| Definition | Listeria monocytogenes Clip81459, complete genome. |
|---|---|
| Accession | NC_012488 |
| Length | 2,912,690 |
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The map label for this gene is lepA
Identifier: 226224080
GI number: 226224080
Start: 1495546
End: 1497372
Strand: Reverse
Name: lepA
Synonym: Lm4b_01489
Alternate gene names: 226224080
Gene position: 1497372-1495546 (Counterclockwise)
Preceding gene: 226224082
Following gene: 226224078
Centisome position: 51.41
GC content: 37.11
Gene sequence:
>1827_bases ATGAACAAAGAAGAAATGAATGCAAGACAAAAGAAAATTAGAAACTTTTCGATTATCGCGCACATAGATCATGGTAAATC TACACTCGCTGATCGGATTTTAGAACAAACGGGTGCTTTGACGCATCGTGAAATGAAAAATCAGCTACTAGATTCGATGG ATTTAGAACGTGAACGCGGGATAACCATAAAATTAAATGCTGTACAATTAAAATATAAAGCAAAAGATGGAGAAACATAT ATCTTCCATCTGATTGATACGCCTGGGCATGTCGATTTCACCTATGAAGTATCAAGAAGTTTAGCTGCATGTGAGGGAGC AATCCTTGTTGTAGATGCTGCGCAAGGAATTGAAGCACAAACCCTTGCTAATGTTTATTTAGCACTAGACAACGATTTAG AAATTTTACCAGTCATTAACAAAATCGATTTACCAGCGGCCGATCCGGAAAGAGTCCGCGAAGAAATTGAAGATGTAATT GGTTTAGATGCTTCTGACGCTGTACTTGCTTCTGCGAAATCTGGTATTGGTATTGAAGACATTCTAGAACAAATTGTCGA AAAAGTTCCTGAGCCATCTGGTGATGTAAATAAACCACTAAAAGCGCTCATTTTTGACTCTGTTTTTGATGCATATCGTG GTGTTATTGCTAATATCCGTATCATGGATGGTGTTGTAAAAGCAGGCGACCGAATTAAAATGATGTCCAATGGCAAAGAA TTCGAAGTAACGGAGGTTGGTGTATTCTCACCAAAGGCAACACCACGTGACGAATTACTGGTTGGTGACGTTGGTTACTT AACAGCAGCTATAAAAAATGTTGGAGATACGCGCGTAGGTGATACAATCACACTTGCGAATAATCCAGCTGAAGAAGCGC TGGATGGTTACCGTAAATTAAATCCAATGGTTTATTGTGGTCTATATCCAATCGACTCCTCTAAATATAATGATCTTCGT GATGCTTTAGAAAAACTAGAATTAAATGACTCTGCTTTGCAATTTGAAGCGGAAACTTCTCAAGCATTAGGTTTTGGTTT CCGTTGTGGTTTCTTAGGATTACTACATATGGAAATTATTCAAGAGCGAATCGAACGTGAATTTAACATTGATTTAATTA CCACTGCTCCAAGTGTTATCTATCATGTCAACTTGACAGATGGTTCTAACATTGTGGTTGATAATCCTGCTGAAATGCCA GAACCTGGTGTTATTGAAAGCGTGGAAGAGCCATATGTAAAAGCAACTGTGATGGTTCCAAATGATTATGTTGGTGCAGT GATGGAACTGGCACAAAACAAACGTGGAAACTTCATTACGATGGAGTACTTAGATGATATTCGCGTAAGTATTGTGTACG AAATTCCATTATCCGAAATCGTATATGACTTTTTTGACCAATTAAAATCATCTACAAAAGGTTATGCGTCCTTTGATTAT GAATTAATTGGCTATAAAGCTTCTAAACTTGTGAAAATGGATATTCTTTTAAATGCAGAAAAAGTTGATGCACTTAGCTT TATCGTTCACCGTGATTTTGCTTATGAGCGTGGAAAAATCATCGTGGAGAAATTAAAAGAACTTATTCCAAGACAACAAT TTGAAGTACCTATTCAAGCAGCAATTGCCACAAAAATTGTTTCTCGTTCTACTATTAAAGCGTTGCGAAAAAACGTACTT GCTAAATGTTACGGTGGGGACGTATCTCGTAAACGAAAACTTTTAGAGAAACAAAAAGAAGGTAAAAAACGAATGAAACA AATCGGTTCAGTTGAAGTCCCGCAAGAAGCATTTATGGCAATCTTGAAAATGGACGAATCCAAATAA
Upstream 100 bases:
>100_bases ATTAATAAAGAAGTCATTGAATGTTAAGCGTTCTACTGATATAATCAAGGATAGCTTGCCATCGGATTTATGCGATGAGT TCTAATCAGGAGCTGGGGAA
Downstream 100 bases:
>100_bases TAAAAAAGTTGTGCCGTGAACAGAAATGTTCACGGCACAACTTTTTTATATATTATACGGATAAATCAAATCATGCTTTT TCTTTTCCATACTGACATAA
Product: GTP-binding protein LepA
Products: NA
Alternate protein names: EF-4; Ribosomal back-translocase LepA [H]
Number of amino acids: Translated: 608; Mature: 608
Protein sequence:
