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The map label for this gene is hprK [H]

Identifier: 226225031

GI number: 226225031

Start: 2530867

End: 2531805

Strand: Reverse

Name: hprK [H]

Synonym: Lm4b_02452

Alternate gene names: 226225031

Gene position: 2531805-2530867 (Counterclockwise)

Preceding gene: 226225032

Following gene: 226225030

Centisome position: 86.92

GC content: 39.4

Gene sequence:

>939_bases
ATGACAAAATCGGTTACGGTAAAGGATTTAAAGGAACGACTTAATTTAGAGTTAATTTGTTCGGAAACGGGACTTGAACG
GCCAATTTCAACAAGTGACTTATCTCGGCCGGGGCTGGAACTTACTGGGTTTTTCTCTTATTATCCAGAAGATCGTGTGC
AACTTTTTGGCATGACTGAAATATCGTTTTCTGAAGGAATGGAACCTGAAGAACGTCTCAAAAGATATAAACAAATGTGT
ACGAAGCGGACGCCTGCTTTTGTGATTTCTAGAAATTTAGAAGTGCCGAAAGAATTAGTAGCAGCAGCGAAAGAAGCTGA
TATTCCGGTATTACGTTCACGACTTAAAACGACACGTTTATCTGTTTATATTACGAATTACTTAGAAAGCAGACTTGCGC
CAGTTATTTCGATGCATGGTGTTCTAGTGGATATATATGGTTTAGGTGTGTTGATTACGGGGAGCAGTGGTGTTGGTAAA
AGTGAAACAGCACTGGAGCTTGTAAAACGCGGGCATAGACTCGTAGCAGATGATAACGTAGAAATTCGCCAAGAGGATGA
AATGACGTTAATCGGTTCTTCTCCAGCGATTATTGAACATTTACTCGAGATTCGCGGGTTGGGGATTATTAATGTAATGA
CTTTATTTGGAGCAGGCGCTGTTCGTTCTAGTAAAAAAATTACTATCGTTGTGCACCTTGAAAATTGGGATCCTGATAAG
CATTATGATCGTGTCGGATTAGACCAAGAAAAGACAAAAATCTTTGATATGGATATTCCGAAAATTACGGTGCCTGTTCG
ACCGGGACGAAATTTATCTGTTATTATTGAGGTAGCGGCAATGAATTTCCGATTAAAGAATATGGGGTACAACGCGGCAG
AGCAATTTACACAAGACCTGAATAATTTAATAGGTCATAACAGCAGTATGAATGATTAA

Upstream 100 bases:

>100_bases
GCTTGATTCCTTCTAAAGTGCTAAAATGAGAAGGAGCTTTCTAAATAATATTTTGTAGCGAACAGTAATGGACTTTTATA
ATTCATTTGGAGGTACTTGC

Downstream 100 bases:

>100_bases
ATAAATAGTGAAAGCATCTCCGCAGCCAAACTTTACAAAAATGCTTGTTTGGTTGCGGAGTTGTCTTTTTGAAAGTAGGG
GAATTATGGGTAATGGTGTT

Product: HPr kinase/phosphorylase

Products: NA

Alternate protein names: HPrK/P; HPr(Ser) kinase/phosphorylase [H]

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MTKSVTVKDLKERLNLELICSETGLERPISTSDLSRPGLELTGFFSYYPEDRVQLFGMTEISFSEGMEPEERLKRYKQMC
TKRTPAFVISRNLEVPKELVAAAKEADIPVLRSRLKTTRLSVYITNYLESRLAPVISMHGVLVDIYGLGVLITGSSGVGK
SETALELVKRGHRLVADDNVEIRQEDEMTLIGSSPAIIEHLLEIRGLGIINVMTLFGAGAVRSSKKITIVVHLENWDPDK
HYDRVGLDQEKTKIFDMDIPKITVPVRPGRNLSVIIEVAAMNFRLKNMGYNAAEQFTQDLNNLIGHNSSMND

Sequences:

>Translated_312_residues
MTKSVTVKDLKERLNLELICSETGLERPISTSDLSRPGLELTGFFSYYPEDRVQLFGMTEISFSEGMEPEERLKRYKQMC
TKRTPAFVISRNLEVPKELVAAAKEADIPVLRSRLKTTRLSVYITNYLESRLAPVISMHGVLVDIYGLGVLITGSSGVGK
SETALELVKRGHRLVADDNVEIRQEDEMTLIGSSPAIIEHLLEIRGLGIINVMTLFGAGAVRSSKKITIVVHLENWDPDK
HYDRVGLDQEKTKIFDMDIPKITVPVRPGRNLSVIIEVAAMNFRLKNMGYNAAEQFTQDLNNLIGHNSSMND
>Mature_311_residues
TKSVTVKDLKERLNLELICSETGLERPISTSDLSRPGLELTGFFSYYPEDRVQLFGMTEISFSEGMEPEERLKRYKQMCT
KRTPAFVISRNLEVPKELVAAAKEADIPVLRSRLKTTRLSVYITNYLESRLAPVISMHGVLVDIYGLGVLITGSSGVGKS
ETALELVKRGHRLVADDNVEIRQEDEMTLIGSSPAIIEHLLEIRGLGIINVMTLFGAGAVRSSKKITIVVHLENWDPDKH
YDRVGLDQEKTKIFDMDIPKITVPVRPGRNLSVIIEVAAMNFRLKNMGYNAAEQFTQDLNNLIGHNSSMND

Specific function: Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-pr

COG id: COG1493

COG function: function code T; Serine kinase of the HPr protein, regulates carbohydrate metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPrK/P family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003755
- InterPro:   IPR011104
- InterPro:   IPR011126 [H]

Pfam domain/function: PF07475 Hpr_kinase_C; PF02603 Hpr_kinase_N [H]

EC number: NA

Molecular weight: Translated: 34951; Mature: 34820

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKSVTVKDLKERLNLELICSETGLERPISTSDLSRPGLELTGFFSYYPEDRVQLFGMTE
CCCCCHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCEEEEEEEE
ISFSEGMEPEERLKRYKQMCTKRTPAFVISRNLEVPKELVAAAKEADIPVLRSRLKTTRL
EHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHE
SVYITNYLESRLAPVISMHGVLVDIYGLGVLITGSSGVGKSETALELVKRGHRLVADDNV
EEEHHHHHHHHHHHHHHHHHHHEEEECCEEEEECCCCCCCHHHHHHHHHCCCEEEECCCC
EIRQEDEMTLIGSSPAIIEHLLEIRGLGIINVMTLFGAGAVRSSKKITIVVHLENWDPDK
EEEECCCEEEECCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCC
HYDRVGLDQEKTKIFDMDIPKITVPVRPGRNLSVIIEVAAMNFRLKNMGYNAAEQFTQDL
HHHHCCCCCHHCEEEECCCCEEEEECCCCCCEEEEEEEEECCEEEECCCCCHHHHHHHHH
NNLIGHNSSMND
HHHHCCCCCCCC
>Mature Secondary Structure 
TKSVTVKDLKERLNLELICSETGLERPISTSDLSRPGLELTGFFSYYPEDRVQLFGMTE
CCCCHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCEEEEEEEE
ISFSEGMEPEERLKRYKQMCTKRTPAFVISRNLEVPKELVAAAKEADIPVLRSRLKTTRL
EHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHE
SVYITNYLESRLAPVISMHGVLVDIYGLGVLITGSSGVGKSETALELVKRGHRLVADDNV
EEEHHHHHHHHHHHHHHHHHHHEEEECCEEEEECCCCCCCHHHHHHHHHCCCEEEECCCC
EIRQEDEMTLIGSSPAIIEHLLEIRGLGIINVMTLFGAGAVRSSKKITIVVHLENWDPDK
EEEECCCEEEECCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCC
HYDRVGLDQEKTKIFDMDIPKITVPVRPGRNLSVIIEVAAMNFRLKNMGYNAAEQFTQDL
HHHHCCCCCHHCEEEECCCCEEEEECCCCCCEEEEEEEEECCEEEECCCCCHHHHHHHHH
NNLIGHNSSMND
HHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]