARRRPDARGV ADIERALTRGEVDARATRLAKRLVAAGVGAEMRVGVALSRSVDLLVGLIAALKSGGAFVPLDPSHPRERLAQMLEDAQIA HVITERGSVDALPLAGATRAWLVDDAIADAEIDGVALPAVSPHQAAYVIYTSGSTGKPKGVVVDHGAFARHCEAIAARYG ATERDVFMLFQSVNFDGAHEGWFSQYMSGAAVAVTADTLWPPARTCALAAREGVTMTYVPPGCATQLAEWALEHGAPPSL RSITVGGEATSREAFALMRRAFPNARVVNGYGPTETVITPMLWMFAPGDDPAKLADAAYLPIGTLVGARTAHVLDARLNP LPVGVIGELYLGGEGVGLARGYLGRAALTAERFVPDPYGAPGARLYRTGDLVRRRADGVFDFIGRIDHQVKLRGLRIELG EIEAQLAAHDDVREAVAVVFGEGAHARLAAFVELTGDARARARRADAAELDAHLRRTLPDYMVPAHIVVLDALPRNANSK VDRAALPEPAHVARAYEAPDGELETALAEIWREVLGVERVGRADHFFELGGHSLAAVRVATRVAERLARDVPVRALFEAP ILAPYAQRVAAAAPAHAPQRAGSASYAPDADGVLPLSAAQRGLWFLWRAQPDSAAYNIPVALRLRGALDVDALADALAHA AVRHPALRTRIVARADGAPGQRIAPARRIELPVVDLRADARIADDDARLAAAIALTDADALAPFDLAADAPLWRARVIRL GAHDHVLSLVVHHIVSDGQSIDLWLDAVRAAYVARRADEPATAAARAAADRRTDRHAGSRAASLAPARAKEAPAQSATIA PIQAPADAPQPAPDAPVLPAAAPHARLAFWREALAGAPSHALPPPRAGRACAPRWDAGRLAFEFDAALVRRARAMALDAH ATLPMLLHAALNAAFYRATGATDQPVGVLASTRELTGDAAERALGLFINAVVVRTRLSGADTPATLVAAVRDAALAAYAH ADAPFCDVVAALRAPRTVNGNPLFQVMFNYLRPAGAAARDWAGLAVDAFNDVRHRVVFELELDIVEHPDGRVTGAFSYAA ERVDGAFVAALAADYLDVVRGFVDAPARALGACAARFPLASHEAYAPPPPAAADARAAARVARALAELWRASLGHAAPAP EANLFEAGATSFDVVRFVDAARSAGFALAIADVFAAPSLAALGERAAHTAGQPATQARDAD
Specific function: Activates the 13th to the 16th (Trp, D-Leu, Trp and Gly) amino acids in linear gramicidin and catalyzes the formation of the peptide bond between them. This enzyme is also responsible for the epimerization of the 14th (D-Leu) amino acid. It also catalyzes
COG id: COG1020
COG function: function code Q; Non-ribosomal peptide synthetase modules and related proteins
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 4 acyl carrier domains [H]
Homologues:
Organism=Homo sapiens, GI45580730, Length=469, Percent_Identity=24.3070362473348, Blast_Score=101, Evalue=7e-21, Organism=Homo sapiens, GI42544132, Length=478, Percent_Identity=21.5481171548117, Blast_Score=73, Evalue=3e-12, Organism=Homo sapiens, GI28416953, Length=572, Percent_Identity=23.4265734265734, Blast_Score=72, Evalue=4e-12, Organism=Escherichia coli, GI1786801, Length=1078, Percent_Identity=29.0352504638219, Blast_Score=273, Evalue=6e-74, Organism=Escherichia coli, GI1790505, Length=379, Percent_Identity=27.9683377308707, Blast_Score=89, Evalue=2e-18, Organism=Escherichia coli, GI221142682, Length=512, Percent_Identity=22.265625, Blast_Score=69, Evalue=4e-12, Organism=Caenorhabditis elegans, GI17550940, Length=568, Percent_Identity=23.0633802816901, Blast_Score=114, Evalue=5e-25, Organism=Caenorhabditis elegans, GI17556356, Length=521, Percent_Identity=24.9520153550864, Blast_Score=110, Evalue=5e-24, Organism=Caenorhabditis elegans, GI71983001, Length=397, Percent_Identity=28.7153652392947, Blast_Score=83, Evalue=1e-15, Organism=Caenorhabditis elegans, GI71982997, Length=397, Percent_Identity=28.7153652392947, Blast_Score=83, Evalue=1e-15, Organism=Saccharomyces cerevisiae, GI6319591, Length=1000, Percent_Identity=24, Blast_Score=214, Evalue=1e-55, Organism=Drosophila