>608_residues MNKEEMNARQKKIRNFSIIAHIDHGKSTLADRILEQTGALTHREMKNQLLDSMDLERERGITIKLNAVQLKYKAKDGETY IFHLIDTPGHVDFTYEVSRSLAACEGAILVVDAAQGIEAQTLANVYLALDNDLEILPVINKIDLPAADPERVREEIEDVI GLDASDAVLASAKSGIGIEDILEQIVEKVPEPSGDVNKPLKALIFDSVFDAYRGVIANIRIMDGVVKAGDRIKMMSNGKE FEVTEVGVFSPKATPRDELLVGDVGYLTAAIKNVGDTRVGDTITLANNPAEEALDGYRKLNPMVYCGLYPIDSSKYNDLR DALEKLELNDSALQFEAETSQALGFGFRCGFLGLLHMEIIQERIEREFNIDLITTAPSVIYHVNLTDGSNIVVDNPAEMP EPGVIESVEEPYVKATVMVPNDYVGAVMELAQNKRGNFITMEYLDDIRVSIVYEIPLSEIVYDFFDQLKSSTKGYASFDY ELIGYKASKLVKMDILLNAEKVDALSFIVHRDFAYERGKIIVEKLKELIPRQQFEVPIQAAIATKIVSRSTIKALRKNVL AKCYGGDVSRKRKLLEKQKEGKKRMKQIGSVEVPQEAFMAILKMDESK
Sequences:
>Translated_608_residues MNKEEMNARQKKIRNFSIIAHIDHGKSTLADRILEQTGALTHREMKNQLLDSMDLERERGITIKLNAVQLKYKAKDGETY IFHLIDTPGHVDFTYEVSRSLAACEGAILVVDAAQGIEAQTLANVYLALDNDLEILPVINKIDLPAADPERVREEIEDVI GLDASDAVLASAKSGIGIEDILEQIVEKVPEPSGDVNKPLKALIFDSVFDAYRGVIANIRIMDGVVKAGDRIKMMSNGKE FEVTEVGVFSPKATPRDELLVGDVGYLTAAIKNVGDTRVGDTITLANNPAEEALDGYRKLNPMVYCGLYPIDSSKYNDLR DALEKLELNDSALQFEAETSQALGFGFRCGFLGLLHMEIIQERIEREFNIDLITTAPSVIYHVNLTDGSNIVVDNPAEMP EPGVIESVEEPYVKATVMVPNDYVGAVMELAQNKRGNFITMEYLDDIRVSIVYEIPLSEIVYDFFDQLKSSTKGYASFDY ELIGYKASKLVKMDILLNAEKVDALSFIVHRDFAYERGKIIVEKLKELIPRQQFEVPIQAAIATKIVSRSTIKALRKNVL AKCYGGDVSRKRKLLEKQKEGKKRMKQIGSVEVPQEAFMAILKMDESK >Mature_608_residues MNKEEMNARQKKIRNFSIIAHIDHGKSTLADRILEQTGALTHREMKNQLLDSMDLERERGITIKLNAVQLKYKAKDGETY IFHLIDTPGHVDFTYEVSRSLAACEGAILVVDAAQGIEAQTLANVYLALDNDLEILPVINKIDLPAADPERVREEIEDVI GLDASDAVLASAKSGIGIEDILEQIVEKVPEPSGDVNKPLKALIFDSVFDAYRGVIANIRIMDGVVKAGDRIKMMSNGKE FEVTEVGVFSPKATPRDELLVGDVGYLTAAIKNVGDTRVGDTITLANNPAEEALDGYRKLNPMVYCGLYPIDSSKYNDLR DALEKLELNDSALQFEAETSQALGFGFRCGFLGLLHMEIIQERIEREFNIDLITTAPSVIYHVNLTDGSNIVVDNPAEMP EPGVIESVEEPYVKATVMVPNDYVGAVMELAQNKRGNFITMEYLDDIRVSIVYEIPLSEIVYDFFDQLKSSTKGYASFDY ELIGYKASKLVKMDILLNAEKVDALSFIVHRDFAYERGKIIVEKLKELIPRQQFEVPIQAAIATKIVSRSTIKALRKNVL AKCYGGDVSRKRKLLEKQKEGKKRMKQIGSVEVPQEAFMAILKMDESK
Specific function: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- transloc
COG id: COG0481
COG function: function code M; Membrane GTPase LepA
Gene ontology:
Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the GTP-binding elongation factor family. LepA subfamily [H]
Homologues:
Organism=Homo sapiens, GI157426893, Length=604, Percent_Identity=50.3311258278146, Blast_Score=635, Evalue=0.0, Organism=Homo sapiens, GI94966754, Length=132, Percent_Identity=45.4545454545455, Blast_Score=115, Evalue=1e-25, Organism=Homo sapiens, GI18390331, Length=205, Percent_Identity=35.1219512195122, Blast_Score=109, Evalue=7e-24, Organism=Homo sapiens, GI4503483, Length=147, Percent_Identity=37.4149659863946, Blast_Score=103, Evalue=6e-22, Organism=Homo sapiens, GI25306283, Length=159, Percent_Identity=41.5094339622642, Blast_Score=102, Evalue=1e-21, Organism=Homo sapiens, GI25306287, Length=159, Percent_Identity=41.5094339622642, Blast_Score=101, Evalue=2e-21, Organism=Homo sapiens, GI19923640, Length=159, Percent_Identity=41.5094339622642, Blast_Score=101, Evalue=2e-21, Organism=Homo