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The map label for this gene is purR [H]

Identifier: 226222821

GI number: 226222821

Start: 192481

End: 193299

Strand: Direct

Name: purR [H]

Synonym: Lm4b_00189

Alternate gene names: 226222821

Gene position: 192481-193299 (Clockwise)

Preceding gene: 226222820

Following gene: 226222822

Centisome position: 6.61

GC content: 38.95

Gene sequence:

>819_bases
ATGAAGATTCGTCGCAGTGAACGATTAATTGATATGACGCAGTTTCTATTATCGCATCCGCGAAAGTTAGTGCCGCTTAC
GATGTTTGCTGAACGTTATGGCTCAGCTAAGTCTTCTATTAGTGAAGATTTGGTTATCATAAAGAAAACATTTGAAGACA
GAGGGATTGGTACGCTCGAAACTGTTCCGGGTGCTGCTGGTGGTGTGCAATATATTTCGATAGCGGGAAATGACGATGTG
CTGGATTTTGTGCATACGCTATGTAATAGAATTGCGGAGCCAAACCGTTTGCTTCCAGGGGGCTATTTGTACTTATCTGA
TTTACTTGGAGAACCAGTAACGCTCAAAGCAATTGGTAAAATTTTAGCAACGAAATTCAATAACCAAAAAATAGATGCGA
TTATGACTGTTGCGACTAAAGGGATTCCGATTGCACAAGCGGTTGCTGAACATTTAAGTGTCCCCTTTGTTATCGTACGT
CGTGATAGCAAAGTGACAGAAGGCTCAACTGTAAGCATTAACTATGTTTCAGGTTCATCCAAACGAATCGAAAAAATGGA
ATTATCCAAACGAAGCTTAGCTGAAGGCTCTAATGTAGTAATTGTGGATGACTTTATGAAAGCTGGAGGAACAATTAATG
GTATGAAAAATCTGCTAGAAGAATTCAACGCGCATTTAGTTGGAATTGGCGTGTTAGTTGAATCCGAATATGCGGAAGAG
CGCTTAGTGGATGATTACGTATCTCTTGTAAAAATAAAAAATGTGAACATGAAAGAAAAACAAATCGAAGTTGTTGATGG
GAATTACTTTAATAGTTGA

Upstream 100 bases:

>100_bases
TTGTCAATTTTATAGAAAACGTTTTATAATAGAGAAAATACGGACAAAATACGTGAAATAGCTTTTTAATATACGGAATT
TTATCAAAGGGAGAGAGATT

Downstream 100 bases:

>100_bases
TTCTAAACCCTGGAAAATATTCTGGGGTTTTTCTTTTTTTGGGGGGCGAATTGCTACTAAAAACAAATCAGTCTTCCGAT
GTACTTCACTCAGTTAACTT

Product: pur operon repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 272; Mature: 272

Protein sequence:

>272_residues
MKIRRSERLIDMTQFLLSHPRKLVPLTMFAERYGSAKSSISEDLVIIKKTFEDRGIGTLETVPGAAGGVQYISIAGNDDV
LDFVHTLCNRIAEPNRLLPGGYLYLSDLLGEPVTLKAIGKILATKFNNQKIDAIMTVATKGIPIAQAVAEHLSVPFVIVR
RDSKVTEGSTVSINYVSGSSKRIEKMELSKRSLAEGSNVVIVDDFMKAGGTINGMKNLLEEFNAHLVGIGVLVESEYAEE
RLVDDYVSLVKIKNVNMKEKQIEVVDGNYFNS

Sequences:

>Translated_272_residues
MKIRRSERLIDMTQFLLSHPRKLVPLTMFAERYGSAKSSISEDLVIIKKTFEDRGIGTLETVPGAAGGVQYISIAGNDDV
LDFVHTLCNRIAEPNRLLPGGYLYLSDLLGEPVTLKAIGKILATKFNNQKIDAIMTVATKGIPIAQAVAEHLSVPFVIVR
RDSKVTEGSTVSINYVSGSSKRIEKMELSKRSLAEGSNVVIVDDFMKAGGTINGMKNLLEEFNAHLVGIGVLVESEYAEE
RLVDDYVSLVKIKNVNMKEKQIEVVDGNYFNS
>Mature_272_residues
MKIRRSERLIDMTQFLLSHPRKLVPLTMFAERYGSAKSSISEDLVIIKKTFEDRGIGTLETVPGAAGGVQYISIAGNDDV
LDFVHTLCNRIAEPNRLLPGGYLYLSDLLGEPVTLKAIGKILATKFNNQKIDAIMTVATKGIPIAQAVAEHLSVPFVIVR
RDSKVTEGSTVSINYVSGSSKRIEKMELSKRSLAEGSNVVIVDDFMKAGGTINGMKNLLEEFNAHLVGIGVLVESEYAEE
RLVDDYVSLVKIKNVNMKEKQIEVVDGNYFNS

Specific function: Controls the transcription of the pur operon for purine biosynthetic genes, binds to the control region of the operon. DNA binding is inhibited by 5-phosphoribosyl 1-pyrophosphate [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR015265
- InterPro:   IPR010078
- InterPro:   IPR011991
- ProDom:   PD029816 [H]

Pfam domain/function: PF00156 Pribosyltran; PF09182 PuR_N [H]

EC number: NA

Molecular weight: Translated: 29923; Mature: 29923

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIRRSERLIDMTQFLLSHPRKLVPLTMFAERYGSAKSSISEDLVIIKKTFEDRGIGTLE
CCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHCCCCCEEEEEECCCCCCCCCHH
TVPGAAGGVQYISIAGNDDVLDFVHTLCNRIAEPNRLLPGGYLYLSDLLGEPVTLKAIGK
CCCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCEEHHHHHH
ILATKFNNQKIDAIMTVATKGIPIAQAVAEHLSVPFVIVRRDSKVTEGSTVSINYVSGSS
HHHHHCCCCHHHHHEEHHHCCCCHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEECCCC
KRIEKMELSKRSLAEGSNVVIVDDFMKAGGTINGMKNLLEEFNAHLVGIGVLVESEYAEE
HHHHHHHHHHHHHCCCCCEEEEECHHHCCCCHHHHHHHHHHHCCEEEEEEEEEECHHHHH
RLVDDYVSLVKIKNVNMKEKQIEVVDGNYFNS
HHHHHHHHHHHHCCCCCCCCEEEEECCCCCCC
>Mature Secondary Structure
MKIRRSERLIDMTQFLLSHPRKLVPLTMFAERYGSAKSSISEDLVIIKKTFEDRGIGTLE
CCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHCCCCCEEEEEECCCCCCCCCHH
TVPGAAGGVQYISIAGNDDVLDFVHTLCNRIAEPNRLLPGGYLYLSDLLGEPVTLKAIGK
CCCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCEEHHHHHH
ILATKFNNQKIDAIMTVATKGIPIAQAVAEHLSVPFVIVRRDSKVTEGSTVSINYVSGSS
HHHHHCCCCHHHHHEEHHHCCCCHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEECCCC
KRIEKMELSKRSLAEGSNVVIVDDFMKAGGTINGMKNLLEEFNAHLVGIGVLVESEYAEE
HHHHHHHHHHHHHCCCCCEEEEECHHHCCCCHHHHHHHHHHHCCEEEEEEEEEECHHHHH
RLVDDYVSLVKIKNVNMKEKQIEVVDGNYFNS
HHHHHHHHHHHHCCCCCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377; 7638212 [H]