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The map label for this gene is rnr [H]

Identifier: 226224997

GI number: 226224997

Start: 2492946

End: 2495327

Strand: Reverse

Name: rnr [H]

Synonym: Lm4b_02418

Alternate gene names: 226224997

Gene position: 2495327-2492946 (Counterclockwise)

Preceding gene: 226224998

Following gene: 226224996

Centisome position: 85.67

GC content: 40.47

Gene sequence:

>2382_bases
GTGGAACAAAAACAAATGGAAGAAAAAATTATGAATCTATTAACTTCAGCGCCTGATAAAACATTTGCGCTTGAAGATTT
GGAAATAGAAATAGCTTTAAACAATGCGGATGACTTTAAATTAATGGTGAAAGCTTTAGTGAAACTGGAAGATTCCGGAA
CTATTGTCCGCTCAAGGAAGAATCGGTATGCATTACCAGAAAAAATGGACTTAGTAAAAGGAACATTTCGTGCACATGAA
CGAGGTTTTGGCTTTGTTCTCCCAGAAGAGAAAGAAATGGACGATATTTTTATCCCGCCAAATGAAGTTAAAGATGCAAT
GAACGGTGATTTAGTTTTTGCAACAATCACGAAACGTAAAGGCGATAATTTGGCAGAAGGTACGATTAAGAAAATTGTCG
AACGGAAGACAACACAAATCGTCGGAACTTATATGGAAGACTTAGCTGGTACTCCAATTGTGATGCCAGATGACAAGCGA
CTTTTTGGTGAAGTGGAAATTGATTTAGAAGACGGCTTAAAACCAGTTGATGGGCATAAAGTTATTGTTGAATTGACGGA
ATATGCAACTGGGCATGCGCGTGCAAGAGGGGTTGTTAAATCAATCATCGGTCACCGTAATGATCCAGGAGTGGATATTT
TATCGATTATTCATAAACACGGTATTTCAATCGGGTTCCCGGAAGAAGTAATGGAGCAGGTAAGTAAAGCGCCGGATGTG
GTGGATGATTCGGATATTGGTAACCGTCGTGATCTTCGTGACCAAATGATTATTACAATTGACGGGGCAGACGCTAAGGA
TTTAGATGATGCTGTTACTGTTAAGCAACTACCGAATGGCAACTGGAAGCTAGGCGTTCATATTGCGGATGTAACGCATT
ATGTGACAGAAGGCTCGCCGCTTGATGTCGAAGCGCAAGAACGTGGAACGAGTGTTTATTTGGTTGACCGCGTAATTCCG
ATGTTGCCACATAAACTATCGAACGGAATTTGCTCGCTTAACCCACAAGTAGATCGTTTTACTATGAGTTGTGAAATGGA
AATCGATGAAGAAGGTCATGTGGTTAATCACGAAATTTTTGAAAGTATTATTAAAACAACAGAACGTATGACGTATACGG
ATGTAAATGATATTTTAGTTGAAAAGGACGAAGCTTTACGGGAAAAATATGCGCCAATTGTTCCAATGCTTGAAAAGATG
CAAGATTTGGCCGAAATACTTCGTCGTAAACGTGAAAAACGTGGCGCGATTGATTTTGACTTTAAAGAAGCACGTGTAGT
TGTTGATGAAGACGGTCATCCAGAAGCAGTCGTTATGCGCGAACGTTCAGCGGGAGAGCATTTGATTGAAGAATTTATGC
TTGCTGCCAATGAAACAGTTGCAGAGCATTTCCACTGGATGGATGTACCATTTATTTACCGTATCCATGAAGATCCAAAA
GAAGATAAATTAGCGCGGTTCTTTGAATTTATTACGAACTTTGGTTTGATTGTGAAGGGGACTGCTAACGATATTCACCC
AGCTGCTTTACAACAAGTACTAGAAGAAGTAAAAGGTAAACCAGAAGAGATGGTTGTTTCGACTGTTATGCTGCGTTCGA
TGCAACAAGCGAAGTATGACACAGTAAGCGCCGGACACTTTGGTTTGTCTACTGATTTTTATACACATTTCACGTCACCA
ATTCGTCGGTACCCGGACTTGATTGTTCACAGGTTGATTAGAGAGTATTTAATTAACGGGGATGTTCGTCCGGAAACGTT
AGAAAAACGCGCTGAGGAGCTTCCTGAGATTGCTGAACACAGCTCGAAAATGGAGCGCCGTGCCGTTGAAGCAGAGCGCG
AAACAGATGAACTGAAGAAAACGGAATTTATGGTCGACAAAGTGGGCGAACGTTTCATCGGAATCATTAGTTCGGTAACC
AATTTTGGCTTATTTATCGAACTTCCAACTACGATTGAAGGTTTAGTTCATGTGAGCGCAATGAAAGGCGATTACTTCAA
ATTCCACCAAAATCAATTAGCGATGATTGGCGAAAGAACAGGCCAAATTTATCGTATTGGTGATGAAGTGGAAGTCGAAG
TAACCAAAGTAGACGTGGATGCTCGTGAAATCGATTTTGCGCTTCGTAGTGAAGGTAAACCAGGTCCAGTGAGCGATAAA
CAAAAACGCCAACGCGAAAAACCGATTGATAAAACAAGAAATTTCAAGAGTAACCAGAAAAAAGGTCGTAACAAACGTAG
AGCTGGTAAATCAGAAGACGTGAAACCAAAATCAGAACGTAAAGAAGACGAATGGCATACAAAACCTAAAAAGAAAAAGA
AGAAAAAACCTTTTTATCAAGGTGTAGCAAAAGAAAGCCCGAAGAAGAAAAAACGTCGCTAG

Upstream 100 bases:

>100_bases
CAAAGAACGAAAAGAAGTAAATCAAGCCATTTTAACATTTTTAGATAGTTTAGATTGGCAAGAATAGACAATTTTTAAAA
CAGAGAGAGGAGGGACAGAA

Downstream 100 bases:

>100_bases
AAAGGATGGGGAGTTATGCCAAAAGGTGATGGTAAGCTAGTTGCGCAAAATAAAAAAGCGCGCCACGATTACGCAATTGA
AGAAACTTTTGAGGCTGGCA

Product: exoribonuclease RNase-R

Products: NA

Alternate protein names: RNase R; VacB protein homolog [H]

Number of amino acids: Translated: 793; Mature: 793

Protein sequence:

>793_residues
MEQKQMEEKIMNLLTSAPDKTFALEDLEIEIALNNADDFKLMVKALVKLEDSGTIVRSRKNRYALPEKMDLVKGTFRAHE
RGFGFVLPEEKEMDDIFIPPNEVKDAMNGDLVFATITKRKGDNLAEGTIKKIVERKTTQIVGTYMEDLAGTPIVMPDDKR
LFGEVEIDLEDGLKPVDGHKVIVELTEYATGHARARGVVKSIIGHRNDPGVDILSIIHKHGISIGFPEEVMEQVSKAPDV
VDDSDIGNRRDLRDQMIITIDGADAKDLDDAVTVKQLPNGNWKLGVHIADVTHYVTEGSPLDVEAQERGTSVYLVDRVIP
MLPHKLSNGICSLNPQVDRFTMSCEMEIDEEGHVVNHEIFESIIKTTERMTYTDVNDILVEKDEALREKYAPIVPMLEKM
QDLAEILRRKREKRGAIDFDFKEARVVVDEDGHPEAVVMRERSAGEHLIEEFMLAANETVAEHFHWMDVPFIYRIHEDPK
EDKLARFFEFITNFGLIVKGTANDIHPAALQQVLEEVKGKPEEMVVSTVMLRSMQQAKYDTVSAGHFGLSTDFYTHFTSP
IRRYPDLIVHRLIREYLINGDVRPETLEKRAEELPEIAEHSSKMERRAVEAERETDELKKTEFMVDKVGERFIGIISSVT
NFGLFIELPTTIEGLVHVSAMKGDYFKFHQNQLAMIGERTGQIYRIGDEVEVEVTKVDVDAREIDFALRSEGKPGPVSDK
QKRQREKPIDKTRNFKSNQKKGRNKRRAGKSEDVKPKSERKEDEWHTKPKKKKKKKPFYQGVAKESPKKKKRR

Sequences:

>Translated_793_residues
MEQKQMEEKIMNLLTSAPDKTFALEDLEIEIALNNADDFKLMVKALVKLEDSGTIVRSRKNRYALPEKMDLVKGTFRAHE
RGFGFVLPEEKEMDDIFIPPNEVKDAMNGDLVFATITKRKGDNLAEGTIKKIVERKTTQIVGTYMEDLAGTPIVMPDDKR
LFGEVEIDLEDGLKPVDGHKVIVELTEYATGHARARGVVKSIIGHRNDPGVDILSIIHKHGISIGFPEEVMEQVSKAPDV
VDDSDIGNRRDLRDQMIITIDGADAKDLDDAVTVKQLPNGNWKLGVHIADVTHYVTEGSPLDVEAQERGTSVYLVDRVIP
MLPHKLSNGICSLNPQVDRFTMSCEMEIDEEGHVVNHEIFESIIKTTERMTYTDVNDILVEKDEALREKYAPIVPMLEKM
QDLAEILRRKREKRGAIDFDFKEARVVVDEDGHPEAVVMRERSAGEHLIEEFMLAANETVAEHFHWMDVPFIYRIHEDPK
EDKLARFFEFITNFGLIVKGTANDIHPAALQQVLEEVKGKPEEMVVSTVMLRSMQQAKYDTVSAGHFGLSTDFYTHFTSP
IRRYPDLIVHRLIREYLINGDVRPETLEKRAEELPEIAEHSSKMERRAVEAERETDELKKTEFMVDKVGERFIGIISSVT
NFGLFIELPTTIEGLVHVSAMKGDYFKFHQNQLAMIGERTGQIYRIGDEVEVEVTKVDVDAREIDFALRSEGKPGPVSDK
QKRQREKPIDKTRNFKSNQKKGRNKRRAGKSEDVKPKSERKEDEWHTKPKKKKKKKPFYQGVAKESPKKKKRR
>Mature_793_residues
MEQKQMEEKIMNLLTSAPDKTFALEDLEIEIALNNADDFKLMVKALVKLEDSGTIVRSRKNRYALPEKMDLVKGTFRAHE
RGFGFVLPEEKEMDDIFIPPNEVKDAMNGDLVFATITKRKGDNLAEGTIKKIVERKTTQIVGTYMEDLAGTPIVMPDDKR
LFGEVEIDLEDGLKPVDGHKVIVELTEYATGHARARGVVKSIIGHRNDPGVDILSIIHKHGISIGFPEEVMEQVSKAPDV
VDDSDIGNRRDLRDQMIITIDGADAKDLDDAVTVKQLPNGNWKLGVHIADVTHYVTEGSPLDVEAQERGTSVYLVDRVIP
MLPHKLSNGICSLNPQVDRFTMSCEMEIDEEGHVVNHEIFESIIKTTERMTYTDVNDILVEKDEALREKYAPIVPMLEKM
QDLAEILRRKREKRGAIDFDFKEARVVVDEDGHPEAVVMRERSAGEHLIEEFMLAANETVAEHFHWMDVPFIYRIHEDPK
EDKLARFFEFITNFGLIVKGTANDIHPAALQQVLEEVKGKPEEMVVSTVMLRSMQQAKYDTVSAGHFGLSTDFYTHFTSP
IRRYPDLIVHRLIREYLINGDVRPETLEKRAEELPEIAEHSSKMERRAVEAERETDELKKTEFMVDKVGERFIGIISSVT
NFGLFIELPTTIEGLVHVSAMKGDYFKFHQNQLAMIGERTGQIYRIGDEVEVEVTKVDVDAREIDFALRSEGKPGPVSDK
QKRQREKPIDKTRNFKSNQKKGRNKRRAGKSEDVKPKSERKEDEWHTKPKKKKKKKPFYQGVAKESPKKKKRR

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI134288890, Length=439, Percent_Identity=33.0296127562642, Blast_Score=218, Evalue=2e-56,
Organism=Homo sapiens, GI190014623, Length=430, Percent_Identity=31.1627906976744, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI190014625, Length=430, Percent_Identity=31.1627906976744, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI19115966, Length=537, Percent_Identity=27.56052141527, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI219521928, Length=537, Percent_Identity=27.56052141527, Blast_Score=181, Evalue=3e-45,
Organism=Homo sapiens, GI156105695, Length=144, Percent_Identity=30.5555555555556, Blast_Score=75, Evalue=3e-13,
Organism=Homo sapiens, GI156105693, Length=144, Percent_Identity=30.5555555555556, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI87082383, Length=748, Percent_Identity=37.8342245989305, Blast_Score=496, Evalue=1e-141,
Organism=Escherichia coli, GI1787542, Length=648, Percent_Identity=27.0061728395062, Blast_Score=166, Evalue=8e-42,
Organism=Caenorhabditis elegans, GI17553506, Length=535, Percent_Identity=29.9065420560748, Blast_Score=204, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI212645896, Length=446, Percent_Identity=30.9417040358744, Blast_Score=183, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6324552, Length=557, Percent_Identity=29.802513464991, Blast_Score=204, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6320499, Length=318, Percent_Identity=26.4150943396226, Blast_Score=92, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6323943, Length=358, Percent_Identity=25.1396648044693, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24649634, Length=508, Percent_Identity=32.4803149606299, Blast_Score=224, Evalue=3e-58,
Organism=Drosophila melanogaster, GI24654592, Length=376, Percent_Identity=30.3191489361702, Blast_Score=174, Evalue=2e-43,
Organism=Drosophila melanogaster, GI19922976, Length=376, Percent_Identity=30.3191489361702, Blast_Score=174, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24654597, Length=376, Percent_Identity=30.3191489361702, Blast_Score=174, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805 [H]

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 90552; Mature: 90552

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQKQMEEKIMNLLTSAPDKTFALEDLEIEIALNNADDFKLMVKALVKLEDSGTIVRSRK
CCHHHHHHHHHHHHHCCCCCEEEEECEEEEEEECCCCHHHHHHHHHHHHCCCCCEEECCC
NRYALPEKMDLVKGTFRAHERGFGFVLPEEKEMDDIFIPPNEVKDAMNGDLVFATITKRK
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCHHHHHHCCCCEEEEEEECCC
GDNLAEGTIKKIVERKTTQIVGTYMEDLAGTPIVMPDDKRLFGEVEIDLEDGLKPVDGHK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCEEEEEEEEHHCCCCCCCCCE
VIVELTEYATGHARARGVVKSIIGHRNDPGVDILSIIHKHGISIGFPEEVMEQVSKAPDV
EEEEHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCC
VDDSDIGNRRDLRDQMIITIDGADAKDLDDAVTVKQLPNGNWKLGVHIADVTHYVTEGSP
CCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHCCCCCEEEEEEEEHHHHHHCCCCC
LDVEAQERGTSVYLVDRVIPMLPHKLSNGICSLNPQVDRFTMSCEMEIDEEGHVVNHEIF
CCCCHHHCCCEEEEHHHHHHHCCHHHCCCEEECCCCCCEEEEEEEEEECCCCCEECHHHH
ESIIKTTERMTYTDVNDILVEKDEALREKYAPIVPMLEKMQDLAEILRRKREKRGAIDFD
HHHHHHHHCCEECCHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
FKEARVVVDEDGHPEAVVMRERSAGEHLIEEFMLAANETVAEHFHWMDVPFIYRIHEDPK
CCCCEEEECCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
EDKLARFFEFITNFGLIVKGTANDIHPAALQQVLEEVKGKPEEMVVSTVMLRSMQQAKYD
HHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCC
TVSAGHFGLSTDFYTHFTSPIRRYPDLIVHRLIREYLINGDVRPETLEKRAEELPEIAEH
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
SSKMERRAVEAERETDELKKTEFMVDKVGERFIGIISSVTNFGLFIELPTTIEGLVHVSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHH
MKGDYFKFHQNQLAMIGERTGQIYRIGDEVEVEVTKVDVDAREIDFALRSEGKPGPVSDK
HCCCHHHHHCCHHHHHHCCCCCEEEECCCEEEEEEEEECCHHHHHHHHHCCCCCCCCCHH
QKRQREKPIDKTRNFKSNQKKGRNKRRAGKSEDVKPKSERKEDEWHTKPKKKKKKKPFYQ
HHHHHCCCHHHHHCCCCHHHHCCHHHCCCCCCCCCCCHHCCCHHHCCCCHHHHHCCCHHH
GVAKESPKKKKRR
HHHHCCCHHHCCC
>Mature Secondary Structure
MEQKQMEEKIMNLLTSAPDKTFALEDLEIEIALNNADDFKLMVKALVKLEDSGTIVRSRK
CCHHHHHHHHHHHHHCCCCCEEEEECEEEEEEECCCCHHHHHHHHHHHHCCCCCEEECCC
NRYALPEKMDLVKGTFRAHERGFGFVLPEEKEMDDIFIPPNEVKDAMNGDLVFATITKRK
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCHHHHHHCCCCEEEEEEECCC
GDNLAEGTIKKIVERKTTQIVGTYMEDLAGTPIVMPDDKRLFGEVEIDLEDGLKPVDGHK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCEEEEEEEEHHCCCCCCCCCE
VIVELTEYATGHARARGVVKSIIGHRNDPGVDILSIIHKHGISIGFPEEVMEQVSKAPDV
EEEEHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCC
VDDSDIGNRRDLRDQMIITIDGADAKDLDDAVTVKQLPNGNWKLGVHIADVTHYVTEGSP
CCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHCCCCCEEEEEEEEHHHHHHCCCCC
LDVEAQERGTSVYLVDRVIPMLPHKLSNGICSLNPQVDRFTMSCEMEIDEEGHVVNHEIF
CCCCHHHCCCEEEEHHHHHHHCCHHHCCCEEECCCCCCEEEEEEEEEECCCCCEECHHHH
ESIIKTTERMTYTDVNDILVEKDEALREKYAPIVPMLEKMQDLAEILRRKREKRGAIDFD
HHHHHHHHCCEECCHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
FKEARVVVDEDGHPEAVVMRERSAGEHLIEEFMLAANETVAEHFHWMDVPFIYRIHEDPK
CCCCEEEECCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
EDKLARFFEFITNFGLIVKGTANDIHPAALQQVLEEVKGKPEEMVVSTVMLRSMQQAKYD
HHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCC
TVSAGHFGLSTDFYTHFTSPIRRYPDLIVHRLIREYLINGDVRPETLEKRAEELPEIAEH
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
SSKMERRAVEAERETDELKKTEFMVDKVGERFIGIISSVTNFGLFIELPTTIEGLVHVSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHH
MKGDYFKFHQNQLAMIGERTGQIYRIGDEVEVEVTKVDVDAREIDFALRSEGKPGPVSDK
HCCCHHHHHCCHHHHHHCCCCCEEEECCCEEEEEEEEECCHHHHHHHHHCCCCCCCCCHH
QKRQREKPIDKTRNFKSNQKKGRNKRRAGKSEDVKPKSERKEDEWHTKPKKKKKKKPFYQ
HHHHHCCCHHHHHCCCCHHHHCCHHHCCCCCCCCCCCHHCCCHHHCCCCHHHHHCCCHHH
GVAKESPKKKKRR
HHHHCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]