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The map label for this gene is gmuR [H]

Identifier: 226223204

GI number: 226223204

Start: 616326

End: 617054

Strand: Direct

Name: gmuR [H]

Synonym: Lm4b_00601

Alternate gene names: 226223204

Gene position: 616326-617054 (Clockwise)

Preceding gene: 226223203

Following gene: 226223205

Centisome position: 21.16

GC content: 39.78

Gene sequence:

>729_bases
GTGGCTCAGAACCAGACAAAATATAGCTTTATTGCTGAAGAAATCCGCAAAAGAATTATGAATCACGCCTATCCGCTTAA
TCAACCTATTCCTGATGAGATAACTTTGGCGAAAGAGTTTGATTGTAGTCGAATGACAATGAAAAAAGCACTGGAAGTCC
TTGTTCTTGAAGGCTTACTATATCGTAAACGCGGACATGGTACTTTCATTATCAAATCGGCGCTGGACGCGGACCGCTTA
CAGATTCATAACCAAGAGGTAAACGGCTTCACTAAACTTTTGAACGGCAAGAAAGTTATTAGTAAAGTTATTGAGTTTAA
AGTTATCTTTCCAACTGAAGAAATTGCAGAGCGTCTTCATATCGAAATGGAAACACCAATCTATGACATTCTTCGTGTTC
GGCTAGTGAAAGATGAGCCATATGTGCTAGAACATACGTATATGCCAGTTGGGGTTATCCCAGGCATCAATCAGCAAATT
TTAGAGGGGTCGATTTATTCGTACATTCAAGACGATTTGAACCTAAAAATTGCTAGTTCCTACAAACAAATTCGCGCGGA
TAAAGCGACACAGCTTGATCAGCAATATCTCGACTGCGCTTCTGATGATCCCGTTGTCGAAGTAGAACAAACCGTGTATT
TAAACAATGGTCTCGCGTTTGAATTTTCCAAATCGCGCCACCGTTATGATAAATTCGTGTTTACAACAGTGAATATAGCT
AGACGATAA

Upstream 100 bases:

>100_bases
AAAGCATCCGGACATTGGTACAAAGAACTTTCAGAAAACAATGGTTTTGAAGACTAAATGTGATAAAATAAAAGTATTAT
GTGTAAAGAGGTGAACTTCC

Downstream 100 bases:

>100_bases
AGTAAAAAAGAAACTAGAAAAAGTGAGAAATCATTTTATCTAGTTTCTTTTTTTAGGAAGAATTAATGAAGTATAGGTCA
TTATTAGATTCACTTTTTTT

Product: transcription regulator GntR family

Products: NA

Alternate protein names: Glucomannan utilization operon repressor; Glucomannan utilization protein R [H]

Number of amino acids: Translated: 242; Mature: 241

Protein sequence:

>242_residues
MAQNQTKYSFIAEEIRKRIMNHAYPLNQPIPDEITLAKEFDCSRMTMKKALEVLVLEGLLYRKRGHGTFIIKSALDADRL
QIHNQEVNGFTKLLNGKKVISKVIEFKVIFPTEEIAERLHIEMETPIYDILRVRLVKDEPYVLEHTYMPVGVIPGINQQI
LEGSIYSYIQDDLNLKIASSYKQIRADKATQLDQQYLDCASDDPVVEVEQTVYLNNGLAFEFSKSRHRYDKFVFTTVNIA
RR

Sequences:

>Translated_242_residues
MAQNQTKYSFIAEEIRKRIMNHAYPLNQPIPDEITLAKEFDCSRMTMKKALEVLVLEGLLYRKRGHGTFIIKSALDADRL
QIHNQEVNGFTKLLNGKKVISKVIEFKVIFPTEEIAERLHIEMETPIYDILRVRLVKDEPYVLEHTYMPVGVIPGINQQI
LEGSIYSYIQDDLNLKIASSYKQIRADKATQLDQQYLDCASDDPVVEVEQTVYLNNGLAFEFSKSRHRYDKFVFTTVNIA
RR
>Mature_241_residues
AQNQTKYSFIAEEIRKRIMNHAYPLNQPIPDEITLAKEFDCSRMTMKKALEVLVLEGLLYRKRGHGTFIIKSALDADRLQ
IHNQEVNGFTKLLNGKKVISKVIEFKVIFPTEEIAERLHIEMETPIYDILRVRLVKDEPYVLEHTYMPVGVIPGINQQIL
EGSIYSYIQDDLNLKIASSYKQIRADKATQLDQQYLDCASDDPVVEVEQTVYLNNGLAFEFSKSRHRYDKFVFTTVNIAR
R

Specific function: Transcriptional repressor of the gmuBACDREFG operon which is involved in the uptake and degradation of glucomannan [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790118, Length=218, Percent_Identity=32.5688073394495, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI1786950, Length=232, Percent_Identity=28.448275862069, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI87082252, Length=238, Percent_Identity=25.6302521008403, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1788418, Length=243, Percent_Identity=24.6913580246914, Blast_Score=72, Evalue=3e-14,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 28075; Mature: 27944

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQNQTKYSFIAEEIRKRIMNHAYPLNQPIPDEITLAKEFDCSRMTMKKALEVLVLEGLL
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEHHHCCHHHHHHHHHHHHHHHHHHH
YRKRGHGTFIIKSALDADRLQIHNQEVNGFTKLLNGKKVISKVIEFKVIFPTEEIAERLH
HHCCCCCEEEEECCCCHHHHHCCCCHHHHHHHHHCCHHHHHHHHHEEEEECHHHHHHHHC
IEMETPIYDILRVRLVKDEPYVLEHTYMPVGVIPGINQQILEGSIYSYIQDDLNLKIASS
EEECCCHHHHHHHHEECCCCEEEEECCCCEECCCCCCHHHHHHHHHHHHHHCCCEEEHHH
YKQIRADKATQLDQQYLDCASDDPVVEVEQTVYLNNGLAFEFSKSRHRYDKFVFTTVNIA
HHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCEEEEECCHHHHHHHEEEEEEEEC
RR
CC
>Mature Secondary Structure 
AQNQTKYSFIAEEIRKRIMNHAYPLNQPIPDEITLAKEFDCSRMTMKKALEVLVLEGLL
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEHHHCCHHHHHHHHHHHHHHHHHHH
YRKRGHGTFIIKSALDADRLQIHNQEVNGFTKLLNGKKVISKVIEFKVIFPTEEIAERLH
HHCCCCCEEEEECCCCHHHHHCCCCHHHHHHHHHCCHHHHHHHHHEEEEECHHHHHHHHC
IEMETPIYDILRVRLVKDEPYVLEHTYMPVGVIPGINQQILEGSIYSYIQDDLNLKIASS
EEECCCHHHHHHHHEECCCCEEEEECCCCEECCCCCCHHHHHHHHHHHHHHCCCEEEHHH
YKQIRADKATQLDQQYLDCASDDPVVEVEQTVYLNNGLAFEFSKSRHRYDKFVFTTVNIA
HHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCEEEEECCHHHHHHHEEEEEEEEC
RR
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9202461; 9384377 [H]