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The map label for this gene is adhA [H]

Identifier: 225852564

GI number: 225852564

Start: 1050784

End: 1051767

Strand: Direct

Name: adhA [H]

Synonym: BMEA_A1102

Alternate gene names: 225852564

Gene position: 1050784-1051767 (Clockwise)

Preceding gene: 225852559

Following gene: 225852569

Centisome position: 49.43

GC content: 62.2

Gene sequence:

>984_bases
ATGAAAGCGATGGTGCTGGAGAAGCCGGGACAGCCACTGGTTCTCGTGGAGCGCCCTGATCCGTTGCCGGGGCCGGGCCA
GATCAGGCTGAAGGTTGAAGCCTGCGCCGTCTGCCGGACAGATTTGCATGTGGTGGATGGAGAGCTTGAAAGGCCAAAGC
TGCCGCTGGTTCCCGGACATGAGATCGTTGGCGTTATCGATGCCGTTGGAACGGGCGTCGATCCGTCACGCACAGGACGG
CGTGTGGGGGTTCCGTGGCTTGGGCATACTTGCGGCGCCTGTGACTATTGTCGCTCCGGCGCTGAAAACCTGTGCGATGC
CCCGCTTTTTACCGGCTACACGCGCGATGGCGGGTTCGCCACCCATGTCGTCGCAGATGCCGATTTTGCTTTCGATCTCG
ATGAGGCCGCCGATCCTGTGGCTCTGGCGCCCTTGCTCTGCGCTGGGCTGATCGGCTGGCGATCGCTGAAGAAAGCAGGC
GAGGGCAAGCGCATCGGCCTTTATGGCTTTGGGGCTGCCGCACACATCATTGCGCAGGTCTGCCGCTGGCAGGACAGGGA
GGTTTACGCTTTCACAAAGCCCGGAGATACGGAAGCGAAAGATTTTGCGCGCAGCCTTGGCGCGGTATGGGCCGGAGATT
CAGATATTCTGCCGCCGTCACCGCTGGATGCAGCTATCATTTTCGCACCCGCCGGGGAGCTCGTTCCAGCCGCCTTGCGT
GCGGTGCGCAAGGGCGGCCGGGTGGTCTGCGGCGGCATCCATATGAGCGATATTCCATCCATGCCCTATTCGATCCTGTG
GGAAGAACGCGCGCTCGTTTCCGTCGCAAACCTCACCCGGAACGATGCAGAAGAGTTTTTCCCGCTTGCCCGCGCGGCAG
GCGTGCGCACTCACACCACAATCTACCCGCTTGAAAGTGCAAACGAGGCGCTCGCCGATCTGCGCTCCGGCCGCCTCAGC
GGGGCGGCTGTTCTTGTGCCATAG

Upstream 100 bases:

>100_bases
TGCCACACAATATCGCTCTTGACGGAAATCAACGCTCATCAGCTTTTATCAGGCCAAGATATAGCCAAGCAATTACGCAA
CTGTCGAAAGGCGAAAGATC

Downstream 100 bases:

>100_bases
CACGACAGCCGCACTCTTCGTGATGCCGGGCAGGAAAACAGCCTCAAGCAAACGGTTCCACAGGGCTTTTCGAGGGCAGG
GTGAACCATTTCGGACCATT

Product: zinc-binding alcohol dehydrogenase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MKAMVLEKPGQPLVLVERPDPLPGPGQIRLKVEACAVCRTDLHVVDGELERPKLPLVPGHEIVGVIDAVGTGVDPSRTGR
RVGVPWLGHTCGACDYCRSGAENLCDAPLFTGYTRDGGFATHVVADADFAFDLDEAADPVALAPLLCAGLIGWRSLKKAG
EGKRIGLYGFGAAAHIIAQVCRWQDREVYAFTKPGDTEAKDFARSLGAVWAGDSDILPPSPLDAAIIFAPAGELVPAALR
AVRKGGRVVCGGIHMSDIPSMPYSILWEERALVSVANLTRNDAEEFFPLARAAGVRTHTTIYPLESANEALADLRSGRLS
GAAVLVP

Sequences:

>Translated_327_residues
MKAMVLEKPGQPLVLVERPDPLPGPGQIRLKVEACAVCRTDLHVVDGELERPKLPLVPGHEIVGVIDAVGTGVDPSRTGR
RVGVPWLGHTCGACDYCRSGAENLCDAPLFTGYTRDGGFATHVVADADFAFDLDEAADPVALAPLLCAGLIGWRSLKKAG
EGKRIGLYGFGAAAHIIAQVCRWQDREVYAFTKPGDTEAKDFARSLGAVWAGDSDILPPSPLDAAIIFAPAGELVPAALR
AVRKGGRVVCGGIHMSDIPSMPYSILWEERALVSVANLTRNDAEEFFPLARAAGVRTHTTIYPLESANEALADLRSGRLS
GAAVLVP
>Mature_327_residues
MKAMVLEKPGQPLVLVERPDPLPGPGQIRLKVEACAVCRTDLHVVDGELERPKLPLVPGHEIVGVIDAVGTGVDPSRTGR
RVGVPWLGHTCGACDYCRSGAENLCDAPLFTGYTRDGGFATHVVADADFAFDLDEAADPVALAPLLCAGLIGWRSLKKAG
EGKRIGLYGFGAAAHIIAQVCRWQDREVYAFTKPGDTEAKDFARSLGAVWAGDSDILPPSPLDAAIIFAPAGELVPAALR
AVRKGGRVVCGGIHMSDIPSMPYSILWEERALVSVANLTRNDAEEFFPLARAAGVRTHTTIYPLESANEALADLRSGRLS
GAAVLVP

