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The map label for this gene is manA [H]

Identifier: 226224750

GI number: 226224750

Start: 2228471

End: 2230213

Strand: Direct

Name: manA [H]

Synonym: Lm4b_02168

Alternate gene names: 226224750

Gene position: 2228471-2230213 (Clockwise)

Preceding gene: 226224748

Following gene: 226224754

Centisome position: 76.51

GC content: 40.68

Gene sequence:

>1743_bases
TTGACCACGTACGATTTAGCACCCGAAGTGAAAATCCACCAATTTGATGGTGCTTGGGCGGGTTACAAAGATATTGCTAC
AGAACTAAGAACGGCTATTCAAAAAAAGAAGCAAGACCAAACTATCGTTGCGATTGAATGTTACCCCGGAACACGAAATG
AAGAAATTGCTGCCGAACTACTTCCATTATTACCAGTCGAAAAAGTGGTTTTTGCAGATGATTGGGCATTAAACAATGAA
GAAGTAACAGCTACAATCCAATCTCACTTAACAGATGACCGGGTGTTCGGAATTATGTCCCACTATGAAGTGAGCGACTT
TTATCCAGCAGAAAAACTTGCTGAAATTCAAGCGGAAATTGCTGCTACTAAAGGGTTAGTTGTGGTTTACGGGACTGGCG
CAACTGTTATAGCACCAACACCAGACATTCTTATTTATGCTGATTTAGCTCGATGGGAGATTCAGTGCCGCTACCGCGGA
GAAAATAAACCTAACTGGAAAGCAGACAATGCCGGTGAAGATGCGCTTCGTAAGTTCAAGCGTGGTTATTTCTTCGAGTG
GCGCATGGCTGATCGGCAAAAGAAAAAGCTTTATCAACAAGTAGATTTCTTACTTGATACCAATAAAAAAAATGAGCCAA
AAATGGTGCGCGGAGAAGATTATCGAAATGGCTTGAATCAAGTTTCCAAAGCCCCTTTTAGAGTAGTTCCTTACTTTGAT
GCAAGTGTATGGGGAGGTCAGTGGATGAAGAATAACTTTGGGCTTGATCCTGCAGCTGATAATTACGGCTGGGCATTTGA
CGGCGTTCCAGAAGAAAATAGTTTATACATGCGATTTGGAGATATTCGGATTGAAGTTCCGTCTACCAATGTAGTAAACC
ATTTTCCGAATGAATTACTTGGGCCAAAAGTACATAGCCGTTTCGGTACGGAATTCCCGATTCGTTTCGACTATCTCGAT
ACAGTGGGTGGAGGGAATTTAAGTCTGCAAGTCCATCCATTAGTAGAGTATGCGCAAGATAAGTTCGGTATCCATTATAC
CCAAGATGAAAGTTATTATATTTTAGAAGCAGATAACGACTCTACCGTGTATCTTGGAACAAAAGAAGGTACAACAAAAG
AAGCGATTATGACAGATTTAGAAAAAGCCGCTGAAGGAAATTACCGTTTTCCCGATGAAAAATATATTAATGTCTTCCCT
GTAAAAAAACATGACCATATTTTAATTCCAGCTGGGACGATTCATTGTGGTGGTCCAAGTACCGTCGTCCTAGAAATTAG
TGCAACTCCTTATATCTTCACGTTTAAATTATGGGACTGGGAACGCACTGGACTCGATGGCATGCCTCGCCCTGTTCATT
TAGAGCACGGCAGAGAAAATTTACAGCTTGACCGCGACACCAAATGGGTAAAAGACAACTTAATAAACCAATTTGAAACA
TTACATGAAGATAACGATTCAAAAGTAGAGCGCACTGGTTTGCATGAATTAGAATTTATTGAAACCCACCGCCACTGGTT
TAAAGAAACGGTTACCGTCCATACAAACGATAGCGTCAATATGCTCAATTTGGTAGAAGGAGAAAGTGCTGTCGTTGAAA
GTATTGACGACTCTTTCGCACCGTTTGAAGTGCATTATGGAGAAACATTTATCGTTCCTGCGATTGTCGGAACTTATCAA
ATCAGAAATACGAGCGATAATGAAGAAGTGGCTGTTATTCAAGCTTTTGTACGTAATTTATAA

Upstream 100 bases:

>100_bases
GTATTGTTATAACAAAAATAGACAATAGATTGTAATGACAAAATAGATATACAATGCTATATTTATATTGTAATAACAAT
ATAATCAAGGAGTGATTGTT

Downstream 100 bases:

>100_bases
AAAAGAAATGCCTATCAATATTTTTGATAGGCTTTCTTTTATTCAAAATCAATATAATAGCGATAATGCTTTCCTATATA
AAAACATTCGCTGTATTCTC

Product: mannose-6-phosphate isomerase

Products: NA

Alternate protein names: Phosphohexomutase; Phosphomannose isomerase; PMI [H]

Number of amino acids: Translated: 580; Mature: 579

Protein sequence:

>580_residues
MTTYDLAPEVKIHQFDGAWAGYKDIATELRTAIQKKKQDQTIVAIECYPGTRNEEIAAELLPLLPVEKVVFADDWALNNE
EVTATIQSHLTDDRVFGIMSHYEVSDFYPAEKLAEIQAEIAATKGLVVVYGTGATVIAPTPDILIYADLARWEIQCRYRG
ENKPNWKADNAGEDALRKFKRGYFFEWRMADRQKKKLYQQVDFLLDTNKKNEPKMVRGEDYRNGLNQVSKAPFRVVPYFD
ASVWGGQWMKNNFGLDPAADNYGWAFDGVPEENSLYMRFGDIRIEVPSTNVVNHFPNELLGPKVHSRFGTEFPIRFDYLD
TVGGGNLSLQVHPLVEYAQDKFGIHYTQDESYYILEADNDSTVYLGTKEGTTKEAIMTDLEKAAEGNYRFPDEKYINVFP
VKKHDHILIPAGTIHCGGPSTVVLEISATPYIFTFKLWDWERTGLDGMPRPVHLEHGRENLQLDRDTKWVKDNLINQFET
LHEDNDSKVERTGLHELEFIETHRHWFKETVTVHTNDSVNMLNLVEGESAVVESIDDSFAPFEVHYGETFIVPAIVGTYQ
IRNTSDNEEVAVIQAFVRNL

Sequences:

>Translated_580_residues
MTTYDLAPEVKIHQFDGAWAGYKDIATELRTAIQKKKQDQTIVAIECYPGTRNEEIAAELLPLLPVEKVVFADDWALNNE
EVTATIQSHLTDDRVFGIMSHYEVSDFYPAEKLAEIQAEIAATKGLVVVYGTGATVIAPTPDILIYADLARWEIQCRYRG
ENKPNWKADNAGEDALRKFKRGYFFEWRMADRQKKKLYQQVDFLLDTNKKNEPKMVRGEDYRNGLNQVSKAPFRVVPYFD
ASVWGGQWMKNNFGLDPAADNYGWAFDGVPEENSLYMRFGDIRIEVPSTNVVNHFPNELLGPKVHSRFGTEFPIRFDYLD
TVGGGNLSLQVHPLVEYAQDKFGIHYTQDESYYILEADNDSTVYLGTKEGTTKEAIMTDLEKAAEGNYRFPDEKYINVFP
VKKHDHILIPAGTIHCGGPSTVVLEISATPYIFTFKLWDWERTGLDGMPRPVHLEHGRENLQLDRDTKWVKDNLINQFET
LHEDNDSKVERTGLHELEFIETHRHWFKETVTVHTNDSVNMLNLVEGESAVVESIDDSFAPFEVHYGETFIVPAIVGTYQ
IRNTSDNEEVAVIQAFVRNL
>Mature_579_residues
TTYDLAPEVKIHQFDGAWAGYKDIATELRTAIQKKKQDQTIVAIECYPGTRNEEIAAELLPLLPVEKVVFADDWALNNEE
VTATIQSHLTDDRVFGIMSHYEVSDFYPAEKLAEIQAEIAATKGLVVVYGTGATVIAPTPDILIYADLARWEIQCRYRGE
NKPNWKADNAGEDALRKFKRGYFFEWRMADRQKKKLYQQVDFLLDTNKKNEPKMVRGEDYRNGLNQVSKAPFRVVPYFDA
SVWGGQWMKNNFGLDPAADNYGWAFDGVPEENSLYMRFGDIRIEVPSTNVVNHFPNELLGPKVHSRFGTEFPIRFDYLDT
VGGGNLSLQVHPLVEYAQDKFGIHYTQDESYYILEADNDSTVYLGTKEGTTKEAIMTDLEKAAEGNYRFPDEKYINVFPV
KKHDHILIPAGTIHCGGPSTVVLEISATPYIFTFKLWDWERTGLDGMPRPVHLEHGRENLQLDRDTKWVKDNLINQFETL
HEDNDSKVERTGLHELEFIETHRHWFKETVTVHTNDSVNMLNLVEGESAVVESIDDSFAPFEVHYGETFIVPAIVGTYQI
RNTSDNEEVAVIQAFVRNL

Specific function: Unknown

COG id: COG1482

COG function: function code G; Phosphomannose isomerase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 1 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR001250
- InterPro:   IPR014628
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01238 PMI_typeI [H]

EC number: =5.3.1.8 [H]

Molecular weight: Translated: 66302; Mature: 66171

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTYDLAPEVKIHQFDGAWAGYKDIATELRTAIQKKKQDQTIVAIECYPGTRNEEIAAEL
CCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHH
LPLLPVEKVVFADDWALNNEEVTATIQSHLTDDRVFGIMSHYEVSDFYPAEKLAEIQAEI
HCCCCCCCEEEECCCCCCCCCEEEEEHHHCCCCHHEEHHHHCCCCCCCCHHHHHHHHHHH
AATKGLVVVYGTGATVIAPTPDILIYADLARWEIQCRYRGENKPNWKADNAGEDALRKFK
HHCCCEEEEEECCCEEEECCCCEEEEEEEEEEEEEEEECCCCCCCCCCCCCCHHHHHHHH
RGYFFEWRMADRQKKKLYQQVDFLLDTNKKNEPKMVRGEDYRNGLNQVSKAPFRVVPYFD
CCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCEECCCHHHHHHHHHHCCCEEEEEEEC
ASVWGGQWMKNNFGLDPAADNYGWAFDGVPEENSLYMRFGDIRIEVPSTNVVNHFPNELL
CCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCEEEEECCEEEECCCCHHHHHCCHHHC
GPKVHSRFGTEFPIRFDYLDTVGGGNLSLQVHPLVEYAQDKFGIHYTQDESYYILEADND
CCHHHHHCCCCCCEEEEEEECCCCCEEEEEEEHHHHHHHHHCCEEEECCCCEEEEEECCC
STVYLGTKEGTTKEAIMTDLEKAAEGNYRFPDEKYINVFPVKKHDHILIPAGTIHCGGPS
CEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCEEEEECCEEECCCCC
TVVLEISATPYIFTFKLWDWERTGLDGMPRPVHLEHGRENLQLDRDTKWVKDNLINQFET
EEEEEEECCCEEEEEEEECCCCCCCCCCCCCEECCCCCCCCEECCCCHHHHHHHHHHHHH
LHEDNDSKVERTGLHELEFIETHRHWFKETVTVHTNDSVNMLNLVEGESAVVESIDDSFA
HHCCCCCCHHHCCCCHHHHHHHHHHHHHEEEEEEECCCCEEEEEECCCHHHHHHHCCCCC
PFEVHYGETFIVPAIVGTYQIRNTSDNEEVAVIQAFVRNL
CEEEECCCEEEEEEEEEEEEEECCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
TTYDLAPEVKIHQFDGAWAGYKDIATELRTAIQKKKQDQTIVAIECYPGTRNEEIAAEL
CCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHH
LPLLPVEKVVFADDWALNNEEVTATIQSHLTDDRVFGIMSHYEVSDFYPAEKLAEIQAEI
HCCCCCCCEEEECCCCCCCCCEEEEEHHHCCCCHHEEHHHHCCCCCCCCHHHHHHHHHHH
AATKGLVVVYGTGATVIAPTPDILIYADLARWEIQCRYRGENKPNWKADNAGEDALRKFK
HHCCCEEEEEECCCEEEECCCCEEEEEEEEEEEEEEEECCCCCCCCCCCCCCHHHHHHHH
RGYFFEWRMADRQKKKLYQQVDFLLDTNKKNEPKMVRGEDYRNGLNQVSKAPFRVVPYFD
CCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCEECCCHHHHHHHHHHCCCEEEEEEEC
ASVWGGQWMKNNFGLDPAADNYGWAFDGVPEENSLYMRFGDIRIEVPSTNVVNHFPNELL
CCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCEEEEECCEEEECCCCHHHHHCCHHHC
GPKVHSRFGTEFPIRFDYLDTVGGGNLSLQVHPLVEYAQDKFGIHYTQDESYYILEADND
CCHHHHHCCCCCCEEEEEEECCCCCEEEEEEEHHHHHHHHHCCEEEECCCCEEEEEECCC
STVYLGTKEGTTKEAIMTDLEKAAEGNYRFPDEKYINVFPVKKHDHILIPAGTIHCGGPS
CEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCEEEEECCEEECCCCC
TVVLEISATPYIFTFKLWDWERTGLDGMPRPVHLEHGRENLQLDRDTKWVKDNLINQFET
EEEEEEECCCEEEEEEEECCCCCCCCCCCCCEECCCCCCCCEECCCCHHHHHHHHHHHHH
LHEDNDSKVERTGLHELEFIETHRHWFKETVTVHTNDSVNMLNLVEGESAVVESIDDSFA
HHCCCCCCHHHCCCCHHHHHHHHHHHHHEEEEEEECCCCEEEEEECCCHHHHHHHCCCCC
PFEVHYGETFIVPAIVGTYQIRNTSDNEEVAVIQAFVRNL
CEEEECCCEEEEEEEEEEEEEECCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]