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The map label for this gene is secA2 [H]

Identifier: 226223212

GI number: 226223212

Start: 624452

End: 626782

Strand: Direct

Name: secA2 [H]

Synonym: Lm4b_00609

Alternate gene names: 226223212

Gene position: 624452-626782 (Clockwise)

Preceding gene: 226223209

Following gene: 226223213

Centisome position: 21.44

GC content: 39.43

Gene sequence:

>2331_bases
ATGAGACAAAATTATGATGATCGAAAAATAGTGAAACAGTATCGAGAAATAGCCCGTCAAATTGTAAAAAAAGAGGGCTT
ATATAAAAATATGGATCAGGCTGAACTTTGTGAACAAACTAATTTTTGGCGCGAGAAGTTTAAGACAAAACCGATGACTG
ATCGAGATAAAATTAATATTTTTGCTTTGGCGAGAGAAGCAGCTAGCCGAATTATTGGTTTGGATGCGGTTGTAGTGCAA
TTAATAGGAGCGCTCGTTCTCGGCGATGGCAAAGTGGCAGAAATGAAAACCGGCGAGGGTAAAACATTGATGTCGTTATT
TGTTATGTTTATAGAAGTAATGCGTGGTAATCGTGTACACCTTGTGACTGCCAATGAGTATTTAGCTAGACGTGACCGGG
AAGAAATTGGACAAGTGCTGGAATATCTTGGTGTTTCCGTTGCGTTAAATGAATCTGGTTTAGACATAGCCCAAAAAAAG
GCCATTTATACAGCAGATGTTATTTATGGAACGGCTTCTGAATTTGGTTTTGATTACTTACGCGACAATATGGTACGCCA
AAAAGAAGATAAAGTACAAAGTGGACTTGATTTTGTTTTAATAGATGAAGCAGATTCAATTTTAATAGATGAAGCGAGAA
CGCCCCTACTGATTTCTGACCGTAAAGAAGAAGATTTGTCCCTTTATCATACAGCGAATAAGCTTGTGAAGAAGATGATG
AAAGATGATTATGAGATGGAAGAACATAAACGCTTTGTTTGGTTGAATGATGCTGGAATTGAGAAAGCCCAGAAGTTTTG
GGGTGTCGAATCACTTTATTCCGCAGAGGCGCAGTCAGAACTTAGAATTACGATGCTTTTAATGCGAGCTCATTTCTTGA
TGCATAAAGATAAAGATTATGTGGTGCTTGATGATGAAGTATTAATTATCGATCCACATACTGGTCGTGCACTTCCAGGG
CGGCGCTTTAATGACGGACTCCATCAGGCAATCGAAGCAAAAGAGGGCGTGGAAGTTAAAGAAGAATCACGTACGCTAGC
AACAATTACAATTCAAAACTACTTCCGGATGTATAAGAAAATTTCTGGAATGACAGGAACGGCTAAAACCGAAGAAGAAG
AATTCCGTCAAATTTATAACATGGATGTCGTAGTAATCCCCACCAATTTACGTGTAAATCGGGAAGATATGCAAGATGAT
ATTTTCTATACGAAAAAGGAAAAAGGTCGTGCGATTGTGTATGAAGTATCATGGCGCTATGAAAAAGGACAGCCAACTTT
AATAGGAACTTCTTCTATTAAAAGTAACGAATGGATCAGTGGCTTATTAGACGCTGCTGGAATTCCCCACCAAGTATTAA
ATGCGAAAAACCATGCCCAAGAAGCGGAAATAATTGCCAAAGCTGGGAAACGCGGAATGGTAACTTTAGCAACGAACATG
GCTGGTCGGGGGACAGATATCAAGCTGGATCCAGATGTACATAAGCTCGGCGGACTAGCTGTAATTGGAACGGAGCGCCA
TGAGAGCCGTCGGATAGATCTACAGCTAATGGGACGTTCTGGACGACGGGGTGACCCTGGTTTCAGTAAGTTTATGATTT
CTTTAGAAGATGATTTATTAGAACAATTTGAAAGTAAGAGCTGGGAGAAACTTTCCACGAAACTTAAACGCAAAGCACCA
CGTGATGGGAAACCAGTTAATTCAAGGAAAATTCATGCTGTCGTTGTGGATGCACAAAAACGCCTAGAAGGAGCAAACTA
CGATATTCGTAAAGATTTGCTTTCCTACGATGAAGTAATCGATTTACAACGCAAAATGGTATATAAAGAACGCGATTTAT
TATTAGAAAGAAATAAACTTGGAGTCTCTTCCGAAAAAATTCTACGTGAAGTTGCCGAATATTCATTTATCCATCCAAGT
GATATTCCGGAAGAAGAGTTAGAAATTTATTATTCACGTCAAAAAGAATTGCTCGGCGGCACGAAATTCCCTATTTCTTT
TGATCAAGTAACGCTGATGGATCCGAGAGAAGTGGTAGAAGAAATCGTATCTTGGCATAAAAAAGAACGCAATAAATTCC
CAGCTGAGACGATTGCTGCAATAGAACGAGAAGTTTATTTGAATTTAATGGACCAAATGTGGGTTATGCATCTGGACGCA
ATGGTACAATTACGCGAAGGTATCCACTTGCGAGCATATGGACAACAAGATCCATTAGTTATGTACCAAAAAGAAGGGGC
TCAATTATTTGAGAAATTCCAAGCAGACTATCATTTCTACTTTGCTCACGCCTTACTTGAACTTGATCCAGACGGCTTAA
TCCAAGGCTAA

