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The map label for this gene is pth [H]

Identifier: 225853015

GI number: 225853015

Start: 1506433

End: 1507185

Strand: Direct

Name: pth [H]

Synonym: BMEA_A1591

Alternate gene names: 225853015

Gene position: 1506433-1507185 (Clockwise)

Preceding gene: 225853014

Following gene: 225853016

Centisome position: 70.87

GC content: 56.84

Gene sequence:

>753_bases
ATGCTGCTCATCGCAGGTCTTGGCAATCCGGGTCCCCAATATGCGCATAACCGGCACAATATCGGTTTCATGGCGGCGGA
TGAAATATTCCGCCGCCATCGCTTTTCCAACTGGCAGAAGAAATTTCAGGCAGAGATCGCCGATGGCGTGATCGACGGCG
AGAAAGTGTTGCTGGTCAAACCGCAGACTTTCATGAACCTTTCCGGCCAGTCTATCGGCGAAGCCATGCGCTTCTACAAG
CTGACGCCTGCCGATCTCGTCGTGATCTATGATGAACTGGACCTCGTTCCGGGCAAGCTGCGCATCAAGACCGGCGGCGG
TTCCGGCGGCCATAACGGCATCAAATCCATCGACGCACATATGCAGTCCTTCCCCGGCGGACAGAATTATCGCCGCATGC
GGCTTGGCATCGGCCATCCCGGCGCGAAGGAACTCGTGCATAATTATGTTCTGGGCGATTTCGCCAAGGCCGACAATGAA
TGGCTGGATACGCTTATGGGCGCCGTCGCCGACAATGTCGCCATGCTTGCCAGACGCGAGGATAACAGCTTCATGAACCG
CATTGCACTCGCCATGGGCGACGGCAATCAGCGGCCAGGCGGCGTCAAGACAGATCCCGCGCAATTGGAGAAGGCTCCGC
CAAAGGCCCAGAGCCATATTCGTCAGGCGCGCCAGAACCAGAAAAAGCCCAATATTCCCGAAAGCGGCCCGATGGCTGAA
ATGCTGAAAAAGCTGCTGGGGAAGAAGGATTAA

Upstream 100 bases:

>100_bases
GCTGCGCCTGCCGGCCTGAAGTCGGAAGAAAACGCAGAAGGCGCTGCGGAAGAAGCCAAGGACGGCGAATAATCGCTTCC
TGATAGGGGGTCTGAATACC

Downstream 100 bases:

>100_bases
TCCCTCGCGACGGCTGCGCCTCTTGACGCTTCCCGGTCCTATGACGCATAGCCACAACAATAAAATTCTAGTCTGATAGG
TAAGATCATGGGTTTCAAAT

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 250; Mature: 250

Protein sequence:

>250_residues
MLLIAGLGNPGPQYAHNRHNIGFMAADEIFRRHRFSNWQKKFQAEIADGVIDGEKVLLVKPQTFMNLSGQSIGEAMRFYK
LTPADLVVIYDELDLVPGKLRIKTGGGSGGHNGIKSIDAHMQSFPGGQNYRRMRLGIGHPGAKELVHNYVLGDFAKADNE
WLDTLMGAVADNVAMLARREDNSFMNRIALAMGDGNQRPGGVKTDPAQLEKAPPKAQSHIRQARQNQKKPNIPESGPMAE
MLKKLLGKKD

Sequences:

>Translated_250_residues
MLLIAGLGNPGPQYAHNRHNIGFMAADEIFRRHRFSNWQKKFQAEIADGVIDGEKVLLVKPQTFMNLSGQSIGEAMRFYK
LTPADLVVIYDELDLVPGKLRIKTGGGSGGHNGIKSIDAHMQSFPGGQNYRRMRLGIGHPGAKELVHNYVLGDFAKADNE
WLDTLMGAVADNVAMLARREDNSFMNRIALAMGDGNQRPGGVKTDPAQLEKAPPKAQSHIRQARQNQKKPNIPESGPMAE
MLKKLLGKKD
>Mature_250_residues
MLLIAGLGNPGPQYAHNRHNIGFMAADEIFRRHRFSNWQKKFQAEIADGVIDGEKVLLVKPQTFMNLSGQSIGEAMRFYK
LTPADLVVIYDELDLVPGKLRIKTGGGSGGHNGIKSIDAHMQSFPGGQNYRRMRLGIGHPGAKELVHNYVLGDFAKADNE
WLDTLMGAVADNVAMLARREDNSFMNRIALAMGDGNQRPGGVKTDPAQLEKAPPKAQSHIRQARQNQKKPNIPESGPMAE
MLKKLLGKKD

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=174, Percent_Identity=32.183908045977, Blast_Score=100, Evalue=1e-21,
Organism=Escherichia coli, GI1787455, Length=174, Percent_Identity=39.6551724137931, Blast_Score=103, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6321983, Length=176, Percent_Identity=29.5454545454545, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 27550; Mature: 27550

Theoretical pI: Translated: 10.23; Mature: 10.23

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1 ; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLIAGLGNPGPQYAHNRHNIGFMAADEIFRRHRFSNWQKKFQAEIADGVIDGEKVLLVK
CEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEC
PQTFMNLSGQSIGEAMRFYKLTPADLVVIYDELDLVPGKLRIKTGGGSGGHNGIKSIDAH
CHHHHCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCHHHHHHHH
MQSFPGGQNYRRMRLGIGHPGAKELVHNYVLGDFAKADNEWLDTLMGAVADNVAMLARRE
HHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCC
DNSFMNRIALAMGDGNQRPGGVKTDPAQLEKAPPKAQSHIRQARQNQKKPNIPESGPMAE
CHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCHHH
MLKKLLGKKD
HHHHHHCCCC
>Mature Secondary Structure
MLLIAGLGNPGPQYAHNRHNIGFMAADEIFRRHRFSNWQKKFQAEIADGVIDGEKVLLVK
CEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEC
PQTFMNLSGQSIGEAMRFYKLTPADLVVIYDELDLVPGKLRIKTGGGSGGHNGIKSIDAH
CHHHHCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCHHHHHHHH
MQSFPGGQNYRRMRLGIGHPGAKELVHNYVLGDFAKADNEWLDTLMGAVADNVAMLARRE
HHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCC
DNSFMNRIALAMGDGNQRPGGVKTDPAQLEKAPPKAQSHIRQARQNQKKPNIPESGPMAE
CHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCHHH
MLKKLLGKKD
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA