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The map label for this gene is gor [H]

Identifier: 226224034

GI number: 226224034

Start: 1447901

End: 1449241

Strand: Reverse

Name: gor [H]

Synonym: Lm4b_01443

Alternate gene names: 226224034

Gene position: 1449241-1447901 (Counterclockwise)

Preceding gene: 226224035

Following gene: 226224033

Centisome position: 49.76

GC content: 38.93

Gene sequence:

>1341_bases
ATGGCAAAATTTACATATGATGTAGTAATAATCGGAAGTGGCGCAAGTGGTACAACGGTAGCATTTGAAGCACAGGCAGC
TGGATTAAAAGTAGCAATTGTAGAGGAGCGGAGTTGGGGTGGAACGTGTGTCCTCAGAGGATGCGACCCTAAAAAAGTTC
TCGTCGGAGCAAGAGAAGCAAGAAATCTTTCTACCAGACTTCGCGGCAAAGGTATTAAGCAAGCAGCGACAATTAGCTGG
ACAGATTTAATGGCATTTAAAGAAACTTTTGTTGAGAATGTGCCAGAAAGTCGTTTGGAAAACTTTCAAGAAGCCGGGAT
TGAAACATTCTTTGGTGCAGCTAGTTTCCAAGATTCCCATTCCTTACAAGTCGGCGATGATTTAATACAAGCTAATAAAA
TTGTCATCGCAACAGGAGCAACACCAAGCACGTTAAAAGTAGAAGGGCAAGAATACATTCAAACCAGTGATGATTTTTTA
TCACTTGAAAAACTCCCTGATTCTGTCGTGTTTATTGGTGGTGGCTATATTTCATTTGAATTTGCTTCCATAGCACTCGC
AGCAGGCAGAGAAGTGCATATTATCCATCATAATAGTGAACCTTTAAAGAAATTTGATTCTGATTTTGTGGCGGCATTAG
TTACCCATATGAAAGAAGAAGGTATCCATTTCCATTTTGACACAGATATTACGAAGGTTGAAAATAAAGGGGAAAAACTG
CATATTCATGGCAAAGATGGATTTTCATTACAGACAGATTTAATTATTGGGGCAACTGGTAGAAAACCAAATATCGCGCA
TTTATCATTGGAAAATGCCAACATTGACTACACTAAAAAAGGCATTATCGTTAATGAAAAACTTCAAACCACTAATAACC
CTCATATCTACGCATGTGGCGATGTCGCGGCAACAAAAGGAGCACCTTTAACACCCGTTGTCAGCATGGAAGCAGCATTT
GTTGCTAAAAATGTCATTGGCGGCGACGAAAAAATGATTTATCCAGCAATACCAAGCGTCGTTTTTACGAGCCCCAAACT
GGCAAGCATTGGTATAAGCGCAGAAGAAGCAAAAGCGCATCCAGAAAAATATCAAATTAAAAATCACGACACAACAAATT
GGTATACTTATAAACGAACAAATGAACAAATCGCGCTTGCAAAAATCATTGAAGATAGAGAGTCGGGGCAAATCAAAGGC
GCTCATTTTCTTAGTGAAGAAGCAGATTATATGATAAATTACGTTGCCATCTTAATGAAAGCTAATCTAACTTTGGCTGA
TTTACAATCTGTTATATTTGCCTATCCATCTCCAGCAAGTGACTTAACTGCTTTGAACTAG

Upstream 100 bases:

>100_bases
ATGGAAGTCTAGAATGAACTGCTGCACATTCGTGTGTGGCAGTTTTTTTCGTTTGAAAGTGAAATCAGACGGGAAAACAA
GCTAGGAAGGAGTGATTTAA

Downstream 100 bases:

>100_bases
AGGCTAAATATGTTATAGTGAGGGAGAAATTCGCATAAAAGGAGCAAATAAGATGGAAATTTGGATCATTGCCGGAATAT
GTGCTTTCTTAATTTTTATC

Product: glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MAKFTYDVVIIGSGASGTTVAFEAQAAGLKVAIVEERSWGGTCVLRGCDPKKVLVGAREARNLSTRLRGKGIKQAATISW
TDLMAFKETFVENVPESRLENFQEAGIETFFGAASFQDSHSLQVGDDLIQANKIVIATGATPSTLKVEGQEYIQTSDDFL
SLEKLPDSVVFIGGGYISFEFASIALAAGREVHIIHHNSEPLKKFDSDFVAALVTHMKEEGIHFHFDTDITKVENKGEKL
HIHGKDGFSLQTDLIIGATGRKPNIAHLSLENANIDYTKKGIIVNEKLQTTNNPHIYACGDVAATKGAPLTPVVSMEAAF
VAKNVIGGDEKMIYPAIPSVVFTSPKLASIGISAEEAKAHPEKYQIKNHDTTNWYTYKRTNEQIALAKIIEDRESGQIKG
AHFLSEEADYMINYVAILMKANLTLADLQSVIFAYPSPASDLTALN

Sequences:

>Translated_446_residues
MAKFTYDVVIIGSGASGTTVAFEAQAAGLKVAIVEERSWGGTCVLRGCDPKKVLVGAREARNLSTRLRGKGIKQAATISW
TDLMAFKETFVENVPESRLENFQEAGIETFFGAASFQDSHSLQVGDDLIQANKIVIATGATPSTLKVEGQEYIQTSDDFL
SLEKLPDSVVFIGGGYISFEFASIALAAGREVHIIHHNSEPLKKFDSDFVAALVTHMKEEGIHFHFDTDITKVENKGEKL
HIHGKDGFSLQTDLIIGATGRKPNIAHLSLENANIDYTKKGIIVNEKLQTTNNPHIYACGDVAATKGAPLTPVVSMEAAF
VAKNVIGGDEKMIYPAIPSVVFTSPKLASIGISAEEAKAHPEKYQIKNHDTTNWYTYKRTNEQIALAKIIEDRESGQIKG
AHFLSEEADYMINYVAILMKANLTLADLQSVIFAYPSPASDLTALN
>Mature_445_residues
AKFTYDVVIIGSGASGTTVAFEAQAAGLKVAIVEERSWGGTCVLRGCDPKKVLVGAREARNLSTRLRGKGIKQAATISWT
DLMAFKETFVENVPESRLENFQEAGIETFFGAASFQDSHSLQVGDDLIQANKIVIATGATPSTLKVEGQEYIQTSDDFLS
LEKLPDSVVFIGGGYISFEFASIALAAGREVHIIHHNSEPLKKFDSDFVAALVTHMKEEGIHFHFDTDITKVENKGEKLH
IHGKDGFSLQTDLIIGATGRKPNIAHLSLENANIDYTKKGIIVNEKLQTTNNPHIYACGDVAATKGAPLTPVVSMEAAFV
AKNVIGGDEKMIYPAIPSVVFTSPKLASIGISAEEAKAHPEKYQIKNHDTTNWYTYKRTNEQIALAKIIEDRESGQIKGA
HFLSEEADYMINYVAILMKANLTLADLQSVIFAYPSPASDLTALN

Specific function: Maintains High Levels Of Reduced Glutathione In The Cytosol. [C]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=464, Percent_Identity=27.5862068965517, Blast_Score=148, Evalue=8e-36,
Organism=Homo sapiens, GI22035672, Length=480, Percent_Identity=28.125, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI91199540, Length=450, Percent_Identity=25.7777777777778, Blast_Score=132, Evalue=9e-31,
Organism=Homo sapiens, GI291045266, Length=474, Percent_Identity=27.0042194092827, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI33519430, Length=475, Percent_Identity=26.3157894736842, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI33519428, Length=475, Percent_Identity=26.3157894736842, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI33519426, Length=475, Percent_Identity=26.3157894736842, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI148277065, Length=475, Percent_Identity=26.3157894736842, Blast_Score=112, Evalue=9e-25,
Organism=Homo sapiens, GI148277071, Length=475, Percent_Identity=26.3157894736842, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI291045268, Length=470, Percent_Identity=24.8936170212766, Blast_Score=96, Evalue=8e-20,
Organism=Escherichia coli, GI1789915, Length=432, Percent_Identity=30.787037037037, Blast_Score=190, Evalue=1e-49,
Organism=Escherichia coli, GI87081717, Length=457, Percent_Identity=28.6652078774617, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1786307, Length=446, Percent_Identity=25.1121076233184, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI87082354, Length=462, Percent_Identity=24.8917748917749, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1789065, Length=227, Percent_Identity=28.1938325991189, Blast_Score=79, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17557007, Length=478, Percent_Identity=26.5690376569038, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI32565766, Length=447, Percent_Identity=26.1744966442953, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI71983429, Length=359, Percent_Identity=29.8050139275766, Blast_Score=134, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI71983419, Length=359, Percent_Identity=29.8050139275766, Blast_Score=134, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI71982272, Length=495, Percent_Identity=26.0606060606061, Blast_Score=105, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6325166, Length=464, Percent_Identity=28.8793103448276, Blast_Score=174, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6325240, Length=474, Percent_Identity=25.5274261603376, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6321091, Length=457, Percent_Identity=25.601750547046, Blast_Score=122, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24640549, Length=478, Percent_Identity=28.0334728033473, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI24640553, Length=478, Percent_Identity=28.0334728033473, Blast_Score=155, Evalue=7e-38,
Organism=Drosophila melanogaster, GI24640551, Length=478, Percent_Identity=28.0334728033473, Blast_Score=155, Evalue=7e-38,
Organism=Drosophila melanogaster, GI21358499, Length=458, Percent_Identity=26.6375545851528, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI17737741, Length=488, Percent_Identity=25.4098360655738, Blast_Score=135, Evalue=8e-32,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006324
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 48511; Mature: 48379

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKFTYDVVIIGSGASGTTVAFEAQAAGLKVAIVEERSWGGTCVLRGCDPKKVLVGAREA
CCEEEEEEEEEECCCCCCEEEEEECCCCEEEEEEEECCCCCEEEEECCCCCCEEEECHHH
RNLSTRLRGKGIKQAATISWTDLMAFKETFVENVPESRLENFQEAGIETFFGAASFQDSH
HCHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHCCCCCCCCCC
SLQVGDDLIQANKIVIATGATPSTLKVEGQEYIQTSDDFLSLEKLPDSVVFIGGGYISFE
CEECCCHHHCCCEEEEEECCCCCEEEECCHHHHCCCCCHHHHHHCCCEEEEEECCEEEEE
FASIALAAGREVHIIHHNSEPLKKFDSDFVAALVTHMKEEGIHFHFDTDITKVENKGEKL
EEEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCEEECCCCCEE
HIHGKDGFSLQTDLIIGATGRKPNIAHLSLENANIDYTKKGIIVNEKLQTTNNPHIYACG
EEECCCCCEEEEEEEEECCCCCCCEEEEEEECCCCCEECCCEEEECEECCCCCCEEEEEC
DVAATKGAPLTPVVSMEAAFVAKNVIGGDEKMIYPAIPSVVFTSPKLASIGISAEEAKAH
CEECCCCCCCCEEEEHHHHHHHHHHCCCCCEEEECCCCCEEECCCCCEEECCCHHHHHCC
PEKYQIKNHDTTNWYTYKRTNEQIALAKIIEDRESGQIKGAHFLSEEADYMINYVAILMK
CCCEEECCCCCCCEEEEEECCCCEEEHHHHHCCCCCCEECEEHHCCHHHHHHHHHHHHHH
ANLTLADLQSVIFAYPSPASDLTALN
CCCCHHHHHHHHEECCCCCCCCCCCC
>Mature Secondary Structure 
AKFTYDVVIIGSGASGTTVAFEAQAAGLKVAIVEERSWGGTCVLRGCDPKKVLVGAREA
CEEEEEEEEEECCCCCCEEEEEECCCCEEEEEEEECCCCCEEEEECCCCCCEEEECHHH
RNLSTRLRGKGIKQAATISWTDLMAFKETFVENVPESRLENFQEAGIETFFGAASFQDSH
HCHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHCCCCCCCCCC
SLQVGDDLIQANKIVIATGATPSTLKVEGQEYIQTSDDFLSLEKLPDSVVFIGGGYISFE
CEECCCHHHCCCEEEEEECCCCCEEEECCHHHHCCCCCHHHHHHCCCEEEEEECCEEEEE
FASIALAAGREVHIIHHNSEPLKKFDSDFVAALVTHMKEEGIHFHFDTDITKVENKGEKL
EEEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCEEECCCCCEE
HIHGKDGFSLQTDLIIGATGRKPNIAHLSLENANIDYTKKGIIVNEKLQTTNNPHIYACG
EEECCCCCEEEEEEEEECCCCCCCEEEEEEECCCCCEECCCEEEECEECCCCCCEEEEEC
DVAATKGAPLTPVVSMEAAFVAKNVIGGDEKMIYPAIPSVVFTSPKLASIGISAEEAKAH
CEECCCCCCCCEEEEHHHHHHHHHHCCCCCEEEECCCCCEEECCCCCEEECCCHHHHHCC
PEKYQIKNHDTTNWYTYKRTNEQIALAKIIEDRESGQIKGAHFLSEEADYMINYVAILMK
CCCEEECCCCCCCEEEEEECCCCEEEHHHHHCCCCCCEECEEHHCCHHHHHHHHHHHHHH
ANLTLADLQSVIFAYPSPASDLTALN
CCCCHHHHHHHHEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7538273 [H]