Click here to switch to the map view.

The map label for this gene is 226224665

Identifier: 226224665

GI number: 226224665

Start: 2140706

End: 2141449

Strand: Direct

Name: 226224665

Synonym: Lm4b_02080

Alternate gene names: NA

Gene position: 2140706-2141449 (Clockwise)

Preceding gene: 226224664

Following gene: 226224669

Centisome position: 73.5

GC content: 36.69

Gene sequence:

>744_bases
TTGGATAAAACAAAGAGAAAAATGATTTATGAGACTTTTATGCTTATTCTCATAGTGCTTTCCCTTGCCCTATTACCGTA
CAGAAACAGCTTTACATTTATTTTAAATTGGATTATTTGGGTGATTTTTACGCTAGATTATCTGGTTCGACTTTATCGTG
CTGATAATAAATGGCATTATGTAAAAACGCATCCGTTTCAACTCATTGCAATCATTCCATTTTACGGTGGATTTAGAGCG
GCTCGGATTGTTAGTTTTGTCCATCTATTAAGTATTACTGCGATGGGGAGACGGTATATTGTACCGATTTATAGCTTTTT
CCGTTCTAATGGTTTAAATCGATTTTTAATGATTTTTGTTTTACTTGTAATTATAATTCCTGTTCCGATGGTATTTATCG
AACCTGAAATAAACAATTATCCTGATGCGCTTTGGTGGGCGATTGTGACTGCGACAACAGTTGGGTACGGTGATATCGTT
CCAGTCACTCCGATTGGGCGGATTTTGGCATCGATTATGATGTTGTTTGGGATAGCGTTTATCGGGATGATAACTAGTAC
GATAACGAACTTTTTCCGCGCTAAGAAAGCTACTACTTCTAGCACACAAAGAGCAAGCAAGATTACCCAATTAATTGCAG
ATACGCCAGATTTAACCAAAGAAGAAATTGCGGTCGTAGAGCAATTTTTGGCACTACGAAAAAAAGAACTGGCTGATGAA
AATATAAAAAGTGATAGCGAATGA

Upstream 100 bases:

>100_bases
GGCTGGCAACTTTTTGTTGTCAGCTTTTTTATTTGTTTACGGCTTTTGCGTCGTTTTATGCTAAAATAAGTGAGAGTATA
AGTCAAACGAGGTGGATAAC

Downstream 100 bases:

>100_bases
TGCTATCACTTTTTTATTTGTTTTTCGACTTGGTTACGGTAACGTTCAGATAAGGCTTCTACCGCCAAAATGCGTTCTAA
GTCTTCTTTTGTCCCATTTT

Product: potassium channel subunit

Products: NA

Alternate protein names: KvAP [H]

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MDKTKRKMIYETFMLILIVLSLALLPYRNSFTFILNWIIWVIFTLDYLVRLYRADNKWHYVKTHPFQLIAIIPFYGGFRA
ARIVSFVHLLSITAMGRRYIVPIYSFFRSNGLNRFLMIFVLLVIIIPVPMVFIEPEINNYPDALWWAIVTATTVGYGDIV
PVTPIGRILASIMMLFGIAFIGMITSTITNFFRAKKATTSSTQRASKITQLIADTPDLTKEEIAVVEQFLALRKKELADE
NIKSDSE

Sequences:

>Translated_247_residues
MDKTKRKMIYETFMLILIVLSLALLPYRNSFTFILNWIIWVIFTLDYLVRLYRADNKWHYVKTHPFQLIAIIPFYGGFRA
ARIVSFVHLLSITAMGRRYIVPIYSFFRSNGLNRFLMIFVLLVIIIPVPMVFIEPEINNYPDALWWAIVTATTVGYGDIV
PVTPIGRILASIMMLFGIAFIGMITSTITNFFRAKKATTSSTQRASKITQLIADTPDLTKEEIAVVEQFLALRKKELADE
NIKSDSE
>Mature_247_residues
MDKTKRKMIYETFMLILIVLSLALLPYRNSFTFILNWIIWVIFTLDYLVRLYRADNKWHYVKTHPFQLIAIIPFYGGFRA
ARIVSFVHLLSITAMGRRYIVPIYSFFRSNGLNRFLMIFVLLVIIIPVPMVFIEPEINNYPDALWWAIVTATTVGYGDIV
PVTPIGRILASIMMLFGIAFIGMITSTITNFFRAKKATTSSTQRASKITQLIADTPDLTKEEIAVVEQFLALRKKELADE
NIKSDSE

Specific function: Mediates a strong voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassi

COG id: COG1226

COG function: function code P; Kef-type K+ transport systems, predicted NAD-binding component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the potassium channel family [H]

Homologues:

Organism=Homo sapiens, GI27436974, Length=198, Percent_Identity=26.2626262626263, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI4826784, Length=198, Percent_Identity=25.7575757575758, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI20070166, Length=194, Percent_Identity=29.8969072164948, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI236462079, Length=226, Percent_Identity=25.2212389380531, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI28373065, Length=226, Percent_Identity=25.2212389380531, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI236461942, Length=226, Percent_Identity=25.2212389380531, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI236461719, Length=226, Percent_Identity=25.2212389380531, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI236462242, Length=226, Percent_Identity=25.2212389380531, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI9789987, Length=206, Percent_Identity=25.7281553398058, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI27436984, Length=201, Percent_Identity=25.8706467661692, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI27436986, Length=201, Percent_Identity=25.8706467661692, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI26638655, Length=220, Percent_Identity=26.8181818181818, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI27436981, Length=196, Percent_Identity=27.0408163265306, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI26638653, Length=220, Percent_Identity=26.8181818181818, Blast_Score=65, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17544122, Length=210, Percent_Identity=24.2857142857143, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71989381, Length=198, Percent_Identity=29.2929292929293, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71989369, Length=198, Percent_Identity=29.2929292929293, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71989376, Length=198, Percent_Identity=29.2929292929293, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71989361, Length=198, Percent_Identity=28.7878787878788, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI17737641, Length=204, Percent_Identity=25.9803921568627, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281365536, Length=186, Percent_Identity=24.1935483870968, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI116007764, Length=186, Percent_Identity=24.1935483870968, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24656289, Length=186, Percent_Identity=24.1935483870968, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24656294, Length=186, Percent_Identity=24.1935483870968, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI161084970, Length=204, Percent_Identity=25.9803921568627, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013099 [H]

Pfam domain/function: PF07885 Ion_trans_2 [H]

EC number: NA

Molecular weight: Translated: 28447; Mature: 28447

Theoretical pI: Translated: 10.10; Mature: 10.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKTKRKMIYETFMLILIVLSLALLPYRNSFTFILNWIIWVIFTLDYLVRLYRADNKWHY
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
VKTHPFQLIAIIPFYGGFRAARIVSFVHLLSITAMGRRYIVPIYSFFRSNGLNRFLMIFV
EEECCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHH
LLVIIIPVPMVFIEPEINNYPDALWWAIVTATTVGYGDIVPVTPIGRILASIMMLFGIAF
HHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
IGMITSTITNFFRAKKATTSSTQRASKITQLIADTPDLTKEEIAVVEQFLALRKKELADE
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
NIKSDSE
CCCCCCC
>Mature Secondary Structure
MDKTKRKMIYETFMLILIVLSLALLPYRNSFTFILNWIIWVIFTLDYLVRLYRADNKWHY
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
VKTHPFQLIAIIPFYGGFRAARIVSFVHLLSITAMGRRYIVPIYSFFRSNGLNRFLMIFV
EEECCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHH
LLVIIIPVPMVFIEPEINNYPDALWWAIVTATTVGYGDIVPVTPIGRILASIMMLFGIAF
HHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
IGMITSTITNFFRAKKATTSSTQRASKITQLIADTPDLTKEEIAVVEQFLALRKKELADE
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
NIKSDSE
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]