Click here to switch to the map view.

The map label for this gene is aroE [H]

Identifier: 226224844

GI number: 226224844

Start: 2333405

End: 2334274

Strand: Direct

Name: aroE [H]

Synonym: Lm4b_02263

Alternate gene names: 226224844

Gene position: 2333405-2334274 (Clockwise)

Preceding gene: 226224843

Following gene: 226224845

Centisome position: 80.11

GC content: 39.08

Gene sequence:

>870_bases
ATGGAAAATAGAATTTCAGGAACGACTAGGCTTCTTGGCTTAATTGGGACACCCGTAGACCATTCAAAATCTCCAATCAT
GTATAATTACAGTTTTCAAAAAGCGGGGTTGGATTATGCTTACCTAGCTTTTGACACACCTATTGAAAAAGTTGCTGATA
CTATAAAAGCAATCAAGACATTTAATCTGCGTGGCGCAAACGTGACCATGCCTTGTAAAAGTGAAGTTTTAAAACACATG
GATGACCTTTCCCCTGCTGCTCGGATGATTGGCGCTGTTAACACTATCGTAAATGAAGACGGGAAGCTAACTGGGCATAT
AACAGATGGCCTTGGTTTTATTGCAAATTTACGAGATGCTAGTGTAGATGTCACCGGCAAAAAAATGACTATAATTGGTG
CTGGTGGTGCAGCTACAGCAATCCAAGTCCAGTGTGCACTTGATGGGGCCAAGGAAATCACCATTTTTAATATTAAAGAC
GCTTTTTATGACAAAGCAAAACAAACTGCTGCTTCCATTAAACAAGAAGTGCCAAATTGCATCGTACATATTTATGATTT
GAACGATACAGAAAAACTAAATGCGGAAATTGCCACTAGCGATATCCTTGTTAATGCGACACTCGTTGGCATGCATCCGA
ATGAACACGAAACACCTATTAGCGATACATCCGTTTTTAGAAAAGAACTTATCGTTGCAGATATTATTTATAACCCTAAA
AAAACGCAACTTCTACTAGATGCTGAAGCTGCTGGTTGTAAGACTGTAGGCGGGTTAGGAATGCTTTTGTGGCAAGGCGC
TGAAGCATACAAATTGTTTACTGGTAAAGATATGCCAGTTTCAGAAGTAAAGAATCTATATTTCAACTAA

Upstream 100 bases:

>100_bases
GATGCAACAAAAGAAGCACTAGACGCTGTATTACAATTATAATTTATCATTCTACTCGCTGTAATGTGCAGCGAGTAGGA
TTCATTCGGAGGAAAACAAA

Downstream 100 bases:

>100_bases
TAAATTCATCAGGATTTCGAGAGGAGAAAAAAATGAACGCAAAAAGATTTTATCCAACAGCAATAGCACTTTATTTTACT
TATTTTATTCACGGTATTGG

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MENRISGTTRLLGLIGTPVDHSKSPIMYNYSFQKAGLDYAYLAFDTPIEKVADTIKAIKTFNLRGANVTMPCKSEVLKHM
DDLSPAARMIGAVNTIVNEDGKLTGHITDGLGFIANLRDASVDVTGKKMTIIGAGGAATAIQVQCALDGAKEITIFNIKD
AFYDKAKQTAASIKQEVPNCIVHIYDLNDTEKLNAEIATSDILVNATLVGMHPNEHETPISDTSVFRKELIVADIIYNPK
KTQLLLDAEAAGCKTVGGLGMLLWQGAEAYKLFTGKDMPVSEVKNLYFN

Sequences:

>Translated_289_residues
MENRISGTTRLLGLIGTPVDHSKSPIMYNYSFQKAGLDYAYLAFDTPIEKVADTIKAIKTFNLRGANVTMPCKSEVLKHM
DDLSPAARMIGAVNTIVNEDGKLTGHITDGLGFIANLRDASVDVTGKKMTIIGAGGAATAIQVQCALDGAKEITIFNIKD
AFYDKAKQTAASIKQEVPNCIVHIYDLNDTEKLNAEIATSDILVNATLVGMHPNEHETPISDTSVFRKELIVADIIYNPK
KTQLLLDAEAAGCKTVGGLGMLLWQGAEAYKLFTGKDMPVSEVKNLYFN
>Mature_289_residues
MENRISGTTRLLGLIGTPVDHSKSPIMYNYSFQKAGLDYAYLAFDTPIEKVADTIKAIKTFNLRGANVTMPCKSEVLKHM
DDLSPAARMIGAVNTIVNEDGKLTGHITDGLGFIANLRDASVDVTGKKMTIIGAGGAATAIQVQCALDGAKEITIFNIKD
AFYDKAKQTAASIKQEVPNCIVHIYDLNDTEKLNAEIATSDILVNATLVGMHPNEHETPISDTSVFRKELIVADIIYNPK
KTQLLLDAEAAGCKTVGGLGMLLWQGAEAYKLFTGKDMPVSEVKNLYFN

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1787983, Length=282, Percent_Identity=43.6170212765958, Blast_Score=261, Evalue=3e-71,
Organism=Escherichia coli, GI1789675, Length=265, Percent_Identity=30.5660377358491, Blast_Score=113, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6320332, Length=293, Percent_Identity=26.962457337884, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151 [H]

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N [H]

EC number: =1.1.1.25 [H]

Molecular weight: Translated: 31302; Mature: 31302

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENRISGTTRLLGLIGTPVDHSKSPIMYNYSFQKAGLDYAYLAFDTPIEKVADTIKAIKT
CCCCCCHHHHHHHHHCCCCCCCCCCEEEEEEHHHCCCCEEEEEECCCHHHHHHHHHHHHH
FNLRGANVTMPCKSEVLKHMDDLSPAARMIGAVNTIVNEDGKLTGHITDGLGFIANLRDA
CCCCCCEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHCCCCC
SVDVTGKKMTIIGAGGAATAIQVQCALDGAKEITIFNIKDAFYDKAKQTAASIKQEVPNC
CEEECCCEEEEEECCCCCEEEEEEEEECCCCEEEEEEEHHHHHHHHHHHHHHHHHHCCCE
IVHIYDLNDTEKLNAEIATSDILVNATLVGMHPNEHETPISDTSVFRKELIVADIIYNPK
EEEEEECCCCHHCCCEEEECEEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHEEEEECCC
KTQLLLDAEAAGCKTVGGLGMLLWQGAEAYKLFTGKDMPVSEVKNLYFN
CCEEEEECCCCCCCHHCCCHHEEECCCCEEEEECCCCCCHHHHHHHCCC
>Mature Secondary Structure
MENRISGTTRLLGLIGTPVDHSKSPIMYNYSFQKAGLDYAYLAFDTPIEKVADTIKAIKT
CCCCCCHHHHHHHHHCCCCCCCCCCEEEEEEHHHCCCCEEEEEECCCHHHHHHHHHHHHH
FNLRGANVTMPCKSEVLKHMDDLSPAARMIGAVNTIVNEDGKLTGHITDGLGFIANLRDA
CCCCCCEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHCCCCC
SVDVTGKKMTIIGAGGAATAIQVQCALDGAKEITIFNIKDAFYDKAKQTAASIKQEVPNC
CEEECCCEEEEEECCCCCEEEEEEEEECCCCEEEEEEEHHHHHHHHHHHHHHHHHHCCCE
IVHIYDLNDTEKLNAEIATSDILVNATLVGMHPNEHETPISDTSVFRKELIVADIIYNPK
EEEEEECCCCHHCCCEEEECEEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHEEEEECCC
KTQLLLDAEAAGCKTVGGLGMLLWQGAEAYKLFTGKDMPVSEVKNLYFN
CCEEEEECCCCCCCHHCCCHHEEECCCCEEEEECCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]