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The map label for this gene is trx [C]

Identifier: 225853532

GI number: 225853532

Start: 2048962

End: 2049285

Strand: Direct

Name: trx [C]

Synonym: BMEA_A2165

Alternate gene names: 225853532

Gene position: 2048962-2049285 (Clockwise)

Preceding gene: 225853531

Following gene: 225853544

Centisome position: 96.39

GC content: 58.02

Gene sequence:

>324_bases
ATGGCAACCGTCAAGGTCGATAACAGCAACTTTCAATCGGACGTTCTCCAGTCGAGCGAGCCGGTTGTAGTGGATTTCTG
GGCAGAATGGTGCGGACCATGCAAGACGATCGCTCCGGCTCTGGACGAAATCGCCGCTGAAATGGCTGGCCAGGTCAAGA
TTGCCAAGGTCAATATCGACGAGAACCCGGAGCTGGCCGCCCAGTTCGGTGTGCGCTCCATCCCGACGCTTCTGATGTTC
AAGGATGGCGAGCTTGCTGCCAATATGGTTGGCGCCGCTCCCAAGAGCCGCCTTGCCGACTGGATCAAGGCATCGGCTGC
GTAA

Upstream 100 bases:

>100_bases
AGTTAGAGCGGTTCCGGCGATTCTGTTAAAATAGAAACTGCTCTAGCGCGTGAGTCTATAGAAGAACATCGCCATTCTAC
CAAAGAGGAGGATTAGTTCC

Downstream 100 bases:

>100_bases
TAAAGATCACCATTACAAAAATGGAAAAACCCGGCCTTTGCGCCGGGTCAGATTGATGAAAAACCCCTCGATTTTTGGCA
GCAGTCAAAAACGAGGGGTT

Product: thioredoxin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 107; Mature: 106

Protein sequence:

>107_residues
MATVKVDNSNFQSDVLQSSEPVVVDFWAEWCGPCKTIAPALDEIAAEMAGQVKIAKVNIDENPELAAQFGVRSIPTLLMF
KDGELAANMVGAAPKSRLADWIKASAA

Sequences:

>Translated_107_residues
MATVKVDNSNFQSDVLQSSEPVVVDFWAEWCGPCKTIAPALDEIAAEMAGQVKIAKVNIDENPELAAQFGVRSIPTLLMF
KDGELAANMVGAAPKSRLADWIKASAA
>Mature_106_residues
ATVKVDNSNFQSDVLQSSEPVVVDFWAEWCGPCKTIAPALDEIAAEMAGQVKIAKVNIDENPELAAQFGVRSIPTLLMFK
DGELAANMVGAAPKSRLADWIKASAA

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=97, Percent_Identity=41.2371134020619, Blast_Score=92, Evalue=9e-20,
Organism=Homo sapiens, GI5031973, Length=97, Percent_Identity=32.9896907216495, Blast_Score=68, Evalue=1e-12,
Organism=Homo sapiens, GI21361657, Length=101, Percent_Identity=35.6435643564356, Blast_Score=65, Evalue=1e-11,
Organism=Homo sapiens, GI20070125, Length=100, Percent_Identity=32, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI87082331, Length=104, Percent_Identity=51.9230769230769, Blast_Score=125, Evalue=8e-31,
Organism=Escherichia coli, GI1788936, Length=91, Percent_Identity=43.956043956044, Blast_Score=101, Evalue=1e-23,
Organism=Escherichia coli, GI87081747, Length=93, Percent_Identity=36.5591397849462, Blast_Score=71, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI212646193, Length=94, Percent_Identity=42.5531914893617, Blast_Score=92, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17554386, Length=102, Percent_Identity=38.2352941176471, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI115532378, Length=72, Percent_Identity=44.4444444444444, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI115532380, Length=72, Percent_Identity=44.4444444444444, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17544108, Length=72, Percent_Identity=44.4444444444444, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71980562, Length=90, Percent_Identity=35.5555555555556, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17556044, Length=85, Percent_Identity=37.6470588235294, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71980565, Length=87, Percent_Identity=35.632183908046, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17509965, Length=89, Percent_Identity=31.4606741573034, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71998175, Length=93, Percent_Identity=38.7096774193548, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17549970, Length=77, Percent_Identity=32.4675324675325, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17510299, Length=91, Percent_Identity=35.1648351648352, Blast_Score=62, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=86, Percent_Identity=44.1860465116279, Blast_Score=73, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6319925, Length=93, Percent_Identity=32.258064516129, Blast_Score=72, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6321648, Length=86, Percent_Identity=39.5348837209302, Blast_Score=70, Evalue=9e-14,
Organism=Drosophila melanogaster, GI28573567, Length=94, Percent_Identity=41.4893617021277, Blast_Score=94, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24639826, Length=96, Percent_Identity=39.5833333333333, Blast_Score=85, Evalue=9e-18,
Organism=Drosophila melanogaster, GI21358065, Length=96, Percent_Identity=39.5833333333333, Blast_Score=80, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17648013, Length=88, Percent_Identity=42.0454545454545, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24583090, Length=88, Percent_Identity=42.0454545454545, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24664269, Length=75, Percent_Identity=38.6666666666667, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI19921434, Length=79, Percent_Identity=39.2405063291139, Blast_Score=71, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24639068, Length=91, Percent_Identity=32.967032967033, Blast_Score=69, Evalue=5e-13,
Organism=Drosophila melanogaster, GI17530795, Length=92, Percent_Identity=29.3478260869565, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11421; Mature: 11290

Theoretical pI: Translated: 4.28; Mature: 4.28

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATVKVDNSNFQSDVLQSSEPVVVDFWAEWCGPCKTIAPALDEIAAEMAGQVKIAKVNID
CCEEEECCCCCHHHHHCCCCCEEEEEHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEECCC
ENPELAAQFGVRSIPTLLMFKDGELAANMVGAAPKSRLADWIKASAA
CCCHHHHHCCCCCCCEEEEEECCCHHHHHHCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
ATVKVDNSNFQSDVLQSSEPVVVDFWAEWCGPCKTIAPALDEIAAEMAGQVKIAKVNID
CEEEECCCCCHHHHHCCCCCEEEEEHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEECCC
ENPELAAQFGVRSIPTLLMFKDGELAANMVGAAPKSRLADWIKASAA
CCCHHHHHCCCCCCCEEEEEECCCHHHHHHCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7021558 [H]