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The map label for this gene is mazG [H]

Identifier: 225852569

GI number: 225852569

Start: 1056397

End: 1057221

Strand: Direct

Name: mazG [H]

Synonym: BMEA_A1108

Alternate gene names: 225852569

Gene position: 1056397-1057221 (Clockwise)

Preceding gene: 225852564

Following gene: 225852572

Centisome position: 49.7

GC content: 53.94

Gene sequence:

>825_bases
ATGAAATCATCCCGCAATATTGATCGTTTGTTGGAAATCATGGCCGCCCTTCGCAACCCCGAAACGGGTTGCCCGTGGGA
TATCGAGCAGAATTTCCGCACCATCGCGCCCTATACGCTCGAAGAAACCTATGAGGTTCTCGACGCCATTGAACGCGACG
ATATGGATGACCTGCGCGAGGAACTTGGCGATCTTTTGCTACAGGTCGTCTTCCATGCCCGAATGGCGGAAGAACAGGGC
TATTTTGCCTTTGGTGACGTCGTGGAAGCCATCACGCATAAGATGATCCGCCGCCACCCGCATGTTTTCGGCGATGCGCA
GGCACGAAGCGCCGGAATGGCCAAGGGTTCATGGAACCGCATCAAGGCGGAGGAAAAGGCAGAGCGCGCGGAAAGGCGTG
CAAAACTGGGACTGGAAAGCATCGGGAAAACCGGCTTTCTGGATGACATTCCCAACGCCTTCCCTGCCCTTCTGCGCGCG
CTGAAATTACAGCAGAAAGCGGCAAAGGTCGGCTTTGACTGGTCTGAGGCAGCCCCCATCCTCGACAAGATTGCCGAGGA
AACAGCGGAATTGAAAGAAGCCATGGCCGCAAGCGACAAGGCCGAAATCGAGGAAGAATATGGCGACCTTCTCTTCGCCA
TGGTCAATCTTGGCCGTCATCTTGAAATCGATGCCGAAACGGCGCTGATTTCCGCAAACGAGAAATTCAAACGCCGTTTT
CATTTCATCGAGGAGGCTTTGAAAACGTCAGGCCGCGATCTCGATGCAGCCAGCCTTGATGAAATGGAAGAAATCTGGAG
CGAAGCGAAGAAAAAAGGCCTGTAA

Upstream 100 bases:

>100_bases
CCCCGGCTGACTATGCAAAATCGGCAACAGACTTCAAGCTGCATGGATCGATTCTCATCAATCGTTTTACCGGGCTTTCA
TGAAGTTTGAAGGAGGGCAG

Downstream 100 bases:

>100_bases
ACCCGGCCTTACCCTTCGTCTTTCCAGCGCGGGCGGTACATCTGGTAAACGCTCTGCGTGGTCGCATAATCCATATAGCC
AAGCCGTGCCACCGGCTTTG

Product: nucleoside triphosphate pyrophosphohydrolase

Products: NA

Alternate protein names: NTP-PPase [H]

Number of amino acids: Translated: 274; Mature: 274

Protein sequence:

>274_residues
MKSSRNIDRLLEIMAALRNPETGCPWDIEQNFRTIAPYTLEETYEVLDAIERDDMDDLREELGDLLLQVVFHARMAEEQG
YFAFGDVVEAITHKMIRRHPHVFGDAQARSAGMAKGSWNRIKAEEKAERAERRAKLGLESIGKTGFLDDIPNAFPALLRA
LKLQQKAAKVGFDWSEAAPILDKIAEETAELKEAMAASDKAEIEEEYGDLLFAMVNLGRHLEIDAETALISANEKFKRRF
HFIEEALKTSGRDLDAASLDEMEEIWSEAKKKGL

Sequences:

>Translated_274_residues
MKSSRNIDRLLEIMAALRNPETGCPWDIEQNFRTIAPYTLEETYEVLDAIERDDMDDLREELGDLLLQVVFHARMAEEQG
YFAFGDVVEAITHKMIRRHPHVFGDAQARSAGMAKGSWNRIKAEEKAERAERRAKLGLESIGKTGFLDDIPNAFPALLRA
LKLQQKAAKVGFDWSEAAPILDKIAEETAELKEAMAASDKAEIEEEYGDLLFAMVNLGRHLEIDAETALISANEKFKRRF
HFIEEALKTSGRDLDAASLDEMEEIWSEAKKKGL
>Mature_274_residues
MKSSRNIDRLLEIMAALRNPETGCPWDIEQNFRTIAPYTLEETYEVLDAIERDDMDDLREELGDLLLQVVFHARMAEEQG
YFAFGDVVEAITHKMIRRHPHVFGDAQARSAGMAKGSWNRIKAEEKAERAERRAKLGLESIGKTGFLDDIPNAFPALLRA
LKLQQKAAKVGFDWSEAAPILDKIAEETAELKEAMAASDKAEIEEEYGDLLFAMVNLGRHLEIDAETALISANEKFKRRF
HFIEEALKTSGRDLDAASLDEMEEIWSEAKKKGL

Specific function: Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the MazEF toxin- antitoxin (TA) module that mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp p

COG id: COG1694

COG function: function code R; Predicted pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nucleoside triphosphate pyrophosphohydrolase family [H]

Homologues:

Organism=Escherichia coli, GI1789144, Length=269, Percent_Identity=52.7881040892193, Blast_Score=287, Evalue=6e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004518
- InterPro:   IPR011551 [H]

Pfam domain/function: PF03819 MazG [H]

EC number: =3.6.1.8 [H]

Molecular weight: Translated: 30998; Mature: 30998

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSSRNIDRLLEIMAALRNPETGCPWDIEQNFRTIAPYTLEETYEVLDAIERDDMDDLRE
CCCCCCHHHHHHHHHHHCCCCCCCCCCHHCCCHHHCCHHHHHHHHHHHHHCCCCHHHHHH
ELGDLLLQVVFHARMAEEQGYFAFGDVVEAITHKMIRRHPHVFGDAQARSAGMAKGSWNR
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCHHH
IKAEEKAERAERRAKLGLESIGKTGFLDDIPNAFPALLRALKLQQKAAKVGFDWSEAAPI
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LDKIAEETAELKEAMAASDKAEIEEEYGDLLFAMVNLGRHLEIDAETALISANEKFKRRF
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHCCHHHHHHH
HFIEEALKTSGRDLDAASLDEMEEIWSEAKKKGL
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKSSRNIDRLLEIMAALRNPETGCPWDIEQNFRTIAPYTLEETYEVLDAIERDDMDDLRE
CCCCCCHHHHHHHHHHHCCCCCCCCCCHHCCCHHHCCHHHHHHHHHHHHHCCCCHHHHHH
ELGDLLLQVVFHARMAEEQGYFAFGDVVEAITHKMIRRHPHVFGDAQARSAGMAKGSWNR
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCHHH
IKAEEKAERAERRAKLGLESIGKTGFLDDIPNAFPALLRALKLQQKAAKVGFDWSEAAPI
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LDKIAEETAELKEAMAASDKAEIEEEYGDLLFAMVNLGRHLEIDAETALISANEKFKRRF
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHCCHHHHHHH
HFIEEALKTSGRDLDAASLDEMEEIWSEAKKKGL
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]