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The map label for this gene is licA [H]

Identifier: 225859063

GI number: 225859063

Start: 1235325

End: 1236194

Strand: Reverse

Name: licA [H]

Synonym: SP70585_1332

Alternate gene names: 225859063

Gene position: 1236194-1235325 (Counterclockwise)

Preceding gene: 225859064

Following gene: 225859062

Centisome position: 56.58

GC content: 35.06

Gene sequence:

>870_bases
GTGGAGAAAATCATTAAAGAAAAAATTTCTTCCTTACTTAGTCAAGAAGAGGAAGTCCTCAGTGTTGAACAACTGGGTGG
AATGACCAATCAAAACTATTTGGCCAAAACAACAAATAAGCAATACATTGTTAAATTCTTTGGTAAAGGGACAGAAAAGC
TTATCAATCGACAAGATGAAAAGTACAATCTTGAACTACTAAAGGATTTAGGCTTAGATGTAAAAAATTATCTTTTTGAT
ATTGAAGCTGCTATCAAAGTAAATGAGTATATCGAATCTGCGATTACGCTTGATTCAACGTCAATCAAGACCAAGTTCGA
CAAAATTGCTCCAATATTACAAACTATTCATACGTCTGCTAAGGAATTAAGAGGAGAATTTGCTCCTTTTGAAGAAATCA
AAAAATACGAATCCTTGATTGAAGAACAAATTCCTTATGCCAACTATGAATCTGTTAGAAATGCAGTCTTCTCCTTAGAG
AAAAGACTGGCTGACTTAGGTGTTGACAGAAAATCTTGTCATATCGATTTGGTGCCTGAAAACTTTATCGAATCACCTCA
AGGACGACTTTATTTGATTGACTGGGAATATTCATCAATGAATGATCCAATGTGGGATTTGGCTGCCCTCTTTTTAGAGT
CTGAATTCACTTCCCAAGAGGAAGAAACTTTCTTATCTCACTATGAGAGTGACCAAACACCGGTTTCTCATGAAAAGATT
GCTATTTATAAAATTTTACAAGATACTATTTGGAGTCTATGGACTGTCTATAAGGAAGAGCAAGGTGAAGATTTTGGTGA
CTATGGTGTGAATCGTTACCAAAGAGCTGTTAAAGGTTTGGCTTCTTATGGAGGAACAGATGAAAAGTAA

Upstream 100 bases:

>100_bases
GTAAGAGAAATTAAAGATATTCATCGTGTCTTTGCAACCGATTTAAACACAGCCTTTAAAACAGTGTTTAAGTGGGAAGT
ATAAGTACTGGAGGTTAATT

Downstream 100 bases:

>100_bases
AAACGGAGTTCCTTTTGGCCTTCTCTCAGGTATTTTCTGGGGCTTGGGTCTAACGGTTAGTGCTTATATCTTTTCGATTT
TTACAGATTTGTCACCCTTT

Product: choline kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MEKIIKEKISSLLSQEEEVLSVEQLGGMTNQNYLAKTTNKQYIVKFFGKGTEKLINRQDEKYNLELLKDLGLDVKNYLFD
IEAAIKVNEYIESAITLDSTSIKTKFDKIAPILQTIHTSAKELRGEFAPFEEIKKYESLIEEQIPYANYESVRNAVFSLE
KRLADLGVDRKSCHIDLVPENFIESPQGRLYLIDWEYSSMNDPMWDLAALFLESEFTSQEEETFLSHYESDQTPVSHEKI
AIYKILQDTIWSLWTVYKEEQGEDFGDYGVNRYQRAVKGLASYGGTDEK

Sequences:

>Translated_289_residues
MEKIIKEKISSLLSQEEEVLSVEQLGGMTNQNYLAKTTNKQYIVKFFGKGTEKLINRQDEKYNLELLKDLGLDVKNYLFD
IEAAIKVNEYIESAITLDSTSIKTKFDKIAPILQTIHTSAKELRGEFAPFEEIKKYESLIEEQIPYANYESVRNAVFSLE
KRLADLGVDRKSCHIDLVPENFIESPQGRLYLIDWEYSSMNDPMWDLAALFLESEFTSQEEETFLSHYESDQTPVSHEKI
AIYKILQDTIWSLWTVYKEEQGEDFGDYGVNRYQRAVKGLASYGGTDEK
>Mature_289_residues
MEKIIKEKISSLLSQEEEVLSVEQLGGMTNQNYLAKTTNKQYIVKFFGKGTEKLINRQDEKYNLELLKDLGLDVKNYLFD
IEAAIKVNEYIESAITLDSTSIKTKFDKIAPILQTIHTSAKELRGEFAPFEEIKKYESLIEEQIPYANYESVRNAVFSLE
KRLADLGVDRKSCHIDLVPENFIESPQGRLYLIDWEYSSMNDPMWDLAALFLESEFTSQEEETFLSHYESDQTPVSHEKI
AIYKILQDTIWSLWTVYKEEQGEDFGDYGVNRYQRAVKGLASYGGTDEK

Specific function: Mediates phase variation of the LOS 6A2 and 12D9 epitopes. Phase variation of H.influenza LOS epitopes expressed by licA is determined by a translational switch [H]

COG id: COG0510

COG function: function code M; Predicted choline kinase involved in LPS biosynthesis

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002573
- InterPro:   IPR011009 [H]

Pfam domain/function: PF01633 Choline_kinase [H]

EC number: NA

Molecular weight: Translated: 33431; Mature: 33431

Theoretical pI: Translated: 4.43; Mature: 4.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKIIKEKISSLLSQEEEVLSVEQLGGMTNQNYLAKTTNKQYIVKFFGKGTEKLINRQDE
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHCCCHHHHHCCCCC
KYNLELLKDLGLDVKNYLFDIEAAIKVNEYIESAITLDSTSIKTKFDKIAPILQTIHTSA
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
KELRGEFAPFEEIKKYESLIEEQIPYANYESVRNAVFSLEKRLADLGVDRKSCHIDLVPE
HHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCH
NFIESPQGRLYLIDWEYSSMNDPMWDLAALFLESEFTSQEEETFLSHYESDQTPVSHEKI
HHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHH
AIYKILQDTIWSLWTVYKEEQGEDFGDYGVNRYQRAVKGLASYGGTDEK
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MEKIIKEKISSLLSQEEEVLSVEQLGGMTNQNYLAKTTNKQYIVKFFGKGTEKLINRQDE
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHCCCHHHHHCCCCC
KYNLELLKDLGLDVKNYLFDIEAAIKVNEYIESAITLDSTSIKTKFDKIAPILQTIHTSA
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
KELRGEFAPFEEIKKYESLIEEQIPYANYESVRNAVFSLEKRLADLGVDRKSCHIDLVPE
HHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCH
NFIESPQGRLYLIDWEYSSMNDPMWDLAALFLESEFTSQEEETFLSHYESDQTPVSHEKI
HHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHH
AIYKILQDTIWSLWTVYKEEQGEDFGDYGVNRYQRAVKGLASYGGTDEK
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2479481; 8861214 [H]