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The map label for this gene is gpmA [H]

Identifier: 226224813

GI number: 226224813

Start: 2299719

End: 2300408

Strand: Reverse

Name: gpmA [H]

Synonym: Lm4b_02232

Alternate gene names: 226224813

Gene position: 2300408-2299719 (Counterclockwise)

Preceding gene: 226224814

Following gene: 226224811

Centisome position: 78.98

GC content: 38.26

Gene sequence:

>690_bases
ATGAAATTAGTATTAATTCGTCATGGTCAAAGTGAATGGAACAAATTGAATTTATTTACAGGTTGGCATGATGTTGACTT
GTCACAAGAAGGCGTTGTAGAAGCAATGACTGCAGGAAAAAGAATTAAAGAAGCGGGCTTAGAATTCGATGTTGCCTTCA
CTTCTGTTTTAACGCGAGCTATTAAAACACTTAATTATGTGTTAGAAGAATCTGACCAAATGTGGGTACCAGTTCATAAA
TCTTGGCGCTTGAACGAACGGCATTATGGCGCACTTCAAGGTCTTAACAAACAAGAAACTGCTGAAAAATATGGTGCTGA
CCAAGTACAAAAATGGCGCAGAAGCTATGACACTCTTCCACCGTTATTAGAAGAAAACGACGAAAGACAAGCCAAAAATG
ATCGCCGTTATCAACTCCTTGATACACACGCTATTCCGGCAGGTGAAAACTTGAAAGTAACATTAGAACGCGTTATTCCT
TATTGGATGGACACGATTGCTCCAGAAATTAAAGAAGGACGGCGAGTAGTCATCGCGGCGCATGGTAACAGTTTACGAGC
ATTAGTGAAATTTCTAGAAGGTATTGGCGATGATGAAATAATGGATTTAGAAATTCCGACAGGCGTGCCACTAGTATATG
AATTAAACGATGATTTAAAACCAGTAAATAAATATTACTTGGATAAATAA

Upstream 100 bases:

>100_bases
CACAGAATAACATAGAAAAGGTTTGACACCTCGCTTGAAAGGGAAAACTTTGGTTGGATTAGTCGTTTAGAAAATAGACG
AAAATGGAAGGATGAGGAAG

Downstream 100 bases:

>100_bases
AAAAGAAGCTCTTTCCAATATATTGGAAAGAGCTTCTTTTTTTGAACTGCACCTGAAAAGTCAGTTCTCGCTATCAGAAA
GTTGGATGTTTACTTAAAGT

Product: phosphoglyceromutase 1

Products: NA

Alternate protein names: BPG-dependent PGAM; PGAM; Phosphoglyceromutase; dPGM [H]

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MKLVLIRHGQSEWNKLNLFTGWHDVDLSQEGVVEAMTAGKRIKEAGLEFDVAFTSVLTRAIKTLNYVLEESDQMWVPVHK
SWRLNERHYGALQGLNKQETAEKYGADQVQKWRRSYDTLPPLLEENDERQAKNDRRYQLLDTHAIPAGENLKVTLERVIP
YWMDTIAPEIKEGRRVVIAAHGNSLRALVKFLEGIGDDEIMDLEIPTGVPLVYELNDDLKPVNKYYLDK

Sequences:

>Translated_229_residues
MKLVLIRHGQSEWNKLNLFTGWHDVDLSQEGVVEAMTAGKRIKEAGLEFDVAFTSVLTRAIKTLNYVLEESDQMWVPVHK
SWRLNERHYGALQGLNKQETAEKYGADQVQKWRRSYDTLPPLLEENDERQAKNDRRYQLLDTHAIPAGENLKVTLERVIP
YWMDTIAPEIKEGRRVVIAAHGNSLRALVKFLEGIGDDEIMDLEIPTGVPLVYELNDDLKPVNKYYLDK
>Mature_229_residues
MKLVLIRHGQSEWNKLNLFTGWHDVDLSQEGVVEAMTAGKRIKEAGLEFDVAFTSVLTRAIKTLNYVLEESDQMWVPVHK
SWRLNERHYGALQGLNKQETAEKYGADQVQKWRRSYDTLPPLLEENDERQAKNDRRYQLLDTHAIPAGENLKVTLERVIP
YWMDTIAPEIKEGRRVVIAAHGNSLRALVKFLEGIGDDEIMDLEIPTGVPLVYELNDDLKPVNKYYLDK

Specific function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate [H]

COG id: COG0588

COG function: function code G; Phosphoglycerate mutase 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily [H]

Homologues:

Organism=Homo sapiens, GI50593010, Length=223, Percent_Identity=53.3632286995516, Blast_Score=258, Evalue=3e-69,
Organism=Homo sapiens, GI4505753, Length=223, Percent_Identity=55.6053811659193, Blast_Score=250, Evalue=8e-67,
Organism=Homo sapiens, GI4502445, Length=228, Percent_Identity=49.5614035087719, Blast_Score=236, Evalue=1e-62,
Organism=Homo sapiens, GI40353764, Length=228, Percent_Identity=49.5614035087719, Blast_Score=236, Evalue=1e-62,
Organism=Homo sapiens, GI71274132, Length=223, Percent_Identity=52.4663677130045, Blast_Score=235, Evalue=3e-62,
Organism=Homo sapiens, GI310129614, Length=164, Percent_Identity=53.6585365853659, Blast_Score=165, Evalue=3e-41,
Organism=Escherichia coli, GI1786970, Length=226, Percent_Identity=61.5044247787611, Blast_Score=295, Evalue=1e-81,
Organism=Saccharomyces cerevisiae, GI6322697, Length=228, Percent_Identity=53.0701754385965, Blast_Score=254, Evalue=7e-69,
Organism=Saccharomyces cerevisiae, GI6320183, Length=283, Percent_Identity=33.5689045936396, Blast_Score=137, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6324516, Length=278, Percent_Identity=32.0143884892086, Blast_Score=136, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6324857, Length=104, Percent_Identity=34.6153846153846, Blast_Score=63, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24646216, Length=224, Percent_Identity=54.9107142857143, Blast_Score=258, Evalue=2e-69,
Organism=Drosophila melanogaster, GI85725270, Length=224, Percent_Identity=54.9107142857143, Blast_Score=250, Evalue=5e-67,
Organism=Drosophila melanogaster, GI85725272, Length=224, Percent_Identity=54.9107142857143, Blast_Score=250, Evalue=5e-67,
Organism=Drosophila melanogaster, GI24650981, Length=224, Percent_Identity=54.9107142857143, Blast_Score=250, Evalue=5e-67,
Organism=Drosophila melanogaster, GI28571815, Length=228, Percent_Identity=40.7894736842105, Blast_Score=175, Evalue=3e-44,
Organism=Drosophila melanogaster, GI28571817, Length=228, Percent_Identity=40.7894736842105, Blast_Score=174, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24648979, Length=228, Percent_Identity=40.7894736842105, Blast_Score=174, Evalue=4e-44,

Paralogues:

None

Copy number: 960 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013078
- InterPro:   IPR001345
- InterPro:   IPR005952 [H]

Pfam domain/function: PF00300 PGAM [H]

EC number: =5.4.2.1 [H]

Molecular weight: Translated: 26415; Mature: 26415

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS00175 PG_MUTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLVLIRHGQSEWNKLNLFTGWHDVDLSQEGVVEAMTAGKRIKEAGLEFDVAFTSVLTRA
CEEEEEECCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
IKTLNYVLEESDQMWVPVHKSWRLNERHYGALQGLNKQETAEKYGADQVQKWRRSYDTLP
HHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHCCCCHHHHHHHHCHHHHHHHHHHHCCCC
PLLEENDERQAKNDRRYQLLDTHAIPAGENLKVTLERVIPYWMDTIAPEIKEGRRVVIAA
CHHCCCCHHHHHCCCCEEEEECCCCCCCCCCEEEHHHHHHHHHHHHCHHHHCCCEEEEEE
HGNSLRALVKFLEGIGDDEIMDLEIPTGVPLVYELNDDLKPVNKYYLDK
CCCHHHHHHHHHHCCCCCCEEEEECCCCCEEEEECCCCCCHHHHHHCCC
>Mature Secondary Structure
MKLVLIRHGQSEWNKLNLFTGWHDVDLSQEGVVEAMTAGKRIKEAGLEFDVAFTSVLTRA
CEEEEEECCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
IKTLNYVLEESDQMWVPVHKSWRLNERHYGALQGLNKQETAEKYGADQVQKWRRSYDTLP
HHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHCCCCHHHHHHHHCHHHHHHHHHHHCCCC
PLLEENDERQAKNDRRYQLLDTHAIPAGENLKVTLERVIPYWMDTIAPEIKEGRRVVIAA
CHHCCCCHHHHHCCCCEEEEECCCCCCCCCCEEEHHHHHHHHHHHHCHHHHCCCEEEEEE
HGNSLRALVKFLEGIGDDEIMDLEIPTGVPLVYELNDDLKPVNKYYLDK
CCCHHHHHHHHHHCCCCCCEEEEECCCCCEEEEECCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]