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The map label for this gene is comC

Identifier: 226224151

GI number: 226224151

Start: 1567626

End: 1568336

Strand: Reverse

Name: comC

Synonym: Lm4b_01561

Alternate gene names: 226224151

Gene position: 1568336-1567626 (Counterclockwise)

Preceding gene: 226224152

Following gene: 226224150

Centisome position: 53.84

GC content: 26.44

Gene sequence:

>711_bases
ATGATTTACTTTTTATTAGCTATTTATAGTGCAGTATTTATGTCGTTCATTCAAGTCGCAGGAGAATGTTTTCCAGTGAA
AAAATCATTTTTATTCCGTTTTTCGGAGTGTAATTTTTGTCAAAAGACACTTGCTTTCTATCATATCATTCCCGTTTTTT
CCTTTCTTTTTTTTAGAGGAAAGTCTAGATGCTGTGAAAGACCTATTCCGATAATCTACTTTTTAATGGAATTAGTAACA
CCAATCTATATACTTCTTCTGTACATTCAATTTTCTTTTTCATATTCGTTTCTTCTTTACTACATTATTTATTTTTTTTT
AGCTTTTTTCTTTATCACAGATATTTTTTATTTGTATGTCCCTAACTCAATATTAATTGTATTTTTCTGTGTACTGGCAA
TCATTGCCATCTTATATAACCAAACTTTGATGGATTTCATTTTTTCAGGGGTAATCAGCTGTCTTTTTTATCTTCTTTTT
TTTATTATTTTTCGAAAAGGAATTGGACTTGGCGATATCAAAATACTTATTATTTTAAGTACTTTTTTAGGTTTTAAAAT
AGGATATTATATCTTTTTTCTAGCAATTATTATAGGGACAATAATATTATTAACTGCATTGATATTAAATAAAGTGAAGA
AAAATAAGCAAGTTCCATTTGTTCCGTATATATATGTTTCCTTTCTGCTGATTAGTATTTTGATAAAATAG

Upstream 100 bases:

>100_bases
GGTGTTTTTGTTATGCAATAGAAGGTGGAAAAGTGATTTTAGCTATGTGCAAAAAGATTTCGTCTCTGCTATTCTGTTTT
TAACAACTAGGAGGTGACAG

Downstream 100 bases:

>100_bases
GAGCTGTTCTTATGTTGATACATGAAATATCAGAGAATGAAAAACCACGCGAAAAGCTACAGAATTATGGGATAGAAGCA
CTTTCATCTTCGGAATTGGT

Product: late competence protein ComC (type IV prepilin peptidase)

Products: NA

Alternate protein names: Late competence protein ComC; Leader peptidase; Prepilin peptidase; N-methyltransferase [H]

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MIYFLLAIYSAVFMSFIQVAGECFPVKKSFLFRFSECNFCQKTLAFYHIIPVFSFLFFRGKSRCCERPIPIIYFLMELVT
PIYILLLYIQFSFSYSFLLYYIIYFFLAFFFITDIFYLYVPNSILIVFFCVLAIIAILYNQTLMDFIFSGVISCLFYLLF
FIIFRKGIGLGDIKILIILSTFLGFKIGYYIFFLAIIIGTIILLTALILNKVKKNKQVPFVPYIYVSFLLISILIK

Sequences:

>Translated_236_residues
MIYFLLAIYSAVFMSFIQVAGECFPVKKSFLFRFSECNFCQKTLAFYHIIPVFSFLFFRGKSRCCERPIPIIYFLMELVT
PIYILLLYIQFSFSYSFLLYYIIYFFLAFFFITDIFYLYVPNSILIVFFCVLAIIAILYNQTLMDFIFSGVISCLFYLLF
FIIFRKGIGLGDIKILIILSTFLGFKIGYYIFFLAIIIGTIILLTALILNKVKKNKQVPFVPYIYVSFLLISILIK
>Mature_236_residues
MIYFLLAIYSAVFMSFIQVAGECFPVKKSFLFRFSECNFCQKTLAFYHIIPVFSFLFFRGKSRCCERPIPIIYFLMELVT
PIYILLLYIQFSFSYSFLLYYIIYFFLAFFFITDIFYLYVPNSILIVFFCVLAIIAILYNQTLMDFIFSGVISCLFYLLF
FIIFRKGIGLGDIKILIILSTFLGFKIGYYIFFLAIIIGTIILLTALILNKVKKNKQVPFVPYIYVSFLLISILIK

Specific function: Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue [H]

COG id: COG1989

COG function: function code NOU; Type II secretory pathway, prepilin signal peptidase PulO and related peptidases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A24 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010627
- InterPro:   IPR000045 [H]

Pfam domain/function: PF06750 DiS_P_DiS; PF01478 Peptidase_A24 [H]

EC number: =3.4.23.43 [H]

Molecular weight: Translated: 27783; Mature: 27783

Theoretical pI: Translated: 9.34; Mature: 9.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYFLLAIYSAVFMSFIQVAGECFPVKKSFLFRFSECNFCQKTLAFYHIIPVFSFLFFRG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KSRCCERPIPIIYFLMELVTPIYILLLYIQFSFSYSFLLYYIIYFFLAFFFITDIFYLYV
CHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PNSILIVFFCVLAIIAILYNQTLMDFIFSGVISCLFYLLFFIIFRKGIGLGDIKILIILS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
TFLGFKIGYYIFFLAIIIGTIILLTALILNKVKKNKQVPFVPYIYVSFLLISILIK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIYFLLAIYSAVFMSFIQVAGECFPVKKSFLFRFSECNFCQKTLAFYHIIPVFSFLFFRG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KSRCCERPIPIIYFLMELVTPIYILLLYIQFSFSYSFLLYYIIYFFLAFFFITDIFYLYV
CHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PNSILIVFFCVLAIIAILYNQTLMDFIFSGVISCLFYLLFFIIFRKGIGLGDIKILIILS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
TFLGFKIGYYIFFLAIIIGTIILLTALILNKVKKNKQVPFVPYIYVSFLLISILIK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2553669; 9384377; 8419299 [H]