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The map label for this gene is lysC [H]

Identifier: 225853310

GI number: 225853310

Start: 1826933

End: 1828204

Strand: Reverse

Name: lysC [H]

Synonym: BMEA_A1925

Alternate gene names: 225853310

Gene position: 1828204-1826933 (Counterclockwise)

Preceding gene: 225853312

Following gene: 225853309

Centisome position: 86.0

GC content: 59.28

Gene sequence:

>1272_bases
ATGGCGCGCATCGTGATGAAATTCGGCGGCACTTCGGTGGCCGATCTGGAACGCATCTATAATGTGGCGCGCCACGTCAA
ACGCGAGGTCGAGGCGGGCAATCAGGTTGCCGTGGTCGTTTCGGCCATGTCCGGCAAGACCAATGAGCTGGTCGACTGGG
TGCAGAACATGCCGAAGGTTTGCGGCGCAAGCTCTCCCTTTTATGATGCGCGCGAATATGACACCATCGTCGCCTCCGGT
GAACAGGTGACAAGCGGCCTTCTGGCAATTGCGCTTCAGTCCATCGGCGTGGATGCGCGCTCGTGGCAGGGCTGGCAGAT
CCCCATCCAGACCGACAATGCACATGGTGCAGCCCGCATTCAGGAAATCGACGGTTCGCAAATCATCCGCCGCATGGAAA
TGGGGCAGGTTGCCGTCGTTGCCGGTTTCCAGGGCATTGGCCCGGACAATCGCGTGGCAACGCTTGGTCGCGGTGGTTCG
GATACGTCCGCGGTTGCTGTTGCCGCTGCCGTGAAGGCGGATCGCTGCGACATCTATACGGATGTGGATGGCGTTTACAC
CACCGACCCGCGCATCGAGCCAAAGGCGCGCCGCCTGCCGAAGATTTCCTTTGAGGAAATGCTGGAAATGGCATCGCTGG
GCGCCAAGGTTCTCCAGGTGCGCTCGGTGGAGCTTGCCATGGTGCACAAGGTGCGTACTTTCGTGCGCTCAAGCTTTACG
GACCCCGATGCGCCGGGCATGGGTGATCCGATCAACCCGCCCGGAACGCTTATTTGCGACGAGGAAGAAATCGTGGAACA
GCAGGTCGTCACAGGTATCGCCTTTGCGAAGGATGAGGCACAGATTTCGCTGCGGCGCGTGGCCGACCGGCCGGGCGTGT
CGGCGGCAATTTTCGGGCCGCTTGCCGAAGAGCACATCAATGTCGACATGATCGTGCAGAACGTGTCGGAAGACGGCTCC
AAGACCGACATGACCTTTACCATTCCCACCGGCGACATCGACAAGGCGCTGAAGGTTCTGGACAAGGCCAAGAGCGAAAT
CAGCTTTGACAATATCCAGTCCGAAACCGGCCTTGCGAAAATCTCCGTTATCGGCATCGGCATGCGCAGCCATGCGGGTG
TCGCGGCTACCGCCTTCAAGGCGCTTGCCGAAAAGGGCATCAATATCCGCGCCATCACCACGTCGGAAATCAAGATTTCC
ATTCTGATCGATGGGCCTTATGCGGAATTGGCGGTGCGCACGCTGCATGCCGTCTATGGTCTCGACAAGTAA

Upstream 100 bases:

>100_bases
CCCCATTTTAGCTATGTGACCACAAGTTTGCCTGTCGCAACAATATAAGGTTTGGGCAGGTGAGAGTGTAATTTTTCTAA
AGAGCGGGACGTAACCTTAA

Downstream 100 bases:

>100_bases
TACAAGTGATACGGGGGCTGGAGTTGCCGACGCTCTCCACACCTTGAAATGCTTAATTGCCGCACGGGCTTAACCAGACC
CGATGAGCCAAGCTCATCGG

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 423; Mature: 422

Protein sequence:

>423_residues
MARIVMKFGGTSVADLERIYNVARHVKREVEAGNQVAVVVSAMSGKTNELVDWVQNMPKVCGASSPFYDAREYDTIVASG
EQVTSGLLAIALQSIGVDARSWQGWQIPIQTDNAHGAARIQEIDGSQIIRRMEMGQVAVVAGFQGIGPDNRVATLGRGGS
DTSAVAVAAAVKADRCDIYTDVDGVYTTDPRIEPKARRLPKISFEEMLEMASLGAKVLQVRSVELAMVHKVRTFVRSSFT
DPDAPGMGDPINPPGTLICDEEEIVEQQVVTGIAFAKDEAQISLRRVADRPGVSAAIFGPLAEEHINVDMIVQNVSEDGS
KTDMTFTIPTGDIDKALKVLDKAKSEISFDNIQSETGLAKISVIGIGMRSHAGVAATAFKALAEKGINIRAITTSEIKIS
ILIDGPYAELAVRTLHAVYGLDK

Sequences:

>Translated_423_residues
MARIVMKFGGTSVADLERIYNVARHVKREVEAGNQVAVVVSAMSGKTNELVDWVQNMPKVCGASSPFYDAREYDTIVASG
EQVTSGLLAIALQSIGVDARSWQGWQIPIQTDNAHGAARIQEIDGSQIIRRMEMGQVAVVAGFQGIGPDNRVATLGRGGS
DTSAVAVAAAVKADRCDIYTDVDGVYTTDPRIEPKARRLPKISFEEMLEMASLGAKVLQVRSVELAMVHKVRTFVRSSFT
DPDAPGMGDPINPPGTLICDEEEIVEQQVVTGIAFAKDEAQISLRRVADRPGVSAAIFGPLAEEHINVDMIVQNVSEDGS
KTDMTFTIPTGDIDKALKVLDKAKSEISFDNIQSETGLAKISVIGIGMRSHAGVAATAFKALAEKGINIRAITTSEIKIS
ILIDGPYAELAVRTLHAVYGLDK
>Mature_422_residues
ARIVMKFGGTSVADLERIYNVARHVKREVEAGNQVAVVVSAMSGKTNELVDWVQNMPKVCGASSPFYDAREYDTIVASGE
QVTSGLLAIALQSIGVDARSWQGWQIPIQTDNAHGAARIQEIDGSQIIRRMEMGQVAVVAGFQGIGPDNRVATLGRGGSD
TSAVAVAAAVKADRCDIYTDVDGVYTTDPRIEPKARRLPKISFEEMLEMASLGAKVLQVRSVELAMVHKVRTFVRSSFTD
PDAPGMGDPINPPGTLICDEEEIVEQQVVTGIAFAKDEAQISLRRVADRPGVSAAIFGPLAEEHINVDMIVQNVSEDGSK
TDMTFTIPTGDIDKALKVLDKAKSEISFDNIQSETGLAKISVIGIGMRSHAGVAATAFKALAEKGINIRAITTSEIKISI
LIDGPYAELAVRTLHAVYGLDK

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=473, Percent_Identity=29.8097251585624, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1790455, Length=468, Percent_Identity=29.4871794871795, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1790376, Length=425, Percent_Identity=25.1764705882353, Blast_Score=78, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320893, Length=398, Percent_Identity=26.6331658291457, Blast_Score=105, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 45352; Mature: 45221

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARIVMKFGGTSVADLERIYNVARHVKREVEAGNQVAVVVSAMSGKTNELVDWVQNMPKV
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHH
CGASSPFYDAREYDTIVASGEQVTSGLLAIALQSIGVDARSWQGWQIPIQTDNAHGAARI
HCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCEE
QEIDGSQIIRRMEMGQVAVVAGFQGIGPDNRVATLGRGGSDTSAVAVAAAVKADRCDIYT
EECCHHHHHHHHHCCCEEEEECCCCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCCCEEE
DVDGVYTTDPRIEPKARRLPKISFEEMLEMASLGAKVLQVRSVELAMVHKVRTFVRSSFT
CCCCEEECCCCCCHHHHCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCC
DPDAPGMGDPINPPGTLICDEEEIVEQQVVTGIAFAKDEAQISLRRVADRPGVSAAIFGP
CCCCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHEECCHHHHHHHHHHCCCCCCEEEECC
LAEEHINVDMIVQNVSEDGSKTDMTFTIPTGDIDKALKVLDKAKSEISFDNIQSETGLAK
HHHHHCCHHHEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCHHHCCCCCCCEE
ISVIGIGMRSHAGVAATAFKALAEKGINIRAITTSEIKISILIDGPYAELAVRTLHAVYG
EEEEEECCCCCCCHHHHHHHHHHHCCCEEEEEEECCEEEEEEECCCHHHHHHHHHHHHHC
LDK
CCC
>Mature Secondary Structure 
ARIVMKFGGTSVADLERIYNVARHVKREVEAGNQVAVVVSAMSGKTNELVDWVQNMPKV
CEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHH
CGASSPFYDAREYDTIVASGEQVTSGLLAIALQSIGVDARSWQGWQIPIQTDNAHGAARI
HCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCEE
QEIDGSQIIRRMEMGQVAVVAGFQGIGPDNRVATLGRGGSDTSAVAVAAAVKADRCDIYT
EECCHHHHHHHHHCCCEEEEECCCCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCCCEEE
DVDGVYTTDPRIEPKARRLPKISFEEMLEMASLGAKVLQVRSVELAMVHKVRTFVRSSFT
CCCCEEECCCCCCHHHHCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCC
DPDAPGMGDPINPPGTLICDEEEIVEQQVVTGIAFAKDEAQISLRRVADRPGVSAAIFGP
CCCCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHEECCHHHHHHHHHHCCCCCCEEEECC
LAEEHINVDMIVQNVSEDGSKTDMTFTIPTGDIDKALKVLDKAKSEISFDNIQSETGLAK
HHHHHCCHHHEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCHHHCCCCCCCEE
ISVIGIGMRSHAGVAATAFKALAEKGINIRAITTSEIKISILIDGPYAELAVRTLHAVYG
EEEEEECCCCCCCHHHHHHHHHHHCCCEEEEEEECCEEEEEEECCCHHHHHHHHHHHHHC
LDK
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]