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The map label for this gene is metC [H]

Identifier: 226224282

GI number: 226224282

Start: 1721176

End: 1722348

Strand: Reverse

Name: metC [H]

Synonym: Lm4b_01692

Alternate gene names: 226224282

Gene position: 1722348-1721176 (Counterclockwise)

Preceding gene: 226224283

Following gene: 226224281

Centisome position: 59.13

GC content: 44.76

Gene sequence:

>1173_bases
GTGGCTAATGAATATGCGCAAGATACGGCTGTGATTAAAGCGAGCCTCGGGATTGATAAAGAGACAGGTGCGCTTAATAC
GCCAATTCATTTATCGTCTACTTTCCATCAGCATGACTTTGATAATTATCACGCTTATGATTATGCGAGAAGTGGGAACC
CAACGAGAGAAAAAGTGGAACAAGCGATTGCGGAACTGGAAGGTGGTACGAATGGTTTTGCCTTTGCTAGTGGGATGGCG
GCTGTTTCTGCAGCGCTCTTTACTCTTTCTAAGGGAGACCATTTTATTATTGCGAAAGATGTGTACGGCGGGACGTTTCG
TTTGGTGGAGCAAGTGTTGCCGCGTTTTGGGATTACGCATACTTTTGTTGATACGACAAATATTGACGAAGTTGCGAAGG
CATTTCAAGCGAATACGAAACTGGTTTACTTGGAAACACCTTCTAATCCGTTGCTGCATGTGACAGATATTCGGACTGTT
GCAAAACTTGCGAAAGCGAATGGGTGTTATACGTTTGTTGATAATACATTTTTGACGCCGTTAATTCAAAAACCGTTAGA
ATTAGGTGCAGACTTGGTTATTCATAGTGCGACGAAATTTCTTGGAGGGCATAGTGATATTTTGGCGGGGCTAATTGTCA
CCAATAATCCTAATCTGGCTGAAGCAGTGTACTTTTTGCAAAATTCGACTGGTGGGGTTCTTGGAGTGCAGGATTCGTGG
TTGTTATTGCGCGGACTAAAAACACTTTCTGTGCGGATGAAGGCTGGGACGGAAACAGCGGAGAAAATTGCGCTATTTTT
AAATGCGGAGCCAGATGTGGTGGCAGTGCATTATCCGGGGTTACCTTCTCATGCGGGTTATGACATCCAAGTGGAACAGG
CGACAAGTGGCGGGGCCGTTTTATCGTTTGATTTAGGCAGTGAGGAAGCTGTGCGAGAACTAGTAACACATTTGGAATTG
CCGGTATTTTCTGTGAGTTTGGGCGCGGTGGAGAGTATTCTTTCTTACCCGGCTAAAATGTCTCATGCGGCTGTTCCGGA
AGAGGAGCGTTTGGCGCAAGGAATTACGCCAGGATTATTACGTTTTTCAGCTGGACTAGAAGATGCCGATGACTTGATTG
CTGATTTAAAACAAGCACTTTCTTTCATTAAGAAGGGAAGTGTTGCGAAATGA

Upstream 100 bases:

>100_bases
GACAAATTATTGCGCATTTCGGTTGGAATTGAAGCTAGTGAAGATTTGATTGCTGATTTATCTAAGGCACTCGATGCGGT
TTTGGAAGGGGTGAGCGCTC

Downstream 100 bases:

>100_bases
ATTTAAGAAAAGATTTAAGTGAAAAAGTATTAATTGCTGACGGCGCGATGGGCACTTTGCTTTATTCTTATGGAGTGGAT
CGTTCGTTTGAAGAGCTAAA

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MANEYAQDTAVIKASLGIDKETGALNTPIHLSSTFHQHDFDNYHAYDYARSGNPTREKVEQAIAELEGGTNGFAFASGMA
AVSAALFTLSKGDHFIIAKDVYGGTFRLVEQVLPRFGITHTFVDTTNIDEVAKAFQANTKLVYLETPSNPLLHVTDIRTV
AKLAKANGCYTFVDNTFLTPLIQKPLELGADLVIHSATKFLGGHSDILAGLIVTNNPNLAEAVYFLQNSTGGVLGVQDSW
LLLRGLKTLSVRMKAGTETAEKIALFLNAEPDVVAVHYPGLPSHAGYDIQVEQATSGGAVLSFDLGSEEAVRELVTHLEL
PVFSVSLGAVESILSYPAKMSHAAVPEEERLAQGITPGLLRFSAGLEDADDLIADLKQALSFIKKGSVAK

Sequences:

>Translated_390_residues
MANEYAQDTAVIKASLGIDKETGALNTPIHLSSTFHQHDFDNYHAYDYARSGNPTREKVEQAIAELEGGTNGFAFASGMA
AVSAALFTLSKGDHFIIAKDVYGGTFRLVEQVLPRFGITHTFVDTTNIDEVAKAFQANTKLVYLETPSNPLLHVTDIRTV
AKLAKANGCYTFVDNTFLTPLIQKPLELGADLVIHSATKFLGGHSDILAGLIVTNNPNLAEAVYFLQNSTGGVLGVQDSW
LLLRGLKTLSVRMKAGTETAEKIALFLNAEPDVVAVHYPGLPSHAGYDIQVEQATSGGAVLSFDLGSEEAVRELVTHLEL
PVFSVSLGAVESILSYPAKMSHAAVPEEERLAQGITPGLLRFSAGLEDADDLIADLKQALSFIKKGSVAK
>Mature_389_residues
ANEYAQDTAVIKASLGIDKETGALNTPIHLSSTFHQHDFDNYHAYDYARSGNPTREKVEQAIAELEGGTNGFAFASGMAA
VSAALFTLSKGDHFIIAKDVYGGTFRLVEQVLPRFGITHTFVDTTNIDEVAKAFQANTKLVYLETPSNPLLHVTDIRTVA
KLAKANGCYTFVDNTFLTPLIQKPLELGADLVIHSATKFLGGHSDILAGLIVTNNPNLAEAVYFLQNSTGGVLGVQDSWL
LLRGLKTLSVRMKAGTETAEKIALFLNAEPDVVAVHYPGLPSHAGYDIQVEQATSGGAVLSFDLGSEEAVRELVTHLELP
VFSVSLGAVESILSYPAKMSHAAVPEEERLAQGITPGLLRFSAGLEDADDLIADLKQALSFIKKGSVAK

Specific function: Catalyzes the transformation of cystathionine into homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=370, Percent_Identity=41.8918918918919, Blast_Score=257, Evalue=1e-68,
Organism=Homo sapiens, GI299473759, Length=370, Percent_Identity=38.1081081081081, Blast_Score=212, Evalue=4e-55,
Organism=Homo sapiens, GI25453487, Length=369, Percent_Identity=36.8563685636856, Blast_Score=203, Evalue=2e-52,
Organism=Escherichia coli, GI1790375, Length=382, Percent_Identity=41.6230366492147, Blast_Score=301, Evalue=3e-83,
Organism=Escherichia coli, GI1789383, Length=398, Percent_Identity=30.1507537688442, Blast_Score=161, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI17560056, Length=359, Percent_Identity=45.125348189415, Blast_Score=285, Evalue=4e-77,
Organism=Caenorhabditis elegans, GI17538055, Length=374, Percent_Identity=41.4438502673797, Blast_Score=273, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI71980708, Length=364, Percent_Identity=39.010989010989, Blast_Score=250, Evalue=7e-67,
Organism=Saccharomyces cerevisiae, GI6319307, Length=367, Percent_Identity=43.8692098092643, Blast_Score=296, Evalue=5e-81,
Organism=Saccharomyces cerevisiae, GI6321254, Length=400, Percent_Identity=36.25, Blast_Score=212, Evalue=9e-56,
Organism=Saccharomyces cerevisiae, GI6323333, Length=389, Percent_Identity=33.4190231362468, Blast_Score=150, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6321170, Length=295, Percent_Identity=31.5254237288136, Blast_Score=147, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6321904, Length=388, Percent_Identity=29.1237113402062, Blast_Score=127, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6322590, Length=347, Percent_Identity=25.6484149855908, Blast_Score=70, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6322970, Length=315, Percent_Identity=24.7619047619048, Blast_Score=66, Evalue=9e-12,
Organism=Drosophila melanogaster, GI19922554, Length=368, Percent_Identity=44.2934782608696, Blast_Score=302, Evalue=3e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 41801; Mature: 41670

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANEYAQDTAVIKASLGIDKETGALNTPIHLSSTFHQHDFDNYHAYDYARSGNPTREKVE
CCCCHHHHHHEEEEECCCCCCCCCCCCCEEECCCHHHCCCCCCCCCHHCCCCCCHHHHHH
QAIAELEGGTNGFAFASGMAAVSAALFTLSKGDHFIIAKDVYGGTFRLVEQVLPRFGITH
HHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHCCEE
TFVDTTNIDEVAKAFQANTKLVYLETPSNPLLHVTDIRTVAKLAKANGCYTFVDNTFLTP
EEECCCCHHHHHHHHHCCCEEEEEECCCCCCEEEHHHHHHHHHHHCCCCEEEECCCHHHH
LIQKPLELGADLVIHSATKFLGGHSDILAGLIVTNNPNLAEAVYFLQNSTGGVLGVQDSW
HHHHHHHCCCHHEEHHHHHHHCCCHHHHEEEEEECCCCHHHHHHEEECCCCCEEECCCCH
LLLRGLKTLSVRMKAGTETAEKIALFLNAEPDVVAVHYPGLPSHAGYDIQVEQATSGGAV
HHHHCHHHHEEEEECCCCCHHEEEEEEECCCCEEEEECCCCCCCCCCEEEEEECCCCCEE
LSFDLGSEEAVRELVTHLELPVFSVSLGAVESILSYPAKMSHAAVPEEERLAQGITPGLL
EEEECCCHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCHHHHHCCCCCHHHHHCCCCHHHH
RFSAGLEDADDLIADLKQALSFIKKGSVAK
HHHCCCCCHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
ANEYAQDTAVIKASLGIDKETGALNTPIHLSSTFHQHDFDNYHAYDYARSGNPTREKVE
CCCHHHHHHEEEEECCCCCCCCCCCCCEEECCCHHHCCCCCCCCCHHCCCCCCHHHHHH
QAIAELEGGTNGFAFASGMAAVSAALFTLSKGDHFIIAKDVYGGTFRLVEQVLPRFGITH
HHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHCCEE
TFVDTTNIDEVAKAFQANTKLVYLETPSNPLLHVTDIRTVAKLAKANGCYTFVDNTFLTP
EEECCCCHHHHHHHHHCCCEEEEEECCCCCCEEEHHHHHHHHHHHCCCCEEEECCCHHHH
LIQKPLELGADLVIHSATKFLGGHSDILAGLIVTNNPNLAEAVYFLQNSTGGVLGVQDSW
HHHHHHHCCCHHEEHHHHHHHCCCHHHHEEEEEECCCCHHHHHHEEECCCCCEEECCCCH
LLLRGLKTLSVRMKAGTETAEKIALFLNAEPDVVAVHYPGLPSHAGYDIQVEQATSGGAV
HHHHCHHHHEEEEECCCCCHHEEEEEEECCCCEEEEECCCCCCCCCCEEEEEECCCCCEE
LSFDLGSEEAVRELVTHLELPVFSVSLGAVESILSYPAKMSHAAVPEEERLAQGITPGLL
EEEECCCHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCHHHHHCCCCCHHHHHCCCCHHHH
RFSAGLEDADDLIADLKQALSFIKKGSVAK
HHHCCCCCHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]