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI71743840, Length=204, Percent_Identity=26.4705882352941, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI262073058, Length=204, Percent_Identity=26.4705882352941, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI4501933, Length=206, Percent_Identity=28.1553398058252, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI34577061, Length=104, Percent_Identity=35.5769230769231, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI71565152, Length=104, Percent_Identity=31.7307692307692, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI4501929, Length=195, Percent_Identity=28.7179487179487, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI87081918, Length=343, Percent_Identity=30.9037900874636, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1787863, Length=222, Percent_Identity=34.6846846846847, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI87082401, Length=317, Percent_Identity=25.5520504731861, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1786518, Length=215, Percent_Identity=33.953488372093, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI1790045, Length=338, Percent_Identity=27.2189349112426, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI226510992, Length=124, Percent_Identity=31.4516129032258, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17562584, Length=339, Percent_Identity=27.1386430678466, Blast_Score=107, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI71988145, Length=334, Percent_Identity=25.4491017964072, Blast_Score=95, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17562582, Length=267, Percent_Identity=29.9625468164794, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17562876, Length=125, Percent_Identity=34.4, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17562878, Length=125, Percent_Identity=34.4, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6323961, Length=160, Percent_Identity=37.5, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6323729, Length=160, Percent_Identity=36.875, Blast_Score=112, Evalue=8e-26,
Organism=Saccharomyces cerevisiae, GI6324486, Length=160, Percent_Identity=36.25, Blast_Score=109, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6319621, Length=160, Percent_Identity=35, Blast_Score=101, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6323980, Length=154, Percent_Identity=35.0649350649351, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319949, Length=201, Percent_Identity=32.8358208955224, Blast_Score=82, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6320033, Length=97, Percent_Identity=35.0515463917526, Blast_Score=63, Evalue=6e-11,
Organism=Drosophila melanogaster, GI17737895, Length=110, Percent_Identity=32.7272727272727, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR014187
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 34647; Mature: 34647

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAMVLEKPGQPLVLVERPDPLPGPGQIRLKVEACAVCRTDLHVVDGELERPKLPLVPGH
CCCEEECCCCCCEEEEECCCCCCCCCCEEEEEEEEHHHHCCCEEECCCCCCCCCCCCCCH
EIVGVIDAVGTGVDPSRTGRRVGVPWLGHTCGACDYCRSGAENLCDAPLFTGYTRDGGFA
HHHHHHHHHCCCCCCCCCCCEECCCCCCCCCCHHHHHHCCHHHHCCCCCCCCCCCCCCEE
THVVADADFAFDLDEAADPVALAPLLCAGLIGWRSLKKAGEGKRIGLYGFGAAAHIIAQV
EEEEECCCCEEEHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHH
CRWQDREVYAFTKPGDTEAKDFARSLGAVWAGDSDILPPSPLDAAIIFAPAGELVPAALR
HCCCCCEEEEEECCCCCHHHHHHHHHHHEECCCCCCCCCCCCCEEEEEECCCHHHHHHHH
AVRKGGRVVCGGIHMSDIPSMPYSILWEERALVSVANLTRNDAEEFFPLARAAGVRTHTT
HHHCCCCEEECCCCCCCCCCCCHHHEEHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEE
IYPLESANEALADLRSGRLSGAAVLVP
EEECCCHHHHHHHHHCCCCCCEEEECC
>Mature Secondary Structure
MKAMVLEKPGQPLVLVERPDPLPGPGQIRLKVEACAVCRTDLHVVDGELERPKLPLVPGH
CCCEEECCCCCCEEEEECCCCCCCCCCEEEEEEEEHHHHCCCEEECCCCCCCCCCCCCCH
EIVGVIDAVGTGVDPSRTGRRVGVPWLGHTCGACDYCRSGAENLCDAPLFTGYTRDGGFA
HHHHHHHHHCCCCCCCCCCCEECCCCCCCCCCHHHHHHCCHHHHCCCCCCCCCCCCCCEE
THVVADADFAFDLDEAADPVALAPLLCAGLIGWRSLKKAGEGKRIGLYGFGAAAHIIAQV
EEEEECCCCEEEHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHH
CRWQDREVYAFTKPGDTEAKDFARSLGAVWAGDSDILPPSPLDAAIIFAPAGELVPAALR
HCCCCCEEEEEECCCCCHHHHHHHHHHHEECCCCCCCCCCCCCEEEEEECCCHHHHHHHH
AVRKGGRVVCGGIHMSDIPSMPYSILWEERALVSVANLTRNDAEEFFPLARAAGVRTHTT
HHHCCCCEEECCCCCCCCCCCCHHHEEHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEE
IYPLESANEALADLRSGRLSGAAVLVP
EEECCCHHHHHHHHHCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]