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The map label for this gene is hisE

Identifier: 225853517

GI number: 225853517

Start: 2027030

End: 2027353

Strand: Direct

Name: hisE

Synonym: BMEA_A2148

Alternate gene names: 225853517

Gene position: 2027030-2027353 (Clockwise)

Preceding gene: 225853516

Following gene: 225853518

Centisome position: 95.36

GC content: 62.04

Gene sequence:

>324_bases
ATGAGCCAGTTTACGCTTGCAGACCTTGAACGGATCGTGGCCGAGCGCGCCAGCGTGACGGATGGTACATCCTATACGGC
AAGCCTTGTGGCGAAAGGGCAGCCGAAGGCTGCGCAGAAACTGGGCGAGGAAGCGGTGGAAACGGTGATAGCAGCCGTTT
CCGGCGACCGTGCCGGTGTCGTCTCGGAAAGTGCCGATCTGCTCTATCATCTGGCGGTGGTCTGGAATATTGCAGGCGTG
GCGCTGGAGGATGTGCTTCAGGAACTTCAGCGCCGCACCGCCCAGACCGGCCTTGCGGAAAAGGCCAGCCGCCCGAAGGG
CTGA

Upstream 100 bases:

>100_bases
GAAATCGCTCTAACTATTTGTTTTGTCGCATTTTCCAACGCAAAACCGTTTCACACTTGTGCTGGAAATGCTCTAAAAAG
ATACCATGAGGGAAACCCCG

Downstream 100 bases:

>100_bases
AAGGCAAATCGTCCATGTGGGAAAAAGTCGATCAGCTCACCCCGTCCCGGTATTCGCCCTACCGCTTCTTTTCGGCGCAG
GAATGGGCAGCCTTCCGGGC

Product: phosphoribosyl-ATP pyrophosphatase

Products: NA

Alternate protein names: PRA-PH

Number of amino acids: Translated: 107; Mature: 106

Protein sequence:

>107_residues
MSQFTLADLERIVAERASVTDGTSYTASLVAKGQPKAAQKLGEEAVETVIAAVSGDRAGVVSESADLLYHLAVVWNIAGV
ALEDVLQELQRRTAQTGLAEKASRPKG

Sequences:

>Translated_107_residues
MSQFTLADLERIVAERASVTDGTSYTASLVAKGQPKAAQKLGEEAVETVIAAVSGDRAGVVSESADLLYHLAVVWNIAGV
ALEDVLQELQRRTAQTGLAEKASRPKG
>Mature_106_residues
SQFTLADLERIVAERASVTDGTSYTASLVAKGQPKAAQKLGEEAVETVIAAVSGDRAGVVSESADLLYHLAVVWNIAGVA
LEDVLQELQRRTAQTGLAEKASRPKG

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0140

COG function: function code E; Phosphoribosyl-ATP pyrophosphohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-PH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=87, Percent_Identity=45.9770114942529, Blast_Score=77, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS2_BRUA1 (B2S985)

Other databases:

- EMBL:   CP000887
- RefSeq:   YP_001935911.1
- ProteinModelPortal:   B2S985
- SMR:   B2S985
- GeneID:   6327059
- GenomeReviews:   CP000887_GR
- KEGG:   bmc:BAbS19_I19550
- HOGENOM:   HBG646527
- OMA:   ETVMAAK
- ProtClustDB:   PRK00400
- GO:   GO:0005737
- HAMAP:   MF_01020
- InterPro:   IPR008179
- InterPro:   IPR021130
- TIGRFAMs:   TIGR03188

Pfam domain/function: PF01503 PRA-PH

EC number: =3.6.1.31

Molecular weight: Translated: 11253; Mature: 11122

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQFTLADLERIVAERASVTDGTSYTASLVAKGQPKAAQKLGEEAVETVIAAVSGDRAGV
CCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
VSESADLLYHLAVVWNIAGVALEDVLQELQRRTAQTGLAEKASRPKG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SQFTLADLERIVAERASVTDGTSYTASLVAKGQPKAAQKLGEEAVETVIAAVSGDRAGV
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
VSESADLLYHLAVVWNIAGVALEDVLQELQRRTAQTGLAEKASRPKG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA