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The map label for this gene is gap [H]

Identifier: 225861832

GI number: 225861832

Start: 1871373

End: 1872380

Strand: Reverse

Name: gap [H]

Synonym: SPT_2008

Alternate gene names: 225861832

Gene position: 1872380-1871373 (Counterclockwise)

Preceding gene: 225861833

Following gene: 225861830

Centisome position: 88.65

GC content: 42.56

Gene sequence:

>1008_bases
ATGGTAGTTAAAGTTGGTATTAACGGTTTCGGACGTATCGGTCGTCTTGCTTTCCGTCGTATCCAAAACGTAGAAGGTGT
TGAAGTTACACGCATCAACGACCTTACAGATCCAGTTATGCTTGCACACTTGTTGAAATACGACACAACTCAAGGTCGTT
TCGACGGTACTGTTGAAGTTAAAGAAGGTGGATTCGAAGTTAACGGTAAATTCGTTAAAGTTTCTGCTGAACGTGATCCA
GAGCAAATCGACTGGGCTACTGACGGTGTAGAAATCGTTCTTGAAGCTACTGGTTTCTTTGCTAAGAAAGAAGCAGCTGA
AAAACACCTTAAAGGTGGAGCTAAAAAAGTTGTTATCACTGCTCCTGGTGGAAACGACGTTAAAACAGTTGTATTCAACA
CTAACCACGACGTTCTTGACGGTACTGAAACAGTTATCTCAGGTGCTTCATGTACTACAAACTGCTTGGCTCCAATGGCT
AAAGCTCTTCAAGATAACTTTGGTGTTGTTGAAGGATTGATGACTACTATCCACGCTTACACTGGTGACCAAATGATCCT
TGACGGACCACACCGTGGTGGTGACCTTCGCCGTGCTCGCGCTGGTGCTGCAAACATCGTTCCTAACTCAACTGGTGCTG
CTAAAGCTATCGGTCTTGTAATCCCAGAATTGAACGGTAAACTTGACGGATCTGCACAACGCGTTCCAACTCCAACTGGA
TCAGTTACTGAATTGGTAGCAGTTCTTGAAAAGAACGTTACTGTTGATGAAGTGAACGCAGCTATGAAAGCAGCTTCAAA
CGAATCATACGGTTACACAGAAGATCCAATCGTATCTTCAGATATCGTAGGTATGTCTTACGGTTCATTGTTTGACGCAA
CTCAAACTAAAGTTCTTGACGTTGACGGTAAACAATTGGTTAAAGTTGTATCATGGTACGACAACGAAATGTCATACACT
GCACAACTTGTTCGTACTCTTGAATACTTCGCAAAAATTGCTAAATAA

Upstream 100 bases:

>100_bases
AATAGTTATATAATAGGTTTGTTGAAAGGTGATTTGTAGTGATTCAAGTTACTCTTTTCACAATAAAAATTTCATGATTT
TCATAAGGAGGAAATCACTA

Downstream 100 bases:

>100_bases
TTCTTGAATCGATAAAAAGCAAGGCCTCTTGGTCTTGCTTTTCTTATATGGAAAAATGGATGACACAATCATCCATTCTT
TTTTAATTCTGTTTCAAAAG

Product: glyceraldehyde-3-phosphate dehydrogenase, type I

Products: NA

Alternate protein names: GAPDH; Plasmin receptor; Plasminogen-binding protein [H]

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MVVKVGINGFGRIGRLAFRRIQNVEGVEVTRINDLTDPVMLAHLLKYDTTQGRFDGTVEVKEGGFEVNGKFVKVSAERDP
EQIDWATDGVEIVLEATGFFAKKEAAEKHLKGGAKKVVITAPGGNDVKTVVFNTNHDVLDGTETVISGASCTTNCLAPMA
KALQDNFGVVEGLMTTIHAYTGDQMILDGPHRGGDLRRARAGAANIVPNSTGAAKAIGLVIPELNGKLDGSAQRVPTPTG
SVTELVAVLEKNVTVDEVNAAMKAASNESYGYTEDPIVSSDIVGMSYGSLFDATQTKVLDVDGKQLVKVVSWYDNEMSYT
AQLVRTLEYFAKIAK

Sequences:

>Translated_335_residues
MVVKVGINGFGRIGRLAFRRIQNVEGVEVTRINDLTDPVMLAHLLKYDTTQGRFDGTVEVKEGGFEVNGKFVKVSAERDP
EQIDWATDGVEIVLEATGFFAKKEAAEKHLKGGAKKVVITAPGGNDVKTVVFNTNHDVLDGTETVISGASCTTNCLAPMA
KALQDNFGVVEGLMTTIHAYTGDQMILDGPHRGGDLRRARAGAANIVPNSTGAAKAIGLVIPELNGKLDGSAQRVPTPTG
SVTELVAVLEKNVTVDEVNAAMKAASNESYGYTEDPIVSSDIVGMSYGSLFDATQTKVLDVDGKQLVKVVSWYDNEMSYT
AQLVRTLEYFAKIAK
>Mature_335_residues
MVVKVGINGFGRIGRLAFRRIQNVEGVEVTRINDLTDPVMLAHLLKYDTTQGRFDGTVEVKEGGFEVNGKFVKVSAERDP
EQIDWATDGVEIVLEATGFFAKKEAAEKHLKGGAKKVVITAPGGNDVKTVVFNTNHDVLDGTETVISGASCTTNCLAPMA
KALQDNFGVVEGLMTTIHAYTGDQMILDGPHRGGDLRRARAGAANIVPNSTGAAKAIGLVIPELNGKLDGSAQRVPTPTG
SVTELVAVLEKNVTVDEVNAAMKAASNESYGYTEDPIVSSDIVGMSYGSLFDATQTKVLDVDGKQLVKVVSWYDNEMSYT
AQLVRTLEYFAKIAK

Specific function: Also binds human plasminogen [H]

COG id: COG0057

COG function: function code G; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7669492, Length=334, Percent_Identity=46.7065868263473, Blast_Score=290, Evalue=1e-78,
Organism=Homo sapiens, GI7657116, Length=331, Percent_Identity=43.5045317220544, Blast_Score=272, Evalue=3e-73,
Organism=Escherichia coli, GI1788079, Length=337, Percent_Identity=50.7418397626113, Blast_Score=329, Evalue=2e-91,
Organism=Escherichia coli, GI1789295, Length=342, Percent_Identity=37.4269005847953, Blast_Score=231, Evalue=5e-62,
Organism=Caenorhabditis elegans, GI17568413, Length=339, Percent_Identity=47.1976401179941, Blast_Score=285, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI32566163, Length=339, Percent_Identity=47.1976401179941, Blast_Score=285, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI17534677, Length=339, Percent_Identity=46.6076696165192, Blast_Score=277, Evalue=5e-75,
Organism=Caenorhabditis elegans, GI17534679, Length=339, Percent_Identity=46.6076696165192, Blast_Score=276, Evalue=1e-74,
Organism=Saccharomyces cerevisiae, GI6322409, Length=337, Percent_Identity=43.9169139465875, Blast_Score=280, Evalue=2e-76,
Organism=Saccharomyces cerevisiae, GI6321631, Length=340, Percent_Identity=45, Blast_Score=276, Evalue=4e-75,
Organism=Saccharomyces cerevisiae, GI6322468, Length=337, Percent_Identity=44.8071216617211, Blast_Score=271, Evalue=8e-74,
Organism=Drosophila melanogaster, GI17933600, Length=332, Percent_Identity=46.6867469879518, Blast_Score=288, Evalue=5e-78,
Organism=Drosophila melanogaster, GI18110149, Length=332, Percent_Identity=46.6867469879518, Blast_Score=288, Evalue=5e-78,
Organism=Drosophila melanogaster, GI85725000, Length=331, Percent_Identity=47.1299093655589, Blast_Score=286, Evalue=2e-77,
Organism=Drosophila melanogaster, GI22023983, Length=331, Percent_Identity=47.1299093655589, Blast_Score=286, Evalue=2e-77,
Organism=Drosophila melanogaster, GI19922412, Length=330, Percent_Identity=44.5454545454545, Blast_Score=274, Evalue=7e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020831
- InterPro:   IPR020830
- InterPro:   IPR020829
- InterPro:   IPR020828
- InterPro:   IPR006424
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02800 Gp_dh_C; PF00044 Gp_dh_N [H]

EC number: =1.2.1.12 [H]

Molecular weight: Translated: 35842; Mature: 35842

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00071 GAPDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVKVGINGFGRIGRLAFRRIQNVEGVEVTRINDLTDPVMLAHLLKYDTTQGRFDGTVEV
CEEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCEEEE
KEGGFEVNGKFVKVSAERDPEQIDWATDGVEIVLEATGFFAKKEAAEKHLKGGAKKVVIT
ECCCEEECCEEEEEECCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCEEEEE
APGGNDVKTVVFNTNHDVLDGTETVISGASCTTNCLAPMAKALQDNFGVVEGLMTTIHAY
CCCCCCEEEEEEECCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHC
TGDQMILDGPHRGGDLRRARAGAANIVPNSTGAAKAIGLVIPELNGKLDGSAQRVPTPTG
CCCEEEEECCCCCCCHHHHHCCCCCCCCCCCCCHHEEEEEEECCCCCCCCCCCCCCCCCC
SVTELVAVLEKNVTVDEVNAAMKAASNESYGYTEDPIVSSDIVGMSYGSLFDATQTKVLD
HHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCEEEE
VDGKQLVKVVSWYDNEMSYTAQLVRTLEYFAKIAK
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVVKVGINGFGRIGRLAFRRIQNVEGVEVTRINDLTDPVMLAHLLKYDTTQGRFDGTVEV
CEEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCEEEE
KEGGFEVNGKFVKVSAERDPEQIDWATDGVEIVLEATGFFAKKEAAEKHLKGGAKKVVIT
ECCCEEECCEEEEEECCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCEEEEE
APGGNDVKTVVFNTNHDVLDGTETVISGASCTTNCLAPMAKALQDNFGVVEGLMTTIHAY
CCCCCCEEEEEEECCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHC
TGDQMILDGPHRGGDLRRARAGAANIVPNSTGAAKAIGLVIPELNGKLDGSAQRVPTPTG
CCCEEEEECCCCCCCHHHHHCCCCCCCCCCCCCHHEEEEEEECCCCCCCCCCCCCCCCCC
SVTELVAVLEKNVTVDEVNAAMKAASNESYGYTEDPIVSSDIVGMSYGSLFDATQTKVLD
HHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCEEEE
VDGKQLVKVVSWYDNEMSYTAQLVRTLEYFAKIAK
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8706717 [H]