sapiens, GI310132016, Length=109, Percent_Identity=44.0366972477064, Blast_Score=97, Evalue=3e-20, Organism=Homo sapiens, GI310110807, Length=109, Percent_Identity=44.0366972477064, Blast_Score=97, Evalue=3e-20, Organism=Homo sapiens, GI310123363, Length=109, Percent_Identity=44.0366972477064, Blast_Score=97, Evalue=3e-20, Organism=Homo sapiens, GI217272892, Length=160, Percent_Identity=33.75, Blast_Score=92, Evalue=1e-18, Organism=Homo sapiens, GI217272894, Length=160, Percent_Identity=33.75, Blast_Score=92, Evalue=1e-18, Organism=Homo sapiens, GI53729339, Length=221, Percent_Identity=29.4117647058824, Blast_Score=78, Evalue=2e-14, Organism=Homo sapiens, GI53729337, Length=221, Percent_Identity=29.4117647058824, Blast_Score=78, Evalue=2e-14, Organism=Homo sapiens, GI34147630, Length=267, Percent_Identity=28.0898876404494, Blast_Score=73, Evalue=8e-13, Organism=Homo sapiens, GI5729864, Length=283, Percent_Identity=27.5618374558304, Blast_Score=72, Evalue=1e-12, Organism=Homo sapiens, GI223555963, Length=283, Percent_Identity=27.5618374558304, Blast_Score=72, Evalue=1e-12, Organism=Homo sapiens, GI94966752, Length=97, Percent_Identity=38.1443298969072, Blast_Score=68, Evalue=3e-11, Organism=Escherichia coli, GI1788922, Length=594, Percent_Identity=60.4377104377104, Blast_Score=734, Evalue=0.0, Organism=Escherichia coli, GI48994988, Length=504, Percent_Identity=30.7539682539683, Blast_Score=175, Evalue=7e-45, Organism=Escherichia coli, GI1790835, Length=154, Percent_Identity=33.7662337662338, Blast_Score=90, Evalue=4e-19, Organism=Escherichia coli, GI1789738, Length=201, Percent_Identity=33.3333333333333, Blast_Score=90, Evalue=5e-19, Organism=Escherichia coli, GI1789559, Length=253, Percent_Identity=29.2490118577075, Blast_Score=80, Evalue=5e-16, Organism=Escherichia coli, GI1789108, Length=481, Percent_Identity=24.3243243243243, Blast_Score=74, Evalue=2e-14, Organism=Escherichia coli, GI1790412, Length=267, Percent_Identity=28.0898876404494, Blast_Score=71, Evalue=2e-13, Organism=Escherichia coli, GI1789737, Length=267, Percent_Identity=28.4644194756554, Blast_Score=71, Evalue=2e-13, Organism=Caenorhabditis elegans, GI17557151, Length=612, Percent_Identity=41.3398692810458, Blast_Score=504, Evalue=1e-143, Organism=Caenorhabditis elegans, GI17556745, Length=156, Percent_Identity=38.4615384615385, Blast_Score=106, Evalue=3e-23, Organism=Caenorhabditis elegans, GI17533571, Length=182, Percent_Identity=35.7142857142857, Blast_Score=98, Evalue=1e-20, Organism=Caenorhabditis elegans, GI17506493, Length=159, Percent_Identity=33.3333333333333, Blast_Score=92, Evalue=1e-18, Organism=Caenorhabditis elegans, GI71988811, Length=133, Percent_Identity=38.3458646616541, Blast_Score=91, Evalue=1e-18, Organism=Caenorhabditis elegans, GI71988819, Length=135, Percent_Identity=37.7777777777778, Blast_Score=91, Evalue=2e-18, Organism=Caenorhabditis elegans, GI17552882, Length=145, Percent_Identity=32.4137931034483, Blast_Score=86, Evalue=4e-17, Organism=Caenorhabditis