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The map label for this gene is atpA

Identifier: 226225079

GI number: 226225079

Start: 2581255

End: 2582769

Strand: Reverse

Name: atpA

Synonym: Lm4b_02500

Alternate gene names: 226225079

Gene position: 2582769-2581255 (Counterclockwise)

Preceding gene: 226225080

Following gene: 226225078

Centisome position: 88.67

GC content: 41.25

Gene sequence:

>1515_bases
ATGAGCATTAAGGCTGAAGAGATCAGCTCAATCATAAAACAGCAGATTGAAAATTATCAATCTGAACTAAAAGTGAGTGA
TGTTGGTACGGTTACCTACATTGGTGACGGTATTGCGCGTGCTCATGGACTCGATAATGCAATGGCTGGTGAATTGTTAG
AGTTCTCAAATGGTGTAATGGGTATGGCCCAAAACTTAGAAACAAATGATGTTGGTATCATTATTCTAGGTCCTTACACT
GAAATCCGTGAAGGCGATGAAGTTCGTCGTACCGGTAAAATCATGGAAGTTCCTGTTGGCGAAGCGCTTATTGGGCGTGT
AGTTAACTCATTAGGTCAACCAGTTGATGGTTTAGGACCTATTGAAACAACTGGAACTCGTCCGATTGAAGCAGTAGCAC
CTGGTGTTATGCAACGTCAATCAGTAAATGAACCATTACAAACAGGTATTAAAGCGATTGATGCACTTGTTCCAATTGGT
CGTGGTCAACGTGAGTTAATCATCGGTGACCGCCAAACTGGTAAAACATCTGTAGCAATTGATACTATTCTAAACCAAGC
TGACCAAGACATGATTTGTATTTATGTTGCTATCGGTCAAAAAGAATCTACTGTACGTAATGCCGTAGAAACATTACGTC
ATCACGGCGCATTAGATTACACAATCGTCGTAACTGCAGCAGCATCTCAACCAGCGCCACTTCTATACTTGGCTCCTTAT
GCTGGTGTTGCAATGGCAGAAGAATTCATGTACAACGGCAAACACGTTTTAGTCGTATATGATGATTTATCCAAACAAGC
AGCCGCTTATCGTGAGCTGTCTCTATTACTTCGTCGTCCTCCAGGTCGTGAAGCATATCCAGGGGATGTTTTCTACTTGC
ACTCCCGTTTACTTGAACGTGCTGCAAAATTAAATGATAGCTTAGGTGGCGGATCCATTACGGCTCTTCCATTCGTAGAA
ACACAAGCCGGAGATATCTCTGCTTATATTCCTACAAACGTTATCTCGATTACAGACGGACAAATCTTCTTGCAATCTGA
TTTATTCTTCTCCGGAGTACGTCCAGCGATCAATGCCGGTCTTTCTGTATCTCGTGTAGGTGGATCAGCGCAAATTAAAG
CAATGAAAACTGTTGCCGGAACACTTCGTCTAGACCTTGCCGCTTACCGTGAGCTAGAATCCTTCTCACAATTCGGCTCT
GACCTAGATGCAGCTACTCGTGCGAAACTAGAACGTGGTAAACGTACAGTAGAAGTTCTAAAACAAGATTTGCACAAACC
TTTGAAAGTTGAAAAACAAGTATTGATTCTTTATGCACTTGTTCATAAATATCTGGATGATGTACCAGTTCATGATGTAC
TGCGTTTTGAGTCCGAAATGAATACATGGTTTGATCATAATCACCCAGAGCTTTTGGAAGAAATTCGTACAACGAAAAAA
CTTCCTGACGAAGCGAAACTTGAAGCAGCATTGAAAGAATTTAAAAATACATTTGTTCCTTCTGAAGAAAAATAA

Upstream 100 bases:

>100_bases
TTATTGGAACCCGTATATATGATGACAGTCTAAAAACGAAATTAAAGGACATGGAACGGCAAATTAAAGCCTAGTTTCCG
TTTAACGAGGGGTGAAATCA

Downstream 100 bases:

>100_bases
TTTAGACTCGGAATAAATTCAAAGGTGGTGAAAATCTTTGGCATCTTTAATCGATATTAAACAACGAATAACTTCTACAC
GTAAAACAAGTCAAATTACA

Product: F0F1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha 2; F-ATPase subunit alpha 2 [H]

Number of amino acids: Translated: 504; Mature: 503

Protein sequence:

>504_residues
MSIKAEEISSIIKQQIENYQSELKVSDVGTVTYIGDGIARAHGLDNAMAGELLEFSNGVMGMAQNLETNDVGIIILGPYT
EIREGDEVRRTGKIMEVPVGEALIGRVVNSLGQPVDGLGPIETTGTRPIEAVAPGVMQRQSVNEPLQTGIKAIDALVPIG
RGQRELIIGDRQTGKTSVAIDTILNQADQDMICIYVAIGQKESTVRNAVETLRHHGALDYTIVVTAAASQPAPLLYLAPY
AGVAMAEEFMYNGKHVLVVYDDLSKQAAAYRELSLLLRRPPGREAYPGDVFYLHSRLLERAAKLNDSLGGGSITALPFVE
TQAGDISAYIPTNVISITDGQIFLQSDLFFSGVRPAINAGLSVSRVGGSAQIKAMKTVAGTLRLDLAAYRELESFSQFGS
DLDAATRAKLERGKRTVEVLKQDLHKPLKVEKQVLILYALVHKYLDDVPVHDVLRFESEMNTWFDHNHPELLEEIRTTKK
LPDEAKLEAALKEFKNTFVPSEEK

Sequences:

>Translated_504_residues
MSIKAEEISSIIKQQIENYQSELKVSDVGTVTYIGDGIARAHGLDNAMAGELLEFSNGVMGMAQNLETNDVGIIILGPYT
EIREGDEVRRTGKIMEVPVGEALIGRVVNSLGQPVDGLGPIETTGTRPIEAVAPGVMQRQSVNEPLQTGIKAIDALVPIG
RGQRELIIGDRQTGKTSVAIDTILNQADQDMICIYVAIGQKESTVRNAVETLRHHGALDYTIVVTAAASQPAPLLYLAPY
AGVAMAEEFMYNGKHVLVVYDDLSKQAAAYRELSLLLRRPPGREAYPGDVFYLHSRLLERAAKLNDSLGGGSITALPFVE
TQAGDISAYIPTNVISITDGQIFLQSDLFFSGVRPAINAGLSVSRVGGSAQIKAMKTVAGTLRLDLAAYRELESFSQFGS
DLDAATRAKLERGKRTVEVLKQDLHKPLKVEKQVLILYALVHKYLDDVPVHDVLRFESEMNTWFDHNHPELLEEIRTTKK
LPDEAKLEAALKEFKNTFVPSEEK
>Mature_503_residues
SIKAEEISSIIKQQIENYQSELKVSDVGTVTYIGDGIARAHGLDNAMAGELLEFSNGVMGMAQNLETNDVGIIILGPYTE
IREGDEVRRTGKIMEVPVGEALIGRVVNSLGQPVDGLGPIETTGTRPIEAVAPGVMQRQSVNEPLQTGIKAIDALVPIGR
GQRELIIGDRQTGKTSVAIDTILNQADQDMICIYVAIGQKESTVRNAVETLRHHGALDYTIVVTAAASQPAPLLYLAPYA
GVAMAEEFMYNGKHVLVVYDDLSKQAAAYRELSLLLRRPPGREAYPGDVFYLHSRLLERAAKLNDSLGGGSITALPFVET
QAGDISAYIPTNVISITDGQIFLQSDLFFSGVRPAINAGLSVSRVGGSAQIKAMKTVAGTLRLDLAAYRELESFSQFGSD
LDAATRAKLERGKRTVEVLKQDLHKPLKVEKQVLILYALVHKYLDDVPVHDVLRFESEMNTWFDHNHPELLEEIRTTKKL
PDEAKLEAALKEFKNTFVPSEEK

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit [H]

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family [H]

Homologues:

