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The map label for this gene is moeA [H]

Identifier: 225852642

GI number: 225852642

Start: 1140020

End: 1141234

Strand: Direct

Name: moeA [H]

Synonym: BMEA_A1187

Alternate gene names: 225852642

Gene position: 1140020-1141234 (Clockwise)

Preceding gene: 225852641

Following gene: 225852643

Centisome position: 53.63

GC content: 60.82

Gene sequence:

>1215_bases
ATGCCCCTTCTTCCGGTCGATGAAGCACTGGCCTATATCCTCAACTCCGCCGCGCCGCATGGCACGGAAGACGTTTCGCT
TACGGACGCAGGCGGGCGCGTTACAGCCTCGGACATCACGGCCCAGCTTCTTCAACCGCCCTTTGATTGCTCGGCCATGG
ATGGCTATGCGCTGATTGCGCCAGAGGAGATCACCTATCCTCTTGAATTGACCGTCATCGGCGAGTCTGCCGCCGGAAAG
CGTTTCGAGGGAACGCTTCGCAAGGGCGAGGCCATTCGCATTTTCACCGGCGCGCCCATGCCGGAAAATGCCGACAGCAT
CATCATACAGGAACATACCGAGCGCGAGGGAAACCGGCTCATTATTCTGCACGGATTGGACAAGGGCCGCCATATCCGCC
GCGCAGGGCTGGATTTCGCACCCGGCAAAGTGGTGGTTCCCGCAGGCCGCGAATTGGATGCACCTGCCCTTTCCCTTGCC
GCAGCAAGCGGCCATGCGCGCCTGCCCGTCTTCACCAGACCGCGTGTTGCCATTCTTGCCACCGGCGATGAACTCGTTCC
GCCCGGAGCAATACCGGGGCCGGACCAGATCGTTGCCTCCAACAGCATCGGCATTGCCGAAATTACGCGCCGTGCGGGCG
GCACGCCTGAAGACCTCGGCATCATAGCCGACGACCCGGCCAGAATTGAAAAAGCCATATCGGATGCGCTGGAGGACGGC
ATCGACATGCTCGTCACCATAGGCGGCGCTTCGGTAGGCGATCGCGATTTTGTCCACGGCGCGCTTCGCAATTGCGGCGT
TGCGCTCGATTTCTGGAAGATCGCCATGCGGCCCGGCAAACCGCTCATGTATGGCCGCAAAGCCGTCAATGGCAAAACGG
TTCACGTTCTGGGATTACCCGGCAATCCCGTATCGAGCCTTGTTTGCAGCCTGCTCTTCCTGCGCCCGCTTGTGGCAAAG
CTTTCCGGCCTCGCGCTGAAGGCAGATATCCGCGCGGCAAAGCTTGGCGTCGCTATGCGCGCGAACGACCATCGCCGCGA
CTTTATCCGCGTAACGGTCGAATCAGAGCCGGACGGAACTCTCGTCGCTACCCCCTTTCCGATGCAGGATTCGTCCATGC
TCTCGGCTTTGGTGTGCTCCGATGCGCTTTTGATCCGCGAGGAAAACGCGCCCGAGGCATTGCCTGGCGATCCCTGCCGC
ATCCTTATGTTATAG

Upstream 100 bases:

>100_bases
GTTAAAAATACGATAAAACAAATGGTTAGAGTGGATCCGGCAATTCTGCTAAAACAGGAACCGCTCTAACGGGTCAAACA
ATTCAGTTCGAGAGGAAACC

Downstream 100 bases:

>100_bases
GTTGCGGCACAGGGCGGGCGGTATTTTTCCTTAGAAACTGCATTTACCGTTCACCGCAACCCATTATAATTAATTAATAT
ACCTTGGCATGAAATTTCCC

Product: molybdenum cofactor synthesis domain-containing protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MPLLPVDEALAYILNSAAPHGTEDVSLTDAGGRVTASDITAQLLQPPFDCSAMDGYALIAPEEITYPLELTVIGESAAGK
RFEGTLRKGEAIRIFTGAPMPENADSIIIQEHTEREGNRLIILHGLDKGRHIRRAGLDFAPGKVVVPAGRELDAPALSLA
AASGHARLPVFTRPRVAILATGDELVPPGAIPGPDQIVASNSIGIAEITRRAGGTPEDLGIIADDPARIEKAISDALEDG
IDMLVTIGGASVGDRDFVHGALRNCGVALDFWKIAMRPGKPLMYGRKAVNGKTVHVLGLPGNPVSSLVCSLLFLRPLVAK
LSGLALKADIRAAKLGVAMRANDHRRDFIRVTVESEPDGTLVATPFPMQDSSMLSALVCSDALLIREENAPEALPGDPCR
ILML

Sequences:

>Translated_404_residues
MPLLPVDEALAYILNSAAPHGTEDVSLTDAGGRVTASDITAQLLQPPFDCSAMDGYALIAPEEITYPLELTVIGESAAGK
RFEGTLRKGEAIRIFTGAPMPENADSIIIQEHTEREGNRLIILHGLDKGRHIRRAGLDFAPGKVVVPAGRELDAPALSLA
AASGHARLPVFTRPRVAILATGDELVPPGAIPGPDQIVASNSIGIAEITRRAGGTPEDLGIIADDPARIEKAISDALEDG
IDMLVTIGGASVGDRDFVHGALRNCGVALDFWKIAMRPGKPLMYGRKAVNGKTVHVLGLPGNPVSSLVCSLLFLRPLVAK
LSGLALKADIRAAKLGVAMRANDHRRDFIRVTVESEPDGTLVATPFPMQDSSMLSALVCSDALLIREENAPEALPGDPCR
ILML
>Mature_403_residues
PLLPVDEALAYILNSAAPHGTEDVSLTDAGGRVTASDITAQLLQPPFDCSAMDGYALIAPEEITYPLELTVIGESAAGKR
FEGTLRKGEAIRIFTGAPMPENADSIIIQEHTEREGNRLIILHGLDKGRHIRRAGLDFAPGKVVVPAGRELDAPALSLAA
ASGHARLPVFTRPRVAILATGDELVPPGAIPGPDQIVASNSIGIAEITRRAGGTPEDLGIIADDPARIEKAISDALEDGI
DMLVTIGGASVGDRDFVHGALRNCGVALDFWKIAMRPGKPLMYGRKAVNGKTVHVLGLPGNPVSSLVCSLLFLRPLVAKL
SGLALKADIRAAKLGVAMRANDHRRDFIRVTVESEPDGTLVATPFPMQDSSMLSALVCSDALLIREENAPEALPGDPCRI
LML

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=333, Percent_Identity=31.8318318318318, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI10880983, Length=333, Percent_Identity=31.8318318318318, Blast_Score=153, Evalue=3e-37,
Organism=Escherichia coli, GI1787049, Length=393, Percent_Identity=35.1145038167939, Blast_Score=211, Evalue=8e-56,
Organism=Caenorhabditis elegans, GI25147659, Length=382, Percent_Identity=32.7225130890052, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17562606, Length=343, Percent_Identity=24.4897959183673, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17136978, Length=394, Percent_Identity=28.9340101522843, Blast_Score=131, Evalue=8e-31,
Organism=Drosophila melanogaster, GI24638841, Length=394, Percent_Identity=28.9340101522843, Blast_Score=131, Evalue=8e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 42655; Mature: 42524

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLLPVDEALAYILNSAAPHGTEDVSLTDAGGRVTASDITAQLLQPPFDCSAMDGYALIA
CCCCCHHHHHHHHHHCCCCCCCCCEEEECCCCEEEHHHHHHHHHCCCCCCCCCCCEEEEC
PEEITYPLELTVIGESAAGKRFEGTLRKGEAIRIFTGAPMPENADSIIIQEHTEREGNRL
CCCCCCEEEEEEEECCCCCCCEECCCCCCCEEEEEECCCCCCCCCEEEEEECCCCCCCEE
IILHGLDKGRHIRRAGLDFAPGKVVVPAGRELDAPALSLAAASGHARLPVFTRPRVAILA
EEEEECCCCCCHHHCCCCCCCCEEEECCCCCCCCCCEEEEECCCCCCCCEECCCCEEEEE
TGDELVPPGAIPGPDQIVASNSIGIAEITRRAGGTPEDLGIIADDPARIEKAISDALEDG
CCCCCCCCCCCCCCCCEEECCCCCHHHHHHHCCCCHHHCCEEECCHHHHHHHHHHHHHCC
IDMLVTIGGASVGDRDFVHGALRNCGVALDFWKIAMRPGKPLMYGRKAVNGKTVHVLGLP
CEEEEEECCCCCCCHHHHHHHHHHCCEEEEEEHEEECCCCCCEECCEECCCCEEEEEECC
GNPVSSLVCSLLFLRPLVAKLSGLALKADIRAAKLGVAMRANDHRRDFIRVTVESEPDGT
CCHHHHHHHHHHHHHHHHHHHCCEEEEECCCEEHEEEEEECCCCCCEEEEEEEECCCCCC
LVATPFPMQDSSMLSALVCSDALLIREENAPEALPGDPCRILML
EEECCCCCCCHHHHHHHHHCCEEEEEECCCCCCCCCCCEEEEEC
>Mature Secondary Structure 
PLLPVDEALAYILNSAAPHGTEDVSLTDAGGRVTASDITAQLLQPPFDCSAMDGYALIA
CCCCHHHHHHHHHHCCCCCCCCCEEEECCCCEEEHHHHHHHHHCCCCCCCCCCCEEEEC
PEEITYPLELTVIGESAAGKRFEGTLRKGEAIRIFTGAPMPENADSIIIQEHTEREGNRL
CCCCCCEEEEEEEECCCCCCCEECCCCCCCEEEEEECCCCCCCCCEEEEEECCCCCCCEE
IILHGLDKGRHIRRAGLDFAPGKVVVPAGRELDAPALSLAAASGHARLPVFTRPRVAILA
EEEEECCCCCCHHHCCCCCCCCEEEECCCCCCCCCCEEEEECCCCCCCCEECCCCEEEEE
TGDELVPPGAIPGPDQIVASNSIGIAEITRRAGGTPEDLGIIADDPARIEKAISDALEDG
CCCCCCCCCCCCCCCCEEECCCCCHHHHHHHCCCCHHHCCEEECCHHHHHHHHHHHHHCC
IDMLVTIGGASVGDRDFVHGALRNCGVALDFWKIAMRPGKPLMYGRKAVNGKTVHVLGLP
CEEEEEECCCCCCCHHHHHHHHHHCCEEEEEEHEEECCCCCCEECCEECCCCEEEEEECC
GNPVSSLVCSLLFLRPLVAKLSGLALKADIRAAKLGVAMRANDHRRDFIRVTVESEPDGT
CCHHHHHHHHHHHHHHHHHHHCCEEEEECCCEEHEEEEEECCCCCCEEEEEEEECCCCCC
LVATPFPMQDSSMLSALVCSDALLIREENAPEALPGDPCRILML
EEECCCCCCCHHHHHHHHHCCEEEEEECCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503; 9515915 [H]