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The map label for this gene is murC

Identifier: 226224206

GI number: 226224206

Start: 1632218

End: 1633561

Strand: Reverse

Name: murC

Synonym: Lm4b_01616

Alternate gene names: 226224206

Gene position: 1633561-1632218 (Counterclockwise)

Preceding gene: 226224207

Following gene: 226224205

Centisome position: 56.08

GC content: 38.02

Gene sequence:

>1344_bases
ATGACTATCTATCATTTTGTTGGAATAAAAGGGTCAGGGATGAGTGCACTTGCTCAAATCCTGCATGATAAAGGTTTCCA
AGTGCAAGGCAGCGATGTGGATAAATATTTCTTTACACAAAAAGCATTAGAAGAAAAGCAAATTCCGATTATGACTTTTT
CGGCTGATAATATTCAAGAAGGCCTAACAATTATTGCTGGGAATGCATTCCCAGATACACATGAAGAAATTGAGCGTGCA
CTGGAGCTTGGGCTTCCGGTGATTCGATATCATAAATTTTTAGGTCAATTAATTGATGGCTATACAAGTATTGCGATAAC
TGGTTCTCATGGTAAAACGTCGACAACTGGTTTACTTTCGCATGTTGTTGGTGCGATTCGTCCAACTTCTTATTTAATCG
GTGATGGTACTGGAAGCGGGACAAAAGGAGCGGAATATTTTGCACTTGAAGCGTGTGAATATCAACGTCATTTCCTTGCT
TATAAACCTACGTATGCAATTATGACGAATATTGATTGGGATCATCCAGACTATTTCAAGAGCGTGGATGATGTATTTAA
CGCATTCGAAACACTGGGTAAACAAGTGAAAAAAGCTGTATTTGCCTTAGGGGACGATGCTGAATTACGTAAGCTTACTT
TAGATATACCGATTATTTACTTTGGTTTTGGCGAGGAAAACGAATTCCAAGCTAAAAATGTAATCAAAGAAACAACTGGA
ACAAAATTCGACGTGTATCATCGCGGCGAGTTCTTAGGTTCGTTTGAAATTCCAGCTTACGGAGACCATAATGTATTAAA
TGCCTTAAGTGTTATTGCACTTTGTGATTATGAAGGTCTACCAGTGGAAGACGTGAAAAAGGAATTAAAAACTTTCGAAG
GTGTCAAAAGAAGATTTAGTATTACAGAAAAAGCTAATCAAGTATTAGTAGATGATTACGCGCACCATCCATCAGAAATC
CGTGCTACAGTAAATGCTGCTAGACAAAAATATCCTGACAAAAAAGTAGTTGCTGTTTTTCAGCCGCATACATTCACGCG
AACTCGCACATTCTTACAAGGTTTTGCGGACAGCTTGAATTTAGCGGATGAAGTGTATCTTTGTGATATCTTTGGTTCCG
CGCGTGAAAAAACAGGGAATTTAACGATTGCTGATTTAGCGCACAAAACAAAAGGAAACCACATTATCAAAGAAGAGCAT
ACAGAAGAACTTTTGAAATACCCAGAAGCTGTTATTTTATTCATGGGAGCAGGGGACGTTCAAAAATTCCAAGCCGCTTA
TGAAAAAGTACTTGATCATGAAGTTTTGACAGAAGCTGACTTGAAAAAAAGCGCGATTAATTAA

Upstream 100 bases:

>100_bases
GGAGACTTTATACTGTTTTCAAAGTTAAGACTTGGTGCTTAACAGTTAACATGTTTTTTTTAGGCACCCTCTTCAAGATA
AATTAATGGGGGTTCAAATA

Downstream 100 bases:

>100_bases
TAACTAAATAAAGCATGCCGATTCGTTGGCGTGCTTTTTTCTTGTTTGTAATTAGTATAAATAAAGCTTTACAGTATTTC
TTAGGTGTATTAAAATATAT

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 447; Mature: 446

Protein sequence:

>447_residues
MTIYHFVGIKGSGMSALAQILHDKGFQVQGSDVDKYFFTQKALEEKQIPIMTFSADNIQEGLTIIAGNAFPDTHEEIERA
LELGLPVIRYHKFLGQLIDGYTSIAITGSHGKTSTTGLLSHVVGAIRPTSYLIGDGTGSGTKGAEYFALEACEYQRHFLA
YKPTYAIMTNIDWDHPDYFKSVDDVFNAFETLGKQVKKAVFALGDDAELRKLTLDIPIIYFGFGEENEFQAKNVIKETTG
TKFDVYHRGEFLGSFEIPAYGDHNVLNALSVIALCDYEGLPVEDVKKELKTFEGVKRRFSITEKANQVLVDDYAHHPSEI
RATVNAARQKYPDKKVVAVFQPHTFTRTRTFLQGFADSLNLADEVYLCDIFGSAREKTGNLTIADLAHKTKGNHIIKEEH
TEELLKYPEAVILFMGAGDVQKFQAAYEKVLDHEVLTEADLKKSAIN

Sequences:

>Translated_447_residues
MTIYHFVGIKGSGMSALAQILHDKGFQVQGSDVDKYFFTQKALEEKQIPIMTFSADNIQEGLTIIAGNAFPDTHEEIERA
LELGLPVIRYHKFLGQLIDGYTSIAITGSHGKTSTTGLLSHVVGAIRPTSYLIGDGTGSGTKGAEYFALEACEYQRHFLA
YKPTYAIMTNIDWDHPDYFKSVDDVFNAFETLGKQVKKAVFALGDDAELRKLTLDIPIIYFGFGEENEFQAKNVIKETTG
TKFDVYHRGEFLGSFEIPAYGDHNVLNALSVIALCDYEGLPVEDVKKELKTFEGVKRRFSITEKANQVLVDDYAHHPSEI
RATVNAARQKYPDKKVVAVFQPHTFTRTRTFLQGFADSLNLADEVYLCDIFGSAREKTGNLTIADLAHKTKGNHIIKEEH
TEELLKYPEAVILFMGAGDVQKFQAAYEKVLDHEVLTEADLKKSAIN
>Mature_446_residues
TIYHFVGIKGSGMSALAQILHDKGFQVQGSDVDKYFFTQKALEEKQIPIMTFSADNIQEGLTIIAGNAFPDTHEEIERAL
ELGLPVIRYHKFLGQLIDGYTSIAITGSHGKTSTTGLLSHVVGAIRPTSYLIGDGTGSGTKGAEYFALEACEYQRHFLAY
KPTYAIMTNIDWDHPDYFKSVDDVFNAFETLGKQVKKAVFALGDDAELRKLTLDIPIIYFGFGEENEFQAKNVIKETTGT
KFDVYHRGEFLGSFEIPAYGDHNVLNALSVIALCDYEGLPVEDVKKELKTFEGVKRRFSITEKANQVLVDDYAHHPSEIR
ATVNAARQKYPDKKVVAVFQPHTFTRTRTFLQGFADSLNLADEVYLCDIFGSAREKTGNLTIADLAHKTKGNHIIKEEHT
EELLKYPEAVILFMGAGDVQKFQAAYEKVLDHEVLTEADLKKSAIN

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=457, Percent_Identity=28.4463894967177, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1790680, Length=388, Percent_Identity=29.3814432989691, Blast_Score=134, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 49904; Mature: 49773

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIYHFVGIKGSGMSALAQILHDKGFQVQGSDVDKYFFTQKALEEKQIPIMTFSADNIQE
CEEEEEEEECCCCHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHCCCCEEEECCCCHHC
GLTIIAGNAFPDTHEEIERALELGLPVIRYHKFLGQLIDGYTSIAITGSHGKTSTTGLLS
CCEEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHH
HVVGAIRPTSYLIGDGTGSGTKGAEYFALEACEYQRHFLAYKPTYAIMTNIDWDHPDYFK
HHHHHCCCCEEEEECCCCCCCCCCCEEEHHHHHHHHHHEEECCCEEEEECCCCCCCHHHH
SVDDVFNAFETLGKQVKKAVFALGDDAELRKLTLDIPIIYFGFGEENEFQAKNVIKETTG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECEEEEEECCCCCCHHHHHHHHHCCC
TKFDVYHRGEFLGSFEIPAYGDHNVLNALSVIALCDYEGLPVEDVKKELKTFEGVKRRFS
CEEEEEECCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
ITEKANQVLVDDYAHHPSEIRATVNAARQKYPDKKVVAVFQPHTFTRTRTFLQGFADSLN
HHHHHCEEEEHHHCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHCC
LADEVYLCDIFGSAREKTGNLTIADLAHKTKGNHIIKEEHTEELLKYPEAVILFMGAGDV
CCCCEEEEEECCCCHHCCCCEEEEHHHHHCCCCCCHHHHHHHHHHCCCCEEEEEECCCCH
QKFQAAYEKVLDHEVLTEADLKKSAIN
HHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TIYHFVGIKGSGMSALAQILHDKGFQVQGSDVDKYFFTQKALEEKQIPIMTFSADNIQE
EEEEEEEECCCCHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHCCCCEEEECCCCHHC
GLTIIAGNAFPDTHEEIERALELGLPVIRYHKFLGQLIDGYTSIAITGSHGKTSTTGLLS
CCEEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHH
HVVGAIRPTSYLIGDGTGSGTKGAEYFALEACEYQRHFLAYKPTYAIMTNIDWDHPDYFK
HHHHHCCCCEEEEECCCCCCCCCCCEEEHHHHHHHHHHEEECCCEEEEECCCCCCCHHHH
SVDDVFNAFETLGKQVKKAVFALGDDAELRKLTLDIPIIYFGFGEENEFQAKNVIKETTG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECEEEEEECCCCCCHHHHHHHHHCCC
TKFDVYHRGEFLGSFEIPAYGDHNVLNALSVIALCDYEGLPVEDVKKELKTFEGVKRRFS
CEEEEEECCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
ITEKANQVLVDDYAHHPSEIRATVNAARQKYPDKKVVAVFQPHTFTRTRTFLQGFADSLN
HHHHHCEEEEHHHCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHCC
LADEVYLCDIFGSAREKTGNLTIADLAHKTKGNHIIKEEHTEELLKYPEAVILFMGAGDV
CCCCEEEEEECCCCHHCCCCEEEEHHHHHCCCCCCHHHHHHHHHHCCCCEEEEEECCCCH
QKFQAAYEKVLDHEVLTEADLKKSAIN
HHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]