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The map label for this gene is capA [H]

Identifier: 226222657

GI number: 226222657

Start: 22388

End: 23506

Strand: Reverse

Name: capA [H]

Synonym: Lm4b_00020

Alternate gene names: 226222657

Gene position: 23506-22388 (Counterclockwise)

Preceding gene: 226222659

Following gene: 226222652

Centisome position: 0.81

GC content: 34.58

Gene sequence:

>1119_bases
ATGAAATCAAGAAAAAAAGGGATTATCTTGGTACTGTCTATTATTATAATTTTTTCCATCGGTTTATTAGTGAACAACAT
CATGACAAATAACAAAGATACCGCTAAGCCAAAAAAGAAAACCGTCGCTGCTGTTAAAAAGAAAAAAGAAACACCTCCAA
AACCAAAAGAACCATTTAACATTGATTTTACAGGTGATATTATGTTTGATTGGGATTTACGCCCCGTTTTAGCAGAGAAG
GGAATGGATTATCCTTTTAATAATGTTCGCGAGGAATTGAAATCAAGCGACTATACATTTGTTGATTTAGAAACAGCTAT
TACAACTCGAACAAAAAAAGTCCCCTACCAAGAATTTTGGATTAAAAGTGATCCTAGTTCTTTAACAGCTCTTAAAAATG
CAGGGGTTGATATGGTTAATATTAGTAATAACCACATTTTAGACTATTACGAAGATGGATTACTCGACACAACGGCTGCT
TTACGCGCCAATAACCTAGCCTATGTTGGCGCCGGTAAAAATGAAGATGAAGCCTATCAACTTAAAGTTGCTGACATCAA
AGGTAATAAAGTTGGATTCATGTCGTTTTGCCACTTTTTCCCAAATACTGGTTGGATTGCCGATGAAGATACTCCTGGGG
TTACTAATGGTTATGATATAAATTTAGTCGAAGAAAAAATCAAAGAAGAACGCGCAAAAAATAAAGATATTGATTATATG
GTCGTCTATTTTCACTGGGGAGTTGAAAAGACGAATACACCTGTAGATTATCAAACCCAATACGTTAAAAAACTCGTGGA
TGATCATTTAGTTGACGCGATTGTTGCTAGCCATCCACACTGGCTCCAAAGTTTTGAAGTATACAAAGATGTTCCAATTG
CTTATTCATTAGGTAATTTCTTGTTTCCTGACTATGTTTCTGGTCATTCAGCAGAAACAGGTATTTATAAACTGAATTTT
AATCAAGGTAAAGTGACTGCGCATTTTGATCCTGGTATTATTTCAGGTAATCAAATTAATATGCTTGACGGTTCTGCCAA
GACAGCACAATTAAATTATCTCCAATCCATTTCTCCAAATGCAACTATTAATAGTAATGGTGATATATCCGCAAAATAA

Upstream 100 bases:

>100_bases
AATTTAGCCATTAAAATCCAAAAAAAAGCCTATTTTTGATAAAAACCCTTTTCTCCATACTGATAGAATTAGATAACTTT
TTAATTTAGGAGGAGAAAAA

Downstream 100 bases:

>100_bases
AAAAAGCTGATGCTAGTTCGGTTTTAACCGTTCTAAGCATCAGCTTTTTTTTATAACAAATGATTCATATGGCCAATTTC
CATTACCCAATAAGAACCAA

Product: polyglutamate capsule biosynthesis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MKSRKKGIILVLSIIIIFSIGLLVNNIMTNNKDTAKPKKKTVAAVKKKKETPPKPKEPFNIDFTGDIMFDWDLRPVLAEK
GMDYPFNNVREELKSSDYTFVDLETAITTRTKKVPYQEFWIKSDPSSLTALKNAGVDMVNISNNHILDYYEDGLLDTTAA
LRANNLAYVGAGKNEDEAYQLKVADIKGNKVGFMSFCHFFPNTGWIADEDTPGVTNGYDINLVEEKIKEERAKNKDIDYM
VVYFHWGVEKTNTPVDYQTQYVKKLVDDHLVDAIVASHPHWLQSFEVYKDVPIAYSLGNFLFPDYVSGHSAETGIYKLNF
NQGKVTAHFDPGIISGNQINMLDGSAKTAQLNYLQSISPNATINSNGDISAK

Sequences:

>Translated_372_residues
MKSRKKGIILVLSIIIIFSIGLLVNNIMTNNKDTAKPKKKTVAAVKKKKETPPKPKEPFNIDFTGDIMFDWDLRPVLAEK
GMDYPFNNVREELKSSDYTFVDLETAITTRTKKVPYQEFWIKSDPSSLTALKNAGVDMVNISNNHILDYYEDGLLDTTAA
LRANNLAYVGAGKNEDEAYQLKVADIKGNKVGFMSFCHFFPNTGWIADEDTPGVTNGYDINLVEEKIKEERAKNKDIDYM
VVYFHWGVEKTNTPVDYQTQYVKKLVDDHLVDAIVASHPHWLQSFEVYKDVPIAYSLGNFLFPDYVSGHSAETGIYKLNF
NQGKVTAHFDPGIISGNQINMLDGSAKTAQLNYLQSISPNATINSNGDISAK
>Mature_372_residues
MKSRKKGIILVLSIIIIFSIGLLVNNIMTNNKDTAKPKKKTVAAVKKKKETPPKPKEPFNIDFTGDIMFDWDLRPVLAEK
GMDYPFNNVREELKSSDYTFVDLETAITTRTKKVPYQEFWIKSDPSSLTALKNAGVDMVNISNNHILDYYEDGLLDTTAA
LRANNLAYVGAGKNEDEAYQLKVADIKGNKVGFMSFCHFFPNTGWIADEDTPGVTNGYDINLVEEKIKEERAKNKDIDYM
VVYFHWGVEKTNTPVDYQTQYVKKLVDDHLVDAIVASHPHWLQSFEVYKDVPIAYSLGNFLFPDYVSGHSAETGIYKLNF
NQGKVTAHFDPGIISGNQINMLDGSAKTAQLNYLQSISPNATINSNGDISAK

Specific function: Essential for the synthesis of the polyglutamate capsule of B.anthracis which is one of the principal virulence factors during anthrax infection. May form a polyglutamyl synthetase complex together with proteins CapB and CapC [H]

COG id: COG2843

COG function: function code M; Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation)

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CapA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019079 [H]

Pfam domain/function: PF09587 PGA_cap [H]

EC number: NA

Molecular weight: Translated: 41775; Mature: 41775

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSRKKGIILVLSIIIIFSIGLLVNNIMTNNKDTAKPKKKTVAAVKKKKETPPKPKEPFN
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEE
IDFTGDIMFDWDLRPVLAEKGMDYPFNNVREELKSSDYTFVDLETAITTRTKKVPYQEFW
EEEEEEEEEECCCCHHHHHCCCCCCHHHHHHHHHCCCCEEEEEHHHHHHHHCCCCHHHEE
IKSDPSSLTALKNAGVDMVNISNNHILDYYEDGLLDTTAALRANNLAYVGAGKNEDEAYQ
EECCCHHHHHHHHCCCEEEECCCCEEEEHHHCCCHHHHHHHHCCCEEEEECCCCCCCEEE
LKVADIKGNKVGFMSFCHFFPNTGWIADEDTPGVTNGYDINLVEEKIKEERAKNKDIDYM
EEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHCCCCCCEE
VVYFHWGVEKTNTPVDYQTQYVKKLVDDHLVDAIVASHPHWLQSFEVYKDVPIAYSLGNF
EEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEECCCC
LFPDYVSGHSAETGIYKLNFNQGKVTAHFDPGIISGNQINMLDGSAKTAQLNYLQSISPN
CCCCCCCCCCCCCCEEEEECCCCEEEEEECCCEECCCEEEEECCCCCEEEHHHHHHCCCC
ATINSNGDISAK
CEECCCCCCCCC
>Mature Secondary Structure
MKSRKKGIILVLSIIIIFSIGLLVNNIMTNNKDTAKPKKKTVAAVKKKKETPPKPKEPFN
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEE
IDFTGDIMFDWDLRPVLAEKGMDYPFNNVREELKSSDYTFVDLETAITTRTKKVPYQEFW
EEEEEEEEEECCCCHHHHHCCCCCCHHHHHHHHHCCCCEEEEEHHHHHHHHCCCCHHHEE
IKSDPSSLTALKNAGVDMVNISNNHILDYYEDGLLDTTAALRANNLAYVGAGKNEDEAYQ
EECCCHHHHHHHHCCCEEEECCCCEEEEHHHCCCHHHHHHHHCCCEEEEECCCCCCCEEE
LKVADIKGNKVGFMSFCHFFPNTGWIADEDTPGVTNGYDINLVEEKIKEERAKNKDIDYM
EEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHCCCCCCEE
VVYFHWGVEKTNTPVDYQTQYVKKLVDDHLVDAIVASHPHWLQSFEVYKDVPIAYSLGNF
EEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEECCCC
LFPDYVSGHSAETGIYKLNFNQGKVTAHFDPGIISGNQINMLDGSAKTAQLNYLQSISPN
CCCCCCCCCCCCCCEEEEECCCCEEEEEECCCEECCCEEEEECCCCCEEEHHHHHHCCCC
ATINSNGDISAK
CEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2536679; 10475962; 12004073 [H]