elegans, GI17556456, Length=260, Percent_Identity=29.6153846153846, Blast_Score=75, Evalue=9e-14, Organism=Caenorhabditis elegans, GI25141371, Length=281, Percent_Identity=28.1138790035587, Blast_Score=74, Evalue=2e-13, Organism=Saccharomyces cerevisiae, GI6323320, Length=598, Percent_Identity=43.9799331103679, Blast_Score=519, Evalue=1e-148, Organism=Saccharomyces cerevisiae, GI6323098, Length=204, Percent_Identity=36.2745098039216, Blast_Score=117, Evalue=5e-27, Organism=Saccharomyces cerevisiae, GI6324707, Length=143, Percent_Identity=39.8601398601399, Blast_Score=104, Evalue=4e-23, Organism=Saccharomyces cerevisiae, GI6320593, Length=143, Percent_Identity=39.8601398601399, Blast_Score=104, Evalue=4e-23, Organism=Saccharomyces cerevisiae, GI6322359, Length=113, Percent_Identity=41.5929203539823, Blast_Score=97, Evalue=7e-21, Organism=Saccharomyces cerevisiae, GI6324166, Length=141, Percent_Identity=36.1702127659575, Blast_Score=85, Evalue=4e-17, Organism=Saccharomyces cerevisiae, GI6324761, Length=264, Percent_Identity=28.030303030303, Blast_Score=80, Evalue=6e-16, Organism=Drosophila melanogaster, GI78706572, Length=601, Percent_Identity=44.7587354409318, Blast_Score=536, Evalue=1e-152, Organism=Drosophila melanogaster, GI24582462, Length=187, Percent_Identity=37.9679144385027, Blast_Score=109, Evalue=6e-24, Organism=Drosophila melanogaster, GI28574573, Length=224, Percent_Identity=34.375, Blast_Score=104, Evalue=2e-22, Organism=Drosophila melanogaster, GI221458488, Length=150, Percent_Identity=41.3333333333333, Blast_Score=96, Evalue=8e-20, Organism=Drosophila melanogaster, GI24585709, Length=151, Percent_Identity=33.112582781457, Blast_Score=95, Evalue=2e-19, Organism=Drosophila melanogaster, GI24585711, Length=151, Percent_Identity=33.112582781457, Blast_Score=94, Evalue=2e-19, Organism=Drosophila melanogaster, GI24585713, Length=151, Percent_Identity=33.112582781457, Blast_Score=94, Evalue=2e-19, Organism=Drosophila melanogaster, GI21357743, Length=160, Percent_Identity=32.5, Blast_Score=87, Evalue=5e-17, Organism=Drosophila melanogaster, GI281363316, Length=271, Percent_Identity=29.520295202952, Blast_Score=82, Evalue=2e-15, Organism=Drosophila melanogaster, GI17864358, Length=271, Percent_Identity=29.520295202952, Blast_Score=82, Evalue=2e-15, Organism=Drosophila melanogaster, GI19921738, Length=235, Percent_Identity=31.9148936170213, Blast_Score=74, Evalue=4e-13, Organism=Drosophila melanogaster, GI45550900, Length=342, Percent_Identity=25.4385964912281, Blast_Score=72, Evalue=1e-12,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR009022 - InterPro: IPR006297 - InterPro: IPR013842 - InterPro: IPR000795 - InterPro: IPR005225 - InterPro: IPR000640 - InterPro: IPR004161 - InterPro: IPR009000 [H]
Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2; PF06421 LepA_C [H]
EC number: NA
Molecular weight: Translated: 67824; Mature: 67824
Theoretical pI: Translated: 4.79; Mature: 4.79
