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The map label for this gene is mutL

Identifier: 226224005

GI number: 226224005

Start: 1416543

End: 1418354

Strand: Direct

Name: mutL

Synonym: Lm4b_01413

Alternate gene names: 226224005

Gene position: 1416543-1418354 (Clockwise)

Preceding gene: 226224004

Following gene: 226224006

Centisome position: 48.63

GC content: 37.8

Gene sequence:

>1812_bases
ATGGCTAAACATATTGTCGAATTAACCGATGCTCTATCCAATAAAATTGCTGCCGGAGAAGTAGTAGAACGCCCTGCTTC
AGTCGTTAAAGAATTAGTAGAAAATGCAATTGATGCAGGGAGCACCGTCATAGATATTTTAGTGGAAGAAGCGGGATTAA
ATAAAATTACCATTATTGATAACGGTAGTGGCATTGAAGAAGAAGATGTCGCAACAGCTTTTTTACGTCACGCCACAAGC
AAAATCAAAAACGAAGCAGATTTATTCCGTGTGCATACACTAGGATTCCGCGGTGAGGCACTTCCAAGTATTGCCTCTGT
GTCCCATTTAGAGATGGAAACTTCCACTGGCGAAGCAAAAGGAACGACCATTTCTTTAGAAGGCGGGAAAATAATCGAAC
AAAAAAGCGGACATGCTAGAAAAGGAACACAAATCGAAGTATCCCAGTTGTTCTTTAATACGCCAGCACGCCTAAAATAT
TTAAAAAGTTTACCAACCGAACTTGGTAACATAACCGATATTCTAAATCGCTTAGCTTTGGCGCATCCAGATATCAGTTT
CCGCTTTTCACACAACGGAAAACCTTTATTACAAACCAATGGGAATGGGGATTTACGCCAAGTAATTGCAGCAATTTACG
GTGTTTCGATTGCAAAAAAATCAGTACCAGTTAAAGCAGAGTCACTTGATTTTAAAATTTCTGGATATGCTGTATTACCA
GAAGTGAACCGCTCTAACCGTAATTATATTTCGACCATCATTAACGGTCGTTTTATTAAAAATTTCGCATTAGTAAAAGC
TATTCAAGAAGGATATCACACGCTCTTACCAATTGGCCGTTTCCCGATTATCGTTCTCCAAATCGAGATGGACCCAATTA
TTGTAGATGTAAACGTTCATCCTGCTAAATTAGAAGTCCGCTTAAGTAAAGAAAAAGAATTAGGACAACTAATTAGTCAA
ATGATTAAAGAGACTTTCCACAAATTGCAACTAATTCCAGATGGAGAGATTTCTAAAAAACAAAAAGAAGACCAAAAATC
GGAACAAATCCAAATATCTTTTGAAGAAAAGAAACCCGTAAAAGAAACACCAACTCTTTTTTCAAAACCAACTATCCCGG
AATATGTCCCTTCAGATGAGGATGCTCCGCGAGAAGATGATTTTATTTTGGAAACAATGCCGTCCTATGAACCAGAATCT
CAAGCGGAGCAAGAAGAGCATACGAAAGAACGTATTCCTAAAATGTATCCAATTGGTCAAATGCATGCAACTTATATTTT
TGCGCAAAATGAAAATGGCTTATATATCATTGATCAACATGCAGCACAGGAACGGATTAAATACGAATTTTATCGTGAGA
AAATTGGAGAAGTTAGTCGCGAGTTGCAAGAATTACTTGTTCCTATTGTGCTTGAATTTCCAGCGGATGAGTATGTTCGT
TTAGAAGAACAAAAAGCTAAATTAGAAGAGGTCGGCGTTTTCCTAGAGAACTTCGGGCAAAATAGTTTTATCATTCGTGC
GCATCCAACTTGGTTCCCGAAAGACCAAGAAGAGGAGATGCTTCGGGAAATTATTGATGAAGCGTTATCCGCTCCAAGCA
TAAGTATTCATAAATTAAGGGAAGACACAGCTATTATGATGAGTTGTAAAAAATCAATTAAAGCAAATCACTATTTAACA
ACGCAAGACATGGAAGCATTACTCGATACACTGAGAGAAGCAAGCGATCCATTCACTTGTCCTCATGGACGTCCGGTGAT
TATCCAATACTCAACATATGAACTAGAAAAAATGTTTAAACGTGTGATGTAA

Upstream 100 bases:

>100_bases
ATTGCCTCCATGAACATTATGCAGATGACACCAATGGACGCGATGAATAAATTATACGAACTTCAAAGTAAAATCCATTA
AAAAGAAAGGCGGGTTTTAA

Downstream 100 bases:

>100_bases
AAGAGGAGGAAATAATTTGGAGTTACCATTTTCCAATCAATCAATCATCCCAGCTGCACATAATCAAAAAGATATGGAAA
AAATTTTAGAGCTTGATTTG

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 603; Mature: 602

Protein sequence:

>603_residues
MAKHIVELTDALSNKIAAGEVVERPASVVKELVENAIDAGSTVIDILVEEAGLNKITIIDNGSGIEEEDVATAFLRHATS
KIKNEADLFRVHTLGFRGEALPSIASVSHLEMETSTGEAKGTTISLEGGKIIEQKSGHARKGTQIEVSQLFFNTPARLKY
LKSLPTELGNITDILNRLALAHPDISFRFSHNGKPLLQTNGNGDLRQVIAAIYGVSIAKKSVPVKAESLDFKISGYAVLP
EVNRSNRNYISTIINGRFIKNFALVKAIQEGYHTLLPIGRFPIIVLQIEMDPIIVDVNVHPAKLEVRLSKEKELGQLISQ
MIKETFHKLQLIPDGEISKKQKEDQKSEQIQISFEEKKPVKETPTLFSKPTIPEYVPSDEDAPREDDFILETMPSYEPES
QAEQEEHTKERIPKMYPIGQMHATYIFAQNENGLYIIDQHAAQERIKYEFYREKIGEVSRELQELLVPIVLEFPADEYVR
LEEQKAKLEEVGVFLENFGQNSFIIRAHPTWFPKDQEEEMLREIIDEALSAPSISIHKLREDTAIMMSCKKSIKANHYLT
TQDMEALLDTLREASDPFTCPHGRPVIIQYSTYELEKMFKRVM

Sequences:

>Translated_603_residues
MAKHIVELTDALSNKIAAGEVVERPASVVKELVENAIDAGSTVIDILVEEAGLNKITIIDNGSGIEEEDVATAFLRHATS
KIKNEADLFRVHTLGFRGEALPSIASVSHLEMETSTGEAKGTTISLEGGKIIEQKSGHARKGTQIEVSQLFFNTPARLKY
LKSLPTELGNITDILNRLALAHPDISFRFSHNGKPLLQTNGNGDLRQVIAAIYGVSIAKKSVPVKAESLDFKISGYAVLP
EVNRSNRNYISTIINGRFIKNFALVKAIQEGYHTLLPIGRFPIIVLQIEMDPIIVDVNVHPAKLEVRLSKEKELGQLISQ
MIKETFHKLQLIPDGEISKKQKEDQKSEQIQISFEEKKPVKETPTLFSKPTIPEYVPSDEDAPREDDFILETMPSYEPES
QAEQEEHTKERIPKMYPIGQMHATYIFAQNENGLYIIDQHAAQERIKYEFYREKIGEVSRELQELLVPIVLEFPADEYVR
LEEQKAKLEEVGVFLENFGQNSFIIRAHPTWFPKDQEEEMLREIIDEALSAPSISIHKLREDTAIMMSCKKSIKANHYLT
TQDMEALLDTLREASDPFTCPHGRPVIIQYSTYELEKMFKRVM
>Mature_602_residues
AKHIVELTDALSNKIAAGEVVERPASVVKELVENAIDAGSTVIDILVEEAGLNKITIIDNGSGIEEEDVATAFLRHATSK
IKNEADLFRVHTLGFRGEALPSIASVSHLEMETSTGEAKGTTISLEGGKIIEQKSGHARKGTQIEVSQLFFNTPARLKYL
KSLPTELGNITDILNRLALAHPDISFRFSHNGKPLLQTNGNGDLRQVIAAIYGVSIAKKSVPVKAESLDFKISGYAVLPE
VNRSNRNYISTIINGRFIKNFALVKAIQEGYHTLLPIGRFPIIVLQIEMDPIIVDVNVHPAKLEVRLSKEKELGQLISQM
IKETFHKLQLIPDGEISKKQKEDQKSEQIQISFEEKKPVKETPTLFSKPTIPEYVPSDEDAPREDDFILETMPSYEPESQ
AEQEEHTKERIPKMYPIGQMHATYIFAQNENGLYIIDQHAAQERIKYEFYREKIGEVSRELQELLVPIVLEFPADEYVRL
EEQKAKLEEVGVFLENFGQNSFIIRAHPTWFPKDQEEEMLREIIDEALSAPSISIHKLREDTAIMMSCKKSIKANHYLTT
QDMEALLDTLREASDPFTCPHGRPVIIQYSTYELEKMFKRVM

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=330, Percent_Identity=36.6666666666667, Blast_Score=195, Evalue=9e-50,
Organism=Homo sapiens, GI310128478, Length=330, Percent_Identity=32.4242424242424, Blast_Score=149, Evalue=1e-35,
Organism=Homo sapiens, GI4505913, Length=330, Percent_Identity=32.4242424242424, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI4505911, Length=373, Percent_Identity=28.686327077748, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI189458898, Length=373, Percent_Identity=28.686327077748, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI189458896, Length=362, Percent_Identity=29.0055248618785, Blast_Score=125, Evalue=2e-28,
Organism=Homo sapiens, GI310128480, Length=296, Percent_Identity=30.4054054054054, Blast_Score=115, Evalue=9e-26,
Organism=Homo sapiens, GI263191589, Length=232, Percent_Identity=32.3275862068966, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI91992160, Length=261, Percent_Identity=28.735632183908, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI91992162, Length=261, Percent_Identity=28.735632183908, Blast_Score=91, Evalue=3e-18,
Organism=Escherichia coli, GI1790612, Length=532, Percent_Identity=32.8947368421053, Blast_Score=228, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI71991825, Length=306, Percent_Identity=34.3137254901961, Blast_Score=175, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI17562796, Length=422, Percent_Identity=28.1990521327014, Blast_Score=138, Evalue=7e-33,
Organism=Saccharomyces cerevisiae, GI6323819, Length=336, Percent_Identity=35.7142857142857, Blast_Score=181, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6324247, Length=395, Percent_Identity=27.8481012658228, Blast_Score=140, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6325093, Length=385, Percent_Identity=23.8961038961039, Blast_Score=84, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6323063, Length=338, Percent_Identity=25.7396449704142, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI17136968, Length=343, Percent_Identity=34.402332361516, Blast_Score=193, Evalue=3e-49,
Organism=Drosophila melanogaster, GI17136970, Length=348, Percent_Identity=28.735632183908, Blast_Score=127, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 68074; Mature: 67943

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKHIVELTDALSNKIAAGEVVERPASVVKELVENAIDAGSTVIDILVEEAGLNKITIID
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEE
NGSGIEEEDVATAFLRHATSKIKNEADLFRVHTLGFRGEALPSIASVSHLEMETSTGEAK
CCCCCCHHHHHHHHHHHHHHHHCCHHHEEEEEECCCCCCCCCHHHHHHHEEEECCCCCCC
GTTISLEGGKIIEQKSGHARKGTQIEVSQLFFNTPARLKYLKSLPTELGNITDILNRLAL
CCEEEECCCEEEECCCCCCCCCCEEEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AHPDISFRFSHNGKPLLQTNGNGDLRQVIAAIYGVSIAKKSVPVKAESLDFKISGYAVLP
CCCCEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCEECCCEEEEECEEEEC
EVNRSNRNYISTIINGRFIKNFALVKAIQEGYHTLLPIGRFPIIVLQIEMDPIIVDVNVH
CCCCCCCHHHHHHHCCHHHHHHHHHHHHHHCHHHHCCCCCCCEEEEEEECCCEEEEEECC
PAKLEVRLSKEKELGQLISQMIKETFHKLQLIPDGEISKKQKEDQKSEQIQISFEEKKPV
CCEEEEEECCHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHCCCCEEEEEECCCCCC
KETPTLFSKPTIPEYVPSDEDAPREDDFILETMPSYEPESQAEQEEHTKERIPKMYPIGQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHCCCCCCCCC
MHATYIFAQNENGLYIIDQHAAQERIKYEFYREKIGEVSRELQELLVPIVLEFPADEYVR
EEEEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHH
LEEQKAKLEEVGVFLENFGQNSFIIRAHPTWFPKDQEEEMLREIIDEALSAPSISIHKLR
HHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHH
EDTAIMMSCKKSIKANHYLTTQDMEALLDTLREASDPFTCPHGRPVIIQYSTYELEKMFK
HHHHHHHHHHHHHCCCCEECHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECHHHHHHHHH
RVM
HCC
>Mature Secondary Structure 
AKHIVELTDALSNKIAAGEVVERPASVVKELVENAIDAGSTVIDILVEEAGLNKITIID
CCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEE
NGSGIEEEDVATAFLRHATSKIKNEADLFRVHTLGFRGEALPSIASVSHLEMETSTGEAK
CCCCCCHHHHHHHHHHHHHHHHCCHHHEEEEEECCCCCCCCCHHHHHHHEEEECCCCCCC
GTTISLEGGKIIEQKSGHARKGTQIEVSQLFFNTPARLKYLKSLPTELGNITDILNRLAL
CCEEEECCCEEEECCCCCCCCCCEEEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AHPDISFRFSHNGKPLLQTNGNGDLRQVIAAIYGVSIAKKSVPVKAESLDFKISGYAVLP
CCCCEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCEECCCEEEEECEEEEC
EVNRSNRNYISTIINGRFIKNFALVKAIQEGYHTLLPIGRFPIIVLQIEMDPIIVDVNVH
CCCCCCCHHHHHHHCCHHHHHHHHHHHHHHCHHHHCCCCCCCEEEEEEECCCEEEEEECC
PAKLEVRLSKEKELGQLISQMIKETFHKLQLIPDGEISKKQKEDQKSEQIQISFEEKKPV
CCEEEEEECCHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHCCCCEEEEEECCCCCC
KETPTLFSKPTIPEYVPSDEDAPREDDFILETMPSYEPESQAEQEEHTKERIPKMYPIGQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHCCCCCCCCC
MHATYIFAQNENGLYIIDQHAAQERIKYEFYREKIGEVSRELQELLVPIVLEFPADEYVR
EEEEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHH
LEEQKAKLEEVGVFLENFGQNSFIIRAHPTWFPKDQEEEMLREIIDEALSAPSISIHKLR
HHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHH
EDTAIMMSCKKSIKANHYLTTQDMEALLDTLREASDPFTCPHGRPVIIQYSTYELEKMFK
HHHHHHHHHHHHHCCCCEECHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECHHHHHHHHH
RVM
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]