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The map label for this gene is secDF [H]

Identifier: 226224128

GI number: 226224128

Start: 1545677

End: 1547941

Strand: Reverse

Name: secDF [H]

Synonym: Lm4b_01537

Alternate gene names: 226224128

Gene position: 1547941-1545677 (Counterclockwise)

Preceding gene: 226224129

Following gene: 226224127

Centisome position: 53.14

GC content: 38.94

Gene sequence:

>2265_bases
ATGGTAAAAAAGAGTAAGATAGTTATTTTCTTTCTAGTAGTTGCAATTATCTTTGGTGCTGTATTTGGTACCGCAAAAAT
GGTTATGCAAAACATCAACCTAGGCTTGGATCTTCAAGGGGGATTCGAAGTTCTATATGAAGTTTCACCAGCTGATGGCA
AAGGAACTGTATCCAAACAAACATTGACAGATACGGTAACTTCACTCGACAAGCGTATCAATTCATTAGGTGTAGCTGAA
CCAAGTATTCAAATCGAAGGGGATAACCGTATTCGTGTTCAACTTGCTGGGGTAACTGATCAGGAAGAAGCACGAAAAAT
GCTATCAACCACAGCCCAATTATCATTTAGAGATGCAAATGACAAGATGATGATGAATGGTAGTGACTTAGTTGCGGGCG
GTGCCAAACAAGCTTTCGATTCAAGCAACAACCCAATCGTTACGCTAAAACTAAAAAGTGCAGATAAATTTGCTAGTGTA
ACAAAAACAATACTAGCGGAAGCGCCTGACAATCAATTAGTTATTTGGTTAGATTGGAAAGAAGGACAAAAATACAAAAC
AGAACGCGAGAAGAAAGACCCAGCTTACTTATCAGCACCAAACGTTAGTAGCGTGCTTGATACAGATAAAGTAGAAATTT
CCGGAAGTTTCACAACGGAAGAAGCAAAAGATTTAGCTGATTTGCTAAACTCTGGTGCACTCCCTGTTAAAATGAAAGAA
GTTTACTCGACATCTGTTGGTGCTCAATTTGGGCAAGATGCGTTACAAGAAACAATTTTAGCTGGTATTATTGGGGTCAT
TGCTATCTTTATTTTCATGATGGCAGTTTACCGTTTACCAGGCGTTATTGCTTGTATCACTTTAGTTGCATACACTTATT
TAGTACTATTAATACTGAGTCTGCTTAACGCAACACTTACTTTACCAGGGATTGCAGGTTTGATTCTGGGGATAGGTATG
GCTGTTGACGCGAACGTAATAACCTACGAGCGGATAAAAGAAGAAATCAAAGTCGGTAGGTCGACGAAAGCGGCTTTTGA
GGTCGGCGGTAAAGAAGCATTCCGTGCGATTTTAGATGGTAACTTGACGACACTTATCGTAGCTGCGGTTCTCTTCTACT
TTGGAACAAGCTCCATCAAAGGTTTTGCTACGGTTCTAATCATTAGTATTTTAGTCAGCTTCTTGACAGCCGTTTGGGGA
TCAAGATTCTTATTAGGCTTATTAGTGAAAAGTAATTGGCTTAACAATAAACCAGGATTCTTTGCAGTTAAACGAAAAGA
TATTCATAATTTACATGAGGGAATTAATAGCTTTAGCTTAAAAACACACTTTGATCGCTTTGATTTTGTAAAACATCATC
GTCTGTTCTTATCTATTTTTGCTGCAATTGTTATTGTCGGTATTGTTATTCTCTCCATATTTAGGCTAAATCTAGGTATT
GACTTTGCCAGTGGGACACGAGCGGAAGTAACAGCTAATCAAACGCTGACAGAAACGCAAATTAAGAAAGATTTAGATGC
GATTGATATGCCATCGGATGATATTGTTTTCCAAGGATCAGGGTCTAAAACAGCCGTTGTTTCTTATAAAGGGACATTAT
CACAAAATGATGTAGCTAAATTTAAAAACTATTTTGAGGACAAGTATAAGCACGAACCAAGCATTAGTACCGTTTCACCA
ACTGTCGGTAAAGAACTTGCCAAAAATGGCTTCTGGGCACTCGGTGTGGCGTCTGTGCTGATTGTACTTTATATTGCAGT
CCGGTTTGAATTTTATATGGGTATTGCGGCGATTCTGTCCTTACTATTCGACGCATTTATCATCTTCATATTCTTCAGTG
TAACAAGGCTGGAGGTTGACTTAACCTTCATTGCCGCGGTGCTGACGGTTATCGGTTATTCCATTAATGACACGATAGTC
ACCGCCGACCGGATACGGGATATTAGTATGAAGATGCAACGTTTCAAAACGAAAGAAGAAATTGCGAATGCGGTTAATAA
AGCATTACGCCAAACATTCACTCGTTCAATTAATACCATTTTAACGGTTATTTTCACCGTACTGGCACTTGTACTATTTG
GTAGTGAGTCTATTCTGAACTTCTCCATCGCCTTACTTGTTGGACTTGTTTCGAGTGTATTCTCCTCCATCTTTATGGCA
ATGCAATTGTGGTACGTATTCAAAGCACGACAACTACGAAAAAAAGGCCCAATTAGCACAGTTAAAAAGAAAAAACCACG
TAATAATGGGCAACCTGTCGTATAA

Upstream 100 bases:

>100_bases
CAGCCTGTTAGCAAATGCTTGGGTTTCATACATAAAATAGAAGTATTTGTTGTTAGACTGGGATTTGTTATGGTTTAGAT
GAGGGAGGAACGAAACAGAA

Downstream 100 bases:

>100_bases
AAACGAACGGCCGAATTTCATAAAAAGAGATTCGGTCGTTTTTAATAGCCTAGAAACGGGTAAATAATAAGATAATTGTG
CAAGGAGGAGAAAAAACATG

Product: bifunctional preprotein translocase subunit SecD/SecF

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 754; Mature: 754

Protein sequence:

>754_residues
MVKKSKIVIFFLVVAIIFGAVFGTAKMVMQNINLGLDLQGGFEVLYEVSPADGKGTVSKQTLTDTVTSLDKRINSLGVAE
PSIQIEGDNRIRVQLAGVTDQEEARKMLSTTAQLSFRDANDKMMMNGSDLVAGGAKQAFDSSNNPIVTLKLKSADKFASV
TKTILAEAPDNQLVIWLDWKEGQKYKTEREKKDPAYLSAPNVSSVLDTDKVEISGSFTTEEAKDLADLLNSGALPVKMKE
VYSTSVGAQFGQDALQETILAGIIGVIAIFIFMMAVYRLPGVIACITLVAYTYLVLLILSLLNATLTLPGIAGLILGIGM
AVDANVITYERIKEEIKVGRSTKAAFEVGGKEAFRAILDGNLTTLIVAAVLFYFGTSSIKGFATVLIISILVSFLTAVWG
SRFLLGLLVKSNWLNNKPGFFAVKRKDIHNLHEGINSFSLKTHFDRFDFVKHHRLFLSIFAAIVIVGIVILSIFRLNLGI
DFASGTRAEVTANQTLTETQIKKDLDAIDMPSDDIVFQGSGSKTAVVSYKGTLSQNDVAKFKNYFEDKYKHEPSISTVSP
TVGKELAKNGFWALGVASVLIVLYIAVRFEFYMGIAAILSLLFDAFIIFIFFSVTRLEVDLTFIAAVLTVIGYSINDTIV
TADRIRDISMKMQRFKTKEEIANAVNKALRQTFTRSINTILTVIFTVLALVLFGSESILNFSIALLVGLVSSVFSSIFMA
MQLWYVFKARQLRKKGPISTVKKKKPRNNGQPVV

Sequences:

>Translated_754_residues
MVKKSKIVIFFLVVAIIFGAVFGTAKMVMQNINLGLDLQGGFEVLYEVSPADGKGTVSKQTLTDTVTSLDKRINSLGVAE
PSIQIEGDNRIRVQLAGVTDQEEARKMLSTTAQLSFRDANDKMMMNGSDLVAGGAKQAFDSSNNPIVTLKLKSADKFASV
TKTILAEAPDNQLVIWLDWKEGQKYKTEREKKDPAYLSAPNVSSVLDTDKVEISGSFTTEEAKDLADLLNSGALPVKMKE
VYSTSVGAQFGQDALQETILAGIIGVIAIFIFMMAVYRLPGVIACITLVAYTYLVLLILSLLNATLTLPGIAGLILGIGM
AVDANVITYERIKEEIKVGRSTKAAFEVGGKEAFRAILDGNLTTLIVAAVLFYFGTSSIKGFATVLIISILVSFLTAVWG
SRFLLGLLVKSNWLNNKPGFFAVKRKDIHNLHEGINSFSLKTHFDRFDFVKHHRLFLSIFAAIVIVGIVILSIFRLNLGI
DFASGTRAEVTANQTLTETQIKKDLDAIDMPSDDIVFQGSGSKTAVVSYKGTLSQNDVAKFKNYFEDKYKHEPSISTVSP
TVGKELAKNGFWALGVASVLIVLYIAVRFEFYMGIAAILSLLFDAFIIFIFFSVTRLEVDLTFIAAVLTVIGYSINDTIV
TADRIRDISMKMQRFKTKEEIANAVNKALRQTFTRSINTILTVIFTVLALVLFGSESILNFSIALLVGLVSSVFSSIFMA
MQLWYVFKARQLRKKGPISTVKKKKPRNNGQPVV
>Mature_754_residues
MVKKSKIVIFFLVVAIIFGAVFGTAKMVMQNINLGLDLQGGFEVLYEVSPADGKGTVSKQTLTDTVTSLDKRINSLGVAE
PSIQIEGDNRIRVQLAGVTDQEEARKMLSTTAQLSFRDANDKMMMNGSDLVAGGAKQAFDSSNNPIVTLKLKSADKFASV
TKTILAEAPDNQLVIWLDWKEGQKYKTEREKKDPAYLSAPNVSSVLDTDKVEISGSFTTEEAKDLADLLNSGALPVKMKE
VYSTSVGAQFGQDALQETILAGIIGVIAIFIFMMAVYRLPGVIACITLVAYTYLVLLILSLLNATLTLPGIAGLILGIGM
AVDANVITYERIKEEIKVGRSTKAAFEVGGKEAFRAILDGNLTTLIVAAVLFYFGTSSIKGFATVLIISILVSFLTAVWG
SRFLLGLLVKSNWLNNKPGFFAVKRKDIHNLHEGINSFSLKTHFDRFDFVKHHRLFLSIFAAIVIVGIVILSIFRLNLGI
DFASGTRAEVTANQTLTETQIKKDLDAIDMPSDDIVFQGSGSKTAVVSYKGTLSQNDVAKFKNYFEDKYKHEPSISTVSP
TVGKELAKNGFWALGVASVLIVLYIAVRFEFYMGIAAILSLLFDAFIIFIFFSVTRLEVDLTFIAAVLTVIGYSINDTIV
TADRIRDISMKMQRFKTKEEIANAVNKALRQTFTRSINTILTVIFTVLALVLFGSESILNFSIALLVGLVSSVFSSIFMA
MQLWYVFKARQLRKKGPISTVKKKKPRNNGQPVV

Specific function: Required for efficient translocation of secretory pre- proteins under conditions of hypersecretion but is not required for the release of mature proteins from the membrane [H]

COG id: COG0342

COG function: function code U; Preprotein translocase subunit SecD

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the secD/secF family. SecF subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786609, Length=373, Percent_Identity=33.2439678284182, Blast_Score=171, Evalue=1e-43,
Organism=Escherichia coli, GI1786610, Length=286, Percent_Identity=31.1188811188811, Blast_Score=125, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005791
- InterPro:   IPR022813
- InterPro:   IPR022646
- InterPro:   IPR022645
- InterPro:   IPR005665 [H]

Pfam domain/function: PF07549 Sec_GG; PF02355 SecD_SecF [H]

EC number: NA

Molecular weight: Translated: 82660; Mature: 82660

Theoretical pI: Translated: 9.84; Mature: 9.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKKSKIVIFFLVVAIIFGAVFGTAKMVMQNINLGLDLQGGFEVLYEVSPADGKGTVSKQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCEEEEEECCCCCCCCCCHH
TLTDTVTSLDKRINSLGVAEPSIQIEGDNRIRVQLAGVTDQEEARKMLSTTAQLSFRDAN
HHHHHHHHHHHHHHHCCCCCCCEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHEEECCC
DKMMMNGSDLVAGGAKQAFDSSNNPIVTLKLKSADKFASVTKTILAEAPDNQLVIWLDWK
CCEEECCCCCCCCCCHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCEEEEEECC
EGQKYKTEREKKDPAYLSAPNVSSVLDTDKVEISGSFTTEEAKDLADLLNSGALPVKMKE
CCCCHHHHHHCCCCCEECCCCHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCCCCEEHHH
VYSTSVGAQFGQDALQETILAGIIGVIAIFIFMMAVYRLPGVIACITLVAYTYLVLLILS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
LLNATLTLPGIAGLILGIGMAVDANVITYERIKEEIKVGRSTKAAFEVGGKEAFRAILDG
HHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHCC
NLTTLIVAAVLFYFGTSSIKGFATVLIISILVSFLTAVWGSRFLLGLLVKSNWLNNKPGF
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
FAVKRKDIHNLHEGINSFSLKTHFDRFDFVKHHRLFLSIFAAIVIVGIVILSIFRLNLGI
EEEEHHHHHHHHHCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DFASGTRAEVTANQTLTETQIKKDLDAIDMPSDDIVFQGSGSKTAVVSYKGTLSQNDVAK
EECCCCCCEEECCCHHHHHHHHHCCCCCCCCCCCEEEECCCCCEEEEEECCCCCHHHHHH
FKNYFEDKYKHEPSISTVSPTVGKELAKNGFWALGVASVLIVLYIAVRFEFYMGIAAILS
HHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLFDAFIIFIFFSVTRLEVDLTFIAAVLTVIGYSINDTIVTADRIRDISMKMQRFKTKEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHCCHHH
IANAVNKALRQTFTRSINTILTVIFTVLALVLFGSESILNFSIALLVGLVSSVFSSIFMA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
MQLWYVFKARQLRKKGPISTVKKKKPRNNGQPVV
HHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MVKKSKIVIFFLVVAIIFGAVFGTAKMVMQNINLGLDLQGGFEVLYEVSPADGKGTVSKQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCEEEEEECCCCCCCCCCHH
TLTDTVTSLDKRINSLGVAEPSIQIEGDNRIRVQLAGVTDQEEARKMLSTTAQLSFRDAN
HHHHHHHHHHHHHHHCCCCCCCEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHEEECCC
DKMMMNGSDLVAGGAKQAFDSSNNPIVTLKLKSADKFASVTKTILAEAPDNQLVIWLDWK
CCEEECCCCCCCCCCHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCEEEEEECC
EGQKYKTEREKKDPAYLSAPNVSSVLDTDKVEISGSFTTEEAKDLADLLNSGALPVKMKE
CCCCHHHHHHCCCCCEECCCCHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCCCCEEHHH
VYSTSVGAQFGQDALQETILAGIIGVIAIFIFMMAVYRLPGVIACITLVAYTYLVLLILS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
LLNATLTLPGIAGLILGIGMAVDANVITYERIKEEIKVGRSTKAAFEVGGKEAFRAILDG
HHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHCC
NLTTLIVAAVLFYFGTSSIKGFATVLIISILVSFLTAVWGSRFLLGLLVKSNWLNNKPGF
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
FAVKRKDIHNLHEGINSFSLKTHFDRFDFVKHHRLFLSIFAAIVIVGIVILSIFRLNLGI
EEEEHHHHHHHHHCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DFASGTRAEVTANQTLTETQIKKDLDAIDMPSDDIVFQGSGSKTAVVSYKGTLSQNDVAK
EECCCCCCEEECCCHHHHHHHHHCCCCCCCCCCCEEEECCCCCEEEEEECCCCCHHHHHH
FKNYFEDKYKHEPSISTVSPTVGKELAKNGFWALGVASVLIVLYIAVRFEFYMGIAAILS
HHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLFDAFIIFIFFSVTRLEVDLTFIAAVLTVIGYSINDTIVTADRIRDISMKMQRFKTKEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHCCHHH
IANAVNKALRQTFTRSINTILTVIFTVLALVLFGSESILNFSIALLVGLVSSVFSSIFMA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
MQLWYVFKARQLRKKGPISTVKKKKPRNNGQPVV
HHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9694879; 9384377 [H]