melanogaster, GI24648676, Length=612, Percent_Identity=28.5947712418301, Blast_Score=168, Evalue=3e-41, Organism=Drosophila melanogaster, GI18859661, Length=382, Percent_Identity=24.6073298429319, Blast_Score=78, Evalue=6e-14, Organism=Drosophila melanogaster, GI24581924, Length=417, Percent_Identity=25.1798561151079, Blast_Score=78, Evalue=7e-14,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR010071 - InterPro: IPR009081 - InterPro: IPR020845 - InterPro: IPR000873 - InterPro: IPR001242 - InterPro: IPR013120 - InterPro: IPR016040 - InterPro: IPR010060 - InterPro: IPR006163 - InterPro: IPR020806 - InterPro: IPR006162 - InterPro: IPR010080 [H]
Pfam domain/function: PF00501 AMP-binding; PF00668 Condensation; PF07993 NAD_binding_4; PF00550 PP-binding [H]
EC number: 2.7.7.- [C]
Molecular weight: Translated: 184903; Mature: 184903
Theoretical pI: Translated: 6.85; Mature: 6.85
Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS50075 ACP_DOMAIN ; PS00455 AMP_BINDING
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.5 %Cys (Translated Protein) 1.1 %Met (Translated Protein) 1.7 %Cys+Met (Translated Protein) 0.5 %Cys (Mature Protein) 1.1 %Met (Mature Protein) 1.7 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MRSTHEGARMTPPDLLSLAARFARLPDTQRKQFLAKLGDAGIDFRMLPIPPREDRAASVP CCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCC ASFAQTRLWLHARLLGESAAYHITERLRLDGGLDANALRLSCDALIARHEALRTTFAEGA HHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH AGVLQTVHAPMRCPWRFTDLADASAGSREQRAAAIAERDEAEPFDLAHGPLVRAHLIRLD HHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHEEC AATHWFVLTTHHIVSDGWSADVMLAELSSFYRSYATGDAVSLAPLPVQYADYALWQRRWL CCCEEEEEEEHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHC DAGEGERQLAYWRATLDASRDALLLPGAATRPAQRGASGARHAFDISAELARRMRALAQA CCCCCCCEEHEEEHHHCCCCCEEEECCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHH RRATPFAVLLAALATLLARASGETGIRIGVPSANRERGETVGLIGFFVNTLTLAASTPAT HCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCEEHHHHHHHHHHHHHCCCCHH LAFDALVDATQRGLIDAQSHQDVPFDQVVDALGVARSASHHPLFQVMAAYGARRVLPSFA HHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH EVCATELPSGMPYAKFDLALSFDERDDGGLDARFVYATDLFDADAIERFAARYVELLAHA HHHHHHCCCCCCCEEEEEEEEECCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHH LDTPGAAIGDLQWLPEAERRQLAAWNGQTHDFTGRASPARAGAGAAVPRERAGQAGGEPF HCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCC VPVHDRIAQHARRRPDARGVADIERALTRGEVDARATRLAKRLVAAGVGAEMRVGVALSR CCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEECCHHHH SVDLLVGLIAALKSGGAFVPLDPSHPRERLAQMLEDAQIAHVITERGSVDALPLAGATRA HHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHH WLVDDAIADAEIDGVALPAVSPHQAAYVIYTSGSTGKPKGVVVDHGAFARHCEAIAARYG HEEHHHHCCCCCCCEECCCCCCCCEEEEEEECCCCCCCCCEEEECCHHHHHHHHHHHHHC ATERDVFMLFQSVNFDGAHEGWFSQYMSGAAVAVTADTLWPPARTCALAAREGVTMTYVP CCHHHHHHHHHHCCCCCCCHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHCCCEEEEEC PGCATQLAEWALEHGAPPSLRSITVGGEATSREAFALMRRAFPNARVVNGYGPTETVITP CCHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCEEECCCCCHHHHHHH MLWMFAPGDDPAKLADAAYLPIGTLVGARTAHVLDARLNPLPVGVIGELYLGGEGVGLAR HHHEECCCCCHHHHHHHHHCCHHHHHHCHHHHHHHCCCCCCCCCHHEEEEECCCCCCHHH GYLGRAALTAERFVPDPYGAPGARLYRTGDLVRRRADGVFDFIGRIDHQVKLRGLRIELG HHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEHH EIEAQLAAHDDVREAVAVVFGEGAHARLAAFVELTGDARARARRADAAELDAHLRRTLPD HHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEEEECCCHHHHHHHCCHHHHHHHHHHHCHH YMVPAHIVVLDALPRNANSKVDRAALPEPAHVARAYEAPDGELETALAEIWREVLGVERV HHCCCCEEEEECCCCCCCCCCCHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHC GRADHFFELGGHSLAAVRVATRVAERLARDVPVRALFEAPILAPYAQRVAAAAPAHAPQR CCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHCCCCCCHH AGSASYAPDADGVLPLSAAQRGLWFLWRAQPDSAAYNIPVALRLRGALDVDALADALAHA CCCCCCCCCCCCEEEHHHHCCCEEEEEECCCCCCCCCCCEEEEECCCCCHHHHHHHHHHH AVRHPALRTRIVARADGAPGQRIAPARRIELPVVDLRADARIADDDARLAAAIALTDADA HHHCHHHHHHHEEECCCCCCCCCCCCHHEECCEEEECCCCEECCCCHHEEEEEEEECCCC LAPFDLAADAPLWRARVIRLGAHDHVLSLVVHHIVSDGQSIDLWLDAVRAAYVARRADEP CCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCC ATAAARAAADRRTDRHAGSRAASLAPARAKEAPAQSATIAPIQAPADAPQPAPDAPVLPA HHHHHHHHHHHHHHHHCCCHHHHCCCHHHHCCCCCCCEECCCCCCCCCCCCCCCCCCCCC AAPHARLAFWREALAGAPSHALPPPRAGRACAPRWDAGRLAFEFDAALVRRARAMALDAH CCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHCCH ATLPMLLHAALNAAFYRATGATDQPVGVLASTRELTGDAAERALGLFINAVVVRTRLSGA HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCC DTPATLVAAVRDAALAAYAHADAPFCDVVAALRAPRTVNGNPLFQVMFNYLRPAGAAARD CCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCC WAGLAVDAFNDVRHRVVFELELDIVEHPDGRVTGAFSYAAERVDGAFVAALAADYLDVVR CCCEEHHHHHHHHHEEEEEEEEEEEECCCCCEEEHHHHHHHHHCHHHHHHHHHHHHHHHH GFVDAPARALGACAARFPLASHEAYAPPPPAAADARAAARVARALAELWRASLGHAAPAP HHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC EANLFEAGATSFDVVRFVDAARSAGFALAIADVFAAPSLAALGERAAHTAGQPATQARDA CCCHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCC D C >Mature Secondary Structure MRSTHEGARMTPPDLLSLAARFARLPDTQRKQFLAKLGDAGIDFRMLPIPPREDRAASVP CCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCC ASFAQTRLWLHARLLGESAAYHITERLRLDGGLDANALRLSCDALIARHEALRTTFAEGA HHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH AGVLQTVHAPMRCPWRFTDLADASAGSREQRAAAIAERDEAEPFDLAHGPLVRAHLIRLD HHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHEEC AATHWFVLTTHHIVSDGWSADVMLAELSSFYRSYATGDAVSLAPLPVQYADYALWQRRWL CCCEEEEEEEHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHC DAGEGERQLAYWRATLDASRDALLLPGAATRPAQRGASGARHAFDISAELARRMRALAQA CCCCCCCEEHEEEHHHCCCCCEEEECCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHH RRATPFAVLLAALATLLARASGETGIRIGVPSANRERGETVGLIGFFVNTLTLAASTPAT HCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCEEHHHHHHHHHHHHHCCCCHH LAFDALVDATQRGLIDAQSHQDVPFDQVVDALGVARSASHHPLFQVMAAYGARRVLPSFA HHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH EVCATELPSGMPYAKFDLALSFDERDDGGLDARFVYATDLFDADAIERFAARYVELLAHA HHHHHHCCCCCCCEEEEEEEEECCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHH LDTPGAAIGDLQWLPEAERRQLAAWNGQTHDFTGRASPARAGAGAAVPRERAGQAGGEPF HCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCC VPVHDRIAQHARRRPDARGVADIERALTRGEVDARATRLAKRLVAAGVGAEMRVGVALSR CCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEECCHHHH SVDLLVGLIAALKSGGAFVPLDPSHPRERLAQMLEDAQIAHVITERGSVDALPLAGATRA HHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHH WLVDDAIADAEIDGVALPAVSPHQAAYVIYTSGSTGKPKGVVVDHGAFARHCEAIAARYG HEEHHHHCCCCCCCEECCCCCCCCEEEEEEECCCCCCCCCEEEECCHHHHHHHHHHHHHC ATERDVFMLFQSVNFDGAHEGWFSQYMSGAAVAVTADTLWPPARTCALAAREGVTMTYVP CCHHHHHHHHHHCCCCCCCHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHCCCEEEEEC PGCATQLAEWALEHGAPPSLRSITVGGEATSREAFALMRRAFPNARVVNGYGPTETVITP CCHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCEEECCCCCHHHHHHH MLWMFAPGDDPAKLADAAYLPIGTLVGARTAHVLDARLNPLPVGVIGELYLGGEGVGLAR HHHEECCCCCHHHHHHHHHCCHHHHHHCHHHHHHHCCCCCCCCCHHEEEEECCCCCCHHH GYLGRAALTAERFVPDPYGAPGARLYRTGDLVRRRADGVFDFIGRIDHQVKLRGLRIELG HHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEHH EIEAQLAAHDDVREAVAVVFGEGAHARLAAFVELTGDARARARRADAAELDAHLRRTLPD HHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEEEECCCHHHHHHHCCHHHHHHHHHHHCHH YMVPAHIVVLDALPRNANSKVDRAALPEPAHVARAYEAPDGELETALAEIWREVLGVERV HHCCCCEEEEECCCCCCCCCCCHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHC GRADHFFELGGHSLAAVRVATRVAERLARDVPVRALFEAPILAPYAQRVAAAAPAHAPQR CCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHCCCCCCHH AGSASYAPDADGVLPLSAAQRGLWFLWRAQPDSAAYNIPVALRLRGALDVDALADALAHA CCCCCCCCCCCCEEEHHHHCCCEEEEEECCCCCCCCCCCEEEEECCCCCHHHHHHHHHHH AVRHPALRTRIVARADGAPGQRIAPARRIELPVVDLRADARIADDDARLAAAIALTDADA HHHCHHHHHHHEEECCCCCCCCCCCCHHEECCEEEECCCCEECCCCHHEEEEEEEECCCC LAPFDLAADAPLWRARVIRLGAHDHVLSLVVHHIVSDGQSIDLWLDAVRAAYVARRADEP CCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCC ATAAARAAADRRTDRHAGSRAASLAPARAKEAPAQSATIAPIQAPADAPQPAPDAPVLPA HHHHHHHHHHHHHHHHCCCHHHHCCCHHHHCCCCCCCEECCCCCCCCCCCCCCCCCCCCC AAPHARLAFWREALAGAPSHALPPPRAGRACAPRWDAGRLAFEFDAALVRRARAMALDAH CCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHCCH ATLPMLLHAALNAAFYRATGATDQPVGVLASTRELTGDAAERALGLFINAVVVRTRLSGA HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCC DTPATLVAAVRDAALAAYAHADAPFCDVVAALRAPRTVNGNPLFQVMFNYLRPAGAAARD CCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCC WAGLAVDAFNDVRHRVVFELELDIVEHPDGRVTGAFSYAAERVDGAFVAALAADYLDVVR CCCEEHHHHHHHHHEEEEEEEEEEEECCCCCEEEHHHHHHHHHCHHHHHHHHHHHHHHHH GFVDAPARALGACAARFPLASHEAYAPPPPAAADARAAARVARALAELWRASLGHAAPAP HHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC EANLFEAGATSFDVVRFVDAARSAGFALAIADVFAAPSLAALGERAAHTAGQPATQARDA CCCHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCC D C
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: Phosphopantetheine. [C]
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: 6 ATP; L-serine; 2,3-dihydroxybenzoate [C]
Specific reaction: 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Seryl-AMP 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Ser
General reaction: Transferases; Acyltransferases; Transferring groups other than amino-acyl groups [C]
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA