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The map label for this gene is vanR [H]

Identifier: 226224969

GI number: 226224969

Start: 2464137

End: 2464832

Strand: Reverse

Name: vanR [H]

Synonym: Lm4b_02390

Alternate gene names: 226224969

Gene position: 2464832-2464137 (Counterclockwise)

Preceding gene: 226224970

Following gene: 226224968

Centisome position: 84.62

GC content: 38.07

Gene sequence:

>696_bases
ATGACAACTTCTATTTTAATTGCTGATGATGACAAAGAAATTGTTGATTTAGTAAAATTATATTTACAAAATGAAGGATA
TACGATTTATCAAGCTTATGATGGTGCTGAAGTATGGCGTTTAGTTCAAGAAAAACAGCCAACTTTAGTGATACTAGATA
TTATGATGCCTGAAATGAACGGCTTAGAAGTATGCCGATTAATGAGAGATAATGGGATTTTGACTCCCATCCTAATGCTT
AGTGCCAAGGCTGAAGACAACGACAAAATCATGGGTCTTTTAACAGGTGCGGACGATTATATGGTCAAGCCATTCAATCC
ATTAGAGCTTTCTGTACGCGTGAAAGCTATTCTAAGAAGAATGCAGCAAATGAGCCAGGCAGAGCCTGTTAGTCAAGATA
AAGTCATCATTGGGCCGATAGTAGTTGACCGTGGCCTTCACGTTGTAACTGTTAGTGGCAAAGAACTTCATTTAACGACT
TCTGAGTTTGATATTCTATTTTTACTAGCGAGTGAGCCAGGGCGCGTTTTTAGTTCAGAATATATTTTTGAGAAGATTTG
GCAAGAAAAGGCCCTTGGAGCGAGTAAGACAGTAATGGTCCATATTAGTAATTTGCGTGATAAGTTACGCGAGGCTATGG
GTGGAGAAAATGTGATTAAGACTATTTGGGGAGTAGGGTACAAAATTGAAATCTAA

Upstream 100 bases:

>100_bases
AAGAACGGGTTCTTACCAGAATTTAATCCGAGCTCTTTCTATTCGATTTGTTGCTAAAGTGTTACAATAGGTAGAAATAA
GACTGGAAAGGACAATGAGT

Downstream 100 bases:

>100_bases
ACTGGAACTGTTGTTTACGAAAATTAGCCATGTGATGAATGTTTGGCAGGCGACTTTTTTTGCAGCTGTTTCTTGGATTT
TGGCGTTGATTAGCATCCAA

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 231; Mature: 230

Protein sequence:

>231_residues
MTTSILIADDDKEIVDLVKLYLQNEGYTIYQAYDGAEVWRLVQEKQPTLVILDIMMPEMNGLEVCRLMRDNGILTPILML
SAKAEDNDKIMGLLTGADDYMVKPFNPLELSVRVKAILRRMQQMSQAEPVSQDKVIIGPIVVDRGLHVVTVSGKELHLTT
SEFDILFLLASEPGRVFSSEYIFEKIWQEKALGASKTVMVHISNLRDKLREAMGGENVIKTIWGVGYKIEI

Sequences:

>Translated_231_residues
MTTSILIADDDKEIVDLVKLYLQNEGYTIYQAYDGAEVWRLVQEKQPTLVILDIMMPEMNGLEVCRLMRDNGILTPILML
SAKAEDNDKIMGLLTGADDYMVKPFNPLELSVRVKAILRRMQQMSQAEPVSQDKVIIGPIVVDRGLHVVTVSGKELHLTT
SEFDILFLLASEPGRVFSSEYIFEKIWQEKALGASKTVMVHISNLRDKLREAMGGENVIKTIWGVGYKIEI
>Mature_230_residues
TTSILIADDDKEIVDLVKLYLQNEGYTIYQAYDGAEVWRLVQEKQPTLVILDIMMPEMNGLEVCRLMRDNGILTPILMLS
AKAEDNDKIMGLLTGADDYMVKPFNPLELSVRVKAILRRMQQMSQAEPVSQDKVIIGPIVVDRGLHVVTVSGKELHLTTS
EFDILFLLASEPGRVFSSEYIFEKIWQEKALGASKTVMVHISNLRDKLREAMGGENVIKTIWGVGYKIEI

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788394, Length=229, Percent_Identity=37.117903930131, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1789809, Length=224, Percent_Identity=33.0357142857143, Blast_Score=137, Evalue=6e-34,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=35.2422907488987, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1786599, Length=231, Percent_Identity=31.1688311688312, Blast_Score=134, Evalue=4e-33,
Organism=Escherichia coli, GI1790860, Length=226, Percent_Identity=32.3008849557522, Blast_Score=133, Evalue=8e-33,
Organism=Escherichia coli, GI1786911, Length=227, Percent_Identity=29.5154185022026, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI1789402, Length=227, Percent_Identity=33.0396475770925, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1790552, Length=227, Percent_Identity=33.920704845815, Blast_Score=117, Evalue=5e-28,
Organism=Escherichia coli, GI1790863, Length=234, Percent_Identity=29.4871794871795, Blast_Score=114, Evalue=5e-27,
Organism=Escherichia coli, GI87082012, Length=225, Percent_Identity=32.8888888888889, Blast_Score=110, Evalue=9e-26,
Organism=Escherichia coli, GI1786784, Length=227, Percent_Identity=30.8370044052863, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=30.1310043668122, Blast_Score=107, Evalue=7e-25,
Organism=Escherichia coli, GI1787375, Length=227, Percent_Identity=28.6343612334802, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI145693140, Length=230, Percent_Identity=27.8260869565217, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1788550, Length=122, Percent_Identity=31.9672131147541, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1788713, Length=126, Percent_Identity=34.9206349206349, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787487, Length=105, Percent_Identity=34.2857142857143, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26074; Mature: 25943

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTSILIADDDKEIVDLVKLYLQNEGYTIYQAYDGAEVWRLVQEKQPTLVILDIMMPEMN
CCEEEEEECCCHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCCCEEEEEEECCCCC
GLEVCRLMRDNGILTPILMLSAKAEDNDKIMGLLTGADDYMVKPFNPLELSVRVKAILRR
HHHHHHHHHCCCCCCEEHEEECCCCCCCEEEEEEECCCCCEECCCCCCCHHHHHHHHHHH
MQQMSQAEPVSQDKVIIGPIVVDRGLHVVTVSGKELHLTTSEFDILFLLASEPGRVFSSE
HHHHHHCCCCCCCCEEEEEEEECCCEEEEEECCCEEEEEECCCEEEEEEECCCCCHHHHH
YIFEKIWQEKALGASKTVMVHISNLRDKLREAMGGENVIKTIWGVGYKIEI
HHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHCCCHHHHHHHCCCEEEEC
>Mature Secondary Structure 
TTSILIADDDKEIVDLVKLYLQNEGYTIYQAYDGAEVWRLVQEKQPTLVILDIMMPEMN
CEEEEEECCCHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCCCEEEEEEECCCCC
GLEVCRLMRDNGILTPILMLSAKAEDNDKIMGLLTGADDYMVKPFNPLELSVRVKAILRR
HHHHHHHHHCCCCCCEEHEEECCCCCCCEEEEEEECCCCCEECCCCCCCHHHHHHHHHHH
MQQMSQAEPVSQDKVIIGPIVVDRGLHVVTVSGKELHLTTSEFDILFLLASEPGRVFSSE
HHHHHHCCCCCCCCEEEEEEEECCCEEEEEECCCEEEEEECCCEEEEEEECCCCCHHHHH
YIFEKIWQEKALGASKTVMVHISNLRDKLREAMGGENVIKTIWGVGYKIEI
HHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHCCCHHHHHHHCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8380148; 1556077; 1320585 [H]