Prosite motif: PS00301 EFACTOR_GTP
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.7 %Cys (Translated Protein) 2.8 %Met (Translated Protein) 3.5 %Cys+Met (Translated Protein) 0.7 %Cys (Mature Protein) 2.8 %Met (Mature Protein) 3.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNKEEMNARQKKIRNFSIIAHIDHGKSTLADRILEQTGALTHREMKNQLLDSMDLERERG CCHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHCC ITIKLNAVQLKYKAKDGETYIFHLIDTPGHVDFTYEVSRSLAACEGAILVVDAAQGIEAQ EEEEEEEEEEEEECCCCCEEEEEEECCCCCEEEEHHHHHHHHHCCCCEEEEECCCCCCHH TLANVYLALDNDLEILPVINKIDLPAADPERVREEIEDVIGLDASDAVLASAKSGIGIED HHEEEEEEECCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHH ILEQIVEKVPEPSGDVNKPLKALIFDSVFDAYRGVIANIRIMDGVVKAGDRIKMMSNGKE HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCE FEVTEVGVFSPKATPRDELLVGDVGYLTAAIKNVGDTRVGDTITLANNPAEEALDGYRKL EEEEEEEEECCCCCCCCCEEECCHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHC NPMVYCGLYPIDSSKYNDLRDALEKLELNDSALQFEAETSQALGFGFRCGFLGLLHMEII CCEEEEEEEECCCCCHHHHHHHHHHHCCCCCCEEEECCHHHHHCCCHHHHHHHHHHHHHH QERIEREFNIDLITTAPSVIYHVNLTDGSNIVVDNPAEMPEPGVIESVEEPYVKATVMVP HHHHHHHCCEEEEECCCEEEEEEEECCCCEEEECCCCCCCCCCCHHHCCCCCEEEEEECC NDYVGAVMELAQNKRGNFITMEYLDDIRVSIVYEIPLSEIVYDFFDQLKSSTKGYASFDY CHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEEECCHHHHHHHHHHHHHHCCCCCEECCE ELIGYKASKLVKMDILLNAEKVDALSFIVHRDFAYERGKIIVEKLKELIPRQQFEVPIQA EEECCCHHHEEEEEEEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHH AIATKIVSRSTIKALRKNVLAKCYGGDVSRKRKLLEKQKEGKKRMKQIGSVEVPQEAFMA HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH ILKMDESK HHHCCCCC >Mature Secondary Structure MNKEEMNARQKKIRNFSIIAHIDHGKSTLADRILEQTGALTHREMKNQLLDSMDLERERG CCHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHCC ITIKLNAVQLKYKAKDGETYIFHLIDTPGHVDFTYEVSRSLAACEGAILVVDAAQGIEAQ EEEEEEEEEEEEECCCCCEEEEEEECCCCCEEEEHHHHHHHHHCCCCEEEEECCCCCCHH TLANVYLALDNDLEILPVINKIDLPAADPERVREEIEDVIGLDASDAVLASAKSGIGIED HHEEEEEEECCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHH ILEQIVEKVPEPSGDVNKPLKALIFDSVFDAYRGVIANIRIMDGVVKAGDRIKMMSNGKE HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCE FEVTEVGVFSPKATPRDELLVGDVGYLTAAIKNVGDTRVGDTITLANNPAEEALDGYRKL EEEEEEEEECCCCCCCCCEEECCHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHC NPMVYCGLYPIDSSKYNDLRDALEKLELNDSALQFEAETSQALGFGFRCGFLGLLHMEII CCEEEEEEEECCCCCHHHHHHHHHHHCCCCCCEEEECCHHHHHCCCHHHHHHHHHHHHHH QERIEREFNIDLITTAPSVIYHVNLTDGSNIVVDNPAEMPEPGVIESVEEPYVKATVMVP HHHHHHHCCEEEEECCCEEEEEEEECCCCEEEECCCCCCCCCCCHHHCCCCCEEEEEECC NDYVGAVMELAQNKRGNFITMEYLDDIRVSIVYEIPLSEIVYDFFDQLKSSTKGYASFDY CHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEEECCHHHHHHHHHHHHHHCCCCCEECCE ELIGYKASKLVKMDILLNAEKVDALSFIVHRDFAYERGKIIVEKLKELIPRQQFEVPIQA EEECCCHHHEEEEEEEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHH AIATKIVSRSTIKALRKNVLAKCYGGDVSRKRKLLEKQKEGKKRMKQIGSVEVPQEAFMA HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH ILKMDESK HHHCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 11679669 [H]