Organism=Homo sapiens, GI50345984, Length=505, Percent_Identity=57.8217821782178, Blast_Score=588, Evalue=1e-168,
Organism=Homo sapiens, GI4757810, Length=505, Percent_Identity=57.8217821782178, Blast_Score=588, Evalue=1e-168,
Organism=Homo sapiens, GI19913428, Length=301, Percent_Identity=30.2325581395349, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI19913426, Length=302, Percent_Identity=30.794701986755, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI32189394, Length=316, Percent_Identity=25.9493670886076, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI19913424, Length=256, Percent_Identity=28.515625, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1790172, Length=510, Percent_Identity=53.921568627451, Blast_Score=565, Evalue=1e-162,
Organism=Escherichia coli, GI1788251, Length=272, Percent_Identity=34.1911764705882, Blast_Score=118, Evalue=1e-27,
Organism=Escherichia coli, GI1790170, Length=318, Percent_Identity=28.3018867924528, Blast_Score=107, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71988063, Length=504, Percent_Identity=57.1428571428571, Blast_Score=588, Evalue=1e-168,
Organism=Caenorhabditis elegans, GI71988080, Length=504, Percent_Identity=57.1428571428571, Blast_Score=586, Evalue=1e-168,
Organism=Caenorhabditis elegans, GI71988074, Length=504, Percent_Identity=53.1746031746032, Blast_Score=531, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI17510931, Length=376, Percent_Identity=27.3936170212766, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17570191, Length=291, Percent_Identity=28.8659793814433, Blast_Score=111, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI25144756, Length=316, Percent_Identity=25, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17509265, Length=51, Percent_Identity=62.7450980392157, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71988068, Length=73, Percent_Identity=39.7260273972603, Blast_Score=70, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17565854, Length=255, Percent_Identity=27.4509803921569, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319370, Length=509, Percent_Identity=57.3673870333988, Blast_Score=592, Evalue=1e-170,
Organism=Saccharomyces cerevisiae, GI6319603, Length=304, Percent_Identity=29.9342105263158, Blast_Score=113, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6322581, Length=413, Percent_Identity=24.9394673123487, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24658560, Length=505, Percent_Identity=55.4455445544555, Blast_Score=566, Evalue=1e-161,
Organism=Drosophila melanogaster, GI281361666, Length=294, Percent_Identity=29.5918367346939, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24646341, Length=294, Percent_Identity=29.5918367346939, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI17136796, Length=294, Percent_Identity=29.5918367346939, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24638766, Length=316, Percent_Identity=26.5822784810127, Blast_Score=96, Evalue=7e-20,
Organism=Drosophila melanogaster, GI28574560, Length=427, Percent_Identity=25.2927400468384, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI20129479, Length=261, Percent_Identity=28.3524904214559, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100 [H]

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N [H]

EC number: =3.6.3.14 [H]

Molecular weight: Translated: 55079; Mature: 54947

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIKAEEISSIIKQQIENYQSELKVSDVGTVTYIGDGIARAHGLDNAMAGELLEFSNGVM
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHCCCHHHHHHHHHHCCCHH
GMAQNLETNDVGIIILGPYTEIREGDEVRRTGKIMEVPVGEALIGRVVNSLGQPVDGLGP
HHHCCCCCCCEEEEEECCCHHHHCCHHHHHCCCEEECCCCHHHHHHHHHHHCCCCCCCCC
IETTGTRPIEAVAPGVMQRQSVNEPLQTGIKAIDALVPIGRGQRELIIGDRQTGKTSVAI
CCCCCCCCHHHHCCHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHH
DTILNQADQDMICIYVAIGQKESTVRNAVETLRHHGALDYTIVVTAAASQPAPLLYLAPY
HHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCEEEECCC
AGVAMAEEFMYNGKHVLVVYDDLSKQAAAYRELSLLLRRPPGREAYPGDVFYLHSRLLER
CHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
AAKLNDSLGGGSITALPFVETQAGDISAYIPTNVISITDGQIFLQSDLFFSGVRPAINAG
HHHHCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEEEECCCHHHCCCHHHHCC
LSVSRVGGSAQIKAMKTVAGTLRLDLAAYRELESFSQFGSDLDAATRAKLERGKRTVEVL
CEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
KQDLHKPLKVEKQVLILYALVHKYLDDVPVHDVLRFESEMNTWFDHNHPELLEEIRTTKK
HHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHC
LPDEAKLEAALKEFKNTFVPSEEK
CCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SIKAEEISSIIKQQIENYQSELKVSDVGTVTYIGDGIARAHGLDNAMAGELLEFSNGVM
CCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHCCCHHHHHHHHHHCCCHH
GMAQNLETNDVGIIILGPYTEIREGDEVRRTGKIMEVPVGEALIGRVVNSLGQPVDGLGP
HHHCCCCCCCEEEEEECCCHHHHCCHHHHHCCCEEECCCCHHHHHHHHHHHCCCCCCCCC
IETTGTRPIEAVAPGVMQRQSVNEPLQTGIKAIDALVPIGRGQRELIIGDRQTGKTSVAI
CCCCCCCCHHHHCCHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHH
DTILNQADQDMICIYVAIGQKESTVRNAVETLRHHGALDYTIVVTAAASQPAPLLYLAPY
HHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCEEEECCC
AGVAMAEEFMYNGKHVLVVYDDLSKQAAAYRELSLLLRRPPGREAYPGDVFYLHSRLLER
CHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
AAKLNDSLGGGSITALPFVETQAGDISAYIPTNVISITDGQIFLQSDLFFSGVRPAINAG
HHHHCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEEEECCCHHHCCCHHHHCC
LSVSRVGGSAQIKAMKTVAGTLRLDLAAYRELESFSQFGSDLDAATRAKLERGKRTVEVL
CEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
KQDLHKPLKVEKQVLILYALVHKYLDDVPVHDVLRFESEMNTWFDHNHPELLEEIRTTKK
HHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHC
LPDEAKLEAALKEFKNTFVPSEEK
CCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]