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The map label for this gene is parC

Identifier: 226223890

GI number: 226223890

Start: 1296636

End: 1299095

Strand: Direct

Name: parC

Synonym: Lm4b_01297

Alternate gene names: 226223890

Gene position: 1296636-1299095 (Clockwise)

Preceding gene: 226223889

Following gene: 226223891

Centisome position: 44.52

GC content: 38.09

Gene sequence:

>2460_bases
TTGAGTAATCCAGAACAACATATCCAAGACTTAGCGCTAGAAGAAGTTATGGGCGACCGTTTTGGTAGATATAGTAAATA
TATTATTCAAGAACGTGCGCTTCCAGATGTTCGTGACGGACTGAAACCTGTACAACGTCGTATTTTATTCGCGATGAATG
TCGAAGGAAATACTGCTGAGAAAGGTTTCCGTAAATCTGCTAAAACGGTCGGAAACGTTATCGGTAACTACCATCCACAT
GGTGACTCTTCAGTTTACGAAGCAATGGTACGGATGAGTCAAGACTGGAAAGTACGTAATATGCTGATTGAAATGCATGG
TAATAACGGTAGTGTCGACGGGGATCCGCCTGCAGCAATGCGTTATACAGAAGCTCGCCTTTCTCCTATATCAGCAGAAC
TTTTACGCGATATTGAAAAGGAAACAGTTGACTTTATTCCTAACTTTGATGATACATCTAGTGAGCCAACTGTTTTACCA
GCACGTTTTCCAAACCTTTTAGTGAATGGTTCTACCGGTATCTCCGCTGGTTATGCAACAGATATTCCGCCGCATAATTT
AACAGAGATCATCGAAGCTGTTATTAAACGATTAGATAACCCACTTTCCACAACGGATGATATTATGAAAATTGTCAAAG
GTCCAGATTTCCCAACAGGTGGGATTATTCAAGGGATTGATGGTATTCGAAAAGCTTACCAAACTGGAAAAGGACGCGTT
GTCGTTCGTTCTAAAACAGAAATTGAAGATATTCGTGGCGGTAGAAAACAAATTACAATTCATGAAATTCCATATGAAGT
AAATAAAGCTAATTTAGTTAAACGCATGGATGAACTTCGAATTGAGAAAAAAATTGAAGGTATTTCAGAAGTACGTGATG
AAACCGACCGCACAGGACTTCGTATTGCTGTTGAACTAAAAAAAGATGCCAATGCTGAAGGTGTTTTGAACTACCTGTTT
AAAAATACAGATTTACAAGTAAGCTATAATTTTAACATGGTTGCTATCAATAAAAAACGTCCGGAGCTAATGGGCATTAT
CCCAATGCTTGACGCTTATATTGAACACCAAAAAGAAATTATTACGAAGCGCTCTGAATACGATATTCGTAAAGCGCGCG
CTCGCCAACATATTTTAGAAGGTTTAATTAAAGCTTTGTCTATTTTAGATGAAGTCATTAAATTAATTCGTGGTTCAAAA
GACAAACGCGATGCAAAACTAAATCTTCAAACAAAATATGATTTCAGCGAAAAACAAGCAGAAGCAATTGTATCTTTACA
ACTTTATCGTTTAACAAATACAGATATACATGAACTTCAAAGTGAAGCAAAATCCTTAGCAGAACAAATTAGTGTTCTTG
AAAAAATCCTAGGTGATGAAGCAGAGCTTATCGCTGTGTTAAAAGAAGAGCTAGCGGAAATTAAGAAAAAATATAAAACT
GCTCGCCGTACAGAAGTGCAAGCAGAAATTACAGAAATCAAAATCGATACAGAAGTACTTGTTGCGAATGAAGATGTGAT
TGTTTCTGTGACAAAAGAAGGCTATGTGAAACGTACGAGCCAACGTTCTTATGCAGCATCAAACGGTGCGGAACTAGCCA
TGAAAGAAGCAGACCATGCCGTCTTTATCCAAAAAATGAATTCACTTGATTCGCTCCTGTTATTCACGAGCAAAGGGAAT
TTCATTTATCGACCAGTACATGAGTTGCCAGATATTCGCTGGAAAAACCTCGGAGATCACGTAAGTCACTTGGCCAGTGA
TTTATCGGCAGGTGAAGAAATCCGTTCTGCTATTGCAATTCAAGCCTTTACGGAAGAAAAACGCTTTTTATTCGTTACTA
AAAACGGCATGACCAAGCAATCAGCTATTACGAATTACAAACCACAACGCTATTCTAAATCCATGATGGCAATTAAATTA
AAAGGTGACGATGAACTGTTAAGTGTTCATTTGATTGATGGCACAGAAGATATTTTCTTAGCAACCAAAAATGGTTACGG
CCTTCGTTATTCTATTACTGAAATTCCAGAATCAGGTGCAAGAACAGCGGGTGTAAAAGCGATTAACTTAAAACAAGATG
ATATAGTTATTGGCGGTATAGTCCTTATGCCGAACGAACAAAAACATATTCTTCTTGCCACACAACGTGGCTCACTCAAA
CAAATGAAAGCAAGCGAATTTGAACCAATCTCAAGAGCGAAACGTGGCTTATTGATGTTACGCGAACTGAAAAGCAATCC
ACATCGCTTCATTGGTATAACTCTTGCTGATAATAACGACCACCTATTTATCGAAACAAACACAGACCAAATTGTTGAAA
TAGACGTTGCCAATCTACGAATAACGGATCGCTATTCTAACGGATCCTTCGTACTCGATGAAACAATGGAAGGCGAACCA
ACTTCTATTTGGCTAGCAATACCCGAAATAAAAGATACCTCAGATGCAAAAGATGAATAA

Upstream 100 bases:

>100_bases
CAAGACGACAATGGATTGAAAAGCATGTCGAGTTTTCTATGGAAGATAGCCAAAATATTTTAGAAAATGAAAACATGATG
GTTGAGGAGGCGAAAGACAT

Downstream 100 bases:

>100_bases
GGAAGAAAAAGAGTTCTTGTATAGAAATATGCAAGGATTCTTTTTTTTGATATAATAACAAAGAATAAGAGGAGGGATAC
GCATGGCAGAAAAAATGAAT

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 819; Mature: 818

Protein sequence:

>819_residues
MSNPEQHIQDLALEEVMGDRFGRYSKYIIQERALPDVRDGLKPVQRRILFAMNVEGNTAEKGFRKSAKTVGNVIGNYHPH
GDSSVYEAMVRMSQDWKVRNMLIEMHGNNGSVDGDPPAAMRYTEARLSPISAELLRDIEKETVDFIPNFDDTSSEPTVLP
ARFPNLLVNGSTGISAGYATDIPPHNLTEIIEAVIKRLDNPLSTTDDIMKIVKGPDFPTGGIIQGIDGIRKAYQTGKGRV
VVRSKTEIEDIRGGRKQITIHEIPYEVNKANLVKRMDELRIEKKIEGISEVRDETDRTGLRIAVELKKDANAEGVLNYLF
KNTDLQVSYNFNMVAINKKRPELMGIIPMLDAYIEHQKEIITKRSEYDIRKARARQHILEGLIKALSILDEVIKLIRGSK
DKRDAKLNLQTKYDFSEKQAEAIVSLQLYRLTNTDIHELQSEAKSLAEQISVLEKILGDEAELIAVLKEELAEIKKKYKT
ARRTEVQAEITEIKIDTEVLVANEDVIVSVTKEGYVKRTSQRSYAASNGAELAMKEADHAVFIQKMNSLDSLLLFTSKGN
FIYRPVHELPDIRWKNLGDHVSHLASDLSAGEEIRSAIAIQAFTEEKRFLFVTKNGMTKQSAITNYKPQRYSKSMMAIKL
KGDDELLSVHLIDGTEDIFLATKNGYGLRYSITEIPESGARTAGVKAINLKQDDIVIGGIVLMPNEQKHILLATQRGSLK
QMKASEFEPISRAKRGLLMLRELKSNPHRFIGITLADNNDHLFIETNTDQIVEIDVANLRITDRYSNGSFVLDETMEGEP
TSIWLAIPEIKDTSDAKDE

Sequences:

>Translated_819_residues
MSNPEQHIQDLALEEVMGDRFGRYSKYIIQERALPDVRDGLKPVQRRILFAMNVEGNTAEKGFRKSAKTVGNVIGNYHPH
GDSSVYEAMVRMSQDWKVRNMLIEMHGNNGSVDGDPPAAMRYTEARLSPISAELLRDIEKETVDFIPNFDDTSSEPTVLP
ARFPNLLVNGSTGISAGYATDIPPHNLTEIIEAVIKRLDNPLSTTDDIMKIVKGPDFPTGGIIQGIDGIRKAYQTGKGRV
VVRSKTEIEDIRGGRKQITIHEIPYEVNKANLVKRMDELRIEKKIEGISEVRDETDRTGLRIAVELKKDANAEGVLNYLF
KNTDLQVSYNFNMVAINKKRPELMGIIPMLDAYIEHQKEIITKRSEYDIRKARARQHILEGLIKALSILDEVIKLIRGSK
DKRDAKLNLQTKYDFSEKQAEAIVSLQLYRLTNTDIHELQSEAKSLAEQISVLEKILGDEAELIAVLKEELAEIKKKYKT
ARRTEVQAEITEIKIDTEVLVANEDVIVSVTKEGYVKRTSQRSYAASNGAELAMKEADHAVFIQKMNSLDSLLLFTSKGN
FIYRPVHELPDIRWKNLGDHVSHLASDLSAGEEIRSAIAIQAFTEEKRFLFVTKNGMTKQSAITNYKPQRYSKSMMAIKL
KGDDELLSVHLIDGTEDIFLATKNGYGLRYSITEIPESGARTAGVKAINLKQDDIVIGGIVLMPNEQKHILLATQRGSLK
QMKASEFEPISRAKRGLLMLRELKSNPHRFIGITLADNNDHLFIETNTDQIVEIDVANLRITDRYSNGSFVLDETMEGEP
TSIWLAIPEIKDTSDAKDE
>Mature_818_residues
SNPEQHIQDLALEEVMGDRFGRYSKYIIQERALPDVRDGLKPVQRRILFAMNVEGNTAEKGFRKSAKTVGNVIGNYHPHG
DSSVYEAMVRMSQDWKVRNMLIEMHGNNGSVDGDPPAAMRYTEARLSPISAELLRDIEKETVDFIPNFDDTSSEPTVLPA
RFPNLLVNGSTGISAGYATDIPPHNLTEIIEAVIKRLDNPLSTTDDIMKIVKGPDFPTGGIIQGIDGIRKAYQTGKGRVV
VRSKTEIEDIRGGRKQITIHEIPYEVNKANLVKRMDELRIEKKIEGISEVRDETDRTGLRIAVELKKDANAEGVLNYLFK
NTDLQVSYNFNMVAINKKRPELMGIIPMLDAYIEHQKEIITKRSEYDIRKARARQHILEGLIKALSILDEVIKLIRGSKD
KRDAKLNLQTKYDFSEKQAEAIVSLQLYRLTNTDIHELQSEAKSLAEQISVLEKILGDEAELIAVLKEELAEIKKKYKTA
RRTEVQAEITEIKIDTEVLVANEDVIVSVTKEGYVKRTSQRSYAASNGAELAMKEADHAVFIQKMNSLDSLLLFTSKGNF
IYRPVHELPDIRWKNLGDHVSHLASDLSAGEEIRSAIAIQAFTEEKRFLFVTKNGMTKQSAITNYKPQRYSKSMMAIKLK
GDDELLSVHLIDGTEDIFLATKNGYGLRYSITEIPESGARTAGVKAINLKQDDIVIGGIVLMPNEQKHILLATQRGSLKQ
MKASEFEPISRAKRGLLMLRELKSNPHRFIGITLADNNDHLFIETNTDQIVEIDVANLRITDRYSNGSFVLDETMEGEPT
SIWLAIPEIKDTSDAKDE

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm. Note=Bipolarly localized [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=176, Percent_Identity=29.5454545454545, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI1788562, Length=842, Percent_Identity=38.8361045130641, Blast_Score=576, Evalue=1e-165,
Organism=Escherichia coli, GI1789396, Length=744, Percent_Identity=32.6612903225806, Blast_Score=353, Evalue=3e-98,
Organism=Caenorhabditis elegans, GI17535065, Length=175, Percent_Identity=33.7142857142857, Blast_Score=77, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI115534553, Length=170, Percent_Identity=30.5882352941176, Blast_Score=71, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI212645657, Length=173, Percent_Identity=32.3699421965318, Blast_Score=70, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI212645845, Length=225, Percent_Identity=29.3333333333333, Blast_Score=69, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324241, Length=167, Percent_Identity=28.1437125748503, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17136538, Length=175, Percent_Identity=29.7142857142857, Blast_Score=68, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760
- InterPro:   IPR005741 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 92189; Mature: 92057

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNPEQHIQDLALEEVMGDRFGRYSKYIIQERALPDVRDGLKPVQRRILFAMNVEGNTAE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEEEEECCCCCHH
KGFRKSAKTVGNVIGNYHPHGDSSVYEAMVRMSQDWKVRNMLIEMHGNNGSVDGDPPAAM
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCCCHHH
RYTEARLSPISAELLRDIEKETVDFIPNFDDTSSEPTVLPARFPNLLVNGSTGISAGYAT
EEHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCEEEECCCCCCCCCCC
DIPPHNLTEIIEAVIKRLDNPLSTTDDIMKIVKGPDFPTGGIIQGIDGIRKAYQTGKGRV
CCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEE
VVRSKTEIEDIRGGRKQITIHEIPYEVNKANLVKRMDELRIEKKIEGISEVRDETDRTGL
EEECCCHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
RIAVELKKDANAEGVLNYLFKNTDLQVSYNFNMVAINKKRPELMGIIPMLDAYIEHQKEI
EEEEEECCCCCHHHHHHHHHCCCCEEEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHH
ITKRSEYDIRKARARQHILEGLIKALSILDEVIKLIRGSKDKRDAKLNLQTKYDFSEKQA
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCHHHH
EAIVSLQLYRLTNTDIHELQSEAKSLAEQISVLEKILGDEAELIAVLKEELAEIKKKYKT
HHHHEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
ARRTEVQAEITEIKIDTEVLVANEDVIVSVTKEGYVKRTSQRSYAASNGAELAMKEADHA
HHHHHHEEEEEEEEECCEEEEECCCEEEEEECCCCHHHCCCCHHCCCCCCHHHHHHCCHH
VFIQKMNSLDSLLLFTSKGNFIYRPVHELPDIRWKNLGDHVSHLASDLSAGEEIRSAIAI
HHHHHHCCCCEEEEEECCCCEEECCHHHCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHH
QAFTEEKRFLFVTKNGMTKQSAITNYKPQRYSKSMMAIKLKGDDELLSVHLIDGTEDIFL
HEEECCCEEEEEECCCCCHHHHHCCCCCHHHCCCEEEEEECCCCCEEEEEEECCCCEEEE
ATKNGYGLRYSITEIPESGARTAGVKAINLKQDDIVIGGIVLMPNEQKHILLATQRGSLK
EECCCCCEEEEHHCCCCCCCCCCCEEEEECCCCCEEEEEEEEECCCCCEEEEEECCCCHH
QMKASEFEPISRAKRGLLMLRELKSNPHRFIGITLADNNDHLFIETNTDQIVEIDVANLR
HHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEEECCCCEEEEEEEEEE
ITDRYSNGSFVLDETMEGEPTSIWLAIPEIKDTSDAKDE
EEEEECCCCEEEECCCCCCCCEEEEEECCCCCCCCCCCC
>Mature Secondary Structure 
SNPEQHIQDLALEEVMGDRFGRYSKYIIQERALPDVRDGLKPVQRRILFAMNVEGNTAE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEEEEECCCCCHH
KGFRKSAKTVGNVIGNYHPHGDSSVYEAMVRMSQDWKVRNMLIEMHGNNGSVDGDPPAAM
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCCCHHH
RYTEARLSPISAELLRDIEKETVDFIPNFDDTSSEPTVLPARFPNLLVNGSTGISAGYAT
EEHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCEEEECCCCCCCCCCC
DIPPHNLTEIIEAVIKRLDNPLSTTDDIMKIVKGPDFPTGGIIQGIDGIRKAYQTGKGRV
CCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEE
VVRSKTEIEDIRGGRKQITIHEIPYEVNKANLVKRMDELRIEKKIEGISEVRDETDRTGL
EEECCCHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
RIAVELKKDANAEGVLNYLFKNTDLQVSYNFNMVAINKKRPELMGIIPMLDAYIEHQKEI
EEEEEECCCCCHHHHHHHHHCCCCEEEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHH
ITKRSEYDIRKARARQHILEGLIKALSILDEVIKLIRGSKDKRDAKLNLQTKYDFSEKQA
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCHHHH
EAIVSLQLYRLTNTDIHELQSEAKSLAEQISVLEKILGDEAELIAVLKEELAEIKKKYKT
HHHHEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
ARRTEVQAEITEIKIDTEVLVANEDVIVSVTKEGYVKRTSQRSYAASNGAELAMKEADHA
HHHHHHEEEEEEEEECCEEEEECCCEEEEEECCCCHHHCCCCHHCCCCCCHHHHHHCCHH
VFIQKMNSLDSLLLFTSKGNFIYRPVHELPDIRWKNLGDHVSHLASDLSAGEEIRSAIAI
HHHHHHCCCCEEEEEECCCCEEECCHHHCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHH
QAFTEEKRFLFVTKNGMTKQSAITNYKPQRYSKSMMAIKLKGDDELLSVHLIDGTEDIFL
HEEECCCEEEEEECCCCCHHHHHCCCCCHHHCCCEEEEEECCCCCEEEEEEECCCCEEEE
ATKNGYGLRYSITEIPESGARTAGVKAINLKQDDIVIGGIVLMPNEQKHILLATQRGSLK
EECCCCCEEEEHHCCCCCCCCCCCEEEEECCCCCEEEEEEEEECCCCCEEEEEECCCCHH
QMKASEFEPISRAKRGLLMLRELKSNPHRFIGITLADNNDHLFIETNTDQIVEIDVANLR
HHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEEECCCCEEEEEEEEEE
ITDRYSNGSFVLDETMEGEPTSIWLAIPEIKDTSDAKDE
EEEEECCCCEEEECCCCCCCCEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969507; 9539793; 9384377 [H]