Upstream 100 bases:

>100_bases
AATATAAAAATCGGCAGTTTTTCCGTTCTTCGTGACTCGAAATGAATTGCCAGATGAGTTTATGGTATTCTATAATAGAA
GGTATGGAGGATGTTATATA

Downstream 100 bases:

>100_bases
AATACAACTTGCGTCTGATTTTTTCCAAATTTATGGGTAATTTAATGAGAACGAGGGTATTAATCTATATAATAGTACCA
AACGAAAATAAATTTAGACA

Product: preprotein translocase subunit SecA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 776; Mature: 776

Protein sequence:

>776_residues
MRQNYDDRKIVKQYREIARQIVKKEGLYKNMDQAELCEQTNFWREKFKTKPMTDRDKINIFALAREAASRIIGLDAVVVQ
LIGALVLGDGKVAEMKTGEGKTLMSLFVMFIEVMRGNRVHLVTANEYLARRDREEIGQVLEYLGVSVALNESGLDIAQKK
AIYTADVIYGTASEFGFDYLRDNMVRQKEDKVQSGLDFVLIDEADSILIDEARTPLLISDRKEEDLSLYHTANKLVKKMM
KDDYEMEEHKRFVWLNDAGIEKAQKFWGVESLYSAEAQSELRITMLLMRAHFLMHKDKDYVVLDDEVLIIDPHTGRALPG
RRFNDGLHQAIEAKEGVEVKEESRTLATITIQNYFRMYKKISGMTGTAKTEEEEFRQIYNMDVVVIPTNLRVNREDMQDD
IFYTKKEKGRAIVYEVSWRYEKGQPTLIGTSSIKSNEWISGLLDAAGIPHQVLNAKNHAQEAEIIAKAGKRGMVTLATNM
AGRGTDIKLDPDVHKLGGLAVIGTERHESRRIDLQLMGRSGRRGDPGFSKFMISLEDDLLEQFESKSWEKLSTKLKRKAP
RDGKPVNSRKIHAVVVDAQKRLEGANYDIRKDLLSYDEVIDLQRKMVYKERDLLLERNKLGVSSEKILREVAEYSFIHPS
DIPEEELEIYYSRQKELLGGTKFPISFDQVTLMDPREVVEEIVSWHKKERNKFPAETIAAIEREVYLNLMDQMWVMHLDA
MVQLREGIHLRAYGQQDPLVMYQKEGAQLFEKFQADYHFYFAHALLELDPDGLIQG

Sequences:

>Translated_776_residues
MRQNYDDRKIVKQYREIARQIVKKEGLYKNMDQAELCEQTNFWREKFKTKPMTDRDKINIFALAREAASRIIGLDAVVVQ
LIGALVLGDGKVAEMKTGEGKTLMSLFVMFIEVMRGNRVHLVTANEYLARRDREEIGQVLEYLGVSVALNESGLDIAQKK
AIYTADVIYGTASEFGFDYLRDNMVRQKEDKVQSGLDFVLIDEADSILIDEARTPLLISDRKEEDLSLYHTANKLVKKMM
KDDYEMEEHKRFVWLNDAGIEKAQKFWGVESLYSAEAQSELRITMLLMRAHFLMHKDKDYVVLDDEVLIIDPHTGRALPG
RRFNDGLHQAIEAKEGVEVKEESRTLATITIQNYFRMYKKISGMTGTAKTEEEEFRQIYNMDVVVIPTNLRVNREDMQDD
IFYTKKEKGRAIVYEVSWRYEKGQPTLIGTSSIKSNEWISGLLDAAGIPHQVLNAKNHAQEAEIIAKAGKRGMVTLATNM
AGRGTDIKLDPDVHKLGGLAVIGTERHESRRIDLQLMGRSGRRGDPGFSKFMISLEDDLLEQFESKSWEKLSTKLKRKAP
RDGKPVNSRKIHAVVVDAQKRLEGANYDIRKDLLSYDEVIDLQRKMVYKERDLLLERNKLGVSSEKILREVAEYSFIHPS
DIPEEELEIYYSRQKELLGGTKFPISFDQVTLMDPREVVEEIVSWHKKERNKFPAETIAAIEREVYLNLMDQMWVMHLDA
MVQLREGIHLRAYGQQDPLVMYQKEGAQLFEKFQADYHFYFAHALLELDPDGLIQG
>Mature_776_residues
MRQNYDDRKIVKQYREIARQIVKKEGLYKNMDQAELCEQTNFWREKFKTKPMTDRDKINIFALAREAASRIIGLDAVVVQ
LIGALVLGDGKVAEMKTGEGKTLMSLFVMFIEVMRGNRVHLVTANEYLARRDREEIGQVLEYLGVSVALNESGLDIAQKK
AIYTADVIYGTASEFGFDYLRDNMVRQKEDKVQSGLDFVLIDEADSILIDEARTPLLISDRKEEDLSLYHTANKLVKKMM
KDDYEMEEHKRFVWLNDAGIEKAQKFWGVESLYSAEAQSELRITMLLMRAHFLMHKDKDYVVLDDEVLIIDPHTGRALPG
RRFNDGLHQAIEAKEGVEVKEESRTLATITIQNYFRMYKKISGMTGTAKTEEEEFRQIYNMDVVVIPTNLRVNREDMQDD
IFYTKKEKGRAIVYEVSWRYEKGQPTLIGTSSIKSNEWISGLLDAAGIPHQVLNAKNHAQEAEIIAKAGKRGMVTLATNM
AGRGTDIKLDPDVHKLGGLAVIGTERHESRRIDLQLMGRSGRRGDPGFSKFMISLEDDLLEQFESKSWEKLSTKLKRKAP
RDGKPVNSRKIHAVVVDAQKRLEGANYDIRKDLLSYDEVIDLQRKMVYKERDLLLERNKLGVSSEKILREVAEYSFIHPS
DIPEEELEIYYSRQKELLGGTKFPISFDQVTLMDPREVVEEIVSWHKKERNKFPAETIAAIEREVYLNLMDQMWVMHLDA
MVQLREGIHLRAYGQQDPLVMYQKEGAQLFEKFQADYHFYFAHALLELDPDGLIQG

Specific function: Part of the Sec protein translocase complex. Interacts with the secYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular mo

COG id: COG0653

COG function: function code U; Preprotein translocase subunit SecA (ATPase, RNA helicase)

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm (By similarity). Note=Distribution is 50-50 (By similarity) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the secA family [H]

Homologues:

Organism=Escherichia coli, GI1786287, Length=801, Percent_Identity=38.5767790262172, Blast_Score=536, Evalue=1e-153,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000185
- InterPro:   IPR011115
- InterPro:   IPR014018
- InterPro:   IPR011130
- InterPro:   IPR011116 [H]

Pfam domain/function: PF07517 SecA_DEAD; PF01043 SecA_PP_bind; PF07516 SecA_SW [H]

EC number: NA

Molecular weight: Translated: 89438; Mature: 89438

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQNYDDRKIVKQYREIARQIVKKEGLYKNMDQAELCEQTNFWREKFKTKPMTDRDKINI
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEH
FALAREAASRIIGLDAVVVQLIGALVLGDGKVAEMKTGEGKTLMSLFVMFIEVMRGNRVH
EEEHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEECCCCCHHHHHHHHHHHHHHCCCEEE
LVTANEYLARRDREEIGQVLEYLGVSVALNESGLDIAQKKAIYTADVIYGTASEFGFDYL
EEECHHHHHHCCHHHHHHHHHHHCCEEEECCCCCCHHHHHHEEEEHHEEECHHHHHHHHH
RDNMVRQKEDKVQSGLDFVLIDEADSILIDEARTPLLISDRKEEDLSLYHTANKLVKKMM
HHHHHHHHHHHHHCCCCEEEECCCCCEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHH
KDDYEMEEHKRFVWLNDAGIEKAQKFWGVESLYSAEAQSELRITMLLMRAHFLMHKDKDY
HCCCCHHHCCEEEEEECCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
VVLDDEVLIIDPHTGRALPGRRFNDGLHQAIEAKEGVEVKEESRTLATITIQNYFRMYKK
EEECCEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEEHHHHHHHHHH
ISGMTGTAKTEEEEFRQIYNMDVVVIPTNLRVNREDMQDDIFYTKKEKGRAIVYEVSWRY
HCCCCCCCCCCHHHHHHHHCCCEEEECCCCEECHHHHCCHHEEEECCCCCEEEEEEEEEE
EKGQPTLIGTSSIKSNEWISGLLDAAGIPHQVLNAKNHAQEAEIIAKAGKRGMVTLATNM
ECCCCEEEECCCCCCCHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHCCCCCEEEEEECC
AGRGTDIKLDPDVHKLGGLAVIGTERHESRRIDLQLMGRSGRRGDPGFSKFMISLEDDLL
CCCCCCEEECCCHHHHCCEEEEECCCCCCCEEEEEEECCCCCCCCCCHHHHEEEHHHHHH
EQFESKSWEKLSTKLKRKAPRDGKPVNSRKIHAVVVDAQKRLEGANYDIRKDLLSYDEVI
HHHHCCCHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEHHHHCCCCCCHHHHHHHHHHHHH
DLQRKMVYKERDLLLERNKLGVSSEKILREVAEYSFIHPSDIPEEELEIYYSRQKELLGG
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCC
TKFPISFDQVTLMDPREVVEEIVSWHKKERNKFPAETIAAIEREVYLNLMDQMWVMHLDA
CCCCCCCCCEEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MVQLREGIHLRAYGQQDPLVMYQKEGAQLFEKFQADYHFYFAHALLELDPDGLIQG
HHHHHCCCEEEEECCCCCEEEEEHHHHHHHHHHHHCHHHEEEHHHHHCCCCCCCCC
>Mature Secondary Structure
MRQNYDDRKIVKQYREIARQIVKKEGLYKNMDQAELCEQTNFWREKFKTKPMTDRDKINI
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEH
FALAREAASRIIGLDAVVVQLIGALVLGDGKVAEMKTGEGKTLMSLFVMFIEVMRGNRVH
EEEHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEECCCCCHHHHHHHHHHHHHHCCCEEE
LVTANEYLARRDREEIGQVLEYLGVSVALNESGLDIAQKKAIYTADVIYGTASEFGFDYL
EEECHHHHHHCCHHHHHHHHHHHCCEEEECCCCCCHHHHHHEEEEHHEEECHHHHHHHHH
RDNMVRQKEDKVQSGLDFVLIDEADSILIDEARTPLLISDRKEEDLSLYHTANKLVKKMM
HHHHHHHHHHHHHCCCCEEEECCCCCEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHH
KDDYEMEEHKRFVWLNDAGIEKAQKFWGVESLYSAEAQSELRITMLLMRAHFLMHKDKDY
HCCCCHHHCCEEEEEECCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
VVLDDEVLIIDPHTGRALPGRRFNDGLHQAIEAKEGVEVKEESRTLATITIQNYFRMYKK
EEECCEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEEHHHHHHHHHH
ISGMTGTAKTEEEEFRQIYNMDVVVIPTNLRVNREDMQDDIFYTKKEKGRAIVYEVSWRY
HCCCCCCCCCCHHHHHHHHCCCEEEECCCCEECHHHHCCHHEEEECCCCCEEEEEEEEEE
EKGQPTLIGTSSIKSNEWISGLLDAAGIPHQVLNAKNHAQEAEIIAKAGKRGMVTLATNM
ECCCCEEEECCCCCCCHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHCCCCCEEEEEECC
AGRGTDIKLDPDVHKLGGLAVIGTERHESRRIDLQLMGRSGRRGDPGFSKFMISLEDDLL
CCCCCCEEECCCHHHHCCEEEEECCCCCCCEEEEEEECCCCCCCCCCHHHHEEEHHHHHH
EQFESKSWEKLSTKLKRKAPRDGKPVNSRKIHAVVVDAQKRLEGANYDIRKDLLSYDEVI
HHHHCCCHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEHHHHCCCCCCHHHHHHHHHHHHH
DLQRKMVYKERDLLLERNKLGVSSEKILREVAEYSFIHPSDIPEEELEIYYSRQKELLGG
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCC
TKFPISFDQVTLMDPREVVEEIVSWHKKERNKFPAETIAAIEREVYLNLMDQMWVMHLDA
CCCCCCCCCEEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MVQLREGIHLRAYGQQDPLVMYQKEGAQLFEKFQADYHFYFAHALLELDPDGLIQG
HHHHHCCCEEEEECCCCCEEEEEHHHHHHHHHHHHCHHHEEEHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]