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The map label for this gene is hemD

Identifier: 226224156

GI number: 226224156

Start: 1575147

End: 1575869

Strand: Reverse

Name: hemD

Synonym: Lm4b_01566

Alternate gene names: 226224156

Gene position: 1575869-1575147 (Counterclockwise)

Preceding gene: 226224157

Following gene: 226224155

Centisome position: 54.1

GC content: 33.75

Gene sequence:

>723_bases
ATGAGTAAAAAAGTTGTTTTAACAAGAGAAGCGAATAAAAACAAACCATGGCAAACCTATTTTTCGCAAAATGGTTTTGA
AGTGACGTCAATCCCGCTGATTAAAACACGACCTATAAAAATGGATTTGAGTCGAGAACAACAACAAACAGACTGGCTTT
TTTTAACAAGTGCAAATGCTGTAGAATATTTCTTTACGAACCAACATGAAAGATTCAATTATAAAATAGCTGTCATCGGT
GAAAAAACAAAAGAAAAACTGGCAGAATTTGGTCACGAACCAAATTTTGTCCCATCTATCTATCAGTCAGAAGTATTTTT
AGAAGAATGGCTAAACGAAAACCCAGAGAAAACAAGTATCTTAATACCACAAAGTAATTTAAGCAGAACAATAATAAAAG
ATAGATTGATTGAAAAAGGTTACATCGTTGTTTCGTTTGAGCTCTATGAAACAATCTTTCCAGAAAATTCTAAAATACGG
TTAATCGAACAACTGAAACTAAATGAAACACAAATAATTGTTTTTGCCAGCCCATCTGCATGGAAAAACTTCTATTCCAC
TGCGAAGTCATTCCCTGCTCAAAAAGAGAAGTGGCATATTGCATCCATTGGTAGTATTACAACAGAAGCCATTATAGCAG
ATGGATGGGAAGTAAAATATCAACCAAAAACCTTCACCATGAAGCACCTAGCTGATTTGATAATACAGGAGGAATTAAAA
TGA

Upstream 100 bases:

>100_bases
CCGAACAAGCTGGTGCAAATCCAAGTGAAATTGGAAATAAAGTAGCAGAAGATTTGCTAAGTGAAGGTGCAGATACTATT
ATCAAAGAACTGAGAAATAT

Downstream 100 bases:

>100_bases
AAAATCAATTTGATAGACATCGTCGTCTAAGAAAAACCAAAACAATGCGTGATTTAGTAAGAGAAACAGTTTTACATACA
GATGATTTAATCTATCCGAT

Product: uroporphyrinogen-III synthase

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 240; Mature: 239

Protein sequence:

>240_residues
MSKKVVLTREANKNKPWQTYFSQNGFEVTSIPLIKTRPIKMDLSREQQQTDWLFLTSANAVEYFFTNQHERFNYKIAVIG
EKTKEKLAEFGHEPNFVPSIYQSEVFLEEWLNENPEKTSILIPQSNLSRTIIKDRLIEKGYIVVSFELYETIFPENSKIR
LIEQLKLNETQIIVFASPSAWKNFYSTAKSFPAQKEKWHIASIGSITTEAIIADGWEVKYQPKTFTMKHLADLIIQEELK

Sequences:

>Translated_240_residues
MSKKVVLTREANKNKPWQTYFSQNGFEVTSIPLIKTRPIKMDLSREQQQTDWLFLTSANAVEYFFTNQHERFNYKIAVIG
EKTKEKLAEFGHEPNFVPSIYQSEVFLEEWLNENPEKTSILIPQSNLSRTIIKDRLIEKGYIVVSFELYETIFPENSKIR
LIEQLKLNETQIIVFASPSAWKNFYSTAKSFPAQKEKWHIASIGSITTEAIIADGWEVKYQPKTFTMKHLADLIIQEELK
>Mature_239_residues
SKKVVLTREANKNKPWQTYFSQNGFEVTSIPLIKTRPIKMDLSREQQQTDWLFLTSANAVEYFFTNQHERFNYKIAVIGE
KTKEKLAEFGHEPNFVPSIYQSEVFLEEWLNENPEKTSILIPQSNLSRTIIKDRLIEKGYIVVSFELYETIFPENSKIRL
IEQLKLNETQIIVFASPSAWKNFYSTAKSFPAQKEKWHIASIGSITTEAIIADGWEVKYQPKTFTMKHLADLIIQEELK

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 28048; Mature: 27917

Theoretical pI: Translated: 7.80; Mature: 7.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKVVLTREANKNKPWQTYFSQNGFEVTSIPLIKTRPIKMDLSREQQQTDWLFLTSANA
CCCEEEEEECCCCCCCCHHHHCCCCEEEEEECEEECCCEEECCCCCCCCCCEEEEEECCE
VEYFFTNQHERFNYKIAVIGEKTKEKLAEFGHEPNFVPSIYQSEVFLEEWLNENPEKTSI
EEEEECCCCCEEEEEEEEECCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEE
LIPQSNLSRTIIKDRLIEKGYIVVSFELYETIFPENSKIRLIEQLKLNETQIIVFASPSA
EEECCCCHHHHHHHHHHHCCEEEEEEEHHHHHCCCCCCEEEEEEECCCCEEEEEEECCHH
WKNFYSTAKSFPAQKEKWHIASIGSITTEAIIADGWEVKYQPKTFTMKHLADLIIQEELK
HHHHHHHHHHCCCCCCCEEEEECCCHHEEEEEECCEEEEECCCEEEHHHHHHHHHHHHCC
>Mature Secondary Structure 
SKKVVLTREANKNKPWQTYFSQNGFEVTSIPLIKTRPIKMDLSREQQQTDWLFLTSANA
CCEEEEEECCCCCCCCHHHHCCCCEEEEEECEEECCCEEECCCCCCCCCCEEEEEECCE
VEYFFTNQHERFNYKIAVIGEKTKEKLAEFGHEPNFVPSIYQSEVFLEEWLNENPEKTSI
EEEEECCCCCEEEEEEEEECCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEE
LIPQSNLSRTIIKDRLIEKGYIVVSFELYETIFPENSKIRLIEQLKLNETQIIVFASPSA
EEECCCCHHHHHHHHHHHCCEEEEEEEHHHHHCCCCCCEEEEEEECCCCEEEEEEECCHH
WKNFYSTAKSFPAQKEKWHIASIGSITTEAIIADGWEVKYQPKTFTMKHLADLIIQEELK
HHHHHHHHHHCCCCCCCEEEEECCCHHEEEEEECCEEEEECCCEEEHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]