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The map label for this gene is qor [C]

Identifier: 226225120

GI number: 226225120

Start: 2622071

End: 2623069

Strand: Reverse

Name: qor [C]

Synonym: Lm4b_02541

Alternate gene names: 226225120

Gene position: 2623069-2622071 (Counterclockwise)

Preceding gene: 226225121

Following gene: 226225119

Centisome position: 90.06

GC content: 40.94

Gene sequence:

>999_bases
ATGAAAGCTGTAGGATTAACGAGAGCGTCAACGGATTTTGTGGATATAGAAATCGACAAGCCAGTACCAGAAAACCATGA
TTTACTAGTTAGAATTAAAGCGATTTCCATCAATCCGGTAGATACTAAACAACGTGAAGCAACGAAGCTATCTGGAGATG
AAGTACGGATTTTAGGTTGGGATGCGGTTGGAGAAGTAGTAGATACTGGGAGTGAAGTTGCATTATTTCAAACCGGGCAA
GACGTTTATTTCGCAGGTGACGTCACAAGGCAAGGAGCGTACGCAGAATACACTTTAATTGATGAGCGGTTAGTTGGTTT
GAAACCACATAACTTGAACGTAGAGGAAGCTGCTGCGATGCCACTGACAACTATTACAGCTTGGGAAGCATTGTTTGATC
GTTTAACTATTACTGAAAATGATAAAGGTAAATCAATTTTAATTATTAATGGCGCTGGTGGTGTTGGTTCTATTGCGACC
CAACTAGCTGCACATGCTGGTCTTGAAGTCATCGCCACGGCCTCACGCCCAGAAACAGTAGAATGGACTAAGAGCCACGG
CGCGAACTATGTTATCAACCACCGAGAAAACATCCCAGAACAACTGGAAGAACTTGGATTTGAGCAGGGAGTTGATTTTA
TTTTATGTTTGCATAACACGAGTGCTCACTGGGATGAGATGCAAGAAGCGATTCGCCCACAAGGGAAAATTTGCTCTATT
GTAGAACTTGCAGAGCCAGTGAAAATGACTCTTTTAAAAGACAAGAGTGCTACTTTCAGCTATGAATTCATGTTTACTCG
TTCGAAATATGATACAACAGATAAAATCAGACAGCATGAAATTTTAACAGAAGCAGCTCATATGCTAGATGCGGGCGAAT
TAACAACGACATTAAATCAAGTTTTATCACCCGTGAACGCGGCGACAATAGAAGAAGCTCACAAAATTATCTCATCCGGA
AAAATGATTGGAAAATTAGTAGTGAAAGGATTTGAGTAA

Upstream 100 bases:

>100_bases
ATAAGTTTTAAAGCCTTCTCAGTGAGTTTGAGAAGGCTTTTTTATCTAAATGTGCATTATTTTAAGAAATTCGGGAAAAG
GAAACGAGAGGTGTTGTCAA

Downstream 100 bases:

>100_bases
TAATGAGTGAAAAACAAGTTGCGCTATATATCGCGGTTAGTTTGGACGGTTATATTGCAGATGAAAACGGAAGTGTCGAA
TGGTTAGAATCTATTGATAG

Product: zinc-binding dehydrogenase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MKAVGLTRASTDFVDIEIDKPVPENHDLLVRIKAISINPVDTKQREATKLSGDEVRILGWDAVGEVVDTGSEVALFQTGQ
DVYFAGDVTRQGAYAEYTLIDERLVGLKPHNLNVEEAAAMPLTTITAWEALFDRLTITENDKGKSILIINGAGGVGSIAT
QLAAHAGLEVIATASRPETVEWTKSHGANYVINHRENIPEQLEELGFEQGVDFILCLHNTSAHWDEMQEAIRPQGKICSI
VELAEPVKMTLLKDKSATFSYEFMFTRSKYDTTDKIRQHEILTEAAHMLDAGELTTTLNQVLSPVNAATIEEAHKIISSG
KMIGKLVVKGFE

Sequences:

>Translated_332_residues
MKAVGLTRASTDFVDIEIDKPVPENHDLLVRIKAISINPVDTKQREATKLSGDEVRILGWDAVGEVVDTGSEVALFQTGQ
DVYFAGDVTRQGAYAEYTLIDERLVGLKPHNLNVEEAAAMPLTTITAWEALFDRLTITENDKGKSILIINGAGGVGSIAT
QLAAHAGLEVIATASRPETVEWTKSHGANYVINHRENIPEQLEELGFEQGVDFILCLHNTSAHWDEMQEAIRPQGKICSI
VELAEPVKMTLLKDKSATFSYEFMFTRSKYDTTDKIRQHEILTEAAHMLDAGELTTTLNQVLSPVNAATIEEAHKIISSG
KMIGKLVVKGFE
>Mature_332_residues
MKAVGLTRASTDFVDIEIDKPVPENHDLLVRIKAISINPVDTKQREATKLSGDEVRILGWDAVGEVVDTGSEVALFQTGQ
DVYFAGDVTRQGAYAEYTLIDERLVGLKPHNLNVEEAAAMPLTTITAWEALFDRLTITENDKGKSILIINGAGGVGSIAT
QLAAHAGLEVIATASRPETVEWTKSHGANYVINHRENIPEQLEELGFEQGVDFILCLHNTSAHWDEMQEAIRPQGKICSI
VELAEPVKMTLLKDKSATFSYEFMFTRSKYDTTDKIRQHEILTEAAHMLDAGELTTTLNQVLSPVNAATIEEAHKIISSG
KMIGKLVVKGFE

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI194239674, Length=201, Percent_Identity=30.3482587064677, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI13236495, Length=201, Percent_Identity=30.3482587064677, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI194239676, Length=181, Percent_Identity=30.939226519337, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI47519420, Length=207, Percent_Identity=29.951690821256, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI22538446, Length=328, Percent_Identity=25.9146341463415, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI22538444, Length=328, Percent_Identity=25.9146341463415, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI28557745, Length=255, Percent_Identity=27.843137254902, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI90669511, Length=184, Percent_Identity=31.5217391304348, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1790485, Length=191, Percent_Identity=30.3664921465969, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17507255, Length=183, Percent_Identity=31.6939890710383, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71987554, Length=175, Percent_Identity=30.2857142857143, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319520, Length=201, Percent_Identity=30.8457711442786, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 36472; Mature: 36472

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVGLTRASTDFVDIEIDKPVPENHDLLVRIKAISINPVDTKQREATKLSGDEVRILGW
CCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEEEEECCCCCCHHHHHCCCCCEEEEEEH
DAVGEVVDTGSEVALFQTGQDVYFAGDVTRQGAYAEYTLIDERLVGLKPHNLNVEEAAAM
HHHHHHHCCCCCEEEEECCCEEEEECCCCCCCCCEEEEEEHHHHHCCCCCCCCHHHHHCC
PLTTITAWEALFDRLTITENDKGKSILIINGAGGVGSIATQLAAHAGLEVIATASRPETV
CHHHHHHHHHHHHCEEEEECCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCCCCE
EWTKSHGANYVINHRENIPEQLEELGFEQGVDFILCLHNTSAHWDEMQEAIRPQGKICSI
EEHHCCCCCEEEECCCCCHHHHHHCCHHCCCCEEEEEECCCCCHHHHHHHHCCCCCEEHH
VELAEPVKMTLLKDKSATFSYEFMFTRSKYDTTDKIRQHEILTEAAHMLDAGELTTTLNQ
HHHHCCCEEEEEECCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHH
VLSPVNAATIEEAHKIISSGKMIGKLVVKGFE
HHCCCCHHHHHHHHHHHHCCHHEEHHHHCCCC
>Mature Secondary Structure
MKAVGLTRASTDFVDIEIDKPVPENHDLLVRIKAISINPVDTKQREATKLSGDEVRILGW
CCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEEEEECCCCCCHHHHHCCCCCEEEEEEH
DAVGEVVDTGSEVALFQTGQDVYFAGDVTRQGAYAEYTLIDERLVGLKPHNLNVEEAAAM
HHHHHHHCCCCCEEEEECCCEEEEECCCCCCCCCEEEEEEHHHHHCCCCCCCCHHHHHCC
PLTTITAWEALFDRLTITENDKGKSILIINGAGGVGSIATQLAAHAGLEVIATASRPETV
CHHHHHHHHHHHHCEEEEECCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCCCCE
EWTKSHGANYVINHRENIPEQLEELGFEQGVDFILCLHNTSAHWDEMQEAIRPQGKICSI
EEHHCCCCCEEEECCCCCHHHHHHCCHHCCCCEEEEEECCCCCHHHHHHHHCCCCCEEHH
VELAEPVKMTLLKDKSATFSYEFMFTRSKYDTTDKIRQHEILTEAAHMLDAGELTTTLNQ
HHHHCCCEEEEEECCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHH
VLSPVNAATIEEAHKIISSGKMIGKLVVKGFE
HHCCCCHHHHHHHHHHHHCCHHEEHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA